Rapamycin induces pluripotent genes associated with avoidance of replicative senescence

MicroRNAs miR-146a/b negatively modulate the senescence-associated inflammatory mediators IL-6 and IL-8

(2016) Dipa Bhaumik et al.   Aging-US

TP53 and MTOR crosstalk to regulate cellular senescence

(2016) Lorenzo Galluzzi et al.   Aging-US

The choice between p53-induced senescence and quiescence is determined in part by the mTOR pathway

(2016) Lioubov G. Korotchkina et al.   Aging-US

Sestrins at the crossroad between stress and aging

(2016) Jun Hee Lee et al.   Aging-US

Hormesis does not make sense except in the light of TOR-driven aging

(2016) Mikhail V. Blagosklonny   Aging-US

Cell cycle arrest is not senescence

(2016) Mikhail V. Blagosklonny   Aging-US

Once again on rapamycin-induced insulin resistance and longevity: despite of or owing to

(2016) Mikhail V. Blagosklonny   Aging-US

Tumor suppression by p53 without apoptosis and senescence: conundrum or rapalog-like gerosuppression?

(2016) Mikhail V. Blagosklonny   Aging-US

Matters of life and breath: A role for hypoxia in determining cell state

(2016) Marco Demaria et al.   Aging-US

Answering the ultimate question “What is the Proximal Cause of Aging?”

(2016) Mikhail V. Blagosklonny   Aging-US

Automated image analysis of nuclear shape: What can we learn from a prematurely aged cell?

(2016) Meghan K. Driscoll et al.   Aging-US

IL1- and TGFβ-Nox4 signaling, oxidative stress and DNA damage response are shared features of replicative, oncogene-induced, and drug-induced paracrine ‘Bystander senescence’

(2016) Sona Hubackova et al.   Aging-US

Cell cycle arrest is not yet senescence, which is not just cell cycle arrest: terminology for TOR-driven aging

(2016) Mikhail V. Blagosklonny   Aging-US

Potential anti-aging agents suppress the level of constitutive mTOR- and DNA damage- signaling

(2016) H. Dorota Halicka et al.   Aging-US

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

A high-content cellular senescence screen identifies candidate tumor suppressors, including EPHA3

(2013) Jenni Lahtela et al.   CELL CYCLE

Xenohormetic and anti-aging activity of secoiridoid polyphenols present in extra virgin olive oil

(2013) Javier A. Menendez et al.   CELL CYCLE

Reprogramming somatic cells to pluripotency: A fresh look at Yamanaka’s model

(2013) Yangxin Li et al.   CELL CYCLE

DNA damage causes TP53-dependent coupling of self-renewal and senescence pathways in embryonal carcinoma cells

(2013) Thomas R. Jackson et al.   CELL CYCLE

α-Fucosidase as a novel convenient biomarker for cellular senescence

(2013) Dominic Hildebrand et al.   CELL CYCLE

p53mutations associated with aging-related rise in cancer incidence rates

(2013) Richard B Richardson   CELL CYCLE

CDK4/6-inhibiting drug substitutes for p21 and p16 in senescence: Duration of cell cycle arrest and MTOR activity determine geroconversion

(2013) Olga V. Leontieva et al.   CELL CYCLE

INK4a/ARF limits the expansion of cells suffering from replication stress

(2013) Angela Monasor et al.   CELL CYCLE

The involvement of a Nanog, Klf4 and c-Myc transcriptional circuitry in the intertwining between neoplastic progression and reprogramming

(2013) Ilaria Marzi et al.   CELL CYCLE

Understanding impediments to cellular conversion to pluripotency by assessing the earliest events in ectopic transcription factor binding to the genome

(2013) Abdenour Soufi et al.   CELL CYCLE

Atypical heterochromatin organization and replication are rapidly acquired by somatic cells following fusion-mediated reprogramming by mouse ESCs

(2013) Karen E Brown et al.   CELL CYCLE

Genome organization by Klf4 regulates transcription in pluripotent stem cells

(2013) David Huang et al.   CELL CYCLE

Cellular senescence or EGFR signaling induces Interleukin 6 (IL-6) receptor expression controlled by mammalian target of rapamycin (mTOR)

(2013) Christoph Garbers et al.   CELL CYCLE

p53 Ser15 phosphorylation and histone modifications contribute to IR-induced miR-34a transcription in mammary epithelial cells

(2013) Bo Wang et al.   CELL CYCLE

Nature vs nurture: Interplay between the genetic control of telomere length and environmental factors

(2013) Yaniv Harari et al.   CELL CYCLE

Nuclear reprogramming of luminal-like breast cancer cells generates Sox2-overexpressing cancer stem-like cellular states harboring transcriptional activation of the mTOR pathway

(2013) BRUNA COROMINAS-FAJA et al.   CELL CYCLE

MEK drives cyclin D1 hyperelevation during geroconversion

(2013) O V Leontieva et al.   CELL DEATH AND DIFFERENTIATION

Cellular senescence and the senescent secretory phenotype: therapeutic opportunities

(2013) Tamara Tchkonia et al.   JOURNAL OF CLINICAL INVESTIGATION

mTOR is a key modulator of ageing and age-related disease

(2013) Simon C. Johnson et al.   NATURE

Prospective Treatment of Age-Related Diseases by Slowing Down Aging

(2012) Mikhail V. Blagosklonny   AMERICAN JOURNAL OF PATHOLOGY

Genetics of Longevity in Model Organisms: Debates and Paradigm Shifts

(2012) David Gems et al.   Annual Review of Physiology

Alternative Perspectives on Aging in Caenorhabditis elegans: Reactive Oxygen Species or Hyperfunction?

(2012) David Gems et al.   ANTIOXIDANTS & REDOX SIGNALING

Hypoxia, MTOR and autophagy

(2012) Mikhail V. Blagosklonny   Autophagy

Attenuation of TORC1 signaling delays replicative and oncogenic RAS-induced senescence

(2012) Marina Kolesnichenko et al.   CELL CYCLE

Suppression of replicative senescence by rapamycin in rodent embryonic cells

(2012) Tatyana V. Pospelova et al.   CELL CYCLE

Telomerase gene therapy in adult and old mice delays aging and increases longevity without increasing cancer

(2012) Bruno Bernardes de Jesus et al.   EMBO Molecular Medicine

Hypoxia suppresses conversion from proliferative arrest to cellular senescence

(2012) O. V. Leontieva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rapamycin and other longevity-promoting compounds enhance the generation of mouse induced pluripotent stem cells

(2011) Taotao Chen et al.   AGING CELL

Underlying principles of cell fate determination during G1 phase of the mammalian cell cycle

(2011) Benjamin Pfeuty et al.   CELL CYCLE

Is NHEJ a tumor suppressor or an aging suppressor?

(2011) Paul Hasty   CELL CYCLE

Distinct roles for p107 and p130 in Rb-independent cellular senescence

(2011) Brian D. Lehmann et al.   CELL CYCLE

Control of senescence by CXCR2 and its ligands

(2011) Juan C. Acosta et al.   CELL CYCLE

The yin and yang of the Cdkn2a locus in senescence and aging

(2011) Darren J. Baker et al.   CELL CYCLE

DNA damage response activation in mouse embryonic fibroblasts undergoing replicative senescence and following spontaneous immortalization

(2011) Raffaella Di Micco et al.   CELL CYCLE

Resveratrol: A multitargeted agent for age-associated chronic diseases

(2011) Kuzhuvelil B. Harikumar et al.   CELL CYCLE

Melanomagenesis: Overcoming the barrier of melanocyte senescence

(2011) Linan Ha et al.   CELL CYCLE

Cleavage of MCM2 licensing protein fosters senescence in human keratinocytes

(2011) Hideki Harada et al.   CELL CYCLE

A novel form of the telomere-associated protein TIN2 localizes to the nuclear matrix

(2011) Patrick G. Kaminker et al.   CELL CYCLE

Induced pluripotent stem cells from swine (Sus scrofa): Why they may prove to be important

(2011) R. Michael Roberts et al.   CELL CYCLE

The p53 tumor suppressor protein is a critical regulator of hematopoietic stem cell behavior

(2011) Yan Liu et al.   CELL CYCLE

The hypoxic response and aging

(2011) Matt Kaeberlein et al.   CELL CYCLE

Effects of p21 deletion in mouse models of premature aging

(2011) Erica K. Benson et al.   CELL CYCLE

Forever young, slim and fit: Rapamycin to the rescue

(2011) Zbigniew Darzynkiewicz   CELL CYCLE

Sir2 and longevity: The p53 connection

(2011) Johannes Bauer et al.   CELL CYCLE

Pharmacologic inhibition of MEK and PI-3K converges on the mTOR/S6 pathway to decelerate cellular senescence

(2011) Zoya N. Demidenko et al.   CELL CYCLE

TOR-driven aging: Speeding car without brakes

(2011) Mikhail V Blagosklonny   CELL CYCLE

Aging-suppressants: Cellular senescence (hyperactivation) and its pharmacologic deceleration

(2011) Mikhail V Blagosklonny   CELL CYCLE

At concentrations that inhibit mTOR, resveratrol suppresses cellular senescence

(2011) Zoya N. Demidenko et al.   CELL CYCLE

The tumorigenicity of diploid and aneuploid human pluripotent stem cells

(2011) Barak Blum et al.   CELL CYCLE

The antidiabetic drug metformin suppresses HER2 (erbB-2) oncoprotein overexpression via inhibition of the mTOR effector p70S6K1 in human breast carcinoma cells

(2011) Alejandro Vazquez-Martin et al.   CELL CYCLE

Rapamycin decelerates cellular senescence

(2011) Zoya N. Demidenko et al.   CELL CYCLE

Pseudo-DNA damage response in senescent cells

(2011) Tatyana V. Pospelova et al.   CELL CYCLE

The Epstein-Barr virus replication and transcription activator, Rta/BRLF1, induces cellular senescence in epithelial cells

(2011) Yu-Lian Chen et al.   CELL CYCLE

Loss of p21CDKN1Aimpairs entry to quiescence and activates a DNA damage response in normal fibroblasts induced to quiescence

(2011) Paola Perucca et al.   CELL CYCLE

MiR-34, SIRT1, and p53: The feedback loop

(2011) Munekazu Yamakuchi et al.   CELL CYCLE

Oncogene-induced senescence pathways in melanocytes 

(2011) Sebastian Haferkamp et al.   CELL CYCLE

Metabolism meets autophagy 

(2011) J. Julie Wu et al.   CELL CYCLE

Increasing healthy lifespan by suppressing aging in our lifetime: Preliminary proposal 

(2011) Mikhail V Blagosklonny   CELL CYCLE

Induction of pluripotency in human endothelial cells resets epigenetic profile on genome scale

(2011) Maria A. Lagarkova et al.   CELL CYCLE

The p53 response element and transcriptional repression

(2011) Bei Wang et al.   CELL CYCLE

Calorie restriction: Decelerating mTOR-driven aging from cells to organisms (including humans)

(2011) Mikhail V Blagosklonny   CELL CYCLE

Rejuvenating senescent and centenarian human cells by reprogramming through the pluripotent state

(2011) L. Lapasset et al.   GENES & DEVELOPMENT

Genes inducing iPS phenotype play a role in hepatocyte survival and proliferation in vitro and liver regeneration in vivo

(2011) Vishakha S. Bhave et al.   HEPATOLOGY

Spatial Coupling of mTOR and Autophagy Augments Secretory Phenotypes

(2011) M. Narita et al.   SCIENCE

Rapamycin Reverses Cellular Phenotypes and Enhances Mutant Protein Clearance in Hutchinson-Gilford Progeria Syndrome Cells

(2011) K. Cao et al.   Science Translational Medicine

Growth stimulation leads to cellular senescence when the cell cycle is blocked

(2010) Zoya N. Demidenko et al.   CELL CYCLE

The common germline Arg72Pro polymorphism of p53 and increased longevity in humans

(2010) Stig E. Bojesen et al.   CELL CYCLE

The tumor suppressor p53: Cancer and aging

(2010) Zhaohui Feng et al.   CELL CYCLE

Inhibition of cell differentiation: A critical mechanism for MYC-mediated carcinogenesis?

(2010) Javier Leon et al.   CELL CYCLE

Somatic cell reprogramming control: Signaling pathway modulation versus transcription factor activities

(2010) Frederic Lluis et al.   CELL CYCLE

Role of p53 in the anti-proliferative effects of Sirt1 inhibition in prostate cancer cells

(2010) Brittney Jung-Hynes et al.   CELL CYCLE

Intriguing novel abilities of Nutlin-3A: Induction of cellular quiescence as opposed to cellular senescence—Implications for chemotherapy

(2010) Linda S. Steelman et al.   CELL CYCLE

Telomerase activation by c-Myc in human mammary epithelial cells requires additional genomic changes

(2010) Alexey V. Bazarov et al.   CELL CYCLE

G1to S transition and pluripotency: Two sides of the same coin?

(2010) Majlinda Lako et al.   CELL CYCLE

Specific activation of the p53 pathway by low dose actinomycin D: A new route to p53 based cyclotherapy

(2010) Meng Ling Choong et al.   CELL CYCLE

Shifting senescence into quiescence by turning up p53

(2010) Manuel Serrano   CELL CYCLE

p53: The pivot between cell cycle arrest and senescence

(2010) Raffaela Santoro et al.   CELL CYCLE

Rb-dependent cellular senescence, multinucleation and susceptibility to oncogenic transformation through PKC scaffolding by SSeCKS/AKAP12

(2010) Shin Akakura et al.   CELL CYCLE

Stem cell pluripotency: Alternative modes of transcription regulation

(2010) Nathan Salomonis et al.   CELL CYCLE

HdmX overexpression inhibits oncogene induced cellular senescence

(2010) Kelly R. Miller et al.   CELL CYCLE

The cell cycle and pluripotency: Is there a direct link?

(2010) Michael J. Edel et al.   CELL CYCLE

MAD2 downregulation in hypoxia is independent of promoter hypermethylation

(2010) Maria Prencipe et al.   CELL CYCLE

p21Waf1is required for cellular senescence but not for cell cycle arrest induced by the HDAC inhibitor sodium butyrate

(2010) Vasily S. Romanov et al.   CELL CYCLE

Rapamycin and quasi-programmed aging: Four years later

(2010) Mikhail V Blagosklonny   CELL CYCLE

A LIF/Nanog axis is revealed in T lymphocytes that lack MARCH-7, a RINGv E3 ligase that regulates the LIF-receptor

(2010) Lorraine H. Thompson et al.   CELL CYCLE

p53 and senescence: A little goes a long way

(2010) Jaclyn S. Long et al.   CELL CYCLE

Are the conspicuous interdependences of fecundity, longevity and cognitive abilities in humans caused in part by p53?

(2010) Klaus Roemer   CELL CYCLE

Myc, Cdk2 and cellular senescence: Old players, new game

(2010) Stefano Campaner et al.   CELL CYCLE

The genetic architecture of aging: Sexual antagonistic plieotropy ofp53andfoxo

(2010) John Tower   CELL CYCLE

FM19G11: A new modulator of HIF that links mTOR activation with the DNA damage checkpoint pathways

(2010) Francisco Javier Rodríguez-Jiménez et al.   CELL CYCLE

Weak p53 permits senescence during cell cycle arrest

(2010) Olga V. Leontieva et al.   CELL CYCLE

p53: Guardian of reprogramming

(2010) Sergio Menendez et al.   CELL CYCLE

Genetic instability in human induced pluripotent stem cells: Classification of causes and possible safeguards

(2010) Uri Ben-David et al.   CELL CYCLE

Removing all obstacles: A critical role for p53 in promoting tissue renewal

(2010) David W. Schoppy et al.   CELL CYCLE

Revisiting the antagonistic pleiotropy theory of aging: TOR-driven program and quasi-program

(2010) Mikhail V Blagosklonny   CELL CYCLE

Nek6 overexpression antagonizes p53-induced senescence in human cancer cells

(2010) Hye Jin Jee et al.   CELL CYCLE

Regulation of the PML tumor suppressor in drug-induced senescence of human normal and cancer cells by JAK/STAT-mediated signaling

(2010) Sona Hubackova et al.   CELL CYCLE

Absence of p53-dependent apoptosis leads to UV radiation hypersensitivity, enhanced immunosuppression and cellular senescence

(2010) Omid Tavana et al.   CELL CYCLE

miR-33-mediated downregulation of p53 controls hematopoietic stem cell self-renewal

(2010) Antonio Herrera-Merchan et al.   CELL CYCLE

Paradoxical suppression of cellular senescence by p53

(2010) Z. N. Demidenko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lack of p21 expression links cell cycle control and appendage regeneration in mice

(2010) K. Bedelbaeva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagy facilitates oncogene-induced senescence

(2009) Masako Narita et al.   Autophagy

Nutrient-dependent regulation of autophagy through the target of rapamycin pathway: Figure 1

(2009) Yu-Yun Chang et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

A simple trypsin-Giemsa technique producing simultaneous G- and C-banding in human chromosomes

(2009) CIHANGIR ÖZKINAY et al.   HEREDITAS

A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity

(2009) Rosa M. Marión et al.   NATURE

Immortalization eliminates a roadblock during cellular reprogramming into iPS cells

(2009) Jochen Utikal et al.   NATURE

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

(2008) Jean-Philippe Coppé et al.   PLOS BIOLOGY