Cell cycle re-entry and arrest in G2/M phase induces senescence and fibrosis in Fuchs Endothelial Corneal Dystrophy

Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study

(2019) Jamie N. Justice et al.   EBioMedicine

Activation of PINK1-Parkin–Mediated Mitophagy Degrades Mitochondrial Quality Control Proteins in Fuchs Endothelial Corneal Dystrophy

(2019) Takashi Miyai et al.   AMERICAN JOURNAL OF PATHOLOGY

Loss of NQO1 generates genotoxic estrogen-DNA adducts in Fuchs Endothelial Corneal Dystrophy

(2019) Taiga Miyajima et al.   FREE RADICAL BIOLOGY AND MEDICINE

Ultraviolet A light induces DNA damage and estrogen-DNA adducts in Fuchs endothelial corneal dystrophy causing females to be more affected

(2019) Cailing Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NQO1 downregulation potentiates menadione-induced endothelial-mesenchymal transition during rosette formation in Fuchs endothelial corneal dystrophy

(2018) Kishore Reddy Katikireddy et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mechanisms and functions of cellular senescence

(2018) Nicolás Herranz et al.   JOURNAL OF CLINICAL INVESTIGATION

Fuchs Endothelial Corneal Dystrophy Through the Prism of Oxidative Stress

(2018) Ula V. Jurkunas   CORNEA

Senolytic drugs target alveolar epithelial cell function and attenuate experimental lung fibrosisex vivo

(2017) Mareike Lehmann et al.   EUROPEAN RESPIRATORY JOURNAL

Ultraviolet A-induced oxidation in cornea: Characterization of the early oxidation-related events

(2017) Corinne Zinflou et al.   FREE RADICAL BIOLOGY AND MEDICINE

Inhibition of Bcl-2/xl With ABT-263 Selectively Kills Senescent Type II Pneumocytes and Reverses Persistent Pulmonary Fibrosis Induced by Ionizing Radiation in Mice

(2017) Jin Pan et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

The DNA Damage Response in Neurons: Die by Apoptosis or Survive in a Senescence-Like State?

(2017) Edward Fielder et al.   JOURNAL OF ALZHEIMERS DISEASE

Cellular senescence mediates fibrotic pulmonary disease

(2017) Marissa J. Schafer et al.   Nature Communications

Menadione-Induced DNA Damage Leads to Mitochondrial Dysfunction and Fragmentation During Rosette Formation in Fuchs Endothelial Corneal Dystrophy

(2016) Adna Halilovic et al.   ANTIOXIDANTS & REDOX SIGNALING

Neuronal cell cycle: the neuron itself and its circumstances

(2015) José M Frade et al.   CELL CYCLE

Involvement of ZEB1 and Snail1 in excessive production of extracellular matrix in Fuchs endothelial corneal dystrophy

(2015) Naoki Okumura et al.   LABORATORY INVESTIGATION

Cellular senescence in aging and age-related disease: from mechanisms to therapy

(2015) Bennett G Childs et al.   NATURE MEDICINE

Epithelial-to-mesenchymal transition induces cell cycle arrest and parenchymal damage in renal fibrosis

(2015) Sara Lovisa et al.   NATURE MEDICINE

Cellular senescence and its effector programs

(2014) R. Salama et al.   GENES & DEVELOPMENT

Ultraviolet light and ocular diseases

(2013) Jason C. S. Yam et al.   INTERNATIONAL OPHTHALMOLOGY

Postmitotic neurons develop a p21-dependent senescence-like phenotype driven by a DNA damage response

(2012) Diana Jurk et al.   AGING CELL

Transforming Growth Factor β-1 Stimulates Profibrotic Epithelial Signaling to Activate Pericyte-Myofibroblast Transition in Obstructive Kidney Fibrosis

(2012) Ching-Fang Wu et al.   AMERICAN JOURNAL OF PATHOLOGY

Ultraviolet Light Transmission through the Human Corneal Stroma Is Reduced in the Periphery

(2012) James J. Doutch et al.   BIOPHYSICAL JOURNAL

Telomerase Immortalization of Human Corneal Endothelial Cells Yields Functional Hexagonal Monolayers

(2012) Thore Schmedt et al.   PLoS One

Evidence of Oxidative Stress in the Pathogenesis of Fuchs Endothelial Corneal Dystrophy

(2010) Ula V. Jurkunas et al.   AMERICAN JOURNAL OF PATHOLOGY

Epithelial cell cycle arrest in G2/M mediates kidney fibrosis after injury

(2010) Li Yang et al.   NATURE MEDICINE