Journal
CELL
Volume 179, Issue 2, Pages 292-311Publisher
CELL PRESS
DOI: 10.1016/j.cell.2019.08.053
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Funding
- Sobek Foundation
- Ernst Jung Foundation
- German Research Foundation (DFG) [SFB 992, SFB1160]
- Ministry of Science, Research and Arts, Baden-Wuerttemberg (Sonderlinie Neuroinflammation)
- BMBF
- DFG under Germany's Excellence Strategy [CIBSS -EXC-2189, 390939984]
- Israeli Science Foundation [887/11]
- European Research Council [Adv ERC 340345]
- International Progressive MS Alliance (PMSA)
- DFG [SFB/TRR167, SFB/TRR265]
- BMBF (AERIAL)
- BIH
- UK DRI (Momentum Award)
- DZNE
- MRC [MC_PC_16031] Funding Source: UKRI
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Microglia were first recognized as a distinct cell population in the CNS one century ago. For a long time, they were primarily considered to be phagocytes responsible for removing debris during CNS development and disease. More recently, advances in imaging and genetics and the advent of single-cell technology provided new insights into the much more complex and fascinatir; biology of microglia. The ontogeny of microglia was identified, and their functions in health and disease were better defined. Although many qL lions about microglia and their roles in human diseases remain unanswered, the prospect of targeting microglia for the treatment of neurological and psychiatric disorders is tantalizing.
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