Microglial Extracellular Vesicles as Vehicles for Neurodegeneration Spreading

Microglial activation contributes to cognitive impairments in rotenone-induced mouse Parkinson’s disease model

(2021) Dongdong Zhang et al.   Journal of Neuroinflammation

Microglial gene signature reveals loss of homeostatic microglia associated with neurodegeneration of Alzheimer’s disease

(2021) Akira Sobue et al.   Acta Neuropathologica Communications

Isolation of extracellular vesicles with combined enrichment methods

(2021) Janine Stam et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Plaque associated microglia hyper-secrete extracellular vesicles and accelerate tau propagation in a humanized APP mouse model

(2021) Kevin Clayton et al.   Molecular Neurodegeneration

Microglial depletion with CSF1R inhibitor during chronic phase of experimental traumatic brain injury reduces neurodegeneration and neurological deficits

(2020) Rebecca J. Henry et al.   JOURNAL OF NEUROSCIENCE

The biology, function, and biomedical applications of exosomes

(2020) Raghu Kalluri et al.   SCIENCE

Glutaminase 1 Regulates Neuroinflammation After Cerebral Ischemia Through Enhancing Microglial Activation and Pro-Inflammatory Exosome Release

(2020) Ge Gao et al.   Frontiers in Immunology

Potential Roles of Exosomes in Parkinson’s Disease: From Pathogenesis, Diagnosis, and Treatment to Prognosis

(2020) Haiyang Yu et al.   Frontiers in Cell and Developmental Biology

Microglial exosomes facilitate α-synuclein transmission in Parkinson’s disease

(2020) Min Guo et al.   BRAIN

Neuroprotective Strategies for Retinal Ganglion Cell Degeneration: Current Status and Challenges Ahead

(2020) Raquel Boia et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Microglial Corpse Clearance: Lessons From Macrophages

(2020) Mar Márquez-Ropero et al.   Frontiers in Immunology

Extracellular vesicle biomarkers of Alzheimer's disease associated with sub‐clinical cognitive decline in late middle age

(2020) Erden Eren et al.   Alzheimers & Dementia

Exosomes derived from microglia exposed to elevated pressure amplify the neuroinflammatory response in retinal cells

(2020) Inês Dinis Aires et al.   GLIA

3,6’-dithiopomalidomide reduces neural loss, inflammation, behavioral deficits in brain injury and microglial activation

(2020) Chih-Tung Lin et al.   eLife

Unleashing the therapeutic potential of apoptotic bodies

(2020) Thanh Kha Phan et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Alcohol Increases Exosome Release from Microglia to Promote Complement C1q-Induced Cellular Death of Proopiomelanocortin Neurons in the Hypothalamus in a Rat Model of Fetal Alcohol Spectrum Disorders

(2020) Sayani Mukherjee et al.   JOURNAL OF NEUROSCIENCE

P2RX7 inhibitor suppresses exosome secretion and disease phenotype in P301S tau transgenic mice

(2020) Zhi Ruan et al.   Molecular Neurodegeneration

Myocardial infarction affects Cx43 content of extracellular vesicles secreted by cardiomyocytes

(2020) Tania Martins-Marques et al.   Life Science Alliance

Alzheimer’s disease brain-derived extracellular vesicles spread tau pathology in interneurons

(2020) Zhi Ruan et al.   BRAIN

Engineering approaches for effective therapeutic applications based on extracellular vesicles

(2020) Seunglee Kwon et al.   JOURNAL OF CONTROLLED RELEASE

Extracellular Microvesicles as New Industrial Therapeutic Frontiers

(2019) Vivek Agrahari et al.   TRENDS IN BIOTECHNOLOGY

Effects of exosomes on pre-metastatic niche formation in tumors

(2019) Yaxin Guo et al.   Molecular Cancer

Blockade of microglial adenosine A 2A receptor suppresses elevated pressure‐induced inflammation, oxidative stress, and cell death in retinal cells

(2019) Inês Dinis Aires et al.   GLIA

Involvement of exosomes in dopaminergic neurodegeneration by microglial activation in midbrain slice cultures

(2019) Reiho Tsutsumi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

ROCK1 but not LIMK1 or PAK2 is a key regulator of apoptotic membrane blebbing and cell disassembly

(2019) Rochelle Tixeira et al.   CELL DEATH AND DIFFERENTIATION

Advances in therapeutic applications of extracellular vesicles

(2019) Oscar P. B. Wiklander et al.   Science Translational Medicine

Exosomes from microglia attenuate photoreceptor injury and neovascularisation in an animal model of retinopathy of prematurity

(2019) Wenqin Xu et al.   Molecular Therapy-Nucleic Acids

Glutaminase C Regulates Microglial Activation and Pro-inflammatory Exosome Release: Relevance to the Pathogenesis of Alzheimer’s Disease

(2019) Ge Gao et al.   Frontiers in Cellular Neuroscience

BIN1 favors the spreading of Tau via extracellular vesicles

(2019) Andrea Crotti et al.   Scientific Reports

The multiple roles of exosomes in Parkinson's disease: an overview

(2019) Chiara Porro et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Exosome Determinants of Physiological Aging and Age-Related Neurodegenerative Diseases

(2019) Marianna D’Anca et al.   Frontiers in Aging Neuroscience

Microglia Biology: One Century of Evolving Concepts

(2019) Marco Prinz et al.   CELL

Plexin B2 Is a Regulator of Monocyte Apoptotic Cell Disassembly

(2019) Georgia K. Atkin-Smith et al.   Cell Reports

Microglial Phagocytosis of Neurons: Diminishing Neuronal Loss in Traumatic, Infectious, Inflammatory, and Autoimmune CNS Disorders

(2019) Samuel F. Yanuck   Frontiers in Psychiatry

Microglia in the developing retina

(2019) Fenge Li et al.   Neural Development

Isolation of microglia-derived extracellular vesicles: towards miRNA signatures and neuroprotection

(2019) Quentin Lemaire et al.   JOURNAL OF NANOBIOTECHNOLOGY

Alzheimer’s disease pathology propagation by exosomes containing toxic amyloid-beta oligomers

(2018) Maitrayee Sardar Sinha et al.   ACTA NEUROPATHOLOGICA

Glia-to-neuron transfer of miRNAs via extracellular vesicles: a new mechanism underlying inflammation-induced synaptic alterations

(2018) Ilaria Prada et al.   ACTA NEUROPATHOLOGICA

Exosomes derived from hypoxia-preconditioned mesenchymal stromal cells ameliorate cognitive decline by rescuing synaptic dysfunction and regulating inflammatory responses in APP/PS1 mice

(2018) Guo-Hong Cui et al.   FASEB JOURNAL

Increased miR-124-3p in microglial exosomes following traumatic brain injury inhibits neuronal inflammation and contributes to neurite outgrowth via their transfer into neurons

(2018) Shan Huang et al.   FASEB JOURNAL

Inflammation leads to distinct populations of extracellular vesicles from microglia

(2018) Yiyi Yang et al.   Journal of Neuroinflammation

In vivo evidence for the contribution of peripheral circulating inflammatory exosomes to neuroinflammation

(2018) Jing Jing Li et al.   Journal of Neuroinflammation

Identification of distinct nanoparticles and subsets of extracellular vesicles by asymmetric flow field-flow fractionation

(2018) Haiying Zhang et al.   NATURE CELL BIOLOGY

Tumor-derived exosomes antagonize innate antiviral immunity

(2018) Liang Gao et al.   NATURE IMMUNOLOGY

Shedding light on the cell biology of extracellular vesicles

(2018) Guillaume van Niel et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The release and transmission of amyloid precursor protein via exosomes

(2018) Tingting Zheng et al.   NEUROCHEMISTRY INTERNATIONAL

Cell-to-cell Communication by Extracellular Vesicles: Focus on Microglia

(2018) Rosa C. Paolicelli et al.   NEUROSCIENCE

Retinal microglia – A key player in healthy and diseased retina

(2018) Gurugirijha Rathnasamy et al.   PROGRESS IN NEUROBIOLOGY

The biology of extracellular microvesicles

(2018) Alanna E. Sedgwick et al.   TRAFFIC

An Update on in Vivo Imaging of Extracellular Vesicles as Drug Delivery Vehicles

(2018) Prakash Gangadaran et al.   Frontiers in Pharmacology

Apoptotic Cell-Derived Extracellular Vesicles: More Than Just Debris

(2018) Sarah Caruso et al.   Frontiers in Immunology

Exosomal lipid composition and the role of ether lipids and phosphoinositides in exosome biology

(2018) Tore Skotland et al.   JOURNAL OF LIPID RESEARCH

Extracellular vesicles are increased in the serum of children with autism spectrum disorder, contain mitochondrial DNA, and stimulate human microglia to secrete IL-1β

(2018) Irene Tsilioni et al.   Journal of Neuroinflammation

The identity and function of microglia in neurodegeneration

(2018) Wilbur M. Song et al.   NATURE IMMUNOLOGY

Microglia in neurodegeneration

(2018) Suzanne Hickman et al.   NATURE NEUROSCIENCE

Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication

(2018) Mathilde Mathieu et al.   NATURE CELL BIOLOGY

Vesiclepedia 2019: a compendium of RNA, proteins, lipids and metabolites in extracellular vesicles

(2018) Mohashin Pathan et al.   NUCLEIC ACIDS RESEARCH

The P2X7 Receptor in Infection and Inflammation

(2017) Francesco Di Virgilio et al.   IMMUNITY

Cellular uptake of extracellular vesicles is mediated by clathrin-independent endocytosis and macropinocytosis

(2017) Helena Costa Verdera et al.   JOURNAL OF CONTROLLED RELEASE

Microglial-derived microparticles mediate neuroinflammation after traumatic brain injury

(2017) Alok Kumar et al.   Journal of Neuroinflammation

Retinopathy of prematurity: inflammation, choroidal degeneration, and novel promising therapeutic strategies

(2017) José Carlos Rivera et al.   Journal of Neuroinflammation

Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer

(2017) Sushrut Kamerkar et al.   NATURE

Disassembly of the Dying: Mechanisms and Functions

(2017) Georgia K. Atkin-Smith et al.   TRENDS IN CELL BIOLOGY

TRPV1 channels are critical brain inflammation detectors and neuropathic pain biomarkers in mice

(2017) Maria Cristina Marrone et al.   Nature Communications

A new bioluminescent reporter system to study the biodistribution of systematically injected tumor-derived bioluminescent extracellular vesicles in mice

(2017) Prakash Gangadaran et al.   Oncotarget

Exosomes secreted by stem cells from human exfoliated deciduous teeth contribute to functional recovery after traumatic brain injury by shifting microglia M1/M2 polarization in rats

(2017) Ye Li et al.   Stem Cell Research & Therapy

Plasma Exosomes Spread and Cluster Around β-Amyloid Plaques in an Animal Model of Alzheimer’s Disease

(2017) Tingting Zheng et al.   Frontiers in Aging Neuroscience

A Critical Assessment of Exosomes in the Pathogenesis and Stratification of Parkinson’s Disease

(2017) George K. Tofaris   Journal of Parkinsons Disease

Exosomes as Carriers of Alzheimer's Amyloid-ß

(2017) Kohei Yuyama et al.   Frontiers in Neuroscience

Exosomes from NSC-34 Cells Transfected with hSOD1-G93A Are Enriched in miR-124 and Drive Alterations in Microglia Phenotype

(2017) Sara Pinto et al.   Frontiers in Neuroscience

Exosomes, an Unmasked Culprit in Neurodegenerative Diseases

(2017) Federico N. Soria et al.   Frontiers in Neuroscience

ATP Modifies the Proteome of Extracellular Vesicles Released by Microglia and Influences Their Action on Astrocytes

(2017) Francesco Drago et al.   Frontiers in Pharmacology

Abnormal Complement Activation and Inflammation in the Pathogenesis of Retinopathy of Prematurity

(2017) Sonika Rathi et al.   Frontiers in Immunology

Extracellular Vesicles in Cancer: Cell-to-Cell Mediators of Metastasis

(2016) Annette Becker et al.   CANCER CELL

Disease Mechanisms in ALS: Misfolded SOD1 Transferred Through Exosome-Dependent and Exosome-Independent Pathways

(2016) Judith M. Silverman et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Extracellular vesicles are the Trojan horses of viral infection

(2016) Nihal Altan-Bonnet   CURRENT OPINION IN MICROBIOLOGY

Identification of a novel mechanism of blood–brain communication during peripheral inflammation via choroid plexus‐derived extracellular vesicles

(2016) Sriram Balusu et al.   EMBO Molecular Medicine

The biology and function of exosomes in cancer

(2016) Raghu Kalluri   JOURNAL OF CLINICAL INVESTIGATION

ExoCarta: A Web-Based Compendium of Exosomal Cargo

(2016) Shivakumar Keerthikumar et al.   JOURNAL OF MOLECULAR BIOLOGY

The clinical symptoms of Parkinson's disease

(2016) Sigurlaug Sveinbjornsdottir   JOURNAL OF NEUROCHEMISTRY

Role of neuroinflammation in neurodegenerative diseases (Review)

(2016) WEI-WEI CHEN et al.   Molecular Medicine Reports

Extracellular vesicles round off communication in the nervous system

(2016) Vivian Budnik et al.   NATURE REVIEWS NEUROSCIENCE

Exosomes in Alzheimer's disease

(2016) Tarja Malm et al.   NEUROCHEMISTRY INTERNATIONAL

Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes

(2016) Joanna Kowal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microvesicles shed from microglia activated by the P2X7-p38 pathway are involved in neuropathic pain induced by spinal nerve ligation in rats

(2016) Jian Li et al.   Purinergic Signalling

Selective A2A receptor antagonist prevents microglia-mediated neuroinflammation and protects retinal ganglion cells from high intraocular pressure–induced transient ischemic injury

(2016) Maria H. Madeira et al.   Translational Research

Role of exosomes in the protection of cellular homeostasis

(2016) Gabriela Desdín-Micó et al.   Cell Adhesion & Migration

Caffeine administration prevents retinal neuroinflammation and loss of retinal ganglion cells in an animal model of glaucoma

(2016) Maria H. Madeira et al.   Scientific Reports

Therapeutic Applications of Extracellular Vesicles: Clinical Promise and Open Questions

(2015) Bence György et al.   Annual Review of Pharmacology and Toxicology

Heparanase activates the syndecan-syntenin-ALIX exosome pathway

(2015) Bart Roucourt et al.   CELL RESEARCH

Neuronal Aggregates: Formation, Clearance, and Spreading

(2015) Junghyun Lim et al.   DEVELOPMENTAL CELL

Active endocannabinoids are secreted on extracellular membrane vesicles

(2015) M. Gabrielli et al.   EMBO REPORTS

Extracellular ATP induces unconventional release of glyceraldehyde-3-phosphate dehydrogenase from microglial cells

(2015) Takato Takenouchi et al.   IMMUNOLOGY LETTERS

Glioblastoma-derived extracellular vesicles modify the phenotype of monocytic cells

(2015) Jeroen de Vrij et al.   INTERNATIONAL JOURNAL OF CANCER

Adenosine A2AR blockade prevents neuroinflammation-induced death of retinal ganglion cells caused by elevated pressure

(2015) Maria H. Madeira et al.   Journal of Neuroinflammation

Contribution of Microglia-Mediated Neuroinflammation to Retinal Degenerative Diseases

(2015) Maria H. Madeira et al.   MEDIATORS OF INFLAMMATION

Tumour exosome integrins determine organotropic metastasis

(2015) Ayuko Hoshino et al.   NATURE

Depletion of microglia and inhibition of exosome synthesis halt tau propagation

(2015) Hirohide Asai et al.   NATURE NEUROSCIENCE

Directly visualized glioblastoma-derived extracellular vesicles transfer RNA to microglia/macrophages in the brain

(2015) Kristan E. van der Vos et al.   NEURO-ONCOLOGY

Microglia constitute a barrier that prevents neurotoxic protofibrillar Aβ42 hotspots around plaques

(2015) Carlo Condello et al.   Nature Communications

Neuronal exosomes facilitate synaptic pruning by up-regulating complement factors in microglia

(2015) Insaf Bahrini et al.   Scientific Reports

Gap junctional protein Cx43 is involved in the communication between extracellular vesicles and mammalian cells

(2015) Ana Rosa Soares et al.   Scientific Reports

R47H Variant ofTREM2Associated With Alzheimer Disease in a Large Late-Onset Family

(2015) Olena Korvatska et al.   JAMA Neurology

Dynamic Biodistribution of Extracellular Vesicles in Vivo Using a Multimodal Imaging Reporter

(2014) Charles P. Lai et al.   ACS Nano

Myeloid microvesicles in cerebrospinal fluid are associated with myelin damage and neuronal loss in mild cognitive impairment and Alzheimer disease

(2014) Federica Agosta et al.   ANNALS OF NEUROLOGY

Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles

(2014) Marina Colombo et al.   Annual Review of Cell and Developmental Biology

Diagnostic and Prognostic Potential of Extracellular Vesicles in Peripheral Blood

(2014) Anne Louise Schacht Revenfeld et al.   CLINICAL THERAPEUTICS

Biogenesis and secretion of exosomes

(2014) Joanna Kowal et al.   CURRENT OPINION IN CELL BIOLOGY

Serotonin stimulates secretion of exosomes from microglia cells

(2014) Konstantin Glebov et al.   GLIA

Decreased Amyloid-β Pathologies by Intracerebral Loading of Glycosphingolipid-enriched Exosomes in Alzheimer Model Mice

(2014) Kohei Yuyama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exosome Uptake through Clathrin-mediated Endocytosis and Macropinocytosis and Mediating miR-21 Delivery

(2014) Tian Tian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dendritic Cell-Derived Exosomes as Immunotherapies in the Fight against Cancer

(2014) J. M. Pitt et al.   JOURNAL OF IMMUNOLOGY

Exosome reduction in vivo is associated with lower amyloid plaque load in the 5XFAD mouse model of Alzheimer's disease

(2014) Michael B. Dinkins et al.   NEUROBIOLOGY OF AGING

The role of extracellular Tau in the spreading of neurofibrillary pathology

(2014) Miguel Medina et al.   Frontiers in Cellular Neuroscience

Shared Mechanisms of Neurodegeneration in Alzheimer’s Disease and Parkinson’s Disease

(2014) Anmu Xie et al.   Biomed Research International

Exosomes as a novel way of interneuronal communication

(2013) Mathilde Chivet et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Microglia convert aggregated amyloid-β into neurotoxic forms through the shedding of microvesicles

(2013) P Joshi et al.   CELL DEATH AND DIFFERENTIATION

Analysis of ESCRT functions in exosome biogenesis, composition and secretion highlights the heterogeneity of extracellular vesicles

(2013) Marina Colombo et al.   JOURNAL OF CELL SCIENCE

Progressive Neurodegeneration After Experimental Brain Trauma

(2013) David J. Loane et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Assessing the role of the TREM2 p.R47H variant as a risk factor for Alzheimer's disease and frontotemporal dementia

(2013) Agustín Ruiz et al.   NEUROBIOLOGY OF AGING

Late exercise reduces neuroinflammation and cognitive dysfunction after traumatic brain injury

(2013) Chun-Shu Piao et al.   NEUROBIOLOGY OF DISEASE

Exosomes of BV-2 cells induced by alpha-synuclein: Important mediator of neurodegeneration in PD

(2013) Chongwang Chang et al.   NEUROSCIENCE LETTERS

Janus-faced microglia: beneficial and detrimental consequences of microglial phagocytosis

(2013) Amanda Sierra et al.   Frontiers in Cellular Neuroscience

Ongoing activation of sphingosine 1-phosphate receptors mediates maturation of exosomal multivesicular endosomes

(2013) Taketoshi Kajimoto et al.   Nature Communications

Exosomes for targeted siRNA delivery across biological barriers

(2012) Samir EL Andaloussi et al.   ADVANCED DRUG DELIVERY REVIEWS

Myeloid microvesicles are a marker and therapeutic target for neuroinflammation

(2012) Claudia Verderio et al.   ANNALS OF NEUROLOGY

Wnt3a induces exosome secretion from primary cultured rat microglia

(2012) Claudie Hooper et al.   BMC NEUROSCIENCE

The ESCRT machinery

(2012) Oliver Schmidt et al.   CURRENT BIOLOGY

Microvesicles released from microglia stimulate synaptic activity via enhanced sphingolipid metabolism

(2012) Flavia Antonucci et al.   EMBO JOURNAL

Sphingolipid-modulated Exosome Secretion Promotes Clearance of Amyloid-β by Microglia

(2012) Kohei Yuyama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Delayed mGluR5 activation limits neuroinflammation and neurodegeneration after traumatic brain injury

(2012) Kimberly R Byrnes et al.   Journal of Neuroinflammation

Syndecan–syntenin–ALIX regulates the biogenesis of exosomes

(2012) Maria Francesca Baietti et al.   NATURE CELL BIOLOGY

Inflammation after trauma: Microglial activation and traumatic brain injury

(2011) Anil F. Ramlackhansingh et al.   ANNALS OF NEUROLOGY

The ESCRT Pathway

(2011) William M. Henne et al.   DEVELOPMENTAL CELL

Selective transfer of exosomes from oligodendrocytes to microglia by macropinocytosis

(2011) D. Fitzner et al.   JOURNAL OF CELL SCIENCE

Glutaminase Dysregulation in HIV-1-Infected Human Microglia Mediates Neurotoxicity: Relevant to HIV-1-Associated Neurocognitive Disorders

(2011) Y. Huang et al.   JOURNAL OF NEUROSCIENCE

Physiology of Microglia

(2011) Helmut Kettenmann et al.   PHYSIOLOGICAL REVIEWS

The Distribution and Function of Phosphatidylserine in Cellular Membranes

(2010) Peter A. Leventis et al.   Annual Review of Biophysics

Exosome secretion of dendritic cells is regulated by Hrs, an ESCRT-0 protein

(2010) Keiichi Tamai et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inflammation in neurodegenerative diseases

(2010) Sandra Amor et al.   IMMUNOLOGY

Statins Promote the Degradation of Extracellular Amyloid β-Peptide by Microglia via Stimulation of Exosome-associated Insulin-degrading Enzyme (IDE) Secretion

(2010) Irfan Y. Tamboli et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Microvesicles: mediators of extracellular communication during cancer progression

(2010) V. Muralidharan-Chari et al.   JOURNAL OF CELL SCIENCE

Early microglia activation in a mouse model of chronic glaucoma

(2010) Alejandra Bosco et al.   JOURNAL OF COMPARATIVE NEUROLOGY

The role of microglia in amyloid clearance from the AD brain

(2010) C. Y. Daniel Lee et al.   JOURNAL OF NEURAL TRANSMISSION

The majority of circulating platelet-derived microparticles fail to bind annexin V, lack phospholipid-dependent procoagulant activity and demonstrate greater expression of glycoprotein Ib

(2010) Thomas Exner et al.   THROMBOSIS AND HAEMOSTASIS

ARF6-Regulated Shedding of Tumor Cell-Derived Plasma Membrane Microvesicles

(2009) Vandhana Muralidharan-Chari et al.   CURRENT BIOLOGY

Acid sphingomyelinase activity triggers microparticle release from glial cells

(2009) Fabio Bianco et al.   EMBO JOURNAL

Transmission and spreading of tauopathy in transgenic mouse brain

(2009) Florence Clavaguera et al.   NATURE CELL BIOLOGY

Rab27a and Rab27b control different steps of the exosome secretion pathway

(2009) Matias Ostrowski et al.   NATURE CELL BIOLOGY

Neuroinflammation in the living brain of Parkinson's disease

(2009) Yasuomi Ouchi et al.   PARKINSONISM & RELATED DISORDERS

Delivery of MicroRNA-126 by Apoptotic Bodies Induces CXCL12-Dependent Vascular Protection

(2009) A. Zernecke et al.   Science Signaling

Multivesicular Endosome Biogenesis in the Absence of ESCRTs

(2009) Susanne Stuffers et al.   TRAFFIC

Shedding microvesicles: artefacts no more

(2009) Emanuele Cocucci et al.   TRENDS IN CELL BIOLOGY

Debris clearance by microglia: an essential link between degeneration and regeneration

(2008) H. Neumann et al.   BRAIN

Dynamics of the Microglial/Amyloid Interaction Indicate a Role in Plaque Maintenance

(2008) T. Bolmont et al.   JOURNAL OF NEUROSCIENCE

Microglial Dysfunction and Defective  -Amyloid Clearance Pathways in Aging Alzheimer's Disease Mice

(2008) S. E. Hickman et al.   JOURNAL OF NEUROSCIENCE

Rapid appearance and local toxicity of amyloid-β plaques in a mouse model of Alzheimer’s disease

(2008) Melanie Meyer-Luehmann et al.   NATURE

Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes

(2008) K. Trajkovic et al.   SCIENCE

Glial reactions in Parkinson's disease

(2007) Patrick L. McGeer et al.   MOVEMENT DISORDERS

Synuclein activates microglia in a model of Parkinson's disease

(2007) Xiaomin Su et al.   NEUROBIOLOGY OF AGING