- Home
- Publications
- Publication Search
- Publication Details
Title
Regulation of mTORC2 Signaling
Authors
Keywords
-
Journal
Genes
Volume 11, Issue 9, Pages 1045
Publisher
MDPI AG
Online
2020-09-04
DOI
10.3390/genes11091045
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- AMPK and TOR: The Yin and Yang of Cellular Nutrient Sensing and Growth Control
- (2020) Asier González et al. Cell Metabolism
- mTORC2-AKT signaling to ATP-citrate lyase drives brown adipogenesis and de novo lipogenesis
- (2020) C. Martinez Calejman et al. Nature Communications
- The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2
- (2019) Joanna R. Kovalski et al. MOLECULAR CELL
- Phosphorylation at distinct subcellular locations underlies specificity in mTORC2 activation of SGK1 and Akt
- (2019) Catherine E. Gleason et al. JOURNAL OF CELL SCIENCE
- Disruption of scaffolding function of mLST8 selectively inhibits mTORC2 assembly and function and suppresses mTORC2-dependent tumor growth in vivo
- (2019) Yoonha Hwang et al. CANCER RESEARCH
- Lysosome Positioning Influences mTORC2 and AKT Signaling
- (2019) Rui Jia et al. MOLECULAR CELL
- Phosphorylated Rho–GDP directly activates mTORC2 kinase towards AKT through dimerization with Ras–GTP to regulate cell migration
- (2019) Hiroshi Senoo et al. NATURE CELL BIOLOGY
- AMPK directly activates mTORC2 to promote cell survival during acute energetic stress
- (2019) Dubek Kazyken et al. Science Signaling
- Non-canonical mTORC2 Signaling Regulates Brown Adipocyte Lipid Catabolism through SIRT6-FoxO1
- (2019) Su Myung Jung et al. MOLECULAR CELL
- Serine 474 phosphorylation is essential for maximal Akt2 kinase activity in adipocytes
- (2019) Alison L. Kearney et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Therapeutic inhibition of mTORC2 rescues the behavioral and neurophysiological abnormalities associated with Pten-deficiency
- (2019) Chien-Ju Chen et al. NATURE MEDICINE
- Growth Factor-Dependent and -Independent Activation of mTORC2
- (2019) Jonas R. Knudsen et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Unmasking the impact of Rictor in cancer: novel insights of mTORC2 complex
- (2018) Anastasios Gkountakos et al. CARCINOGENESIS
- Cryo-EM structure of human mTOR complex 2
- (2018) Xizi Chen et al. CELL RESEARCH
- The Dictyostelium GSK3 kinase GlkA coordinates signal relay and chemotaxis in response to growth conditions
- (2018) Jesus Lacal Romero et al. DEVELOPMENTAL BIOLOGY
- Insulin resistance causes inflammation in adipose tissue
- (2018) Mitsugu Shimobayashi et al. JOURNAL OF CLINICAL INVESTIGATION
- mTORC2 Signaling: A Path for Pancreatic β Cell's Growth and Function
- (2018) Ting Yuan et al. JOURNAL OF MOLECULAR BIOLOGY
- mTORC2, but not mTORC1, is required for hippocampal mGluR-LTD and associated behaviors
- (2018) Ping Jun Zhu et al. NATURE NEUROSCIENCE
- Architecture of the human mTORC2 core complex
- (2018) Edward Stuttfeld et al. eLife
- Akt Kinase Activation Mechanisms Revealed Using Protein Semisynthesis
- (2018) Nam Chu et al. CELL
- Decrease in plasma membrane tension triggers PtdIns(4,5)P2 phase separation to inactivate TORC2
- (2018) Margot Riggi et al. NATURE CELL BIOLOGY
- The Hippo Pathway: Biology and Pathophysiology
- (2018) Shenghong Ma et al. Annual Review of Biochemistry
- mTORC1 and mTORC2 as regulators of cell metabolism in immunity
- (2017) Monika Linke et al. FEBS LETTERS
- Localization of mTORC2 activity inside cells
- (2017) Michael Ebner et al. JOURNAL OF CELL BIOLOGY
- mTORC2 Regulates Amino Acid Metabolism in Cancer by Phosphorylation of the Cystine-Glutamate Antiporter xCT
- (2017) Yuchao Gu et al. MOLECULAR CELL
- PI(3,4,5)P 3 Engagement Restricts Akt Activity to Cellular Membranes
- (2017) Michael Ebner et al. MOLECULAR CELL
- GSK3β Controls mTOR and Prosurvival Signaling in Neurons
- (2017) Malgorzata Urbanska et al. MOLECULAR NEUROBIOLOGY
- TRAF2 and OTUD7B govern a ubiquitin-dependent switch that regulates mTORC2 signalling
- (2017) Bin Wang et al. NATURE
- Specific blockade of Rictor-mTOR association inhibits mTORC2 activity and is cytotoxic in glioblastoma
- (2017) Angelica Benavides-Serrato et al. PLoS One
- Distinct Akt phosphorylation states are required for insulin regulated Glut4 and Glut1-mediated glucose uptake
- (2017) Muheeb Beg et al. eLife
- The metabolic waste ammonium regulates mTORC2 and mTORC1 signaling
- (2017) Ahmad Merhi et al. Scientific Reports
- mTORC2 mediates CXCL12-induced angiogenesis
- (2016) Mary E. Ziegler et al. ANGIOGENESIS
- Targeted Inhibition of Rictor/mTORC2 in Cancer Treatment: A New Era after Rapamycin
- (2016) Zhipeng Zou et al. CURRENT CANCER DRUG TARGETS
- PRICKLE1 Contributes to Cancer Cell Dissemination through Its Interaction with mTORC2
- (2016) Avais M. Daulat et al. DEVELOPMENTAL CELL
- mTORC2 Responds to Glutamine Catabolite Levels to Modulate the Hexosamine Biosynthesis Enzyme GFAT1
- (2016) Joseph G. Moloughney et al. MOLECULAR CELL
- mTORC1 and mTORC2 in cancer and the tumor microenvironment
- (2016) L C Kim et al. ONCOGENE
- Adipose tissue mTORC2 regulates ChREBP-driven de novo lipogenesis and hepatic glucose metabolism
- (2016) Yuefeng Tang et al. Nature Communications
- mTOR complex-2 stimulates acetyl-CoA and de novo lipogenesis through ATP citrate lyase in HER2/PIK3CA-hyperactive breast cancer
- (2016) Yaqing Chen et al. Oncotarget
- The small GTPases Ras and Rap1 bind to and control TORC2 activity
- (2016) Ankita Khanna et al. Scientific Reports
- mTORC2 promotes type I insulin-like growth factor receptor and insulin receptor activation through the tyrosine kinase activity of mTOR
- (2015) Yancun Yin et al. CELL RESEARCH
- Rictor Undergoes Glycogen Synthase Kinase 3 (GSK3)-dependent, FBXW7-mediated Ubiquitination and Proteasomal Degradation
- (2015) Junghui Koo et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Methylglyoxal Activates the Target of Rapamycin Complex 2-Protein Kinase C Signaling Pathway in Saccharomyces cerevisiae
- (2015) Wataru Nomura et al. MOLECULAR AND CELLULAR BIOLOGY
- ERK2 Mediates Metabolic Stress Response to Regulate Cell Fate
- (2015) Sejeong Shin et al. MOLECULAR CELL
- Lysosomal mTORC2/PHLPP1/Akt Regulate Chaperone-Mediated Autophagy
- (2015) Esperanza Arias et al. MOLECULAR CELL
- Thermal proteome profiling monitors ligand interactions with cellular membrane proteins
- (2015) Friedrich B M Reinhard et al. NATURE METHODS
- Glucose-dependent acetylation of Rictor promotes targeted cancer therapy resistance
- (2015) Kenta Masui et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Identification of an oncogenic RAB protein
- (2015) D. B. Wheeler et al. SCIENCE
- PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase Complex
- (2015) P. Liu et al. Cancer Discovery
- A Positive Feedback Loop between Akt and mTORC2 via SIN1 Phosphorylation
- (2015) Guang Yang et al. Cell Reports
- Characterization of Sin1 Isoforms Reveals an mTOR-Dependent and Independent Function of Sin1γ
- (2015) Yuanyang Yuan et al. PLoS One
- Phosphorylation of Akt at the C-terminal tail triggers Akt Activation
- (2014) Pengda Liu et al. CELL CYCLE
- Where is mTOR and what is it doing there?
- (2014) Charles Betz et al. JOURNAL OF CELL BIOLOGY
- Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus
- (2014) Pengda Liu et al. NATURE
- Making new contacts: the mTOR network in metabolism and signalling crosstalk
- (2014) Mitsugu Shimobayashi et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- mTORC2 Is Required for Rit-Mediated Oxidative Stress Resistance
- (2014) Weikang Cai et al. PLoS One
- Dual phosphorylation of Sin1 at T86 and T398 negatively regulates mTORC2 complex integrity and activity
- (2014) Pengda Liu et al. Protein & Cell
- Elevated SGK1 predicts resistance of breast cancer cells to Akt inhibitors
- (2013) Eeva M. Sommer et al. BIOCHEMICAL JOURNAL
- On mTOR nomenclature
- (2013) Michael N. Hall BIOCHEMICAL SOCIETY TRANSACTIONS
- WNT-LRP5 Signaling Induces Warburg Effect through mTORC2 Activation during Osteoblast Differentiation
- (2013) Emel Esen et al. Cell Metabolism
- mTOR Complex 2 Controls Glycolytic Metabolism in Glioblastoma through FoxO Acetylation and Upregulation of c-Myc
- (2013) Kenta Masui et al. Cell Metabolism
- Dynamic Adipocyte Phosphoproteome Reveals that Akt Directly Regulates mTORC2
- (2013) Sean J. Humphrey et al. Cell Metabolism
- mTORC2 phosphorylates protein kinase Cζ to regulate its stability and activity
- (2013) Xin Li et al. EMBO REPORTS
- Roles of PINK1, mTORC2, and mitochondria in preserving brain tumor-forming stem cells in a noncanonical Notch signaling pathway
- (2013) K.-S. Lee et al. GENES & DEVELOPMENT
- Tricornered/NDR kinase signaling mediates PINK1-directed mitochondrial quality control and tissue maintenance
- (2013) Z. Wu et al. GENES & DEVELOPMENT
- mTOR complex 2 phosphorylates IMP1 cotranslationally to promote IGF2 production and the proliferation of mouse embryonic fibroblasts
- (2013) N. Dai et al. GENES & DEVELOPMENT
- mTOR complex 2-Akt signaling at mitochondria-associated endoplasmic reticulum membranes (MAM) regulates mitochondrial physiology
- (2013) C. Betz et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Hepatic mTORC2 Activates Glycolysis and Lipogenesis through Akt, Glucokinase, and SREBP1c
- (2012) Asami Hagiwara et al. Cell Metabolism
- TGF- -induced activation of mTOR complex 2 drives epithelial-mesenchymal transition and cell invasion
- (2012) S. Lamouille et al. DEVELOPMENT
- Daydreamer, a Ras effector and GSK-3 substrate, is important for directional sensing and cell motility
- (2012) Verena Kölsch et al. MOLECULAR BIOLOGY OF THE CELL
- mTOR Complex 2 Regulates Proper Turnover of Insulin Receptor Substrate-1 via the Ubiquitin Ligase Subunit Fbw8
- (2012) Sung Jin Kim et al. MOLECULAR CELL
- PRR5L degradation promotes mTORC2-mediated PKC-δ phosphorylation and cell migration downstream of Gα12
- (2012) Xiaoqing Gan et al. NATURE CELL BIOLOGY
- Plasma membrane stress induces relocalization of Slm proteins and activation of TORC2 to promote sphingolipid synthesis
- (2012) Doris Berchtold et al. NATURE CELL BIOLOGY
- YAP mediates crosstalk between the Hippo and PI(3)K–TOR pathways by suppressing PTEN via miR-29
- (2012) Karen Tumaneng et al. NATURE CELL BIOLOGY
- Plasma membrane recruitment and activation of the AGC kinase Ypk1 is mediated by target of rapamycin complex 2 (TORC2) and its effector proteins Slm1 and Slm2
- (2012) B. J. Niles et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Activation of mTORC2 by Association with the Ribosome
- (2011) Vittoria Zinzalla et al. CELL
- mTOR protein localization is cell cycle-regulated
- (2011) Margit Rosner et al. CELL CYCLE
- mTOR complex 2 signaling and functions
- (2011) Won Jun Oh et al. CELL CYCLE
- Multiple Site Acetylation of Rictor Stimulates Mammalian Target of Rapamycin Complex 2 (mTORC2)-dependent Phosphorylation of Akt Protein
- (2011) Emily J. Glidden et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- mSIN1 Protein Mediates SGK1 Protein Interaction with mTORC2 Protein Complex and Is Required for Selective Activation of the Epithelial Sodium Channel
- (2011) Ming Lu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- mTORC2 Protein-mediated Protein Kinase B (Akt) Serine 473 Phosphorylation Is Not Required for Akt1 Activity in Human Platelets
- (2011) Samantha F. Moore et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Evidence for Direct Activation of mTORC2 Kinase Activity by Phosphatidylinositol 3,4,5-Trisphosphate
- (2011) Xiaoqing Gan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Rac1 Regulates the Activity of mTORC1 and mTORC2 and Controls Cellular Size
- (2011) Abdelhafid Saci et al. MOLECULAR CELL
- Wnt7a–Fzd7 signalling directly activates the Akt/mTOR anabolic growth pathway in skeletal muscle
- (2011) Julia von Maltzahn et al. NATURE CELL BIOLOGY
- Phosphoproteomic Analysis Identifies Grb10 as an mTORC1 Substrate That Negatively Regulates Insulin Signaling
- (2011) Y. Yu et al. SCIENCE
- The mTOR-Regulated Phosphoproteome Reveals a Mechanism of mTORC1-Mediated Inhibition of Growth Factor Signaling
- (2011) P. P. Hsu et al. SCIENCE
- ER Stress Inhibits mTORC2 and Akt Signaling Through GSK-3 -Mediated Phosphorylation of Rictor
- (2011) C.-H. Chen et al. Science Signaling
- Glycogen synthase kinase 3: A point of convergence for the host inflammatory response
- (2010) Huizhi Wang et al. CYTOKINE
- mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide
- (2010) Won Jun Oh et al. EMBO JOURNAL
- Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes
- (2010) H. Takai et al. GENES & DEVELOPMENT
- Amino Acids Activate Mammalian Target of Rapamycin Complex 2 (mTORC2) via PI3K/Akt Signaling
- (2010) Irantzu Tato et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Tti1 and Tel2 Are Critical Factors in Mammalian Target of Rapamycin Complex Assembly
- (2010) Takeshi Kaizuka et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Glycogen Synthase Kinase-3 Is Required for Efficient Dictyostelium Chemotaxis
- (2010) Regina Teo et al. MOLECULAR BIOLOGY OF THE CELL
- Rictor Phosphorylation on the Thr-1135 Site Does Not Require Mammalian Target of Rapamycin Complex 2
- (2010) D. Boulbes et al. MOLECULAR CANCER RESEARCH
- Genome-wide shRNA screen reveals increased mitochondrial dependence upon mTORC2 addiction
- (2010) M Colombi et al. ONCOGENE
- TORC-Specific Phosphorylation of Mammalian Target of Rapamycin (mTOR): Phospho-Ser2481 Is a Marker for Intact mTOR Signaling Complex 2
- (2009) J. Copp et al. CANCER RESEARCH
- DEPTOR Is an mTOR Inhibitor Frequently Overexpressed in Multiple Myeloma Cells and Required for Their Survival
- (2009) Timothy R. Peterson et al. CELL
- mTOR Ser-2481 Autophosphorylation Monitors mTORC-specific Catalytic Activity and Clarifies Rapamycin Mechanism of Action
- (2009) Ghada A. Soliman et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Characterization of Rictor Phosphorylation Sites Reveals Direct Regulation of mTOR Complex 2 by S6K1
- (2009) C. C. Dibble et al. MOLECULAR AND CELLULAR BIOLOGY
- mTORC1-Activated S6K1 Phosphorylates Rictor on Threonine 1135 and Regulates mTORC2 Signaling
- (2009) L.-A. Julien et al. MOLECULAR AND CELLULAR BIOLOGY
- TORC2 Plasma Membrane Localization Is Essential for Cell Viability and Restricted to a Distinct Domain
- (2009) Doris Berchtold et al. MOLECULAR BIOLOGY OF THE CELL
- Rictor is a novel target of p70 S6 kinase-1
- (2009) C Treins et al. ONCOGENE
- mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)
- (2008) Juan M. García-Martínez et al. BIOCHEMICAL JOURNAL
- The Endosomal Protein Appl1 Mediates Akt Substrate Specificity and Cell Survival in Vertebrate Development
- (2008) Annette Schenck et al. CELL
- Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling
- (2008) Tsuneo Ikenoue et al. EMBO JOURNAL
- The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C
- (2008) Valeria Facchinetti et al. EMBO JOURNAL
- Cytoplasmic and nuclear distribution of the protein complexes mTORC1 and mTORC2: rapamycin triggers dephosphorylation and delocalization of the mTORC2 components rictor and sin1
- (2008) M. Rosner et al. HUMAN MOLECULAR GENETICS
- AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint
- (2008) Dana M. Gwinn et al. MOLECULAR CELL
- The aurora kinase A regulates GSK-3β in gastric cancer cells
- (2008) A A Dar et al. ONCOGENE
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started