Therapy-induced polyploidization and senescence: Coincidence or interconnection?

Poly‐aneuploid cancer cells promote evolvability, generating lethal cancer

(2020) Kenneth J. Pienta et al.   Evolutionary Applications

Intratumor Heterogeneity and Therapy Resistance: Contributions of Dormancy, Apoptosis Reversal (Anastasis) and Cell Fusion to Disease Recurrence

(2020) Razmik Mirzayans et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing

(2020) Isidro Cortés-Ciriano et al.   NATURE GENETICS

Deciphering the Molecular Mechanism of Spontaneous Senescence in Primary Epithelial Ovarian Cancer Cells

(2020) Martyna Pakuła et al.   Cancers

“Mitotic Slippage” and Extranuclear DNA in Cancer Chemoresistance: A Focus on Telomeres

(2020) Kristine Salmina et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Senescent Cells: Emerging Targets for Human Aging and Age-Related Diseases

(2020) Shuling Song et al.   TRENDS IN BIOCHEMICAL SCIENCES

Reducing Senescent Cell Burden in Aging and Disease

(2020) Robert J. Pignolo et al.   TRENDS IN MOLECULAR MEDICINE

Therapy-Induced Senescence: An “Old” Friend Becomes the Enemy

(2020) Tareq Saleh et al.   Cancers

The Premature Senescence in Breast Cancer Treatment Strategy

(2020) Małgorzata Milczarek   Cancers

Senescence and Cancer: A Review of Clinical Implications of Senescence and Senotherapies

(2020) Lynda Wyld et al.   Cancers

Improved Autophagic Flux in Escapers from Doxorubicin-Induced Senescence/Polyploidy of Breast Cancer Cells

(2020) Agnieszka Bojko et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cancer regeneration: Polyploid cells are the key drivers of tumor progression

(2020) Shiva Moein et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Regulation of senescence escape by TSP1 and CD47 following chemotherapy treatment

(2019) Jordan Guillon et al.   Cell Death & Disease

Length‐independent telomere damage drives post‐mitotic cardiomyocyte senescence

(2019) Rhys Anderson et al.   EMBO JOURNAL

Excessive Cell Growth Causes Cytoplasm Dilution And Contributes to Senescence

(2019) Gabriel E. Neurohr et al.   CELL

Polyploid Giant Cancer Cells (PGCCs): The Evil Roots of Cancer

(2019) Junsong Chen et al.   CURRENT CANCER DRUG TARGETS

Doxorubicin-Induced Cancer Cell Senescence Shows a Time Delay Effect and Is Inhibited by Epithelial-Mesenchymal Transition (EMT)

(2019) Xuerui Hu et al.   MEDICAL SCIENCE MONITOR

SETD1A protects from senescence through regulation of the mitotic gene expression program

(2019) Ken Tajima et al.   Nature Communications

Mechanisms and significance of therapy-induced and spontaneous senescence of cancer cells

(2019) Justyna Mikuła-Pietrasik et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Molecular pathways of senescence regulate placental structure and function

(2019) Hilah Gal et al.   EMBO JOURNAL

Chemotherapy-induced senescent cancer cells engulf other cells to enhance their survival

(2019) Crystal A. Tonnessen-Murray et al.   JOURNAL OF CELL BIOLOGY

The “life code”: a theory that unifies the human life cycle and the origin of human tumors

(2019) Liu Jinsong   SEMINARS IN CANCER BIOLOGY

Targeting normal and cancer senescent cells as a strategy of senotherapy

(2019) Ewa Sikora et al.   AGEING RESEARCH REVIEWS

Cardiomyocyte Polyploidy and Implications for Heart Regeneration

(2019) Peiheng Gan et al.   Annual Review of Physiology

Connecting cancer relapse with senescence

(2019) Olivier Pluquet et al.   CANCER LETTERS

Cellular Senescence: Defining a Path Forward

(2019) Vassilis Gorgoulis et al.   CELL

Senescence in polyploid giant cancer cells: A road that leads to chemoresistance

(2019) Deblina Bharadwaj et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Chemotherapy-induced cellular senescence suppresses progression of Notch-driven T-ALL

(2019) Ying Zhang et al.   PLoS One

Diversity of the Senescence Phenotype of Cancer Cells Treated with Chemotherapeutic Agents

(2019) Agnieszka Bojko et al.   Cells

Polyploidy in tissue homeostasis and regeneration

(2018) Jan Inge Øvrebø et al.   DEVELOPMENT

Is DNA damage indispensable for stress-induced senescence?

(2018) Anna Bielak-Zmijewska et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Genome doubling shapes the evolution and prognosis of advanced cancers

(2018) Craig M. Bielski et al.   NATURE GENETICS

The Dualistic Origin of Human Tumors

(2018) Jinsong Liu   SEMINARS IN CANCER BIOLOGY

Endoreplication: The Good, the Bad, and the Ugly

(2018) Zhiqiang Shu et al.   TRENDS IN CELL BIOLOGY

Senescence-associated secretory factors induced by cisplatin in melanoma cells promote non-senescent melanoma cell growth through activation of the ERK1/2-RSK1 pathway

(2018) Xuerong Sun et al.   Cell Death & Disease

Insight into the role of PIKK family members and NF-кB in DNAdamage-induced senescence and senescence-associated secretory phenotype of colon cancer cells

(2018) Anna Strzeszewska et al.   Cell Death & Disease

Increased insulin-like growth factor 1 production by polyploid adipose stem cells promotes growth of breast cancer cells

(2018) Roberta Fajka-Boja et al.   BMC CANCER

Tumor cell escape from therapy-induced senescence

(2018) Tareq Saleh et al.   BIOCHEMICAL PHARMACOLOGY

MDM2-mediated degradation of WRN promotes cellular senescence in a p53-independent manner

(2018) Boya Liu et al.   ONCOGENE

Senescence-associated reprogramming promotes cancer stemness

(2017) Maja Milanovic et al.   NATURE

Senescent cells: an emerging target for diseases of ageing

(2017) Bennett G. Childs et al.   NATURE REVIEWS DRUG DISCOVERY

The evolutionary significance of polyploidy

(2017) Yves Van de Peer et al.   NATURE REVIEWS GENETICS

Dedifferentiation into blastomere-like cancer stem cells via formation of polyploid giant cancer cells

(2017) N Niu et al.   ONCOGENE

Hepatocyte polyploidization and its association with pathophysiological processes

(2017) Min-Jun Wang et al.   Cell Death & Disease

Morphological and Functional Characteristic of Senescent Cancer Cells

(2016) Ewa Sikora et al.   CURRENT DRUG TARGETS

Disentangling the aneuploidy and senescence paradoxes: a study of triploid breast cancers non-responsive to neoadjuvant therapy

(2016) B. I. Gerashchenko et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Curcumin-treated cancer cells show mitotic disturbances leading to growth arrest and induction of senescence phenotype

(2016) Grażyna Mosieniak et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Reed-Sternberg cells in Hodgkin’s lymphoma present features of cellular senescence

(2016) J Gopas et al.   Cell Death & Disease

Bafilomycin A1 triggers proliferative potential of senescent cancer cells in vitro and in NOD/SCID mice

(2016) Halina Was et al.   Oncotarget

The Role of Aneuploidy in Cancer Evolution

(2016) Laurent Sansregret et al.   Cold Spring Harbor Perspectives in Medicine

Linking genomic reorganization to tumor initiation via the giant cell cycle

(2016) N Niu et al.   Oncogenesis

Role of stress-activated OCT4A in the cell fate decisions of embryonal carcinoma cells treated with etoposide

(2015) Anda Huna et al.   CELL CYCLE

Clonal Evolution in Cancer: A Tale of Twisted Twines

(2015) Michalina Janiszewska et al.   Cell Stem Cell

When bigger is better: the role of polyploidy in organogenesis

(2015) Terry L. Orr-Weaver   TRENDS IN GENETICS

In vitro evidence for senescent multinucleated melanocytes as a source for tumor-initiating cells

(2015) C Leikam et al.   Cell Death & Disease

A multi-stage process including transient polyploidization and EMT precedes the emergence of chemoresistent ovarian carcinoma cells with a dedifferentiated and pro-inflammatory secretory phenotype

(2015) Verena Rohnalter et al.   Oncotarget

Polyploidy Formation in Doxorubicin-Treated Cancer Cells Can Favor Escape from Senescence

(2015) Grazyna Mosieniak et al.   NEOPLASIA

Irinotecan treatment and senescence failure promote the emergence of more transformed and invasive cells that depend on anti-apoptotic Mcl-1

(2015) Barbara Jonchère et al.   Oncotarget

Evolution of the Cancer Stem Cell Model

(2014) Antonija Kreso et al.   Cell Stem Cell

Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases

(2014) C. Franceschi et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Size Does Matter: Why Polyploid Tumor Cells are Critical Drug Targets in the War on Cancer

(2014) Jermaine Coward et al.   Frontiers in Oncology

Immunosurveillance of senescent cells: the bright side of the senescence program

(2013) Adi Sagiv et al.   BIOGERONTOLOGY

Three steps to the immortality of cancer cells: senescence, polyploidy and self-renewal

(2013) Jekaterina Erenpreisa et al.   Cancer Cell International

Sunitinib induces cellular senescence via p53/Dec1 activation in renal cell carcinoma cells

(2013) Yu Zhu et al.   CANCER SCIENCE

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Programmed Cell Senescence during Mammalian Embryonic Development

(2013) Daniel Muñoz-Espín et al.   CELL

Senescence Is a Developmental Mechanism that Contributes to Embryonic Growth and Patterning

(2013) Mekayla Storer et al.   CELL

Cell fusion induced by ERVWE1 or measles virus causes cellular senescence

(2013) A. Chuprin et al.   GENES & DEVELOPMENT

Ionizing Radiation-Induced Responses in Human Cells with Differing TP53 Status

(2013) Razmik Mirzayans et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Molecular Balancing Act of p16 INK4a in Cancer and Aging

(2013) Kyle M. LaPak et al.   MOLECULAR CANCER RESEARCH

A complex secretory program orchestrated by the inflammasome controls paracrine senescence

(2013) Juan Carlos Acosta et al.   NATURE CELL BIOLOGY

Pan-cancer patterns of somatic copy number alteration

(2013) Travis I Zack et al.   NATURE GENETICS

Generation of cancer stem-like cells through the formation of polyploid giant cancer cells

(2013) S Zhang et al.   ONCOGENE

Clonal evolution in cancer

(2012) Mel Greaves et al.   NATURE

Induction of Cellular Senescence by Doxorubicin Is Associated with Upregulated miR-375 and Induction of Autophagy in K562 Cells

(2012) Ming-Yu Yang et al.   PLoS One

Senescence-associated secretory phenotype favors the emergence of cancer stem-like cells

(2012) J Cahu et al.   Cell Death & Disease

Formation of solid tumors by a single multinucleated cancer cell

(2011) Zhang Weihua et al.   CANCER

Genetic stability of senescence reverted cells: Genome reduction division of polyploidy cells, aneuploidy and neoplasia

(2011) Kirsten H. Walen   CELL CYCLE

Cancer stem cells and escape from drug-induced premature senescence in human lung tumor cells: Implications for drug resistance and in vitro drug screening models

(2011) Michal Sabisz et al.   CELL CYCLE

Effects of chemical manipulation of mitotic arrest and slippage on cancer cell survival and proliferation

(2011) Jenna L. Riffell et al.   CELL CYCLE

GROα regulates human embryonic stem cell self-renewal or adoption of a neuronal fate

(2011) Ana Krtolica et al.   DIFFERENTIATION

Control of the senescence-associated secretory phenotype by NF- B promotes senescence and enhances chemosensitivity

(2011) Y. Chien et al.   GENES & DEVELOPMENT

Mitotic catastrophe: a mechanism for avoiding genomic instability

(2011) Ilio Vitale et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

Polyploidy: The Link Between Senescence and Cancer

(2010) G. Mosieniak et al.   CURRENT PHARMACEUTICAL DESIGN

The essence of senescence

(2010) T. Kuilman et al.   GENES & DEVELOPMENT

Ageing, telomeres, senescence, and liver injury

(2010) Matthew Hoare et al.   JOURNAL OF HEPATOLOGY

A Senescence-Like Cell-Cycle Arrest Occurs During Megakaryocytic Maturation: Implications for Physiological and Pathological Megakaryocytic Proliferation

(2010) Rodolphe Besancenot et al.   PLOS BIOLOGY

A nuclear budding mechanism in transiently arrested cells generates drug-sensitive and drug-resistant cells

(2009) Sylvia Mansilla et al.   BIOCHEMICAL PHARMACOLOGY

Senescence-Associated Oxidative DNA Damage Promotes the Generation of Neoplastic Cells

(2009) K. Gosselin et al.   CANCER RESEARCH

Interleukin-6 maintains bone marrow-derived mesenchymal stem cell stemness by an ERK1/2-dependent mechanism

(2009) Katie L. Pricola et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Genes and signals regulating murine trophoblast cell development

(2009) Ahmed H.K. El-Hashash et al.   MECHANISMS OF DEVELOPMENT

Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion

(2009) Francis Rodier et al.   NATURE CELL BIOLOGY

Oncogene-Induced Senescence Relayed by an Interleukin-Dependent Inflammatory Network

(2008) Thomas Kuilman et al.   CELL

Tumor cells can escape DNA-damaging cisplatin through DNA endoreduplication and reversible polyploidy

(2008) Pierre-Emmanuel Puig et al.   CELL BIOLOGY INTERNATIONAL

The evolution of haploidy and diploidy

(2008) Sarah P. Otto et al.   CURRENT BIOLOGY

Modulation of Cellular Response to Anticancer Treatment by Caffeine: Inhibition of Cell Cycle Checkpoints, DNA Repair and More

(2008) Michal Sabisz et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Induction of senescence with doxorubicin leads to increased genomic instability of HCT116 cells

(2008) Malgorzata A. Sliwinska et al.   MECHANISMS OF AGEING AND DEVELOPMENT