“Mitotic Slippage” and Extranuclear DNA in Cancer Chemoresistance: A Focus on Telomeres

Intratumor Heterogeneity and Therapy Resistance: Contributions of Dormancy, Apoptosis Reversal (Anastasis) and Cell Fusion to Disease Recurrence

(2020) Razmik Mirzayans et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Cancer Aneuploidy Paradox: In the Light of Evolution

(2019) Kristine Salmina et al.   Genes

Extranuclear DNA accumulates in aged cells and contributes to senescence and inflammation

(2019) Yuk Yuen Lan et al.   AGING CELL

All Eukaryotes Are Sexual, unless Proven Otherwise

(2019) Paulo G. Hofstatter et al.   BIOESSAYS

Polyploid Giant Cancer Cells (PGCCs): The Evil Roots of Cancer

(2019) Junsong Chen et al.   CURRENT CANCER DRUG TARGETS

Polyploid giant cancer cells: Unrecognized actuators of tumorigenesis, metastasis, and resistance

(2019) Sarah R. Amend et al.   PROSTATE

Connecting cancer relapse with senescence

(2019) Olivier Pluquet et al.   CANCER LETTERS

Senescence in polyploid giant cancer cells: A road that leads to chemoresistance

(2019) Deblina Bharadwaj et al.   CYTOKINE & GROWTH FACTOR REVIEWS

The Chromatin Extrusion Phenomenon in Amoeba proteus Cell Cycle

(2019) Andrew V. Goodkov et al.   JOURNAL OF EUKARYOTIC MICROBIOLOGY

Diversity of the Senescence Phenotype of Cancer Cells Treated with Chemotherapeutic Agents

(2019) Agnieszka Bojko et al.   Cells

Inverted meiosis and the evolution of sex by loss of complementation

(2019) Marco Archetti   JOURNAL OF EVOLUTIONARY BIOLOGY

A Distinct Oncogenerative Multinucleated Cancer Cell Serves as a Source of Stemness and Tumor Heterogeneity

(2018) David Díaz-Carballo et al.   CANCER RESEARCH

Telomere Length Maintenance in Cancer: At the Crossroad between Telomerase and Alternative Lengthening of Telomeres (ALT)

(2018) Marco De Vitis et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Chromosomal instability drives metastasis through a cytosolic DNA response

(2018) Samuel F. Bakhoum et al.   NATURE

The Dualistic Origin of Human Tumors

(2018) Jinsong Liu   SEMINARS IN CANCER BIOLOGY

Roles of Polyploid/Multinucleated Giant Cancer Cells in Metastasis and Disease Relapse Following Anticancer Treatment

(2018) et al.   Cancers

Shelterin-Mediated Telomere Protection

(2018) Titia de Lange   Annual Review of Genetics

Autophagy Governs Protumorigenic Effects of Mitotic Slippage–induced Senescence

(2018) Rekha Jakhar et al.   MOLECULAR CANCER RESEARCH

The reproductive life cycle of cancer: Hypotheses of cell of origin, TP53 drivers and stem cell conversions in the light of the atavistic cancer cell theory

(2018) Vladimir F. Niculescu   MEDICAL HYPOTHESES

Multinucleated Giant Cancer Cells Produced in Response to Ionizing Radiation Retain Viability and Replicate Their Genome

(2017) Razmik Mirzayans et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Senescence-associated reprogramming promotes cancer stemness

(2017) Maja Milanovic et al.   NATURE

Rare cell variability and drug-induced reprogramming as a mode of cancer drug resistance

(2017) Sydney M. Shaffer et al.   NATURE

Cytoplasmic chromatin triggers inflammation in senescence and cancer

(2017) Zhixun Dou et al.   NATURE

Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence

(2017) Selene Glück et al.   NATURE CELL BIOLOGY

Dedifferentiation into blastomere-like cancer stem cells via formation of polyploid giant cancer cells

(2017) N Niu et al.   ONCOGENE

Absolute measurement of gene transcripts with Selfie-digital PCR

(2017) Petar Podlesniy et al.   Scientific Reports

Conservation and Variability of Meiosis Across the Eukaryotes

(2016) Josef Loidl   Annual Review of Genetics

SQSTM1/p62 mediates crosstalk between autophagy and the UPS in DNA repair

(2016) Graeme Hewitt et al.   Autophagy

Morphological and Functional Characteristic of Senescent Cancer Cells

(2016) Ewa Sikora et al.   CURRENT DRUG TARGETS

Disentangling the aneuploidy and senescence paradoxes: a study of triploid breast cancers non-responsive to neoadjuvant therapy

(2016) B. I. Gerashchenko et al.   HISTOCHEMISTRY AND CELL BIOLOGY

OCT4 spliced variants are highly expressed in brain cancer tissues and inhibition of OCT4B1 causes G2/M arrest in brain cancer cells

(2016) Malek Hossein Asadi et al.   JOURNAL OF NEURO-ONCOLOGY

Telomere Length in Aged Mayak PA Nuclear Workers Chronically Exposed to Internal Alpha and External Gamma Radiation

(2016) Harry Scherthan et al.   RADIATION RESEARCH

Inverted meiosis and its place in the evolution of sexual reproduction pathways

(2016) Yu. F. Bogdanov   RUSSIAN JOURNAL OF GENETICS

Asexual Amoebae Escape Muller's Ratchet through Polyploidy

(2016) Sutherland K. Maciver   TRENDS IN PARASITOLOGY

Bafilomycin A1 triggers proliferative potential of senescent cancer cells in vitro and in NOD/SCID mice

(2016) Halina Was et al.   Oncotarget

Switch telomerase to ALT mechanism by inducing telomeric DNA damages and dysfunction of ATRX and DAXX

(2016) Yang Hu et al.   Scientific Reports

Role of stress-activated OCT4A in the cell fate decisions of embryonal carcinoma cells treated with etoposide

(2015) Anda Huna et al.   CELL CYCLE

Genome management and mismanagement—cell-level opportunities and challenges of whole-genome duplication

(2015) Levi Yant et al.   GENES & DEVELOPMENT

Autophagy mediates degradation of nuclear lamina

(2015) Zhixun Dou et al.   NATURE

Genome-wide maps of recombination and chromosome segregation in human oocytes and embryos show selection for maternal recombination rates

(2015) Christian S Ottolini et al.   NATURE GENETICS

Distinct predictive performance of Rac1 and Cdc42 in cell migration

(2015) Masataka Yamao et al.   Scientific Reports

Tumor Invasion Optimization by Mesenchymal-Amoeboid Heterogeneity

(2015) Inbal Hecht et al.   Scientific Reports

Is there evidence of sexual reproduction (meiosis) inAcanthamoeba?

(2015) Naveed A. Khan et al.   Pathogens and Global Health

Polyploidy Formation in Doxorubicin-Treated Cancer Cells Can Favor Escape from Senescence

(2015) Grazyna Mosieniak et al.   NEOPLASIA

ALT Telomeres Borrow from Meiosis to Get Moving

(2014) Nausica Arnoult et al.   CELL

Atypical Cell Populations Associated with Acquired Resistance to Cytostatics and Cancer Stem Cell Features: The Role of Mitochondria in Nuclear Encapsulation

(2014) David Díaz-Carballo et al.   DNA AND CELL BIOLOGY

Mitotic arrest and slippage induced by pharmacological inhibition of Polo-like kinase 1

(2014) Monika Raab et al.   Molecular Oncology

Synaptonemal Complex Protein 3 Is a Prognostic Marker in Cervical Cancer

(2014) Hanbyoul Cho et al.   PLoS One

Alternative meiotic chromatid segregation in the holocentric plant Luzula elegans

(2014) Stefan Heckmann et al.   Nature Communications

Dnase2a Deficiency Uncovers Lysosomal Clearance of Damaged Nuclear DNA via Autophagy

(2014) Yuk Yuen Lan et al.   Cell Reports

Three steps to the immortality of cancer cells: senescence, polyploidy and self-renewal

(2013) Jekaterina Erenpreisa et al.   Cancer Cell International

Invasion and genome reproduction of the trophoblast cells of placenta junctional zone in the field vole,Microtus rossiaemeridionalis

(2013) Tatiana G. Zybina et al.   CELL BIOLOGY INTERNATIONAL

DNA damage causes TP53-dependent coupling of self-renewal and senescence pathways in embryonal carcinoma cells

(2013) Thomas R. Jackson et al.   CELL CYCLE

Lysosome-mediated processing of chromatin in senescence

(2013) Andre Ivanov et al.   JOURNAL OF CELL BIOLOGY

Cystathionase mediates senescence evasion in melanocytes and melanoma cells

(2013) C Leikam et al.   ONCOGENE

Generation of cancer stem-like cells through the formation of polyploid giant cancer cells

(2013) S Zhang et al.   ONCOGENE

DNA Break Site at Fragile Subtelomeres Determines Probability and Mechanism of Antigenic Variation in African Trypanosomes

(2013) Lucy Glover et al.   PLoS Pathogens

Telomere-Driven Tetraploidization Occurs in Human Cells Undergoing Crisis and Promotes Transformation of Mouse Cells

(2012) Teresa Davoli et al.   CANCER CELL

Doxorubicin: an update on anticancer molecular action, toxicity and novel drug delivery systems

(2012) Oktay Tacar et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

PML body meets telomere

(2012) Inn Chung et al.   Nucleus

Telomere-independent functions of telomerase in nuclei, cytoplasm, and mitochondria

(2012) Ilaria Chiodi et al.   Frontiers in Oncology

Effects of chemical manipulation of mitotic arrest and slippage on cancer cell survival and proliferation

(2011) Jenna L. Riffell et al.   CELL CYCLE

The small GTPase Cdc42 promotes membrane protrusion during polar body emission via ARP2-nucleated actin polymerization

(2011) J. Leblanc et al.   MOLECULAR HUMAN REPRODUCTION

Twisted Epithelial-to-Mesenchymal Transition Promotes Progression of Surviving Bladder Cancer T24 Cells with hTERT-Dysfunction

(2011) Yan Xue et al.   PLoS One

TM9 and cannibalism: how to learn more about cancer by studying amoebae and invertebrates

(2011) Stefano Fais et al.   TRENDS IN MOLECULAR MEDICINE

Persistent Telomere Damage Induces Bypass of Mitosis and Tetraploidy

(2010) Teresa Davoli et al.   CELL

Up-regulation of the embryonic self-renewal network through reversible polyploidy in irradiated p53-mutant tumour cells

(2010) Kristine Salmina et al.   EXPERIMENTAL CELL RESEARCH

MOS, aneuploidy and the ploidy cycle of cancer cells

(2010) J Erenpreisa et al.   ONCOGENE

Activation of Meiosis-Specific Genes Is Associated with Depolyploidization of Human Tumor Cells following Radiation-Induced Mitotic Catastrophe

(2009) F. Ianzini et al.   CANCER RESEARCH

Control of telomere length by a trimming mechanism that involves generation of t-circles

(2009) Hilda A Pickett et al.   EMBO JOURNAL

The role of meiotic cohesin REC8 in chromosome segregation in γ irradiation-induced endopolyploid tumour cells

(2009) Jekaterina Erenpreisa et al.   EXPERIMENTAL CELL RESEARCH

How Shelterin Protects Mammalian Telomeres

(2008) Wilhelm Palm et al.   Annual Review of Genetics

Tumor cells can escape DNA-damaging cisplatin through DNA endoreduplication and reversible polyploidy

(2008) Pierre-Emmanuel Puig et al.   CELL BIOLOGY INTERNATIONAL

Local DNA underreplication correlates with accumulation of phosphorylated H2Av in the Drosophila melanogaster polytene chromosomes

(2008) E. N. Andreyeva et al.   CHROMOSOME RESEARCH

Induction of senescence with doxorubicin leads to increased genomic instability of HCT116 cells

(2008) Malgorzata A. Sliwinska et al.   MECHANISMS OF AGEING AND DEVELOPMENT

The Parasexual Cycle in Candida albicans Provides an Alternative Pathway to Meiosis for the Formation of Recombinant Strains

(2008) Anja Forche et al.   PLOS BIOLOGY