Role of stress-activated OCT4A in the cell fate decisions of embryonal carcinoma cells treated with etoposide

Cell cycle arrest is not senescence

(2016) Mikhail V. Blagosklonny   Aging-US

A prospective epigenetic paradigm between cellular senescence and epithelial-mesenchymal transition in organismal development and aging

(2015) Shuji Kishi et al.   Translational Research

Sustained activation of DNA damage response in irradiated apoptosis-resistant cells induces reversible senescence associated with mTOR downregulation and expression of stem cell markers

(2014) Zhanna V Chitikova et al.   CELL CYCLE

Autophagy supports genomic stability by degrading retrotransposon RNA

(2014) Huishan Guo et al.   Nature Communications

An epichromatin epitope: Persistence in the cell cycle and conservation in evolution

(2014) Ada L. Olins et al.   Nucleus

Genomes of replicatively senescent cells undergo global epigenetic changes leading to gene silencing and activation of transposable elements

(2013) Marco De Cecco et al.   AGING CELL

AMP-activated protein kinase (AMPK) beyond metabolism

(2013) Toran Sanli et al.   CANCER BIOLOGY & THERAPY

Senescence Is a Developmental Mechanism that Contributes to Embryonic Growth and Patterning

(2013) Mekayla Storer et al.   CELL

DNA damage causes TP53-dependent coupling of self-renewal and senescence pathways in embryonal carcinoma cells

(2013) Thomas R. Jackson et al.   CELL CYCLE

Probing the depths of cellular senescence

(2013) Darren J. Baker et al.   JOURNAL OF CELL BIOLOGY

Lysosome-mediated processing of chromatin in senescence

(2013) Andre Ivanov et al.   JOURNAL OF CELL BIOLOGY

Short-term single treatment of chemotherapy results in the enrichment of ovarian cancer stem cell-like cells leading to an increased tumor burden

(2013) Khalid Abubaker et al.   Molecular Cancer

Synthetic lethal metabolic targeting of cellular senescence in cancer therapy

(2013) Jan R. Dörr et al.   NATURE

Autophagy and chemotherapy resistance: a promising therapeutic target for cancer treatment

(2013) X Sui et al.   Cell Death & Disease

AMPK Promotes p53 Acetylation via Phosphorylation and Inactivation of SIRT1 in Liver Cancer Cells

(2012) C.-W. Lee et al.   CANCER RESEARCH

CDK inhibitors (p16/p19/p21) induce senescence and autophagy in cancer-associated fibroblasts, “fueling” tumor growth via paracrine interactions, without an increase in neo-angiogenesis

(2012) Claudia Capparelli et al.   CELL CYCLE

Nuclear Cloning and Direct Reprogramming: The Long and the Short Path to Stockholm

(2012) Rudolf Jaenisch   Cell Stem Cell

Cyclin-Dependent Kinase Inhibitor p21 Controls Adult Neural Stem Cell Expansion by Regulating Sox2 Gene Expression

(2012) M. Ángeles Marqués-Torrejón et al.   Cell Stem Cell

Polyploidy road to therapy-induced cellular senescence and escape

(2012) Qin Wang et al.   INTERNATIONAL JOURNAL OF CANCER

p53 Dynamics Control Cell Fate

(2012) J. E. Purvis et al.   SCIENCE

Radiation-Induced Reprogramming of Breast Cancer Cells

(2012) Chann Lagadec et al.   STEM CELLS

Expression of OCT4 in human esophageal squamous cell carcinoma is significantly associated with poorer prognosis

(2012) Wei He   WORLD JOURNAL OF GASTROENTEROLOGY

Oncogenes induce senescence with incomplete growth arrest and suppress the DNA damage response in immortalized cells

(2011) Michael Y. Sherman et al.   AGING CELL

Expression of the embryonic stem cell marker SOX2 in early-stage breast carcinoma

(2011) Claudia Lengerke et al.   BMC CANCER

Cancer stem cells and escape from drug-induced premature senescence in human lung tumor cells: Implications for drug resistance and in vitro drug screening models

(2011) Michal Sabisz et al.   CELL CYCLE

Mitotic kinase dynamics of the active form of AMPK (Phospho-AMPKαThr172) in human cancer cells

(2011) Alejandro Vazquez-Martin et al.   CELL CYCLE

Metformin activates an Ataxia Telangiectasia Mutated (ATM)/Chk2-regulated DNA damage-like response

(2011) Alejandro Vazquez-Martin et al.   CELL CYCLE

Inhibition of activated pericentromeric SINE/Alu repeat transcription in senescent human adult stem cells reinstates self-renewal

(2011) Jianrong Wang et al.   CELL CYCLE

Cellular senescence and tumor suppressor gene p16

(2011) Hani Rayess et al.   INTERNATIONAL JOURNAL OF CANCER

Overexpression of Nanog protein is associated with poor prognosis in gastric adenocarcinoma

(2011) Ting Lin et al.   MEDICAL ONCOLOGY

Implications of transcriptional factor, OCT-4, in human bladder malignancy and tumor recurrence

(2011) Peng Huang et al.   MEDICAL ONCOLOGY

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Sox2 nuclear expression is closely associated with poor prognosis in patients with histologically node-negative oral tongue squamous cell carcinoma

(2011) Lutao Du et al.   ORAL ONCOLOGY

Recruitment of Oct4 Protein to UV-Damaged Chromatin in Embryonic Stem Cells

(2011) Eva Bártová et al.   PLoS One

Over-expression of Nanog predicts tumor progression and poor prognosis in colorectal cancer

(2010) Hui-Min Meng et al.   CANCER BIOLOGY & THERAPY

Up-regulation of the embryonic self-renewal network through reversible polyploidy in irradiated p53-mutant tumour cells

(2010) Kristine Salmina et al.   EXPERIMENTAL CELL RESEARCH

Correlations, risk and crisis: From physiology to finance

(2010) Alexander N. Gorban et al.   PHYSICA A-STATISTICAL MECHANICS AND ITS APPLICATIONS

Signaling Kinase AMPK Activates Stress-Promoted Transcription via Histone H2B Phosphorylation

(2010) D. Bungard et al.   SCIENCE

Oct-4 controls cell-cycle progression of embryonic stem cells

(2009) Jungwoon Lee et al.   BIOCHEMICAL JOURNAL

Non-genetic heterogeneity of cells in development: more than just noise

(2009) S. Huang   DEVELOPMENT

Senescence impairs successful reprogramming to pluripotent stem cells

(2009) A. Banito et al.   GENES & DEVELOPMENT

Non-genetic heterogeneity — a mutation-independent driving force for the somatic evolution of tumours

(2009) Amy Brock et al.   NATURE REVIEWS GENETICS

Regulated Fluctuations in Nanog Expression Mediate Cell Fate Decisions in Embryonic Stem Cells

(2009) Tibor Kalmar et al.   PLOS BIOLOGY

Tumor cells can escape DNA-damaging cisplatin through DNA endoreduplication and reversible polyploidy

(2008) Pierre-Emmanuel Puig et al.   CELL BIOLOGY INTERNATIONAL

Positive Correlations of Oct-4 and Nanog in Oral Cancer Stem-Like Cells and High-Grade Oral Squamous Cell Carcinoma

(2008) S.-H. Chiou et al.   CLINICAL CANCER RESEARCH

An embryonic stem cell–like gene expression signature in poorly differentiated aggressive human tumors

(2008) Ittai Ben-Porath et al.   NATURE GENETICS