Rapamycin reduces fibroblast proliferation without causing quiescence and induces STAT5A/B-mediated cytokine production

MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation

(2015) Remi-Martin Laberge et al.   NATURE CELL BIOLOGY

Intersection of mTOR and STAT signaling in immunity

(2015) Diana Saleiro et al.   TRENDS IN IMMUNOLOGY

Suppressor of cytokine signalling (SOCS) proteins as guardians of inflammatory responses critical for regulating insulin sensitivity

(2014) Sandra Galic et al.   BIOCHEMICAL JOURNAL

Deciphering the Systems Biology of mTOR Inhibition by Integrative Transcriptome Analysis

(2014) Sophie Domhan et al.   CURRENT PHARMACEUTICAL DESIGN

Emerging roles of the p38 MAPK and PI3K/AKT/mTOR pathways in oncogene-induced senescence

(2014) Yingxi Xu et al.   TRENDS IN BIOCHEMICAL SCIENCES

Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys

(2014) Ricki J. Colman et al.   Nature Communications

SOCS1 and Regulation of Regulatory T Cells Plasticity

(2014) Reiko Takahashi et al.   Journal of Immunology Research

Cellular senescence or EGFR signaling induces Interleukin 6 (IL-6) receptor expression controlled by mammalian target of rapamycin (mTOR)

(2013) Christoph Garbers et al.   CELL CYCLE

Rapamycin Enhances TNF-α-Induced Secretion of IL-6 and IL-8 through Suppressing PDCD4 Degradation in Orbital Fibroblasts

(2013) Won-Mo Lee et al.   CURRENT EYE RESEARCH

Regulation of mTORC1 and its impact on gene expression at a glance

(2013) M. Laplante et al.   JOURNAL OF CELL SCIENCE

Rapamycin extends murine lifespan but has limited effects on aging

(2013) Frauke Neff et al.   JOURNAL OF CLINICAL INVESTIGATION

Rapamycin Extends Life and Health in C57BL/6 Mice

(2013) Yiqiang Zhang et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Nutrient regulation of the mTOR Complex 1 signaling pathway

(2013) Sang Gyun Kim et al.   MOLECULES AND CELLS

Amino acid signalling upstream of mTOR

(2013) Jenna L. Jewell et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Nutrient signaling to mTOR and cell growth

(2013) Jenna L. Jewell et al.   TRENDS IN BIOCHEMICAL SCIENCES

Immunohistochemical detection of cytoplasmic LC3 puncta in human cancer specimens

(2012) Sylvain Ladoire et al.   Autophagy

TOR Signaling and Rapamycin Influence Longevity by Regulating SKN-1/Nrf and DAF-16/FoxO

(2012) Stacey Robida-Stubbs et al.   Cell Metabolism

GeneCodis3: a non-redundant and modular enrichment analysis tool for functional genomics

(2012) D. Tabas-Madrid et al.   NUCLEIC ACIDS RESEARCH

Nuclear RNA Sequencing of the Mouse Erythroid Cell Transcriptome

(2012) Jennifer A. Mitchell et al.   PLoS One

Coupling nutrient sensing to metabolic homoeostasis: the role of the mammalian target of rapamycin complex 1 pathway

(2012) Caroline André et al.   PROCEEDINGS OF THE NUTRITION SOCIETY

Amino acids and mTORC1: from lysosomes to disease

(2012) Alejo Efeyan et al.   TRENDS IN MOLECULAR MEDICINE

A longer and healthier life with TOR down-regulation: genetics and drugs: Figure 1

(2011) Ivana Bjedov et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Rapamycin decelerates cellular senescence

(2011) Zoya N. Demidenko et al.   CELL CYCLE

Negative Cross Talk between NFAT1 and Stat5 Signaling in Breast Cancer

(2011) Jiamao Zheng et al.   MOLECULAR ENDOCRINOLOGY

Fasting vs dietary restriction in cellular protection and cancer treatment: from model organisms to patients

(2011) C Lee et al.   ONCOGENE

Rapamycin Reverses Cellular Phenotypes and Enhances Mutant Protein Clearance in Hutchinson-Gilford Progeria Syndrome Cells

(2011) K. Cao et al.   Science Translational Medicine

Interactions among Polycomb Domains Are Guided by Chromosome Architecture

(2011) Bas Tolhuis et al.   PLoS Genetics

Farnesyltransferase inhibitor treatment restores chromosome territory positions and active chromosome dynamics in Hutchinson-Gilford progeria syndrome cells

(2011) Ishita S Mehta et al.   GENOME BIOLOGY

Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster

(2010) Ivana Bjedov et al.   Cell Metabolism

With TOR, Less Is More: A Key Role for the Conserved Nutrient-Sensing TOR Pathway in Aging

(2010) Pankaj Kapahi et al.   Cell Metabolism

Mammalian target of rapamycin (mTOR) regulates TLR3 induced cytokines in human oral keratinocytes

(2010) Jiawei Zhao et al.   MOLECULAR IMMUNOLOGY

Rapid chromosome territory relocation by nuclear motor activity in response to serum removal in primary human fibroblasts

(2010) Ishita S Mehta et al.   GENOME BIOLOGY

A human functional protein interaction network and its application to cancer data analysis

(2010) Guanming Wu et al.   GENOME BIOLOGY

Preferential associations between co-regulated genes reveal a transcriptional interactome in erythroid cells

(2009) Stefan Schoenfelder et al.   NATURE GENETICS

GeneCodis: interpreting gene lists through enrichment analysis and integration of diverse biological information

(2009) R. Nogales-Cadenas et al.   NUCLEIC ACIDS RESEARCH

Putting out the fire: coordinated suppression of the innate and adaptive immune systems by SOCS1 and SOCS3 proteins

(2008) Ioannis D. Dimitriou et al.   IMMUNOLOGICAL REVIEWS

Caloric Restriction and Aging: Studies in Mice and Monkeys

(2008) Rozalyn M. Anderson et al.   TOXICOLOGIC PATHOLOGY