Insight into the role of PIKK family members and NF-кB in DNAdamage-induced senescence and senescence-associated secretory phenotype of colon cancer cells

Morphological and Functional Characteristic of Senescent Cancer Cells

(2016) Ewa Sikora et al.   CURRENT DRUG TARGETS

Mitochondria are required for pro‐ageing features of the senescent phenotype

(2016) Clara Correia‐Melo et al.   EMBO JOURNAL

Hyperactivation of ATM upon DNA-PKcs inhibition modulates p53 dynamics and cell fate in response to DNA damage

(2016) Ana Finzel et al.   MOLECULAR BIOLOGY OF THE CELL

Cytokines shape chemotherapy-induced and ‘bystander' senescence

(2016) Zdenek Hodny et al.   Aging-US

Deciphering the role of Nuclear Factor-κB in cellular senescence

(2016) Simon Vaughan et al.   Aging-US

Screening of a kinase library reveals novel pro-senescence kinases and their common NF-κB-dependent transcriptional program

(2015) Mylène Ferrand et al.   Aging-US

MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation

(2015) Remi-Martin Laberge et al.   NATURE CELL BIOLOGY

Controlled induction of DNA double-strand breaks in the mouse liver induces features of tissue ageing

(2015) Ryan R. White et al.   Nature Communications

Polyploidy Formation in Doxorubicin-Treated Cancer Cells Can Favor Escape from Senescence

(2015) Grazyna Mosieniak et al.   NEOPLASIA

Preventing Damage Limitation: Targeting DNA-PKcs and DNA Double-Strand Break Repair Pathways for Ovarian Cancer Therapy

(2015) Daniela A. Dungl et al.   Frontiers in Oncology

DNA-Dependent Protein Kinase As Molecular Target for Radiosensitization of Neuroblastoma Cells

(2015) M. Emmy M. Dolman et al.   PLoS One

Depletion of ATR selectively sensitizes ATM-deficient human mammary epithelial cells to ionizing radiation and DNA-damaging agents

(2014) Yuxia Cui et al.   CELL CYCLE

DNA-PK inhibition by NU7441 sensitizes breast cancer cells to ionizing radiation and doxorubicin

(2013) Wojciech M. Ciszewski et al.   BREAST CANCER RESEARCH AND TREATMENT

A senescent cell bystander effect: senescence-induced senescence

(2012) Glyn Nelson et al.   AGING CELL

New Insights into p53 Signaling and Cancer Cell Response to DNA Damage: Implications for Cancer Therapy

(2012) Razmik Mirzayans et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

The catalytic subunit of DNA-dependent protein kinase is downstream of ATM and feeds forward oxidative stress in the selenium-induced senescence response

(2012) Caroline R.B. Rocourt et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Curcumin induces permanent growth arrest of human colon cancer cells: Link between senescence and autophagy

(2012) Grazyna Mosieniak et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Importance of PIKKs in NF-κB activation by genotoxic stress

(2011) Hélène Sabatel et al.   BIOCHEMICAL PHARMACOLOGY

Cancer stem cells and escape from drug-induced premature senescence in human lung tumor cells: Implications for drug resistance and in vitro drug screening models

(2011) Michal Sabisz et al.   CELL CYCLE

Emerging role of NF-κB signaling in the induction of senescence-associated secretory phenotype (SASP)

(2011) Antero Salminen et al.   CELLULAR SIGNALLING

p38MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory phenotype

(2011) Adam Freund et al.   EMBO JOURNAL

Control of the senescence-associated secretory phenotype by NF- B promotes senescence and enhances chemosensitivity

(2011) Y. Chien et al.   GENES & DEVELOPMENT

Inhibition of DNA-Dependent Protein Kinase Induces Accelerated Senescence in Irradiated Human Cancer Cells

(2011) A. Azad et al.   MOLECULAR CANCER RESEARCH

Activation of nuclear factor-kappa B signalling promotes cellular senescence

(2011) E Rovillain et al.   ONCOGENE

Impact of cellular senescence signature on ageing research

(2010) Ewa Sikora et al.   AGEING RESEARCH REVIEWS

A positive role for c-Abl in Atm and Atr activation in DNA damage response

(2010) X Wang et al.   CELL DEATH AND DIFFERENTIATION

Therapy-Induced Senescence in Cancer

(2010) Jonathan A. Ewald et al.   JNCI-Journal of the National Cancer Institute

Inflammatory networks during cellular senescence: causes and consequences

(2010) Adam Freund et al.   TRENDS IN MOLECULAR MEDICINE

Methotrexate-induced senescence in human adenocarcinoma cells is accompanied by induction of p21waf1/cip1 expression and lack of polyploidy

(2009) Magdalena Dabrowska et al.   CANCER LETTERS

Distinct roles of ATR and DNA-PKcs in triggering DNA damage responses in ATM-deficient cells

(2009) Nozomi Tomimatsu et al.   EMBO REPORTS

The combined status of ATM and p53 link tumor development with therapeutic response

(2009) H. Jiang et al.   GENES & DEVELOPMENT

Mitochondrial Dysfunction Contributes to Oncogene-Induced Senescence

(2009) O. Moiseeva et al.   MOLECULAR AND CELLULAR BIOLOGY

Essential Role for DNA-PKcs in DNA Double-Strand Break Repair and Apoptosis in ATM-Deficient Lymphocytes

(2009) Elsa Callén et al.   MOLECULAR CELL

Single-Stranded DNA Orchestrates an ATM-to-ATR Switch at DNA Breaks

(2009) Bunsyo Shiotani et al.   MOLECULAR CELL

The DNA-damage response in human biology and disease

(2009) Stephen P. Jackson et al.   NATURE

Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion

(2009) Francis Rodier et al.   NATURE CELL BIOLOGY

Accelerated senescence: An emerging role in tumor cell response to chemotherapy and radiation

(2008) David A. Gewirtz et al.   BIOCHEMICAL PHARMACOLOGY

Ataxia Telangiectasia Mutated and p21CIP1 Modulate Cell Survival of Drug-Induced Senescent Tumor Cells: Implications for Chemotherapy

(2008) E. Crescenzi et al.   CLINICAL CANCER RESEARCH

Modulation of Cellular Response to Anticancer Treatment by Caffeine: Inhibition of Cell Cycle Checkpoints, DNA Repair and More

(2008) Michal Sabisz et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Induction of senescence with doxorubicin leads to increased genomic instability of HCT116 cells

(2008) Malgorzata A. Sliwinska et al.   MECHANISMS OF AGEING AND DEVELOPMENT

p53 stabilization in response to DNA damage requires Akt/PKB and DNA-PK

(2008) K. A. Boehme et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA