Alzheimer’s disease brain-derived extracellular vesicles spread tau pathology in interneurons

Assessment of separation methods for extracellular vesicles from human and mouse brain tissues and human cerebrospinal fluids

(2020) Satoshi Muraoka et al.   METHODS

Novel tau filament fold in corticobasal degeneration

(2020) Wenjuan Zhang et al.   NATURE

Proteomic and biological profiling of extracellular vesicles from Alzheimer's disease human brain tissues

(2020) Satoshi Muraoka et al.   Alzheimers & Dementia

Neuroimmune Crosstalk through Extracellular Vesicles in Health and Disease

(2019) Jean-Christophe Delpech et al.   TRENDS IN NEUROSCIENCES

Novel tau filament fold in chronic traumatic encephalopathy encloses hydrophobic molecules

(2019) Benjamin Falcon et al.   NATURE

Single-cell transcriptomic analysis of Alzheimer’s disease

(2019) Hansruedi Mathys et al.   NATURE

Cell-autonomous and non-cell autonomous effects of neuronal BIN1 loss in vivo

(2019) Kathleen M. McAvoy et al.   PLoS One

From the prion-like propagation hypothesis to therapeutic strategies of anti-tau immunotherapy

(2019) Morvane Colin et al.   ACTA NEUROPATHOLOGICA

Mechanisms of secretion and spreading of pathological tau protein

(2019) Cecilia A. Brunello et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Emerging roles of extracellular vesicles in neurodegenerative disorders

(2019) Yang You et al.   NEUROBIOLOGY OF DISEASE

Proteomic Profiling of Extracellular Vesicles Isolated From Cerebrospinal Fluid of Former National Football League Players at Risk for Chronic Traumatic Encephalopathy

(2019) Satoshi Muraoka et al.   Frontiers in Neuroscience

Activated human astrocyte-derived extracellular vesicles modulate neuronal uptake, differentiation and firing

(2019) Yang You et al.   Journal of Extracellular Vesicles

Suppression of tau propagation using an inhibitor that targets the DK-switch of nSMase2

(2018) Tina Bilousova et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Shedding light on the cell biology of extracellular vesicles

(2018) Guillaume van Niel et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Extracellular Monomeric and Aggregated Tau Efficiently Enter Human Neurons through Overlapping but Distinct Pathways

(2018) Lewis D. Evans et al.   Cell Reports

Structures of filaments from Pick’s disease reveal a novel tau protein fold

(2018) Benjamin Falcon et al.   NATURE

Soluble tau aggregates, not large fibrils, are the toxic species that display seeding and cross-seeding behavior

(2018) Gaurav Ghag et al.   PROTEIN SCIENCE

TIA1 regulates the generation and response to toxic tau oligomers

(2018) Lulu Jiang et al.   ACTA NEUROPATHOLOGICA

Tau Immunotherapies for Alzheimer’s Disease and Related Tauopathies: Progress and Potential Pitfalls

(2018) Einar M. Sigurdsson   JOURNAL OF ALZHEIMERS DISEASE

Neuronal Exosome-Derived Human Tau is Toxic to Recipient Mouse Neurons in vivo

(2018) Charisse N. Winston et al.   JOURNAL OF ALZHEIMERS DISEASE

A randomized, double-blind, placebo-controlled crossover study of the effects of levetiracetam on cognition, mood, and balance in healthy older adults

(2017) Mike R. Schoenberg et al.   EPILEPSIA

The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases

(2017) Susanne Krasemann et al.   IMMUNITY

Towards a Better Understanding of GABAergic Remodeling in Alzheimer’s Disease

(2017) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Extracellular Vesicle Biology in Alzheimer’s Disease and Related Tauopathy

(2017) Annina M. DeLeo et al.   Journal of Neuroimmune Pharmacology

Pathological Tau Strains from Human Brains Recapitulate the Diversity of Tauopathies in Nontransgenic Mouse Brain

(2017) Sneha Narasimhan et al.   JOURNAL OF NEUROSCIENCE

Cryo-EM structures of tau filaments from Alzheimer’s disease

(2017) Anthony W. P. Fitzpatrick et al.   NATURE

Reducing the RNA binding protein TIA1 protects against tau-mediated neurodegeneration in vivo

(2017) Daniel J. Apicco et al.   NATURE NEUROSCIENCE

The GABAergic septohippocampal connection is impaired in a mouse model of tauopathy

(2017) Helena Soler et al.   NEUROBIOLOGY OF AGING

Hyperphosphorylation determines both the spread and the morphology of tau pathology

(2016) Wen Hu et al.   Alzheimers & Dementia

Extracellular Vesicles Containing P301L Mutant Tau Accelerate Pathological Tau Phosphorylation and Oligomer Formation but Do Not Seed Mature Neurofibrillary Tangles in ALZ17 Mice

(2016) Siân Baker et al.   JOURNAL OF ALZHEIMERS DISEASE

Preliminary Study of Plasma Exosomal Tau as a Potential Biomarker for Chronic Traumatic Encephalopathy

(2016) Robert A. Stern et al.   JOURNAL OF ALZHEIMERS DISEASE

Extracellular Vesicles Isolated from the Brains of rTg4510 Mice Seed Tau Protein Aggregation in a Threshold-dependent Manner

(2016) Juan Carlos Polanco et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Unique pathological tau conformers from Alzheimer’s brains transmit tau pathology in nontransgenic mice

(2016) Jing L. Guo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Extracellular vesicles round off communication in the nervous system

(2016) Vivian Budnik et al.   NATURE REVIEWS NEUROSCIENCE

Detailed Analysis of Protein Topology of Extracellular Vesicles–Evidence of Unconventional Membrane Protein Orientation

(2016) Aleksander Cvjetkovic et al.   Scientific Reports

Identification of preclinical Alzheimer's disease by a profile of pathogenic proteins in neurally derived blood exosomes: A case-control study

(2015) Massimo S. Fiandaca et al.   Alzheimers & Dementia

Fibronectin on the Surface of Myeloma Cell-derived Exosomes Mediates Exosome-Cell Interactions

(2015) Anurag Purushothaman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tau Trimers Are the Minimal Propagation Unit Spontaneously Internalized to Seed Intracellular Aggregation

(2015) Hilda Mirbaha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tumour exosome integrins determine organotropic metastasis

(2015) Ayuko Hoshino et al.   NATURE

Depletion of microglia and inhibition of exosome synthesis halt tau propagation

(2015) Hirohide Asai et al.   NATURE NEUROSCIENCE

From molecule to molecule and cell to cell: Prion-like mechanisms in amyotrophic lateral sclerosis

(2015) Leslie I. Grad et al.   NEUROBIOLOGY OF DISEASE

Directional cell movement through tissues is controlled by exosome secretion

(2015) Bong Hwan Sung et al.   Nature Communications

Neuronal activity regulates extracellular tau in vivo

(2014) Kaoru Yamada et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Prognostic serum miRNA biomarkers associated with Alzheimer’s disease shows concordance with neuropsychological and neuroimaging assessment

(2014) L Cheng et al.   MOLECULAR PSYCHIATRY

Label-free detection and molecular profiling of exosomes with a nano-plasmonic sensor

(2014) Hyungsoon Im et al.   NATURE BIOTECHNOLOGY

Ectosomes: A New Mechanism for Non-Exosomal Secretion of Tau Protein

(2014) Simon Dujardin et al.   PLoS One

Proteopathic tau seeding predicts tauopathy in vivo

(2014) B. B. Holmes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancer cell exosomes depend on cell-surface heparan sulfate proteoglycans for their internalization and functional activity

(2013) H. C. Christianson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Plasma tau levels in Alzheimer's disease

(2013) Henrik Zetterberg et al.   Alzheimers Research & Therapy

Seizures and Epileptiform Activity in the Early Stages of Alzheimer Disease

(2013) Keith A. Vossel et al.   JAMA Neurology

Tau pathology induces loss of GABAergic interneurons leading to altered synaptic plasticity and behavioral impairments

(2013) Josien Levenga et al.   Acta Neuropathologica Communications

The Exosome Secretory Pathway Transports Amyloid Precursor Protein Carboxyl-terminal Fragments from the Cell into the Brain Extracellular Space

(2012) Rocio Perez-Gonzalez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exosomal cell-to-cell transmission of alpha synuclein oligomers

(2012) Karin M Danzer et al.   Molecular Neurodegeneration

CD81 is essential for the formation of membrane protrusions and regulates Rac1-activation in adhesion-dependent immune cell migration

(2011) T. Quast et al.   BLOOD

Stereologic estimation of hippocampal GluR2/3- and calretinin-immunoreactive hilar neurons (presumptive mossy cells) in two mouse models of temporal lobe epilepsy

(2011) Florian Volz et al.   EPILEPSIA

Exosome-associated Tau Is Secreted in Tauopathy Models and Is Selectively Phosphorylated in Cerebrospinal Fluid in Early Alzheimer Disease

(2011) Sudad Saman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cell Surface Tetraspanin Tspan8 Contributes to Molecular Pathways of Exosome-Induced Endothelial Cell Activation

(2010) I. Nazarenko et al.   CANCER RESEARCH

Epilepsy and Cognitive Impairments in Alzheimer Disease

(2009) Jorge J. Palop   ARCHIVES OF NEUROLOGY

Galectin-5 is bound onto the surface of rat reticulocyte exosomes and modulates vesicle uptake by macrophages

(2009) C. Barres et al.   BLOOD

Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease

(2009) Jean-Charles Lambert et al.   NATURE GENETICS