An Update on in Vivo Imaging of Extracellular Vesicles as Drug Delivery Vehicles

Exosome levels in human body fluids: A tumor marker by themselves?

(2017) Francesco Cappello et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Cell type-specific and common characteristics of exosomes derived from mouse cell lines: Yield, physicochemical properties, and pharmacokinetics

(2017) Chonlada Charoenviriyakul et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Exosomes as novel bio-carriers for gene and drug delivery

(2017) Xin-Chi Jiang et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Extracellular vesicles from mesenchymal stem cells activates VEGF receptors and accelerates recovery of hindlimb ischemia

(2017) Prakash Gangadaran et al.   JOURNAL OF CONTROLLED RELEASE

Dendritic cell-derived exosomes elicit tumor regression in autochthonous hepatocellular carcinoma mouse models

(2017) Zhen Lu et al.   JOURNAL OF HEPATOLOGY

NK Cell–derived Exosomes From NK Cells Previously Exposed to Neuroblastoma Cells Augment the Antitumor Activity of Cytokine-activated NK Cells

(2017) Alireza Shoae-Hassani et al.   JOURNAL OF IMMUNOTHERAPY

Milk-derived exosomes for oral delivery of paclitaxel

(2017) Ashish K. Agrawal et al.   Nanomedicine-Nanotechnology Biology and Medicine

Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer

(2017) Sushrut Kamerkar et al.   NATURE

Extracellular vesicles from activated platelets: a semiquantitative cryo-electron microscopy and immuno-gold labeling study

(2017) Alain R. Brisson et al.   PLATELETS

Extracellular vesicle mimetics: Novel alternatives to extracellular vesicle-based theranostics, drug delivery, and vaccines

(2017) Oh Youn Kim et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Chemotherapy administration to breast cancer patients affects extracellular vesicles thrombogenicity and function

(2017) Anat Aharon et al.   Oncotarget

A new bioluminescent reporter system to study the biodistribution of systematically injected tumor-derived bioluminescent extracellular vesicles in mice

(2017) Prakash Gangadaran et al.   Oncotarget

Adipocyte-derived exosomes promote lung cancer metastasis by increasing MMP9 activity via transferring MMP3 to lung cancer cells

(2017) Jiaoli Wang et al.   Oncotarget

Exosomes of invasive urothelial carcinoma cells are characterized by a specific miRNA expression signature

(2017) Sophie Baumgart et al.   Oncotarget

Extracellular vesicles derived from MSCs activates dermal papilla cell in vitro and promotes hair follicle conversion from telogen to anagen in mice

(2017) Ramya Lakshmi Rajendran et al.   Scientific Reports

Serum-derived extracellular vesicles (EVs) impact on vascular remodeling and prevent muscle damage in acute hind limb ischemia

(2017) Claudia Cavallari et al.   Scientific Reports

Exosomes Derived From Natural Killer Cells Exert Therapeutic Effect in Melanoma

(2017) Liya Zhu et al.   Theranostics

Interleukin 3- receptor targeted exosomes inhibit in vitro and in vivo Chronic Myelogenous Leukemia cell growth

(2017) Daniele Bellavia et al.   Theranostics

Current Perspectives on In Vivo Noninvasive Tracking of Extracellular Vesicles with Molecular Imaging

(2017) Prakash Gangadaran et al.   Biomed Research International

In Vivo Tracking of Chemokine Receptor CXCR4-Engineered Mesenchymal Stem Cell Migration by Optical Molecular Imaging

(2017) Senthilkumar Kalimuthu et al.   Stem Cells International

Exosomes: Origins and Therapeutic Potential for Neurodegenerative Disease

(2017) Diana K. Sarko et al.   Frontiers in Neuroscience

Exosome Mediated Delivery of miR-124 Promotes Neurogenesis after Ischemia

(2017) Jialei Yang et al.   Molecular Therapy-Nucleic Acids

Molecular Imaging: A Useful Tool for the Development of Natural Killer Cell-Based Immunotherapies

(2017) Prakash Gangadaran et al.   Frontiers in Immunology

Exosomes from metastatic cancer cells transfer amoeboid phenotype to non-metastatic cells and increase endothelial permeability: their emerging role in tumor heterogeneity

(2017) Odessa Schillaci et al.   Scientific Reports

Bioinspired Cell-Derived Nanovesicles versus Exosomes as Drug Delivery Systems: a Cost-Effective Alternative

(2017) Wei Jiang Goh et al.   Scientific Reports

Efficient production and enhanced tumor delivery of engineered extracellular vesicles

(2016) Dionysios C. Watson et al.   BIOMATERIALS

Radiolabeling of Extracellular Vesicles with99mTc for QuantitativeIn VivoImaging Studies

(2016) Zoltán Varga et al.   CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS

The Biodistribution and Immune Suppressive Effects of Breast Cancer–Derived Exosomes

(2016) Shu Wen Wen et al.   CANCER RESEARCH

Degradable Controlled-Release Polymers and Polymeric Nanoparticles: Mechanisms of Controlling Drug Release

(2016) Nazila Kamaly et al.   CHEMICAL REVIEWS

Role of pulmonary macrophages in initiation of lung metastasis in anaplastic thyroid cancer

(2016) Xiu Juan Li et al.   INTERNATIONAL JOURNAL OF CANCER

Magnetic resonance imaging of ultrasmall superparamagnetic iron oxide-labeled exosomes from stem cells: a new method to obtain labeled exosomes

(2016) Pasquina Marzola et al.   International Journal of Nanomedicine

Exosomes: Tunable Nano Vehicles for Macromolecular Delivery of Transferrin and Lactoferrin to Specific Intracellular Compartment

(2016) Himanshu Malhotra et al.   Journal of Biomedical Nanotechnology

Polymeric nanoparticles for targeted drug delivery system for cancer therapy

(2016) Farha Masood   Materials Science & Engineering C-Materials for Biological Applications

Post isolation modification of exosomes for nanomedicine applications

(2016) Joshua L Hood   Nanomedicine

Development of exosome-encapsulated paclitaxel to overcome MDR in cancer cells

(2016) Myung Soo Kim et al.   Nanomedicine-Nanotechnology Biology and Medicine

Exosomes in Viral Disease

(2016) Monique R. Anderson et al.   Neurotherapeutics

Extracellular vesicles and viruses: Are they close relatives?

(2016) Esther Nolte-‘t Hoen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes

(2016) Joanna Kowal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Visualization of exosome-mediated miR-210 transfer from hypoxic tumor cells

(2016) Kyung Oh Jung et al.   Oncotarget

In Vivo therapeutic potential of mesenchymal stem cell-derived extracellular vesicles with optical imaging reporter in tumor mice model

(2016) Senthilkumar Kalimuthu et al.   Scientific Reports

Illuminating the physiology of extracellular vesicles

(2016) Hongyoon Choi et al.   Stem Cell Research & Therapy

Advances in Molecular Imaging Strategies forIn VivoTracking of Immune Cells

(2016) Ho Won Lee et al.   Biomed Research International

Towards Therapeutic Delivery of Extracellular Vesicles: Strategies forIn VivoTracking and Biodistribution Analysis

(2016) Giuliana Di Rocco et al.   Stem Cells International

In Vivo Imaging Reveals Extracellular Vesicle-Mediated Phenocopying of Metastatic Behavior

(2015) Anoek Zomer et al.   CELL

Organotropic metastasis: role of tumor exosomes

(2015) Yang Liu et al.   CELL RESEARCH

Exosomes: A Role for Naturally Occurring Nanovesicles in Cancer Growth, Diagnosis and Treatment

(2015) Akhil Srivastava et al.   CURRENT GENE THERAPY

Biodistribution and delivery efficiency of unmodified tumor-derived exosomes

(2015) Tyson Smyth et al.   JOURNAL OF CONTROLLED RELEASE

Exosomes as drug delivery vehicles for Parkinson's disease therapy

(2015) Matthew J. Haney et al.   JOURNAL OF CONTROLLED RELEASE

Microvesicle- and exosome-mediated drug delivery enhances the cytotoxicity of Paclitaxel in autologous prostate cancer cells

(2015) Heikki Saari et al.   JOURNAL OF CONTROLLED RELEASE

Quantitative Analysis of Tissue Distribution of the B16BL6-Derived Exosomes Using a Streptavidin-Lactadherin Fusion Protein and Iodine-125-Labeled Biotin Derivative After Intravenous Injection in Mice

(2015) Masaki Morishita et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Tumour exosome integrins determine organotropic metastasis

(2015) Ayuko Hoshino et al.   NATURE

Exosome Delivered Anticancer Drugs Across the Blood-Brain Barrier for Brain Cancer Therapy in Danio Rerio

(2015) Tianzhi Yang et al.   PHARMACEUTICAL RESEARCH

Visualization and tracking of tumour extracellular vesicle delivery and RNA translation using multiplexed reporters

(2015) Charles P. Lai et al.   Nature Communications

Noninvasive imaging of radiolabeled exosome-mimetic nanovesicle using 99mTc-HMPAO

(2015) Do Won Hwang et al.   Scientific Reports

Advances and Challenges of Liposome Assisted Drug Delivery

(2015) Lisa Sercombe et al.   Frontiers in Pharmacology

Dendritic cell-derived exosomes as maintenance immunotherapy after first line chemotherapy in NSCLC

(2015) Benjamin Besse et al.   OncoImmunology

Dynamic Biodistribution of Extracellular Vesicles in Vivo Using a Multimodal Imaging Reporter

(2014) Charles P. Lai et al.   ACS Nano

Bioengineered Bacterial Outer Membrane Vesicles as Cell-Specific Drug-Delivery Vehicles for Cancer Therapy

(2014) Vipul Gujrati et al.   ACS Nano

Biodistribution of mesenchymal stem cell-derived extracellular vesicles in a model of acute kidney injury monitored by optical imaging

(2014) CRISTINA GRANGE et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

In vitro evaluation of endothelial exosomes as carriers for small interfering ribonucleic acid delivery

(2014) Jiang He et al.   International Journal of Nanomedicine

Paclitaxel is incorporated by mesenchymal stromal cells and released in exosomes that inhibit in vitro tumor growth: A new approach for drug delivery

(2014) Luisa Pascucci et al.   JOURNAL OF CONTROLLED RELEASE

Requisites for successful theranostics with radionuclide-based reporter gene imaging

(2014) Byeong-Cheol Ahn   JOURNAL OF DRUG TARGETING

Magnetic resonance imaging of melanoma exosomes in lymph nodes

(2014) Lingzhi Hu et al.   MAGNETIC RESONANCE IN MEDICINE

Exosome-mediated delivery of functionally active miRNA-155 inhibitor to macrophages

(2014) Fatemeh Momen-Heravi et al.   Nanomedicine-Nanotechnology Biology and Medicine

Bioinspired Exosome-Mimetic Nanovesicles for Targeted Delivery of Chemotherapeutics to Malignant Tumors

(2013) Su Chul Jang et al.   ACS Nano

Maximizing exosome colloidal stability following electroporation

(2013) Joshua L. Hood et al.   ANALYTICAL BIOCHEMISTRY

A doxorubicin delivery platform using engineered natural membrane vesicle exosomes for targeted tumor therapy

(2013) Yanhua Tian et al.   BIOMATERIALS

Exosomes are natural carriers of exogenous siRNA to human cells in vitro

(2013) Tatyana A Shtam et al.   Cell Communication and Signaling

Exosome Uptake Depends on ERK1/2-Heat Shock Protein 27 Signaling and Lipid Raft-mediated Endocytosis Negatively Regulated by Caveolin-1

(2013) Katrin J. Svensson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Visualization and in vivo tracking of the exosomes of murine melanoma B16-BL6 cells in mice after intravenous injection

(2013) Yuki Takahashi et al.   JOURNAL OF BIOTECHNOLOGY

Extracellular vesicles: biology and emerging therapeutic opportunities

(2013) Samir EL Andaloussi et al.   NATURE REVIEWS DRUG DISCOVERY

Glutathione levels in human tumors

(2012) Michael P. Gamcsik et al.   BIOMARKERS

Systemically Injected Exosomes Targeted to EGFR Deliver Antitumor MicroRNA to Breast Cancer Cells

(2012) Shin-ichiro Ohno et al.   MOLECULAR THERAPY

Plasma exosomes can deliver exogenous short interfering RNA to monocytes and lymphocytes

(2012) Jessica Wahlgren et al.   NUCLEIC ACIDS RESEARCH

Recent advances on the role of tumor exosomes in immunosuppression and disease progression

(2012) Paola Filipazzi et al.   SEMINARS IN CANCER BIOLOGY

A systematic approach to exosome-based translational nanomedicine

(2012) Joshua L. Hood et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

Interaction and uptake of exosomes by ovarian cancer cells

(2011) Cristina Escrevente et al.   BMC CANCER

Selective transfer of exosomes from oligodendrocytes to microglia by macropinocytosis

(2011) D. Fitzner et al.   JOURNAL OF CELL SCIENCE

Treatment of Brain Inflammatory Diseases by Delivering Exosome Encapsulated Anti-inflammatory Drugs From the Nasal Region to the Brain

(2011) Xiaoying Zhuang et al.   MOLECULAR THERAPY

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

(2011) Lydia Alvarez-Erviti et al.   NATURE BIOTECHNOLOGY

ExoCarta 2012: database of exosomal proteins, RNA and lipids

(2011) S. Mathivanan et al.   NUCLEIC ACIDS RESEARCH

Detachment of Breast Tumor Cells Induces Rapid Secretion of Exosomes Which Subsequently Mediate Cellular Adhesion and Spreading

(2011) Rainelli B. Koumangoye et al.   PLoS One

Exosome Secretion: Molecular Mechanisms and Roles in Immune Responses

(2011) Angélique Bobrie et al.   TRAFFIC

Guidelines for the labelling of leucocytes with 111In-oxine

(2010) Manel Roca et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Guidelines for the labelling of leucocytes with 99mTc-HMPAO

(2010) Erik F. J. de Vries et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

A Novel Nanoparticle Drug Delivery System: The Anti-inflammatory Activity of Curcumin Is Enhanced When Encapsulated in Exosomes

(2010) Dongmei Sun et al.   MOLECULAR THERAPY

ARF6-Regulated Shedding of Tumor Cell-Derived Plasma Membrane Microvesicles

(2009) Vandhana Muralidharan-Chari et al.   CURRENT BIOLOGY

Imaging of HIF-1-Active Tumor Hypoxia Using a Protein Effectively Delivered to and Specifically Stabilized in HIF-1-Active Tumor Cells

(2009) T. Kudo et al.   JOURNAL OF NUCLEAR MEDICINE

Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes

(2008) K. Trajkovic et al.   SCIENCE