P2RX7 inhibitor suppresses exosome secretion and disease phenotype in P301S tau transgenic mice

LRP1 is a master regulator of tau uptake and spread

(2020) Jennifer N. Rauch et al.   NATURE

Internalization mechanisms of brain-derived tau oligomers from patients with Alzheimer’s disease, progressive supranuclear palsy and dementia with Lewy bodies

(2020) Nicha Puangmalai et al.   Cell Death & Disease

Neuroimmune Crosstalk through Extracellular Vesicles in Health and Disease

(2019) Jean-Christophe Delpech et al.   TRENDS IN NEUROSCIENCES

BIN1 favors the spreading of Tau via extracellular vesicles

(2019) Andrea Crotti et al.   Scientific Reports

Cell-autonomous and non-cell autonomous effects of neuronal BIN1 loss in vivo

(2019) Kathleen M. McAvoy et al.   PLoS One

Emerging roles of extracellular vesicles in neurodegenerative disorders

(2019) Yang You et al.   NEUROBIOLOGY OF DISEASE

Activated human astrocyte-derived extracellular vesicles modulate neuronal uptake, differentiation and firing

(2019) Yang You et al.   Journal of Extracellular Vesicles

Synthesis and in vitro characterization of a P2X7 radioligand [ 123 I]TZ6019 and its response to neuroinflammation in a mouse model of Alzheimer disease

(2018) Hongjun Jin et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

New role of P2X7 receptor in an Alzheimer’s disease mouse model

(2018) Elodie Martin et al.   MOLECULAR PSYCHIATRY

Re-evaluation of neuronal P2X7 expression using novel mouse models and a P2X7-specific nanobody

(2018) Karina Kaczmarek-Hajek et al.   eLife

The P2X7 Receptor in Infection and Inflammation

(2017) Francesco Di Virgilio et al.   IMMUNITY

Extracellular Vesicle Biology in Alzheimer’s Disease and Related Tauopathy

(2017) Annina M. DeLeo et al.   Journal of Neuroimmune Pharmacology

Cryo-EM structures of tau filaments from Alzheimer’s disease

(2017) Anthony W. P. Fitzpatrick et al.   NATURE

Extracellular Vesicles Containing P301L Mutant Tau Accelerate Pathological Tau Phosphorylation and Oligomer Formation but Do Not Seed Mature Neurofibrillary Tangles in ALZ17 Mice

(2016) Siân Baker et al.   JOURNAL OF ALZHEIMERS DISEASE

Genetically dissecting P2rx7 expression within the central nervous system using conditional humanized mice

(2016) Michael W. Metzger et al.   Purinergic Signalling

Emerging role of P2X7 receptors in CNS health and disease

(2015) Manju Tewari et al.   AGEING RESEARCH REVIEWS

Depletion of microglia and inhibition of exosome synthesis halt tau propagation

(2015) Hirohide Asai et al.   NATURE NEUROSCIENCE

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

(2014) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

Ectosomes: A New Mechanism for Non-Exosomal Secretion of Tau Protein

(2014) Simon Dujardin et al.   PLoS One

Analysis of ESCRT functions in exosome biogenesis, composition and secretion highlights the heterogeneity of extracellular vesicles

(2013) Marina Colombo et al.   JOURNAL OF CELL SCIENCE

Myeloid microvesicles are a marker and therapeutic target for neuroinflammation

(2012) Claudia Verderio et al.   ANNALS OF NEUROLOGY

Pharmacokinetic and pharmacodynamic profiling of a P2X7 receptor allosteric modulator GSK1482160 in healthy human subjects

(2012) Zahid Ali et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Discovery and structure–activity relationships of a series of pyroglutamic acid amide antagonists of the P2X7 receptor

(2010) Muna H. Abdi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

P2X7 receptors regulate multiple types of membrane trafficking responses and non-classical secretion pathways

(2009) Yan Qu et al.   Purinergic Signalling

Purinergic signalling and disorders of the central nervous system

(2008) Geoffrey Burnstock   NATURE REVIEWS DRUG DISCOVERY