Increased miR-124-3p in microglial exosomes following traumatic brain injury inhibits neuronal inflammation and contributes to neurite outgrowth via their transfer into neurons

MiR-124 contributes to M2 polarization of microglia and confers brain inflammatory protection via the C/EBP-α pathway in intracerebral hemorrhage

(2017) Anyong Yu et al.   IMMUNOLOGY LETTERS

Flow Cytometric Characterization of T Cell Subsets and Microglia After Repetitive Mild Traumatic Brain Injury in Rats

(2017) Ruojing Bai et al.   NEUROCHEMICAL RESEARCH

Discovery of long-range inhibitory signaling to ensure single axon formation

(2017) Tetsuya Takano et al.   Nature Communications

Long-Term Kinetics of Immunologic Components and Neurological Deficits in Rats Following Repetitive Mild Traumatic Brain Injury

(2017) Ruojing Bai et al.   MEDICAL SCIENCE MONITOR

miR-21-5p alleviates leakage of injured brain microvascular endothelial barrier in vitro through suppressing inflammation and apoptosis

(2016) Xintong Ge et al.   BRAIN RESEARCH

RAD001 (everolimus) attenuates experimental autoimmune neuritis by inhibiting the mTOR pathway, elevating Akt activity and polarizing M2 macrophages

(2016) Ranran Han et al.   EXPERIMENTAL NEUROLOGY

mTORC1 pathway disruption ameliorates brain inflammation following stroke via a shift in microglia phenotype from M1 type to M2 type

(2016) Daojing Li et al.   FASEB JOURNAL

Neuroinflammation in animal models of traumatic brain injury

(2016) Chong-Chi Chiu et al.   JOURNAL OF NEUROSCIENCE METHODS

Exploring New Inflammatory Biomarkers and Pathways during LPS-Induced M1 Polarization

(2016) Carolina Cunha et al.   MEDIATORS OF INFLAMMATION

Liraglutide attenuates the osteoblastic differentiation of MC3T3-E1 cells by modulating AMPK/mTOR signaling

(2016) Xiong-Ke Hu et al.   Molecular Medicine Reports

Exosomes Derived from Mesenchymal Stromal Cells Promote Axonal Growth of Cortical Neurons

(2016) Yi Zhang et al.   MOLECULAR NEUROBIOLOGY

Extracellular vesicles in neurodegenerative disease — pathogenesis to biomarkers

(2016) Alexander G. Thompson et al.   Nature Reviews Neurology

Extracellular vesicles round off communication in the nervous system

(2016) Vivian Budnik et al.   NATURE REVIEWS NEUROSCIENCE

Escitalopram attenuates β-amyloid-induced tau hyperphosphorylation in primary hippocampal neurons through the 5-HT1A receptor mediated Akt/GSK-3β pathway

(2016) Yan-Juan Wang et al.   Oncotarget

Reducing Peripheral Inflammation with Infliximab Reduces Neuroinflammation and Improves Cognition in Rats with Hepatic Encephalopathy

(2016) Sherry Dadsetan et al.   Frontiers in Molecular Neuroscience

Emerging Roles for the Immune System in Traumatic Brain Injury

(2016) Celia A. McKee et al.   Frontiers in Immunology

miR-21 alleviates secondary blood–brain barrier damage after traumatic brain injury in rats

(2015) Xintong Ge et al.   BRAIN RESEARCH

Lack of Neuronal IFN-β-IFNAR Causes Lewy Body- and Parkinson’s Disease-like Dementia

(2015) Patrick Ejlerskov et al.   CELL

miR-124 disinhibits neurite outgrowth in an inflammatory environment

(2015) Hanna Hartmann et al.   CELL AND TISSUE RESEARCH

Establishment of Lipofection Protocol for Efficient miR-21 Transfection into Cortical NeuronsIn Vitro

(2015) Zhaoli Han et al.   DNA AND CELL BIOLOGY

Emerging potential of exosomes and noncoding microRNAs for the treatment of neurological injury/diseases

(2015) Michael Chopp et al.   EXPERT OPINION ON EMERGING DRUGS

Investigational agents for treatment of traumatic brain injury

(2015) Ye Xiong et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

MicroRNA-124 regulates glucocorticoid sensitivity by targeting phosphodiesterase 4B in diffuse large B cell lymphoma

(2015) Jinyoung Kim et al.   GENE

Effect of exosomes derived from multipluripotent mesenchymal stromal cells on functional recovery and neurovascular plasticity in rats after traumatic brain injury

(2015) Yanlu Zhang et al.   JOURNAL OF NEUROSURGERY

Depletion of microglia and inhibition of exosome synthesis halt tau propagation

(2015) Hirohide Asai et al.   NATURE NEUROSCIENCE

Chromatographically isolated CD63+CD81+extracellular vesicles from mesenchymal stromal cells rescue cognitive impairments after TBI

(2015) Dong-ki Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

miR-21 alleviated apoptosis of cortical neurons through promoting PTEN-Akt signaling pathway in vitro after experimental traumatic brain injury

(2014) Zhaoli Han et al.   BRAIN RESEARCH

Genomic analysis of drug resistant gastric cancer cell lines by combining mRNA and microRNA expression profiling

(2014) Zhangqian Chen et al.   CANCER LETTERS

Serotonin stimulates secretion of exosomes from microglia cells

(2014) Konstantin Glebov et al.   GLIA

Effect of Erythropoietin and Transfusion Threshold on Neurological Recovery After Traumatic Brain Injury

(2014) Claudia S. Robertson et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Role of Akt and Mammalian Target of Rapamycin in Functional Outcome after Concussive Brain Injury in Mice

(2014) Xiaoxia Zhu et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Comprehensive analysis of microRNA-regulated protein interaction network reveals the tumor suppressive role of microRNA-149 in human hepatocellular carcinoma via targeting AKT-mTOR pathway

(2014) Yanqiong Zhang et al.   Molecular Cancer

Phosphodiesterase-4 (PDE4) Molecular Pharmacology and Alzheimer’s Disease

(2014) Mark E. Gurney et al.   Neurotherapeutics

Bone Marrow Mesenchymal Stromal Cells Drive Protective M2 Microglia Polarization After Brain Trauma

(2014) Elisa R. Zanier et al.   Neurotherapeutics

Chronic Neurodegeneration After Traumatic Brain Injury: Alzheimer Disease, Chronic Traumatic Encephalopathy, or Persistent Neuroinflammation?

(2014) Alan I. Faden et al.   Neurotherapeutics

Very Early Administration of Progesterone for Acute Traumatic Brain Injury

(2014) David W. Wright et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Clinical Trial of Progesterone for Severe Traumatic Brain Injury

(2014) Brett E. Skolnick et al.   NEW ENGLAND JOURNAL OF MEDICINE

TSC1 controls macrophage polarization to prevent inflammatory disease

(2014) Linnan Zhu et al.   Nature Communications

miR-21 improves the neurological outcome after traumatic brain injury in rats

(2014) Xin-Tong Ge et al.   Scientific Reports

Identification of the fused bicyclic 4-amino-2-phenylpyrimidine derivatives as novel and potent PDE4 inhibitors

(2013) Taiji Goto et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Inflammation and white matter degeneration persist for years after a single traumatic brain injury

(2013) Victoria E. Johnson et al.   BRAIN

High-dose glucocorticoid aggravates TBI-associated corticosteroid insufficiency by inducing hypothalamic neuronal apoptosis

(2013) Hui Zhu et al.   BRAIN RESEARCH

Microglia during development and aging

(2013) G. Jean Harry   PHARMACOLOGY & THERAPEUTICS

The TSC-mTOR pathway regulates macrophage polarization

(2013) Vanessa Byles et al.   Nature Communications

Wnt3a induces exosome secretion from primary cultured rat microglia

(2012) Claudie Hooper et al.   BMC NEUROSCIENCE

Neuroinflammation after traumatic brain injury: Opportunities for therapeutic intervention

(2012) Alok Kumar et al.   BRAIN BEHAVIOR AND IMMUNITY

Incidence of traumatic brain injury in New Zealand: a population-based study

(2012) Valery L Feigin et al.   LANCET NEUROLOGY

The Neuropathology and Neurobiology of Traumatic Brain Injury

(2012) Kaj Blennow et al.   NEURON

Exosome-Mediated Transfer of miR-133b from Multipotent Mesenchymal Stromal Cells to Neural Cells Contributes to Neurite Outgrowth

(2012) Hongqi Xin et al.   STEM CELLS

Inflammation after trauma: Microglial activation and traumatic brain injury

(2011) Anil F. Ramlackhansingh et al.   ANNALS OF NEUROLOGY

Gene Set Enrichment Analysis Unveils the Mechanism for the Phosphodiesterase 4B Control of Glucocorticoid Response in B-cell Lymphoma

(2011) S.-W. Kim et al.   CLINICAL CANCER RESEARCH

Downregulation of miR-21 inhibits EGFR pathway and suppresses the growth of human glioblastoma cells independent of PTEN status

(2010) Xuan Zhou et al.   LABORATORY INVESTIGATION

MicroRNA-124 promotes microglia quiescence and suppresses EAE by deactivating macrophages via the C/EBP-α–PU.1 pathway

(2010) Eugene D Ponomarev et al.   NATURE MEDICINE

Genetic and histologic evidence implicates role of inflammation in traumatic brain injury-induced apoptosis in the rat cerebral cortex following moderate fluid percussion injury

(2010) H. Shojo et al.   NEUROSCIENCE

Increasing tPA Activity in Astrocytes Induced by Multipotent Mesenchymal Stromal Cells Facilitate Neurite Outgrowth after Stroke in the Mouse

(2010) Hongqi Xin et al.   PLoS One

Discovery of selective PDE4B inhibitors

(2009) Kenji Naganuma et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS