Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer

Extracellular vesicles for drug delivery

(2016) Pieter Vader et al.   ADVANCED DRUG DELIVERY REVIEWS

Genetics and biology of pancreatic ductal adenocarcinoma

(2016) Haoqiang Ying et al.   GENES & DEVELOPMENT

KRAS Mutant Pancreatic Cancer: No Lone Path to an Effective Treatment

(2016) Daniel Zeitouni et al.   Cancers

A rapid, automated surface protein profiling of single circulating exosomes in human blood

(2016) Golam Kibria et al.   Scientific Reports

Improving Prospects for Targeting RAS

(2015) Harshabad Singh et al.   JOURNAL OF CLINICAL ONCOLOGY

Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer

(2015) Xiaofeng Zheng et al.   NATURE

Glypican-1 identifies cancer exosomes and detects early pancreatic cancer

(2015) Sonia A. Melo et al.   NATURE

RNAi therapy targeting KRAS in combination with chemotherapy for locally advanced pancreatic cancer patients

(2015) Talia Golan et al.   Oncotarget

Active macropinocytosis induction by stimulation of epidermal growth factor receptor and oncogenic Ras expression potentiates cellular uptake efficacy of exosomes

(2015) Ikuhiko Nakase et al.   Scientific Reports

Oncogenic KRAS signalling in pancreatic cancer

(2014) S Eser et al.   BRITISH JOURNAL OF CANCER

Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival

(2014) Berna C. Özdemir et al.   CANCER CELL

Cancer Exosomes Perform Cell-Independent MicroRNA Biogenesis and Promote Tumorigenesis

(2014) Sonia A. Melo et al.   CANCER CELL

Vitamin D Receptor-Mediated Stromal Reprogramming Suppresses Pancreatitis and Enhances Pancreatic Cancer Therapy

(2014) Mara H. Sherman et al.   CELL

Biogenesis and secretion of exosomes

(2014) Joanna Kowal et al.   CURRENT OPINION IN CELL BIOLOGY

Pancreatic cancer genomics

(2014) David K Chang et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Extracellular vesicles as drug delivery systems: Lessons from the liposome field

(2014) Roy van der Meel et al.   JOURNAL OF CONTROLLED RELEASE

CD47-dependent immunomodulatory and angiogenic activities of extracellular vesicles produced by T cells

(2014) Sukhbir Kaur et al.   MATRIX BIOLOGY

Therapeutic Silencing of KRAS Using Systemically Delivered siRNAs

(2014) C. V. Pecot et al.   MOLECULAR CANCER THERAPEUTICS

Small RNA combination therapy for lung cancer

(2014) W. Xue et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Development of siRNA Payloads to Target KRAS-Mutant Cancer

(2014) T. L. Yuan et al.   Cancer Discovery

Genetically engineered mouse models of pancreatic adenocarcinoma

(2013) Carmen Guerra et al.   Molecular Oncology

Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells

(2013) Cosimo Commisso et al.   NATURE

Mutant KRAS is a druggable target for pancreatic cancer

(2013) E. Zorde Khvalevsky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipid-Based Nanoparticles for siRNA Delivery in Cancer Therapy: Paradigms and Challenges

(2012) Lígia C. Gomes-da-Silva et al.   ACCOUNTS OF CHEMICAL RESEARCH

Enzymatic Targeting of the Stroma Ablates Physical Barriers to Treatment of Pancreatic Ductal Adenocarcinoma

(2012) Paolo P. Provenzano et al.   CANCER CELL

Oncogenic Kras-Induced GM-CSF Production Promotes the Development of Pancreatic Neoplasia

(2012) Yuliya Pylayeva-Gupta et al.   CANCER CELL

Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism

(2012) Haoqiang Ying et al.   CELL

Translational Therapeutic Opportunities in Ductal Adenocarcinoma of the Pancreas

(2012) M. Hidalgo et al.   CLINICAL CANCER RESEARCH

The CD47–SIRPα pathway in cancer immune evasion and potential therapeutic implications

(2012) Mark P Chao et al.   CURRENT OPINION IN IMMUNOLOGY

Oncogenic Kras is required for both the initiation and maintenance of pancreatic cancer in mice

(2012) Meredith A. Collins et al.   JOURNAL OF CLINICAL INVESTIGATION

Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes

(2012) Andrew V. Biankin et al.   NATURE

Exosome-mediated delivery of siRNA in vitro and in vivo

(2012) Samir El-Andaloussi et al.   Nature Protocols

Metastatic Pancreatic Cancer Is Dependent on Oncogenic Kras in Mice

(2012) Meredith A. Collins et al.   PLoS One

The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors

(2012) S. B. Willingham et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activated KrasG12D is associated with invasion and metastasis of pancreatic cancer cells through inhibition of E-cadherin

(2011) S Rachagani et al.   BRITISH JOURNAL OF CANCER

Inhibiting Cxcr2 disrupts tumor-stromal interactions and improves survival in a mouse model of pancreatic ductal adenocarcinoma

(2011) Hideaki Ijichi et al.   JOURNAL OF CLINICAL INVESTIGATION

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

(2011) Lydia Alvarez-Erviti et al.   NATURE BIOTECHNOLOGY

A coding-independent function of gene and pseudogene mRNAs regulates tumour biology

(2010) Laura Poliseno et al.   NATURE

Context-Dependent Transformation of Adult Pancreatic Cells by Oncogenic K-Ras

(2009) Sharon Y. Gidekel Friedlander et al.   CANCER CELL

CD47 Is Upregulated on Circulating Hematopoietic Stem Cells and Leukemia Cells to Avoid Phagocytosis

(2009) Siddhartha Jaiswal et al.   CELL

Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer

(2009) K. P. Olive et al.   SCIENCE