Oncogene-induced telomere dysfunction enforces cellular senescence in human cancer precursor lesions
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Title
Oncogene-induced telomere dysfunction enforces cellular senescence in human cancer precursor lesions
Authors
Keywords
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Journal
EMBO JOURNAL
Volume 31, Issue 13, Pages 2839-2851
Publisher
Wiley
Online
2012-05-08
DOI
10.1038/emboj.2012.132
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- Telomeric damage in early stage of chronic lymphocytic leukemia correlates with shelterin dysregulation
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- Mammalian Telomeres Resemble Fragile Sites and Require TRF1 for Efficient Replication
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- Increased telomere fragility and fusions resulting from TRF1 deficiency lead to degenerative pathologies and increased cancer in mice
- (2009) P. Martinez et al. GENES & DEVELOPMENT
- A two-step model for senescence triggered by a single critically short telomere
- (2009) Pauline Abdallah et al. NATURE CELL BIOLOGY
- c-Myc Accelerates S-Phase and Requires WRN to Avoid Replication Stress
- (2009) Kristin Robinson et al. PLoS One
- A Prostatic Intraepithelial Neoplasia-Dependent p27Kip1 Checkpoint Induces Senescence and Inhibits Cell Proliferation and Cancer Progression
- (2008) Pradip K. Majumder et al. CANCER CELL
- Telomerase inhibition induces acute ATM-dependent growth arrest in human astrocytomas
- (2008) Vincent C.H. Wong et al. CANCER LETTERS
- Many roads lead to oncogene-induced senescence
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- An Oncogene-Induced DNA Damage Model for Cancer Development
- (2008) T. D. Halazonetis et al. SCIENCE
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