Blockade of microglial adenosine A 2A receptor suppresses elevated pressure‐induced inflammation, oxidative stress, and cell death in retinal cells

Elevated Pressure Changes the Purinergic System of Microglial Cells

(2018) Ana C. Rodrigues-Neves et al.   Frontiers in Pharmacology

Müller glia and phagocytosis of cell debris in retinal tissue

(2017) Ruth Bejarano-Escobar et al.   JOURNAL OF ANATOMY

Caveolin-1–mediated internalization of the vitamin C transporter SVCT2 in microglia triggers an inflammatory phenotype

(2017) Camila C. Portugal et al.   Science Signaling

Treatment with A2A receptor antagonist KW6002 and caffeine intake regulate microglia reactivity and protect retina against transient ischemic damage

(2017) Raquel Boia et al.   Cell Death & Disease

The Role of Microglia in Retinal Neurodegeneration: Alzheimer's Disease, Parkinson, and Glaucoma

(2017) Ana I. Ramirez et al.   Frontiers in Aging Neuroscience

Caveolin-1–mediated internalization of the vitamin C transporter SVCT2 in microglia triggers an inflammatory phenotype

(2017) Camila C. Portugal et al.   Science Signaling

Quantitative microglia analyses reveal diverse morphologic responses in the rat cortex after diffuse brain injury

(2017) Helena Morrison et al.   Scientific Reports

Microglia show altered morphology and reduced arborization in human brain during aging and Alzheimer's disease

(2016) Danielle S. Davies et al.   BRAIN PATHOLOGY

Employing an open-source tool to assess astrocyte tridimensional structure

(2016) Gabriela Tavares et al.   Brain Structure & Function

Electron transport chain inhibitors induce microglia activation through enhancing mitochondrial reactive oxygen species production

(2016) Junli Ye et al.   EXPERIMENTAL CELL RESEARCH

Retinal Microglia in Glaucoma

(2016) Jia-Wei Wang et al.   JOURNAL OF GLAUCOMA

Neuroinflammation in glaucoma: soluble tumor necrosis factor alpha and the connection with excitotoxic damage

(2016) Adriana Di Polo et al.   Neural Regeneration Research

Modeling Human Glaucoma: Lessons from the in vitro Models

(2016) Inês Dinis Aires et al.   OPHTHALMIC RESEARCH

Therapeutic Opportunities for Caffeine and A2A Receptor Antagonists in Retinal Diseases

(2016) Raquel Boia et al.   OPHTHALMIC RESEARCH

Selective A2A receptor antagonist prevents microglia-mediated neuroinflammation and protects retinal ganglion cells from high intraocular pressure–induced transient ischemic injury

(2016) Maria H. Madeira et al.   Translational Research

Retinal Macroglial Responses in Health and Disease

(2016) Rosa de Hoz et al.   Biomed Research International

Caffeine administration prevents retinal neuroinflammation and loss of retinal ganglion cells in an animal model of glaucoma

(2016) Maria H. Madeira et al.   Scientific Reports

Glial cell interactions and glaucoma

(2015) Rachel S. Chong et al.   CURRENT OPINION IN OPHTHALMOLOGY

Neurodegeneration severity can be predicted from early microglia alterations monitored in vivo in a mouse model of chronic glaucoma

(2015) A. Bosco et al.   Disease Models & Mechanisms

Different danger signals differently impact on microglial proliferation through alterations of ATP release and extracellular metabolism

(2015) Jimmy George et al.   GLIA

Adenosine A2AR blockade prevents neuroinflammation-induced death of retinal ganglion cells caused by elevated pressure

(2015) Maria H. Madeira et al.   Journal of Neuroinflammation

Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) Deficiency Attenuates Phagocytic Activities of Microglia and Exacerbates Ischemic Damage in Experimental Stroke

(2015) M. Kawabori et al.   JOURNAL OF NEUROSCIENCE

Contribution of Microglia-Mediated Neuroinflammation to Retinal Degenerative Diseases

(2015) Maria H. Madeira et al.   MEDIATORS OF INFLAMMATION

Automatic Counting of Microglial Cells in Healthy and Glaucomatous Mouse Retinas

(2015) Pablo de Gracia et al.   PLoS One

Retinal microglia: Just bystander or target for therapy?

(2015) Marcus Karlstetter et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Microglia in action: how aging and injury can change the brain’s guardians

(2015) Athanasios Lourbopoulos et al.   Frontiers in Cellular Neuroscience

Nitric oxide/cyclic GMP signaling regulates motility of a microglial cell line and primary microglia in vitro

(2014) Hannah Scheiblich et al.   BRAIN RESEARCH

Diabetes induces changes in KIF1A, KIF5B and dynein distribution in the rat retina: Implications for axonal transport

(2014) Filipa I. Baptista et al.   EXPERIMENTAL EYE RESEARCH

Microglial cells in organotypic cultures of developing and adult mouse retina and their relationship with cell death

(2014) Rosa M. Ferrer-Martín et al.   EXPERIMENTAL EYE RESEARCH

Translocator protein (18 kDa) (TSPO) is expressed in reactive retinal microglia and modulates microglial inflammation and phagocytosis

(2014) Marcus Karlstetter et al.   Journal of Neuroinflammation

Macroglia-Microglia Interactions via TSPO Signaling Regulates Microglial Activation in the Mouse Retina

(2014) M. Wang et al.   JOURNAL OF NEUROSCIENCE

Role of Microglia Adenosine A2AReceptors in Retinal and Brain Neurodegenerative Diseases

(2014) Ana R. Santiago et al.   MEDIATORS OF INFLAMMATION

Phagocytosis of Microglia in the Central Nervous System Diseases

(2014) Ruying Fu et al.   MOLECULAR NEUROBIOLOGY

Microglial phagocytosis of live neurons

(2014) Guy C. Brown et al.   NATURE REVIEWS NEUROSCIENCE

Adenosine A2A receptor antagonism reverses inflammation-induced impairment of microglial process extension in a model of Parkinson's disease

(2014) Stefka Gyoneva et al.   NEUROBIOLOGY OF DISEASE

Colony-Stimulating Factor 1 Receptor Signaling Is Necessary for Microglia Viability, Unmasking a Microglia Progenitor Cell in the Adult Brain

(2014) Monica R.P. Elmore et al.   NEURON

Adenosine A2A Receptor Up-Regulates Retinal Wave Frequency via Starburst Amacrine Cells in the Developing Rat Retina

(2014) Pin-Chien Huang et al.   PLoS One

The Complex Role of Neuroinflammation in Glaucoma

(2014) I. Soto et al.   Cold Spring Harbor Perspectives in Medicine

Adenosine, adenosine receptors and glaucoma: An updated overview

(2013) Yisheng Zhong et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Neurotransmitters and Microglial-Mediated Neuroinflammation

(2013) Moonhee Lee   CURRENT PROTEIN & PEPTIDE SCIENCE

Microglia release ATP by exocytosis

(2013) Yoshio Imura et al.   GLIA

Activation of microglial cells triggers a release of brain-derived neurotrophic factor (BDNF) inducing their proliferation in an adenosine A2A receptor-dependent manner: A2A receptor blockade prevents BDNF release and proliferation of microglia

(2013) Catarina Gomes et al.   Journal of Neuroinflammation

Regulation of Microglial Proliferation during Chronic Neurodegeneration

(2013) D. Gomez-Nicola et al.   JOURNAL OF NEUROSCIENCE

Microglia: New Roles for the Synaptic Stripper

(2013) Helmut Kettenmann et al.   NEURON

Effect of Diabetes/Hyperglycemia on the Rat Retinal Adenosinergic System

(2013) Joana Vindeirinho et al.   PLoS One

The Role of Inflammation in the Pathogenesis of Glaucoma

(2013) Rupali Vohra et al.   SURVEY OF OPHTHALMOLOGY

Neuropeptide Y receptors activation protects rat retinal neural cells against necrotic and apoptotic cell death induced by glutamate

(2013) A Santos-Carvalho et al.   Cell Death & Disease

Regulation of Inflammation by Adenosine

(2013) György Haskó et al.   Frontiers in Immunology

Microglial migration mediated by ATP-induced ATP release from lysosomes

(2012) Ying Dou et al.   CELL RESEARCH

Purinergic receptors in microglia: Functional modal shifts of microglia mediated by P2 and P1 receptors

(2012) Schuichi Koizumi et al.   GLIA

Regulation of podosome formation, microglial migration and invasion by Ca2+-signaling molecules expressed in podosomes

(2012) Tamjeed A Siddiqui et al.   Journal of Neuroinflammation

Liposomal clodronate selectively eliminates microglia from primary astrocyte cultures

(2012) Hiromi Kumamaru et al.   Journal of Neuroinflammation

Activation of Neuronal NMDA Receptors Induces Superoxide-Mediated Oxidative Stress in Neighboring Neurons and Astrocytes

(2012) R. C. Reyes et al.   JOURNAL OF NEUROSCIENCE

The Spider Effect: Morphological and Orienting Classification of Microglia in Response to Stimuli in Vivo

(2012) Rahul A. Jonas et al.   PLoS One

Role of pro-inflammatory cytokines released from microglia in neurodegenerative diseases

(2011) Joshua A. Smith et al.   BRAIN RESEARCH BULLETIN

Microglial phagocytosis induced by fibrillar β-amyloid is attenuated by oligomeric β-amyloid: implications for Alzheimer's disease

(2011) Xiao-dong Pan et al.   Molecular Neurodegeneration

Physiology of Microglia

(2011) Helmut Kettenmann et al.   PHYSIOLOGICAL REVIEWS

The molecular basis of retinal ganglion cell death in glaucoma

(2011) Mohammadali Almasieh et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Adenosine receptors and brain diseases: Neuroprotection and neurodegeneration

(2010) Catarina V. Gomes et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The development of human organotypic retinal cultures (HORCs) to study retinal neurodegeneration

(2010) N. Niyadurupola et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

The immune response in glaucoma: A perspective on the roles of oxidative stress

(2010) Gülgün Tezel   EXPERIMENTAL EYE RESEARCH

Microglia in the healthy and degenerating retina: Insights from novel mouse models

(2010) Marcus Karlstetter et al.   IMMUNOBIOLOGY

Early microglia activation in a mouse model of chronic glaucoma

(2010) Alejandra Bosco et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Microglial activation and chronic neurodegeneration

(2010) Melinda E. Lull et al.   Neurotherapeutics

A role for TREM2 ligands in the phagocytosis of apoptotic neuronal cells by microglia

(2009) Christine L. Hsieh et al.   JOURNAL OF NEUROCHEMISTRY

Adenosine A2A receptor mediates microglial process retraction

(2009) Anna G Orr et al.   NATURE NEUROSCIENCE

Differential regulation of microglial motility by ATP/ADP and adenosine

(2009) Stefka Gyoneva et al.   PARKINSONISM & RELATED DISORDERS

Debris clearance by microglia: an essential link between degeneration and regeneration

(2008) H. Neumann et al.   BRAIN

Neuropeptide Y stimulates retinal neural cell proliferation - involvement of nitric oxide

(2008) Ana Rita Álvaro et al.   JOURNAL OF NEUROCHEMISTRY

Interleukin-1beta and tumor necrosis factor-alpha are expressed by different subsets of microglia and macrophages after ischemic stroke in mice

(2008) Bettina H Clausen et al.   Journal of Neuroinflammation

Microglial clearance function in health and disease

(2008) I. Napoli et al.   NEUROSCIENCE

A chemical method for fast and sensitive detection of DNA synthesis in vivo

(2008) A. Salic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA