Therapy-Induced Senescence: An “Old” Friend Becomes the Enemy

Dasatinib plus quercetin prevents uterine age-related dysfunction and fibrosis in mice

(2020) Marcelo B. Cavalcante et al.   Aging-US

Targeted Reduction of Senescent Cell Burden Alleviates Focal Radiotherapy‐Related Bone Loss

(2020) Abhishek Chandra et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Pharmacological or genetic depletion of senescent astrocytes prevents whole brain irradiation–induced impairment of neurovascular coupling responses protecting cognitive function in mice

(2020) Andriy Yabluchanskiy et al.   GeroScience

Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis

(2019) Mikolaj Ogrodnik et al.   Cell Metabolism

HER2-Targeted Tyrosine Kinase Inhibitors Cause Therapy-Induced-Senescence in Breast Cancer Cells

(2019) Martina S.J. McDermott et al.   Cancers

Senolytics and senostatics as adjuvant tumour therapy

(2019) Susan Short et al.   EBioMedicine

Metabolic gene NR4A1 as a potential therapeutic target for non-smoking female non-small cell lung cancer patients

(2019) Rong Sun et al.   Thoracic Cancer

Gene expression profiling of homologous recombination repair pathway indicates susceptibility for olaparib treatment in malignant pleural mesothelioma in vitro

(2019) Sabrina Borchert et al.   BMC CANCER

The mTORC1-autophagy pathway is a target for senescent cell elimination

(2019) Olena Kucheryavenko et al.   BIOGERONTOLOGY

The curcumin analog EF24 is a novel senolytic agent

(2019) Wen Li et al.   Aging-US

Pharmacological clearance of senescent cells improves survival and recovery in aged mice following acute myocardial infarction

(2019) Anna Walaszczyk et al.   AGING CELL

A cmap-enabled gene expression signature-matching approach identifies small-molecule inducers of accelerated cell senescence

(2019) Ding Wu et al.   BMC GENOMICS

Senolytic therapy alleviates Aβ-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer’s disease model

(2019) Peisu Zhang et al.   NATURE NEUROSCIENCE

Curcumin and o-Vanillin Exhibit Evidence of Senolytic Activity in Human IVD Cells In Vitro

(2019) Hosni Cherif et al.   Journal of Clinical Medicine

Dasatinib can Impair Left Ventricular Mechanical Function But May Lack Proarrhythmic Effect: A Proposal of Non-clinical Guidance for Predicting Clinical Cardiovascular Adverse Events of Tyrosine Kinase Inhibitors

(2019) Hiroko Izumi-Nakaseko et al.   Cardiovascular Toxicology

Acceleration of β Cell Aging Determines Diabetes and Senolysis Improves Disease Outcomes

(2019) Cristina Aguayo-Mazzucato et al.   Cell Metabolism

Regulation of Survival Networks in Senescent Cells: From Mechanisms to Interventions

(2019) Abel Soto-Gamez et al.   JOURNAL OF MOLECULAR BIOLOGY

Exploiting interconnected synthetic lethal interactions between PARP inhibition and cancer cell reversible senescence

(2019) Hubert Fleury et al.   Nature Communications

Fibrates as drugs with senolytic and autophagic activity for osteoarthritis therapy

(2019) Uxía Nogueira-Recalde et al.   EBioMedicine

Effects of quercetin and rosuvastatin each alone or in combination on cyclophosphamide-induced premature ovarian failure in female albino mice

(2019) MA Elkady et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Chemotherapy-induced senescent cancer cells engulf other cells to enhance their survival

(2019) Crystal A. Tonnessen-Murray et al.   JOURNAL OF CELL BIOLOGY

Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease

(2019) LaTonya J. Hickson et al.   EBioMedicine

Cellular Senescence: Defining a Path Forward

(2019) Vassilis Gorgoulis et al.   CELL

Identification and characterization of Cardiac Glycosides as senolytic compounds

(2019) Francisco Triana-Martínez et al.   Nature Communications

Diversity of the Senescence Phenotype of Cancer Cells Treated with Chemotherapeutic Agents

(2019) Agnieszka Bojko et al.   Cells

HSP90 inhibition targets autophagy and induces a CASP9-dependent resistance mechanism in NSCLC

(2018) Jie Han et al.   Autophagy

Thermal proteome profiling of breast cancer cells reveals proteasomal activation by CDK4/6 inhibitor palbociclib

(2018) Teemu P Miettinen et al.   EMBO JOURNAL

A versatile drug delivery system targeting senescent cells

(2018) Daniel Muñoz‐Espín et al.   EMBO Molecular Medicine

Long-term treatment with anti-VEGF does not induce cell aging in primary retinal pigment epithelium

(2018) Johann Schottler et al.   EXPERIMENTAL EYE RESEARCH

Autophagic cell death and premature senescence: New mechanism of 5-fluorouracil and sulforaphane synergistic anticancer effect in MDA-MB-231 triple negative breast cancer cell line

(2018) Małgorzata Milczarek et al.   FOOD AND CHEMICAL TOXICOLOGY

Dexamethasone alleviates pemetrexed-induced senescence in Non-Small-Cell Lung Cancer

(2018) Haiyan Ge et al.   FOOD AND CHEMICAL TOXICOLOGY

Senolytics improve physical function and increase lifespan in old age

(2018) Ming Xu et al.   NATURE MEDICINE

Hallmarks of Cellular Senescence

(2018) Alejandra Hernandez-Segura et al.   TRENDS IN CELL BIOLOGY

Senescence-associated secretory factors induced by cisplatin in melanoma cells promote non-senescent melanoma cell growth through activation of the ERK1/2-RSK1 pathway

(2018) Xuerong Sun et al.   Cell Death & Disease

Oncodriver inhibition and CD4+ Th1 cytokines cooperate through Stat1 activation to induce tumor senescence and apoptosis in HER2+ and triple negative breast cancer: implications for combining immune and targeted therapies

(2018) Cinthia Rosemblit et al.   Oncotarget

Novel drug-resistance mechanisms of pemetrexed-treated non-small cell lung cancer

(2018) Ryosuke Tanino et al.   Oncotarget

CDK4/6 inhibition as maintenance and combination therapy for high grade serous ovarian cancer

(2018) Mangala Iyengar et al.   Oncotarget

Effects of senolytic drugs on human mesenchymal stromal cells

(2018) Clara Grezella et al.   Stem Cell Research & Therapy

Non-Cell Autonomous Effects of the Senescence-Associated Secretory Phenotype in Cancer Therapy

(2018) Tareq Saleh et al.   Frontiers in Oncology

Tau protein aggregation is associated with cellular senescence in the brain

(2018) Nicolas Musi et al.   AGING CELL

Ageing, Cellular Senescence and Neurodegenerative Disease

(2018) Marios Kritsilis et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Application of ex-vivo spheroid model system for the analysis of senescence and senolytic phenotypes in uterine leiomyoma

(2018) Jia Xie et al.   LABORATORY INVESTIGATION

The Senescence–Stemness Alliance – A Cancer-Hijacked Regeneration Principle

(2018) Maja Milanovic et al.   TRENDS IN CELL BIOLOGY

Acquired resistance to BRAFi reverses senescence-like phenotype in mutant BRAF melanoma

(2018) Mohammad Krayem et al.   Oncotarget

Fisetin is a senotherapeutic that extends health and lifespan

(2018) Matthew J. Yousefzadeh et al.   EBioMedicine

The bystander effect contributes to the accumulation of senescent cells in vivo

(2018) Paulo F. L. da Silva et al.   AGING CELL

Azithromycin and Roxithromycin define a new family of “senolytic” drugs that target senescent human fibroblasts

(2018) Bela Ozsvari et al.   Aging-US

Methotrexate-induced senescence of human colon cancer cells depends on p53 acetylation, but not genomic aberrations

(2018) Magdalena Dabrowska et al.   ANTI-CANCER DRUGS

Tumor cell escape from therapy-induced senescence

(2018) Tareq Saleh et al.   BIOCHEMICAL PHARMACOLOGY

Epigallocatechin gallate suppresses premature senescence of preadipocytes by inhibition of PI3K/Akt/mTOR pathway and induces senescent cell death by regulation of Bax/Bcl-2 pathway

(2018) Ravi Kumar et al.   BIOGERONTOLOGY

Temozolomide Induces Senescence and Repression of DNA Repair Pathways in Glioblastoma Cells via Activation of ATR–CHK1, p21, and NF-κB

(2018) Dorthe Aasland et al.   CANCER RESEARCH

Targeting BCL-xL improves the efficacy of bromodomain and extra-terminal protein inhibitors in triple-negative breast cancer by eliciting the death of senescent cells

(2018) Sylvia S. Gayle et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Whole-exome sequencing reveals novel genetic variants associated with diverse phenotypes of melanoma cells

(2018) Mariusz L. Hartman et al.   MOLECULAR CARCINOGENESIS

NK cell–mediated cytotoxicity contributes to tumor control by a cytostatic drug combination

(2018) Marcus Ruscetti et al.   SCIENCE

Senolytic Cocktail Dasatinib+Quercetin (D+Q) Does Not Enhance the Efficacy of Senescence-Inducing Chemotherapy in Liver Cancer

(2018) Kristina Kovacovicova et al.   Frontiers in Oncology

Senolytic drugs target alveolar epithelial cell function and attenuate experimental lung fibrosisex vivo

(2017) Mareike Lehmann et al.   EUROPEAN RESPIRATORY JOURNAL

Palbociclib-induced autophagy and senescence in gastric cancer cells

(2017) Claudio A. Valenzuela et al.   EXPERIMENTAL CELL RESEARCH

mTOR as Regulator of Lifespan, Aging, and Cellular Senescence: A Mini-Review

(2017) Thomas Weichhart   GERONTOLOGY

Antioxidant and Anti-Senescence Effect of Metformin on Mouse Olfactory Ensheathing Cells (mOECs) May Be Associated with Increased Brain-Derived Neurotrophic Factor Levels—An Ex Vivo Study

(2017) Agnieszka Śmieszek et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Inhibition of Bcl-2/xl With ABT-263 Selectively Kills Senescent Type II Pneumocytes and Reverses Persistent Pulmonary Fibrosis Induced by Ionizing Radiation in Mice

(2017) Jin Pan et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Vinblastine and antihelmintic mebendazole potentiate temozolomide in resistant gliomas

(2017) Franciele Cristina Kipper et al.   INVESTIGATIONAL NEW DRUGS

Stimulation of cellular senescent processes, including secretory phenotypes and anti-oxidant responses, after androgen deprivation therapy in human prostate cancer

(2017) Hirotoshi Kawata et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Senescence-associated reprogramming promotes cancer stemness

(2017) Maja Milanovic et al.   NATURE

cGAS is essential for cellular senescence

(2017) Hui Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nucleus accumbens-1/GADD45GIP1 axis mediates cisplatin resistance through cellular senescence in ovarian cancer

(2017) Kentaro Nakayama et al.   Oncology Letters

Cellular senescence mediates fibrotic pulmonary disease

(2017) Marissa J. Schafer et al.   Nature Communications

Identification of HSP90 inhibitors as a novel class of senolytics

(2017) Heike Fuhrmann-Stroissnigg et al.   Nature Communications

Cellular senescence drives age-dependent hepatic steatosis

(2017) Mikolaj Ogrodnik et al.   Nature Communications

Preclinical characterization of abemaciclib in hormone receptor positive breast cancer

(2017) Raquel Torres-Guzmán et al.   Oncotarget

High-Throughput Functional Genetic and Compound Screens Identify Targets for Senescence Induction in Cancer

(2017) Liqin Wang et al.   Cell Reports

Cellular senescence in the aging and diseased kidney

(2017) F. A. Valentijn et al.   Journal of Cell Communication and Signaling

A Novel Indication for Panobinostat as a Senolytic Drug in NSCLC and HNSCC

(2017) Leleesha Samaraweera et al.   Scientific Reports

Small molecule compounds that induce cellular senescence

(2016) Nadezhda V. Petrova et al.   AGING CELL

Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice

(2016) Carolyn M. Roos et al.   AGING CELL

Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors

(2016) Yi Zhu et al.   AGING CELL

Discovery of piperlongumine as a potential novel lead for the development of senolytic agents

(2016) Yingying Wang et al.   Aging-US

Effects of 5-Aza-2'-Deoxycytidine, Bromodeoxyuridine, Interferons and Hydrogen Peroxide on Cellular Senescence in Cholangiocarcinoma Cells

(2016) Benchamart Moolmuang et al.   Asian Pacific Journal of Cancer Prevention

Autophagy impairment with lysosomal and mitochondrial dysfunction is an important characteristic of oxidative stress-induced senescence

(2016) Haoran Tai et al.   Autophagy

How autophagy both activates and inhibits cellular senescence

(2016) Chanhee Kang et al.   Autophagy

Gemcitabine induces cell senescence in human pancreatic cancer cell lines

(2016) Yao Song et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Induction of Therapeutic Senescence in Vemurafenib-Resistant Melanoma by Extended Inhibition of CDK4/6

(2016) A. Yoshida et al.   CANCER RESEARCH

Palbociclib (PD-0332991), a selective CDK4/6 inhibitor, restricts tumour growth in preclinical models of hepatocellular carcinoma

(2016) Julien Bollard et al.   GUT

Intermittent Administration of Rapamycin Extends the Life Span of Female C57BL/6J Mice

(2016) Sebastian I. Arriola Apelo et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Stromal Senescence By Prolonged CDK4/6 Inhibition Potentiates Tumor Growth

(2016) Xiangnan Guan et al.   MOLECULAR CANCER RESEARCH

CD20-Targeting Immunotherapy Promotes Cellular Senescence in B-Cell Lymphoma

(2016) J. H. M. Da britz et al.   MOLECULAR CANCER THERAPEUTICS

Radiosensitization by PARP Inhibition in DNA Repair Proficient and Deficient Tumor Cells: Proliferative Recovery in Senescent Cells

(2016) Moureq Alotaibi et al.   RADIATION RESEARCH

Tumor Cell Recovery from Senescence Induced by Radiation with PARP Inhibition

(2016) David A. Gewirtz et al.   RADIATION RESEARCH

Senescent intimal foam cells are deleterious at all stages of atherosclerosis

(2016) B. G. Childs et al.   SCIENCE

Tissue damage and senescence provide critical signals for cellular reprogramming in vivo

(2016) Lluc Mosteiro et al.   SCIENCE

Senescence-associated secretory phenotype contributes to pathological angiogenesis in retinopathy

(2016) M. Oubaha et al.   Science Translational Medicine

Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse

(2016) Marco Demaria et al.   Cancer Discovery

Detection of cellular senescence within human invasive breast carcinomas distinguishes different breast tumor subtypes

(2016) Cristina L. Cotarelo et al.   Oncotarget

Axitinib induces senescence-associated cell death and necrosis in glioma cell lines: The proteasome inhibitor, bortezomib, potentiates axitinib-induced cytotoxicity in a p21(Waf/Cip1) dependent manner

(2016) Maria Beatrice Morelli et al.   Oncotarget

Bafilomycin A1 triggers proliferative potential of senescent cancer cells in vitro and in NOD/SCID mice

(2016) Halina Was et al.   Oncotarget

Hypermethylation of the HIC1 promoter and aberrant expression of HIC1/SIRT1 contribute to the development of thyroid papillary carcinoma

(2016) Wenyi Wu et al.   Oncotarget

Natural killer cell recognition of in vivo drug-induced senescent multiple myeloma cells

(2016) Fabrizio Antonangeli et al.   OncoImmunology

Identification of cellular senescence-specific genes by comparative transcriptomics

(2016) Taiki Nagano et al.   Scientific Reports

The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs

(2015) Yi Zhu et al.   AGING CELL

EGFR-independent autophagy induction with gefitinib and enhancement of its cytotoxic effect by targeting autophagy with clarithromycin in non-small cell lung cancer cells

(2015) Shohei Sugita et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Clinical strategies and animal models for developing senolytic agents

(2015) James L. Kirkland et al.   EXPERIMENTAL GERONTOLOGY

Connecting the Dots: Therapy-Induced Senescence and a Tumor-Suppressive Immune Microenvironment

(2015) Anna E. Vilgelm et al.   JNCI-Journal of the National Cancer Institute

mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype

(2015) Nicolás Herranz et al.   NATURE CELL BIOLOGY

Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice

(2015) Jianhui Chang et al.   NATURE MEDICINE

Cellular senescence in aging and age-related disease: from mechanisms to therapy

(2015) Bennett G Childs et al.   NATURE MEDICINE

Synthetic lethal targeting of oncogenic transcription factors in acute leukemia by PARP inhibitors

(2015) Maria Teresa Esposito et al.   NATURE MEDICINE

Mechanism of heat stress-induced cellular senescence elucidates the exclusive vulnerability of early S-phase cells to mild genotoxic stress

(2015) Artem K. Velichko et al.   NUCLEIC ACIDS RESEARCH

Paclitaxel targets FOXM1 to regulate KIF20A in mitotic catastrophe and breast cancer paclitaxel resistance

(2015) P Khongkow et al.   ONCOGENE

CCAAT/Enhancer binding protein β controls androgen-deprivation-induced senescence in prostate cancer cells

(2015) D J Barakat et al.   ONCOGENE

Efficacy of CDK4 inhibition against sarcomas depends on their levels of CDK4 and p16ink4 mRNA

(2015) Marco Perez et al.   Oncotarget

Metronomic topotecan impedes tumor growth of MYCN-amplified neuroblastoma cells in vitro and in vivo by therapy induced senescence

(2015) Sabine Taschner-Mandl et al.   Oncotarget

Dasatinib induces DNA damage and activates DNA repair pathways leading to senescence in non-small cell lung cancer cell lines with kinase-inactivating BRAF mutations

(2015) Shaohua Peng et al.   Oncotarget

A multi-stage process including transient polyploidization and EMT precedes the emergence of chemoresistent ovarian carcinoma cells with a dedifferentiated and pro-inflammatory secretory phenotype

(2015) Verena Rohnalter et al.   Oncotarget

MDM2 turnover and expression of ATRX determine the choice between quiescence and senescence in response to CDK4 inhibition

(2015) Marta Kovatcheva et al.   Oncotarget

Connecting the Dots: Therapy-Induced Senescence and a Tumor-Suppressive Immune Microenvironment

(2015) Anna E. Vilgelm et al.   JNCI-Journal of the National Cancer Institute

Polyploidy Formation in Doxorubicin-Treated Cancer Cells Can Favor Escape from Senescence

(2015) Grazyna Mosieniak et al.   NEOPLASIA

Secretome from senescent melanoma engages the STAT3 pathway to favor reprogramming of naive melanoma towards a tumor-initiating cell phenotype.

(2015) Mickaël Ohanna et al.   Oncotarget

Senescence of tumor cells induced by oxaliplatin increases the efficiency of a lipid A immunotherapy via the recruitment of neutrophils

(2015) Cédric Seignez et al.   Oncotarget

Autophagy inhibition switches low-dose camptothecin-induced premature senescence to apoptosis in human colorectal cancer cells

(2014) Jian-wei Zhang et al.   BIOCHEMICAL PHARMACOLOGY

Fulvestrant treatment alters MDM2 protein turnover and sensitivity of human breast carcinoma cells to chemotherapeutic drugs

(2014) Sonia C. Dolfi et al.   CANCER LETTERS

Busulfan inhibits growth of human osteosarcoma through miR-200 family microRNAsin vitroandin vivo

(2014) Qiang Mei et al.   CANCER SCIENCE

Geroconversion: irreversible step to cellular senescence

(2014) Mikhail V Blagosklonny   CELL CYCLE

Sustained activation of DNA damage response in irradiated apoptosis-resistant cells induces reversible senescence associated with mTOR downregulation and expression of stem cell markers

(2014) Zhanna V Chitikova et al.   CELL CYCLE

Tumour-infiltrating Gr-1+ myeloid cells antagonize senescence in cancer

(2014) Diletta Di Mitri et al.   NATURE

Cisplatin-induced senescence in ovarian cancer cells is mediated by GRP78

(2014) WEI LI et al.   ONCOLOGY REPORTS

Enhancing Chemotherapy Efficacy in Pten -Deficient Prostate Tumors by Activating the Senescence-Associated Antitumor Immunity

(2014) Alberto Toso et al.   Cell Reports

Combining the pan-aurora kinase inhibitor AMG 900 with histone deacetylase inhibitors enhances antitumor activity in prostate cancer

(2014) Channing J. Paller et al.   Cancer Medicine

Reactive oxygen species generation is essential for cisplatininduced accelerated senescence in hepatocellular carcinoma

(2014) Kai Qu et al.   Frontiers of Medicine

Metformin inhibits the senescence-associated secretory phenotype by interfering with IKK/NF-κB activation

(2013) Olga Moiseeva et al.   AGING CELL

Autophagy and senescence

(2013) David A. Gewirtz   Autophagy

Immunosurveillance of senescent cells: the bright side of the senescence program

(2013) Adi Sagiv et al.   BIOGERONTOLOGY

Three steps to the immortality of cancer cells: senescence, polyploidy and self-renewal

(2013) Jekaterina Erenpreisa et al.   Cancer Cell International

Vemurafenib Induces Senescence Features in Melanoma Cells

(2013) Sebastian Haferkamp et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Premature senescence in human breast cancer and colon cancer cells by tamoxifen-mediated reactive oxygen species generation

(2013) Young-Hoon Lee et al.   LIFE SCIENCES

Preclinical FLT-PET and FDG-PET imaging of tumor response to the multi-targeted Aurora B kinase inhibitor, TAK-901

(2013) Carleen Cullinane et al.   NUCLEAR MEDICINE AND BIOLOGY

Androgen Deprivation-Induced Senescence Promotes Outgrowth of Androgen-Refractory Prostate Cancer Cells

(2013) Dominick G. A. Burton et al.   PLoS One

PARP Inhibition Sensitizes to Low Dose-Rate Radiation TMPRSS2-ERG Fusion Gene-Expressing and PTEN-Deficient Prostate Cancer Cells

(2013) Payel Chatterjee et al.   PLoS One

Anti-tumor activity of obinutuzumab and rituximab in a follicular lymphoma 3D model

(2013) E Decaup et al.   Blood Cancer Journal

A senescent cell bystander effect: senescence-induced senescence

(2012) Glyn Nelson et al.   AGING CELL

Therapeutic Ranges of Serum Digoxin Concentrations in Patients With Heart Failure

(2012) Zachary D. Goldberger et al.   AMERICAN JOURNAL OF CARDIOLOGY

Aging, Cellular Senescence, and Cancer

(2012) Judith Campisi   Annual Review of Physiology

Negative regulation of transcription factor FoxM1 by p53 enhances oxaliplatin-induced senescence in hepatocellular carcinoma

(2012) Kai Qu et al.   CANCER LETTERS

Mesenchymal stem cells derived from different origins have unique sensitivities to different chemotherapeutic agents

(2012) Zhengyu Qi et al.   CELL BIOLOGY INTERNATIONAL

Persistent DNA damage caused by low levels of mitomycin C induces irreversible cell senescence

(2012) Elise McKenna et al.   CELL CYCLE

Targeting aurora kinases limits tumour growth through DNA damage-mediated senescence and blockade of NF-κB impairs this drug-induced senescence

(2012) Yan Liu et al.   EMBO Molecular Medicine

Polyploidy road to therapy-induced cellular senescence and escape

(2012) Qin Wang et al.   INTERNATIONAL JOURNAL OF CANCER

Induction of Cellular Senescence by Doxorubicin Is Associated with Upregulated miR-375 and Induction of Autophagy in K562 Cells

(2012) Ming-Yu Yang et al.   PLoS One

Sensitive Detection and Monitoring of Senescence-Associated Secretory Phenotype by SASP-RAP Assay

(2012) Liubao Gu et al.   PLoS One

Androgen deprivation induces senescence characteristics in prostate cancer cells in vitro and in vivo

(2012) Jonathan A. Ewald et al.   PROSTATE

Kinase-Impaired BRAF Mutations in Lung Cancer Confer Sensitivity to Dasatinib

(2012) B. Sen et al.   Science Translational Medicine

Apoptosis and autophagy have opposite roles on imatinib-induced K562 leukemia cell senescence

(2012) C Drullion et al.   Cell Death & Disease

A Systematic Screen for CDK4/6 Substrates Links FOXM1 Phosphorylation to Senescence Suppression in Cancer Cells

(2011) Lars Anders et al.   CANCER CELL

Cetuximab enhances the activities of irinotecan on gastric cancer cell lines through downregulating the EGFR pathway upregulated by irinotecan

(2011) Xin Liu et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

EGF Receptor Inhibition Radiosensitizes NSCLC Cells by Inducing Senescence in Cells Sustaining DNA Double-Strand Breaks

(2011) M. Wang et al.   CANCER RESEARCH

Cancer stem cells and escape from drug-induced premature senescence in human lung tumor cells: Implications for drug resistance and in vitro drug screening models

(2011) Michal Sabisz et al.   CELL CYCLE

Novel senescence associated gene, YPEL3, is repressed by estrogen in ER+ mammary tumor cells and required for tamoxifen-induced cellular senescence

(2011) Rebecca Tuttle et al.   INTERNATIONAL JOURNAL OF CANCER

Inhibition of VEGF induces cellular senescence in colorectal cancer cells

(2011) Mohammad R. Hasan et al.   INTERNATIONAL JOURNAL OF CANCER

Drug-induced Senescence Generates Chemoresistant Stemlike Cells with Low Reactive Oxygen Species

(2011) Santhi Achuthan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

(2011) Darren J. Baker et al.   NATURE

Functional gene expression profile underlying methotrexate-induced senescence in human colon cancer cells

(2011) Magdalena Dabrowska et al.   TUMOR BIOLOGY

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

Synergistic effect of mTOR inhibitor rapamycin and fluorouracil in inducing apoptosis and cell senescence in hepatocarcinoma cells

(2010) Xinxin Bu et al.   CANCER BIOLOGY & THERAPY

A chemotherapy-associated senescence bystander effect in breast cancer cells

(2010) Xu Di et al.   CANCER BIOLOGY & THERAPY

A Synthetic Lethal Interaction between K-Ras Oncogenes and Cdk4 Unveils a Therapeutic Strategy for Non-small Cell Lung Carcinoma

(2010) Marta Puyol et al.   CANCER CELL

Pharmacologic Inhibition of Cyclin-Dependent Kinases 4 and 6 Arrests the Growth of Glioblastoma Multiforme Intracranial Xenografts

(2010) K. Michaud et al.   CANCER RESEARCH

New biomarkers probing depth of cell senescence assessed by laser scanning cytometry

(2010) Hong Zhao et al.   CYTOMETRY PART A

Survivin and escaping in therapy-induced cellular senescence

(2010) Qin Wang et al.   INTERNATIONAL JOURNAL OF CANCER

Therapy-Induced Senescence in Cancer

(2010) Jonathan A. Ewald et al.   JNCI-Journal of the National Cancer Institute

MLN8054, an Inhibitor of Aurora A Kinase, Induces Senescence in Human Tumor Cells Both In vitro and In vivo

(2010) J. J. Huck et al.   MOLECULAR CANCER RESEARCH

SIRT1 Negatively Regulates the Mammalian Target of Rapamycin

(2010) Hiyaa Singhee Ghosh et al.   PLoS One

BMP4-Smad Signaling Pathway Mediates Adriamycin-induced Premature Senescence in Lung Cancer Cells

(2009) Dongmei Su et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sirolimus and Everolimus Induce Endothelial Cellular Senescence Via Sirtuin 1 Down-Regulation

(2009) Hidetaka Ota et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Ceramide Regulates Gemcitabine-Induced Senescence and Apoptosis in Human Pancreatic Cancer Cell Lines

(2009) D. E. Modrak et al.   MOLECULAR CANCER RESEARCH

Temozolomide and carmustine cause large-scale heterochromatin reorganization in glioma cells

(2008) Roberto Papait et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Accelerated senescence: An emerging role in tumor cell response to chemotherapy and radiation

(2008) David A. Gewirtz et al.   BIOCHEMICAL PHARMACOLOGY

Drug-induced senescence bystander proliferation in prostate cancer cells in vitro and in vivo

(2008) J A Ewald et al.   BRITISH JOURNAL OF CANCER

Oncogene-Induced Senescence Relayed by an Interleukin-Dependent Inflammatory Network

(2008) Thomas Kuilman et al.   CELL

Tumor cells can escape DNA-damaging cisplatin through DNA endoreduplication and reversible polyploidy

(2008) Pierre-Emmanuel Puig et al.   CELL BIOLOGY INTERNATIONAL

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

(2008) Jean-Philippe Coppé et al.   PLOS BIOLOGY