Adenosine A2AR blockade prevents neuroinflammation-induced death of retinal ganglion cells caused by elevated pressure

ATP as a multi-target danger signal in the brain

(2015) Ricardo J. Rodrigues et al.   Frontiers in Neuroscience

Microglial cells in organotypic cultures of developing and adult mouse retina and their relationship with cell death

(2014) Rosa M. Ferrer-Martín et al.   EXPERIMENTAL EYE RESEARCH

Systemic inflammation regulates microglial responses to tissue damagein vivo

(2014) Stefka Gyoneva et al.   GLIA

Mechanosensitive release of adenosine 5′-triphosphate through pannexin channels and mechanosensitive upregulation of pannexin channels in optic nerve head astrocytes: A mechanism for purinergic involvement in chronic strain

(2014) Jonathan M. Beckel et al.   GLIA

Fractalkine receptor regulates microglial neurotoxicity in an experimental mouse glaucoma model

(2014) Ke Wang et al.   GLIA

Role of Microglia Adenosine A2AReceptors in Retinal and Brain Neurodegenerative Diseases

(2014) Ana R. Santiago et al.   MEDIATORS OF INFLAMMATION

From Mechanosensitivity to Inflammatory Responses: New Players in the Pathology of Glaucoma

(2013) David Križaj et al.   CURRENT EYE RESEARCH

Microglia release ATP by exocytosis

(2013) Yoshio Imura et al.   GLIA

Potential role of A2A adenosine receptor in traumatic optic neuropathy

(2013) Saif Ahmad et al.   JOURNAL OF NEUROIMMUNOLOGY

Activation of microglial cells triggers a release of brain-derived neurotrophic factor (BDNF) inducing their proliferation in an adenosine A2A receptor-dependent manner: A2A receptor blockade prevents BDNF release and proliferation of microglia

(2013) Catarina Gomes et al.   Journal of Neuroinflammation

A quantitative spatiotemporal analysis of microglia morphology during ischemic stroke and reperfusion

(2013) Helena W Morrison et al.   Journal of Neuroinflammation

Ecto-5'-Nucleotidase (CD73)-Mediated Formation of Adenosine Is Critical for the Striatal Adenosine A2A Receptor Functions

(2013) E. Augusto et al.   JOURNAL OF NEUROSCIENCE

Enhanced Insight into the Autoimmune Component of Glaucoma: IgG Autoantibody Accumulation and Pro-Inflammatory Conditions in Human Glaucomatous Retina

(2013) Oliver W. Gramlich et al.   PLoS One

Adenosine Receptor Antagonists Including Caffeine Alter Fetal Brain Development in Mice

(2013) C. G. Silva et al.   Science Translational Medicine

Blockade of adenosine A2A receptors prevents interleukin-1β-induced exacerbation of neuronal toxicity through a p38 mitogen-activated protein kinase pathway

(2012) Ana Patrícia Simões et al.   Journal of Neuroinflammation

Neurons respond directly to mechanical deformation with pannexin-mediated ATP release and autostimulation of P2X7receptors

(2012) Jingsheng Xia et al.   JOURNAL OF PHYSIOLOGY-LONDON

Retinal Ganglion Cell Loss Is Accompanied by Antibody Depositions and Increased Levels of Microglia after Immunization with Retinal Antigens

(2012) Stephanie C. Joachim et al.   PLoS One

Clinical Evidence for Neuroprotection in Glaucoma

(2011) M. Francesca Cordeiro et al.   AMERICAN JOURNAL OF OPHTHALMOLOGY

A2A Adenosine Receptor (A2AAR) as a Therapeutic Target in Diabetic Retinopathy

(2011) Ahmed S. Ibrahim et al.   AMERICAN JOURNAL OF PATHOLOGY

Glial cell response and iNOS expression in the optic nerve head and retina of the rat following acute high IOP ischemia–reperfusion

(2011) Kyong Jin Cho et al.   BRAIN RESEARCH

Retinal Microglial Activation and Inflammation Induced by Amadori-Glycated Albumin in a Rat Model of Diabetes

(2011) A. S. Ibrahim et al.   DIABETES

Involvement of the CD200 receptor complex in microglia activation in experimental glaucoma

(2011) Sarah Taylor et al.   EXPERIMENTAL EYE RESEARCH

Sustained elevation of extracellular ATP in aqueous humor from humans with primary chronic angle-closure glaucoma

(2011) Ang Li et al.   EXPERIMENTAL EYE RESEARCH

Brain derived neurotrophic factor maintains Brn3a expression in axotomized rat retinal ganglion cells

(2011) M.C. Sánchez-Migallón et al.   EXPERIMENTAL EYE RESEARCH

Molecular clustering identifies complement and endothelin induction as early events in a mouse model of glaucoma

(2011) Gareth R. Howell et al.   JOURNAL OF CLINICAL INVESTIGATION

Adenosine A2A receptors control neuroinflammation and consequent hippocampal neuronal dysfunction

(2011) Nelson Rebola et al.   JOURNAL OF NEUROCHEMISTRY

Retinal ganglion cell death is induced by microglia derived pro-inflammatory cytokines in the hypoxic neonatal retina

(2011) Viswanathan Sivakumar et al.   JOURNAL OF PATHOLOGY

International Union of Basic and Clinical Pharmacology. LXXXI. Nomenclature and Classification of Adenosine Receptors--An Update

(2011) B. B. Fredholm et al.   PHARMACOLOGICAL REVIEWS

Physiology of Microglia

(2011) Helmut Kettenmann et al.   PHYSIOLOGICAL REVIEWS

Features of Microglia and Neuroinflammation Relevant to Environmental Exposure and Neurotoxicity

(2011) Andrew D. Kraft et al.   International Journal of Environmental Research and Public Health

Adenosine receptors and brain diseases: Neuroprotection and neurodegeneration

(2010) Catarina V. Gomes et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Progressive Activation of CyclinB1-Cdk1 Coordinates Entry to Mitosis

(2010) Olivier Gavet et al.   DEVELOPMENTAL CELL

Stimulation of the P2X7 receptor kills rat retinal ganglion cells in vivo

(2010) Huiling Hu et al.   EXPERIMENTAL EYE RESEARCH

Early microglia activation in a mouse model of chronic glaucoma

(2010) Alejandra Bosco et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Local Glutamate Level Dictates Adenosine A2A Receptor Regulation of Neuroinflammation and Traumatic Brain Injury

(2010) S. S. Dai et al.   JOURNAL OF NEUROSCIENCE

Adenosine A2A Receptor Blockade Prevents Synaptotoxicity and Memory Dysfunction Caused by  -Amyloid Peptides via p38 Mitogen-Activated Protein Kinase Pathway

(2009) P. M. Canas et al.   JOURNAL OF NEUROSCIENCE

Adenosine receptors: therapeutic aspects for inflammatory and immune diseases

(2008) György Haskó et al.   NATURE REVIEWS DRUG DISCOVERY

Adenosine A2A Receptors Are Essential for Long-Term Potentiation of NMDA-EPSCs at Hippocampal Mossy Fiber Synapses

(2008) Nelson Rebola et al.   NEURON

Elevated pressure triggers a physiological release of ATP from the retina: Possible role for pannexin hemichannels

(2008) D. Reigada et al.   NEUROSCIENCE

Chronic but not acute treatment with caffeine attenuates traumatic brain injury in the mouse cortical impact model

(2007) W. Li et al.   NEUROSCIENCE