Statins Promote the Degradation of Extracellular Amyloid β-Peptide by Microglia via Stimulation of Exosome-associated Insulin-degrading Enzyme (IDE) Secretion

Can Statins Prevent or Help Treat Alzheimer's Disease?

(2017) Bernadette McGuinness et al.   JOURNAL OF ALZHEIMERS DISEASE

Insulin-Degrading Enzyme Sorting in Exosomes: A Secretory Pathway for a Key Brain Amyloid-β Degrading Protease

(2017) Ayelén Bulloj et al.   JOURNAL OF ALZHEIMERS DISEASE

Microglial Cx3cr1 knockout prevents neuron loss in a mouse model of Alzheimer's disease

(2010) Martin Fuhrmann et al.   NATURE NEUROSCIENCE

Statins Reduce the Neurofibrillary Tangle Burden in a Mouse Model of Tauopathy

(2009) Moran Boimel et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Therapeutic potential of statins in Alzheimer's disease

(2009) Nagaendran Kandiah et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Detergent resistant membrane-associated IDE in brain tissue and cultured cells: Relevance to Aβ and insulin degradation

(2009) Ayelén Bulloj et al.   Molecular Neurodegeneration

Insulin-degrading enzyme is exported via an unconventional protein secretion pathway

(2009) Ji Zhao et al.   Molecular Neurodegeneration

Formation and maintenance of Alzheimer's disease β-amyloid plaques in the absence of microglia

(2009) Stefan A Grathwohl et al.   NATURE NEUROSCIENCE

Rab GTPases as coordinators of vesicle traffic

(2009) Harald Stenmark   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Statins: Mechanisms of neuroprotection

(2009) Peter J. van der Most et al.   PROGRESS IN NEUROBIOLOGY

Unconventional Mechanisms of Protein Transport to the Cell Surface of Eukaryotic Cells

(2008) Walter Nickel et al.   Annual Review of Cell and Developmental Biology

Soluble oligomers of the amyloid β-protein impair synaptic plasticity and behavior

(2008) Dennis J. Selkoe   BEHAVIOURAL BRAIN RESEARCH

SYMPOSIUM: Clearance of Aβ from the Brain in Alzheimer' Disease: The Role of the Immune System in Clearance of Aβ from the Brain

(2008) Delphine Boche et al.   BRAIN PATHOLOGY

Active Caspase-1 Is a Regulator of Unconventional Protein Secretion

(2008) Martin Keller et al.   CELL

Autophagy and multivesicular bodies: two closely related partners

(2008) C M Fader et al.   CELL DEATH AND DIFFERENTIATION

Membrane traffic in the secretory pathway

(2008) M. Fukuda   CELLULAR AND MOLECULAR LIFE SCIENCES

Inhibition of γ-secretase causes increased secretion of amyloid precursor protein C-terminal fragments in association with exosomes

(2008) Robyn A. Sharples et al.   FASEB JOURNAL

Neuroprotective and neurotoxic properties of glial cells in the pathogenesis of Alzheimer's disease

(2008) D. Farfara et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

apoE isoform–specific disruption of amyloid β peptide clearance from mouse brain

(2008) Rashid Deane et al.   JOURNAL OF CLINICAL INVESTIGATION

Statins are associated with a reduced risk of Alzheimer disease regardless of lipophilicity. The Rotterdam Study

(2008) M D M Haag et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Loss of  -Secretase Function Impairs Endocytosis of Lipoprotein Particles and Membrane Cholesterol Homeostasis

(2008) I. Y. Tamboli et al.   JOURNAL OF NEUROSCIENCE

ApoE Promotes the Proteolytic Degradation of Aβ

(2008) Qingguang Jiang et al.   NEURON

Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes

(2008) K. Trajkovic et al.   SCIENCE

New structures help the modeling of toxic amyloidß ion channels

(2008) Hyunbum Jang et al.   TRENDS IN BIOCHEMICAL SCIENCES

Itinerant exosomes: emerging roles in cell and tissue polarity

(2008) Aparna Lakkaraju et al.   TRENDS IN CELL BIOLOGY

Geranylgeranyl pyrophosphate stimulates γ-secretase to increase the generation of Aβ and APP-CTFγ

(2007) Yan Zhou et al.   FASEB JOURNAL