Deterioration of nuclear morphology and architecture: A hallmark of senescence and aging

The interplay between immunosenescence and age-related diseases

(2020) Florencia Barbé-Tuana et al.   Seminars in Immunopathology

Nucleophagy: from homeostasis to disease

(2019) Margarita-Elena Papandreou et al.   CELL DEATH AND DIFFERENTIATION

Skeletal Muscles Do Not Undergo Apoptosis During Either Atrophy or Programmed Cell Death-Revisiting the Myonuclear Domain Hypothesis

(2019) Lawrence M. Schwartz   Frontiers in Physiology

Imbalanced nucleocytoskeletal connections create common polarity defects in progeria and physiological aging

(2019) Wakam Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Excessive Cell Growth Causes Cytoplasm Dilution And Contributes to Senescence

(2019) Gabriel E. Neurohr et al.   CELL

Extranuclear DNA accumulates in aged cells and contributes to senescence and inflammation

(2019) Yuk Yuen Lan et al.   AGING CELL

Loss of Cajal bodies in motor neurons from patients with novel mutations in VRK1

(2019) Lara El-Bazzal et al.   HUMAN MOLECULAR GENETICS

Age-dependent deterioration of nuclear pore assembly in mitotic cells decreases transport dynamics

(2019) Irina L Rempel et al.   eLife

Protein quality control in the nucleolus safeguards recovery of epigenetic regulators after heat shock

(2019) Maria Azkanaz et al.   eLife

Nuclear envelope rupture: little holes, big openings

(2018) Emily M .Hatch   CURRENT OPINION IN CELL BIOLOGY

PML nuclear bodies: from architecture to function

(2018) Valérie Lallemand-Breitenbach et al.   CURRENT OPINION IN CELL BIOLOGY

Comparison of Nuclear Matrix and Mitotic Chromosome Scaffold proteins in Drosophila S2 cells – Transmission of hallmarks of nuclear organization through mitosis

(2018) Rahul Sureka et al.   MOLECULAR & CELLULAR PROTEOMICS

Epigenetic Reprogramming of Pericentromeric Satellite DNA in Premalignant and Malignant Lesions

(2018) Nadine Heidi Brückmann et al.   MOLECULAR CANCER RESEARCH

Quantitative SUMO proteomics reveals the modulation of several PML nuclear body associated proteins and an anti-senescence function of UBC9

(2018) Francis P. McManus et al.   Scientific Reports

Regulation of Cellular Senescence by Polycomb Chromatin Modifiers through Distinct DNA Damage- and Histone Methylation-Dependent Pathways

(2018) Takahiro Ito et al.   Cell Reports

Tau-induced nuclear envelope invagination causes a toxic accumulation of mRNA in Drosophila

(2018) Garrett L. Cornelison et al.   AGING CELL

The dynamic nature of senescence in cancer

(2018) Soyoung Lee et al.   NATURE CELL BIOLOGY

The dark side of centromeres: types, causes and consequences of structural abnormalities implicating centromeric DNA

(2018) V. Barra et al.   Nature Communications

Cytoplasmic chromatin triggers inflammation in senescence and cancer

(2017) Zhixun Dou et al.   NATURE

Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence

(2017) Selene Glück et al.   NATURE CELL BIOLOGY

Shared molecular and cellular mechanisms of premature ageing and ageing-associated diseases

(2017) Nard Kubben et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Accumulation of histone variant H3.3 with age is associated with profound changes in the histone methylation landscape

(2017) Andrey Tvardovskiy et al.   NUCLEIC ACIDS RESEARCH

The nuclear mitotic apparatus protein NuMA controls rDNA transcription and mediates the nucleolar stress response in a p53-independent manner

(2017) Swaathi Jayaraman et al.   NUCLEIC ACIDS RESEARCH

Integrity of the human centromere DNA repeats is protected by CENP-A, CENP-C, and CENP-T

(2017) Simona Giunta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

cGAS is essential for cellular senescence

(2017) Hui Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nucleolar expansion and elevated protein translation in premature aging

(2017) Abigail Buchwalter et al.   Nature Communications

CENP-A chromatin disassembly in stressed and senescent murine cells

(2017) Sabrine Hédouin et al.   Scientific Reports

Cajal body function in genome organization and transcriptome diversity

(2016) Iain A. Sawyer et al.   BIOESSAYS

Satellite cell depletion prevents fiber hypertrophy in skeletal muscle

(2016) Ingrid M. Egner et al.   DEVELOPMENT

Nuclear bodies: Built to boost

(2016) Iain A. Sawyer et al.   JOURNAL OF CELL BIOLOGY

Splicing factor 1 modulates dietary restriction and TORC1 pathway longevity in C. elegans

(2016) Caroline Heintz et al.   NATURE

Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

(2016) Darren J. Baker et al.   NATURE

p53 induces formation of NEAT1 lncRNA-containing paraspeckles that modulate replication stress response and chemosensitivity

(2016) Carmen Adriaens et al.   NATURE MEDICINE

Specific genomic cues regulate Cajal body assembly

(2016) Iain A. Sawyer et al.   RNA Biology

ESCRT III repairs nuclear envelope ruptures during cell migration to limit DNA damage and cell death

(2016) M. Raab et al.   SCIENCE

Repair Pathway Choices and Consequences at the Double-Strand Break

(2016) Raphael Ceccaldi et al.   TRENDS IN CELL BIOLOGY

Defective DNA single-strand break repair is responsible for senescence and neoplastic escape of epithelial cells

(2016) Joe Nassour et al.   Nature Communications

CENP-A, a protein required for chromosome segregation in mitosis, declines with age in islet but not exocrine cells

(2016) Seung-Hee Lee et al.   Aging-US

Robust nuclear lamina-based cell classification of aging and senescent cells

(2016) Christiaan H. Righolt et al.   Aging-US

Transposable elements become active and mobile in the genomes of aging mammalian somatic tissues

(2016) Marco De Cecco et al.   Aging-US

Nuclear Pore Basket Proteins Are Tethered to the Nuclear Envelope and Can Regulate Membrane Curvature

(2015) Noémi Mészáros et al.   DEVELOPMENTAL CELL

The molecular basis for centromere identity and function

(2015) Kara L. McKinley et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging

(2015) W. Zhang et al.   SCIENCE

Human telomere biology: A contributory and interactive factor in aging, disease risks, and protection

(2015) E. H. Blackburn et al.   SCIENCE

Long Non-Coding RNA Expression during Aging in the Human Subependymal Zone

(2015) Guy Barry et al.   Frontiers in Neurology

Age-Associated Loss of Lamin-B Leads to Systemic Inflammation and Gut Hyperplasia

(2014) Haiyang Chen et al.   CELL

Nucleosome loss leads to global transcriptional up-regulation and genomic instability during yeast aging

(2014) Z. Hu et al.   GENES & DEVELOPMENT

Histone variants: dynamic punctuation in transcription

(2014) C. M. Weber et al.   GENES & DEVELOPMENT

Oxidative stress–induced assembly of PML nuclear bodies controls sumoylation of partner proteins

(2014) Umut Sahin et al.   JOURNAL OF CELL BIOLOGY

A Cellular System that Degrades Misfolded Proteins and Protects against Neurodegeneration

(2014) Lili Guo et al.   MOLECULAR CELL

The role of senescent cells in ageing

(2014) Jan M. van Deursen   NATURE

Mosaic loss of chromosome Y in peripheral blood is associated with shorter survival and higher risk of cancer

(2014) Lars A Forsberg et al.   NATURE GENETICS

PML-nuclear bodies decrease with age and their stress response is impaired in aged individuals

(2014) Barbara Wenger et al.   BMC Geriatrics

Blocking protein farnesylation improves nuclear shape abnormalities in keratinocytes of mice expressing the prelamin A variant in Hutchinson-Gilford progeria syndrome

(2014) Yuexia Wang et al.   Nucleus

Senescence-associated lncRNAs: senescence-associated long noncoding RNAs

(2013) Kotb Abdelmohsen et al.   AGING CELL

Three wise centromere functions: see no error, hear no break, speak no delay

(2013) Tomoyuki U Tanaka et al.   EMBO REPORTS

Compromised paraspeckle formation as a pathogenic factor in FUSopathies

(2013) Tatyana A. Shelkovnikova et al.   HUMAN MOLECULAR GENETICS

Higher-order unfolding of satellite heterochromatin is a consistent and early event in cell senescence

(2013) Eric C. Swanson et al.   JOURNAL OF CELL BIOLOGY

Lysosome-mediated processing of chromatin in senescence

(2013) Andre Ivanov et al.   JOURNAL OF CELL BIOLOGY

Widespread splicing changes in human brain development and aging

(2013) P. Mazin et al.   Molecular Systems Biology

Mechanical model of blebbing in nuclear lamin meshworks

(2013) Chloe M. Funkhouser et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nuclear Lamin-A Scales with Tissue Stiffness and Enhances Matrix-Directed Differentiation

(2013) J. Swift et al.   SCIENCE

Chromatin Modifications as Determinants of Muscle Stem Cell Quiescence and Chronological Aging

(2013) Ling Liu et al.   Cell Reports

Aging, Cellular Senescence, and Cancer

(2012) Judith Campisi   Annual Review of Physiology

Accumulation of the Inner Nuclear Envelope Protein Sun1 Is Pathogenic in Progeric and Dystrophic Laminopathies

(2012) Chia-Yen Chen et al.   CELL

Outfits for different occasions: tissue-specific roles of Nuclear Envelope proteins

(2012) J Sebastian Gomez-Cavazos et al.   CURRENT OPINION IN CELL BIOLOGY

A Change in Nuclear Pore Complex Composition Regulates Cell Differentiation

(2012) Maximiliano A. D'Angelo et al.   DEVELOPMENTAL CELL

Global heterochromatin loss

(2012) Amy Tsurumi et al.   Epigenetics

The Nuclear Envelope Protein Emerin Binds Directly to Histone Deacetylase 3 (HDAC3) and Activates HDAC3 Activity

(2012) Justin Demmerle et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lamin B1 loss is a senescence-associated biomarker

(2012) Adam Freund et al.   MOLECULAR BIOLOGY OF THE CELL

Transcription as a source of genome instability

(2012) Nayun Kim et al.   NATURE REVIEWS GENETICS

Improved Visualization of Vertebrate Nuclear Pore Complexes by Field Emission Scanning Electron Microscopy

(2012) Lihi Shaulov et al.   STRUCTURE

Post-transcriptional spliceosomes are retained in nuclear speckles until splicing completion

(2012) Cyrille Girard et al.   Nature Communications

Heterochromatin Formation Promotes Longevity and Represses Ribosomal RNA Synthesis

(2012) Kimberly Larson et al.   PLoS Genetics

Computational image analysis of nuclear morphology associated with various nuclear-specific aging disorders

(2012) Siwon Choi et al.   Nucleus

Loss of intestinal nuclei and intestinal integrity in aging C. elegans

(2011) Matthew D. McGee et al.   AGING CELL

Two SET domain containing genes link epigenetic changes and aging in Caenorhabditis elegans

(2011) Zhuoyu Ni et al.   AGING CELL

Senescence-associated heterochromatin foci are dispensable for cellular senescence, occur in a cell type- and insult-dependent manner and follow expression of p16ink4a

(2011) Martin Kosar et al.   CELL CYCLE

A view of nuclear Polycomb bodies

(2011) Vincenzo Pirrotta et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Regulation of E2Fs and senescence by PML nuclear bodies

(2011) M. Vernier et al.   GENES & DEVELOPMENT

Repetitive disruptions of the nuclear envelope invoke temporary loss of cellular compartmentalization in laminopathies

(2011) Winnok H. De Vos et al.   HUMAN MOLECULAR GENETICS

Dynamics of nuclear matrix proteome during embryonic development in Drosophila melanogaster

(2011) Parul Varma et al.   JOURNAL OF BIOSCIENCES

Telomeres and lifestyle factors: Roles in cellular aging

(2011) Jue Lin et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

(2011) Darren J. Baker et al.   NATURE

Nuclear actin and myosins: Life without filaments

(2011) Primal de Lanerolle et al.   NATURE CELL BIOLOGY

Nucleation of nuclear bodies by RNA

(2011) Sergey P. Shevtsov et al.   NATURE CELL BIOLOGY

The nucleoplasmic reticulum: form and function

(2011) Ashraf Malhas et al.   TRENDS IN CELL BIOLOGY

The lamin protein family

(2011) Travis A Dittmer et al.   GENOME BIOLOGY

Age-associated increase in heterochromatic marks in murine and primate tissues

(2010) Jill A. Kreiling et al.   AGING CELL

In vivo labeling with 2H2O reveals a human neutrophil lifespan of 5.4 days

(2010) J. Pillay et al.   BLOOD

Nucleolar Disruption and Cajal Body Disassembly are Nuclear Hallmarks of DNA Damage-Induced Neurodegeneration in Purkinje Cells

(2010) Fernando C. Baltanás et al.   BRAIN PATHOLOGY

Sarcopenia

(2010) David R. Thomas   CLINICS IN GERIATRIC MEDICINE

Evidence that Weakened Centromere Cohesion Is a Leading Cause of Age-Related Aneuploidy in Oocytes

(2010) Teresa Chiang et al.   CURRENT BIOLOGY

The essence of senescence

(2010) T. Kuilman et al.   GENES & DEVELOPMENT

Nuclear Matrix Proteome Analysis ofDrosophila melanogaster

(2010) Satish Kallappagoudar et al.   MOLECULAR & CELLULAR PROTEOMICS

CENP-A Reduction Induces a p53-Dependent Cellular Senescence Response To Protect Cells from Executing Defective Mitoses

(2010) K. Maehara et al.   MOLECULAR AND CELLULAR BIOLOGY

Elevated Histone Expression Promotes Life Span Extension

(2010) Jason Feser et al.   MOLECULAR CELL

The Nuclear-Retained Noncoding RNA MALAT1 Regulates Alternative Splicing by Modulating SR Splicing Factor Phosphorylation

(2010) Vidisha Tripathi et al.   MOLECULAR CELL

Myonuclei acquired by overload exercise precede hypertrophy and are not lost on detraining

(2010) J. C. Bruusgaard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nuclear Lamins

(2010) T. Dechat et al.   Cold Spring Harbor Perspectives in Biology

Age-Dependent Deterioration of Nuclear Pore Complexes Causes a Loss of Nuclear Integrity in Postmitotic Cells

(2009) Maximiliano A. D'Angelo et al.   CELL

Nuclei Take a Position: Managing Nuclear Location

(2009) Brian Burke et al.   DEVELOPMENTAL CELL

The Nuclear Envelope as a Signaling Node in Development and Disease

(2009) William T. Dauer et al.   DEVELOPMENTAL CELL

Evidence for a Shared Nuclear Pore Complex Architecture That Is Conserved from the Last Common Eukaryotic Ancestor

(2009) Jeffrey A. DeGrasse et al.   MOLECULAR & CELLULAR PROTEOMICS

Small Cajal Body–specific RNAs of Drosophila Function in the Absence of Cajal Bodies

(2009) Svetlana Deryusheva et al.   MOLECULAR BIOLOGY OF THE CELL

An Architectural Role for a Nuclear Noncoding RNA: NEAT1 RNA Is Essential for the Structure of Paraspeckles

(2009) Christine M. Clemson et al.   MOLECULAR CELL

Altered Nuclear Retention of mRNAs Containing Inverted Repeats in Human Embryonic Stem Cells: Functional Role of a Nuclear Noncoding RNA

(2009) Ling-Ling Chen et al.   MOLECULAR CELL

Histone H4 lysine 16 acetylation regulates cellular lifespan

(2009) Weiwei Dang et al.   NATURE

Transcription factories: gene expression in unions?

(2009) Heidi Sutherland et al.   NATURE REVIEWS GENETICS

DNA Damage, Aging, and Cancer

(2009) Jan H.J. Hoeijmakers   NEW ENGLAND JOURNAL OF MEDICINE

The farnesylated nuclear proteins KUGELKERN and LAMIN B promote aging-like phenotypes inDrosophilaflies

(2008) Annely Brandt et al.   AGING CELL

How Shelterin Protects Mammalian Telomeres

(2008) Wilhelm Palm et al.   Annual Review of Genetics

Micropatterning of Single Endothelial Cell Shape Reveals a Tight Coupling between Nuclear Volume in G1 and Proliferation

(2008) Pere Roca-Cusachs et al.   BIOPHYSICAL JOURNAL

Nuclear Pore Composition Regulates Neural Stem/Progenitor Cell Differentiation in the Mouse Embryo

(2008) Floria Lupu et al.   DEVELOPMENTAL CELL

The human granulocyte nucleus: Unusual nuclear envelope and heterochromatin composition

(2008) A OLINS et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Werner syndrome helicase activity is essential in maintaining fragile site stability

(2008) Livia Maria Pirzio et al.   JOURNAL OF CELL BIOLOGY

Nuclear envelope defects cause stem cell dysfunction in premature-aging mice

(2008) Jesús Espada et al.   JOURNAL OF CELL BIOLOGY

Changes in the Distributions and Dynamics of Polycomb Repressive Complexes during Embryonic Stem Cell Differentiation

(2008) X. Ren et al.   MOLECULAR AND CELLULAR BIOLOGY

Nuclear order out of chaos

(2008) Tom Misteli   NATURE

Lamin A-dependent misregulation of adult stem cells associated with accelerated ageing

(2008) Paola Scaffidi et al.   NATURE CELL BIOLOGY