Nutrient sensing, growth and senescence

Persistent mTORC1 signaling in cell senescence results from defects in amino acid and growth factor sensing

(2017) Bernadette Carroll et al.   JOURNAL OF CELL BIOLOGY

The Clinical Potential of Senolytic Drugs

(2017) James L. Kirkland et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Transcriptional activation of RagD GTPase controls mTORC1 and promotes cancer growth

(2017) Chiara Di Malta et al.   SCIENCE

Mitochondria in Cell Senescence: Is Mitophagy the Weakest Link?

(2017) Viktor I. Korolchuk et al.   EBioMedicine

Age-related changes in AMPK activation: Role for AMPK phosphatases and inhibitory phosphorylation by upstream signaling pathways

(2016) Antero Salminen et al.   AGEING RESEARCH REVIEWS

AMPK activation protects cells from oxidative stress-induced senescence via autophagic flux restoration and intracellular NAD+elevation

(2016) Xiaojuan Han et al.   AGING CELL

Autophagy impairment with lysosomal and mitochondrial dysfunction is an important characteristic of oxidative stress-induced senescence

(2016) Haoran Tai et al.   Autophagy

Powering senescence: The ugly side of mitochondria

(2016) Clara Correia-Melo et al.   CELL CYCLE

Mitochondria are required for pro‐ageing features of the senescent phenotype

(2016) Clara Correia‐Melo et al.   EMBO JOURNAL

Inpp5e suppresses polycystic kidney disease via inhibition of PI3K/Akt-dependent mTORC1 signaling

(2016) Sandra Hakim et al.   HUMAN MOLECULAR GENETICS

Loss of Glis2/NPHP7 causes kidney epithelial cell senescence and suppresses cyst growth in the Kif3a mouse model of cystic kidney disease

(2016) Dongmei Lu et al.   KIDNEY INTERNATIONAL

Autophagy maintains stemness by preventing senescence

(2016) Laura García-Prat et al.   NATURE

Primary-cilium-dependent autophagy controls epithelial cell volume in response to fluid flow

(2016) Idil Orhon et al.   NATURE CELL BIOLOGY

Lysosomal recruitment of TSC2 is a universal response to cellular stress

(2016) Constantinos Demetriades et al.   Nature Communications

Control of TSC2-Rheb signaling axis by arginine regulates mTORC1 activity

(2016) Bernadette Carroll et al.   eLife

Dynamics of mTORC1 activation in response to amino acids

(2016) Maria Manifava et al.   eLife

Replicatively senescent cells are arrested in G1 and G2 phases

(2016) Zhiyong Mao et al.   Aging-US

Reciprocal regulation of cilia and autophagy via the MTOR and proteasome pathways

(2015) Shixuan Wang et al.   Autophagy

p53-mediated autophagic regulation: A prospective strategy for cancer therapy

(2015) Juanjuan Tang et al.   CANCER LETTERS

Senescence from G2 arrest, revisited

(2015) Véronique Gire et al.   CELL CYCLE

Aberrant mTOR activation in senescence and aging: A mitochondrial stress response?

(2015) Timothy Nacarelli et al.   EXPERIMENTAL GERONTOLOGY

Impaired mitophagy leads to cigarette smoke stress-induced cellular senescence: implications for chronic obstructive pulmonary disease

(2015) Tanveer Ahmad et al.   FASEB JOURNAL

mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype

(2015) Nicolás Herranz et al.   NATURE CELL BIOLOGY

MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation

(2015) Remi-Martin Laberge et al.   NATURE CELL BIOLOGY

The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4

(2015) C. Kang et al.   SCIENCE

Amino acids and autophagy: cross-talk and co-operation to control cellular homeostasis

(2014) Bernadette Carroll et al.   AMINO ACIDS

Spatial Control of the TSC Complex Integrates Insulin and Nutrient Regulation of mTORC1 at the Lysosome

(2014) Suchithra Menon et al.   CELL

Regulation of TORC1 in Response to Amino Acid Starvation via Lysosomal Recruitment of TSC2

(2014) Constantinos Demetriades et al.   CELL

Ciliary abnormalities in senescent human fibroblasts impair proliferative capacity

(2014) Loretta Breslin et al.   CELL CYCLE

Hsp90  forms a stable complex at the cilium neck for the interaction of signalling molecules in IGF-1 receptor signalling

(2014) H. Wang et al.   JOURNAL OF CELL SCIENCE

PINK1 deficiency impairs mitochondrial homeostasis and promotes lung fibrosis

(2014) Marta Bueno et al.   JOURNAL OF CLINICAL INVESTIGATION

Geriatric muscle stem cells switch reversible quiescence into senescence

(2014) Pedro Sousa-Victor et al.   NATURE

Potassium channels in cell cycle and cell proliferation

(2014) D. Urrego et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Dynamic Modelling of Pathways to Cellular Senescence Reveals Strategies for Targeted Interventions

(2014) Piero Dalle Pezze et al.   PLoS Computational Biology

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Autophagy and ageing: implications for age-related neurodegenerative diseases

(2013) Bernadette Carroll et al.   Essays in Biochemistry

Functional interaction between autophagy and ciliogenesis

(2013) Olatz Pampliega et al.   NATURE

Autophagy promotes primary ciliogenesis by removing OFD1 from centriolar satellites

(2013) Zaiming Tang et al.   NATURE

Synthetic lethal metabolic targeting of cellular senescence in cancer therapy

(2013) Jan R. Dörr et al.   NATURE

Autophagy-dependent senescence in response to DNA damage and chronic apoptotic stress

(2012) Kamini Singh et al.   Autophagy

Autophagy proteins LC3B, ATG5 and ATG12 participate in quality control after mitochondrial damage and influence lifespan

(2012) Sören Mai et al.   Autophagy

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Attenuation of TORC1 signaling delays replicative and oncogenic RAS-induced senescence

(2012) Marina Kolesnichenko et al.   CELL CYCLE

Suppression of replicative senescence by rapamycin in rodent embryonic cells

(2012) Tatyana V. Pospelova et al.   CELL CYCLE

CDK inhibitors (p16/p19/p21) induce senescence and autophagy in cancer-associated fibroblasts, “fueling” tumor growth via paracrine interactions, without an increase in neo-angiogenesis

(2012) Claudia Capparelli et al.   CELL CYCLE

Autophagic activity dictates the cellular response to oncogenic RAS

(2012) Y. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Hedgehog signalling pathway regulates autophagy

(2012) Maria Jimenez-Sanchez et al.   Nature Communications

DNA damage response activation in mouse embryonic fibroblasts undergoing replicative senescence and following spontaneous immortalization

(2011) Raffaella Di Micco et al.   CELL CYCLE

Pharmacologic inhibition of MEK and PI-3K converges on the mTOR/S6 pathway to decelerate cellular senescence

(2011) Zoya N. Demidenko et al.   CELL CYCLE

Rapamycin decelerates cellular senescence

(2011) Zoya N. Demidenko et al.   CELL CYCLE

Primary cilia and coordination of receptor tyrosine kinase (RTK) signalling

(2011) Søren T Christensen et al.   JOURNAL OF PATHOLOGY

Hypoxia and Senescence: The Impact of Oxygenation on Tumor Suppression

(2011) S. M. Welford et al.   MOLECULAR CANCER RESEARCH

Spatial Coupling of mTOR and Autophagy Augments Secretory Phenotypes

(2011) M. Narita et al.   SCIENCE

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

Growth stimulation leads to cellular senescence when the cell cycle is blocked

(2010) Zoya N. Demidenko et al.   CELL CYCLE

SIRT1 Promotes Proliferation and Prevents Senescence Through Targeting LKB1 in Primary Porcine Aortic Endothelial Cells

(2010) Yi Zu et al.   CIRCULATION RESEARCH

The primary cilium at a glance

(2010) P. Satir et al.   JOURNAL OF CELL SCIENCE

Primary Cilium-Dependent and -Independent Hedgehog Signaling Inhibits p16INK4A

(2010) Cleo L. Bishop et al.   MOLECULAR CELL

Feedback between p21 and reactive oxygen production is necessary for cell senescence

(2010) João F Passos et al.   Molecular Systems Biology

Primary cilia regulate mTORC1 activity and cell size through Lkb1

(2010) Christopher Boehlke et al.   NATURE CELL BIOLOGY

Protein quality control during aging involves recruitment of the macroautophagy pathway by BAG3

(2009) Martin Gamerdinger et al.   EMBO JOURNAL

Autophagy mediates the mitotic senescence transition

(2009) A. R.J. Young et al.   GENES & DEVELOPMENT

Growth arrest induces primary-cilium formation and sensitizes IGF-1-receptor signaling during differentiation induction of 3T3-L1 preadipocytes

(2009) D. Zhu et al.   JOURNAL OF CELL SCIENCE

Mitochondrial Dysfunction Contributes to Oncogene-Induced Senescence

(2009) O. Moiseeva et al.   MOLECULAR AND CELLULAR BIOLOGY

Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion

(2009) Francis Rodier et al.   NATURE CELL BIOLOGY