Disruptive chemicals, senescence and immortality

The relative contributions of the p53 and pRb pathways in oncogene-induced melanocyte senescence

(2016) Sebastian Haferkamp et al.   Aging-US

The regulation of p53 by phosphorylation: a model for how distinct signals integrate into the p53 pathway

(2016) Nicola J. Maclaine et al.   Aging-US

The choice between p53-induced senescence and quiescence is determined in part by the mTOR pathway

(2016) Lioubov G. Korotchkina et al.   Aging-US

Mitochondrial dysfunction and cell senescence — skin deep into mammalian aging

(2016) Joao F. Passos et al.   Aging-US

The RB Tumor Suppressor Positively Regulates Transcription of the Anti-angiogenic Protein NOL7

(2015) Tanmayi P. Mankame et al.   NEOPLASIA

Telomerase-Based Pharmacologic Enhancement of Antiviral Function of Human CD8+ T Lymphocytes

(2014) S. R. Fauce et al.   JOURNAL OF IMMUNOLOGY

Paracetamol treatment increases telomerase activity in rat embryonic liver cells

(2014) Augustinus Bader et al.   Pharmacological Reports

Application of Interleukin-22 Mediates Protection in Experimental Acetaminophen-Induced Acute Liver Injury

(2013) Patrick Scheiermann et al.   AMERICAN JOURNAL OF PATHOLOGY

Selective poisoning of Ctnnb1-mutated hepatoma cells in mouse liver tumors by a single application of acetaminophen

(2013) Yasmin Singh et al.   ARCHIVES OF TOXICOLOGY

Molecular mechanisms underlying chronic inflammation-associated cancers

(2013) Yongzhong Wu et al.   CANCER LETTERS

Strategies for co-targeting the PI3K/AKT/mTOR pathway in NSCLC

(2013) Susan Heavey et al.   CANCER TREATMENT REVIEWS

Programmed Cell Senescence during Mammalian Embryonic Development

(2013) Daniel Muñoz-Espín et al.   CELL

Senescence Is a Developmental Mechanism that Contributes to Embryonic Growth and Patterning

(2013) Mekayla Storer et al.   CELL

Nuclear reprogramming of luminal-like breast cancer cells generates Sox2-overexpressing cancer stem-like cellular states harboring transcriptional activation of the mTOR pathway

(2013) BRUNA COROMINAS-FAJA et al.   CELL CYCLE

Everolimus in Combination with Exemestane: A Review of its Use in the Treatment of Patients with Postmenopausal Hormone Receptor-Positive, HER2-Negative Advanced Breast Cancer

(2013) Sohita Dhillon   DRUGS

Crosstalk between oxygen- and nitric oxide-dependent signaling pathways in angiogenesis

(2013) Peter Fraisl   EXPERIMENTAL CELL RESEARCH

ATF4 activation by the p38MAPK-eIF4E axis mediates apoptosis and autophagy induced by selenite in Jurkat cells

(2013) Qian Jiang et al.   FEBS LETTERS

RB goes mitochondrial

(2013) L. D. Attardi et al.   GENES & DEVELOPMENT

Loss of RBF1 changes glutamine catabolism

(2013) B. N. Nicolay et al.   GENES & DEVELOPMENT

RB1 in cancer: Different mechanisms of RB1 inactivation and alterations of pRb pathway in tumorigenesis

(2013) Riccardo Di Fiore et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Pancreatic cancer–associated retinoblastoma 1 dysfunction enables TGF-β to promote proliferation

(2013) A. Jesse Gore et al.   JOURNAL OF CLINICAL INVESTIGATION

mTOR regulates DNA damage response through NF-κB-mediated FANCD2 pathway in hematopoietic cells

(2013) F Guo et al.   LEUKEMIA

Evaluation of Selenite Effects on Selenoproteins and Cytokinome in Human Hepatoma Cell Lines

(2013) Fabiola Rusolo et al.   MOLECULES

A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence

(2013) Joanna Kaplon et al.   NATURE

Synthetic lethal metabolic targeting of cellular senescence in cancer therapy

(2013) Jan R. Dörr et al.   NATURE

A complex secretory program orchestrated by the inflammasome controls paracrine senescence

(2013) Juan Carlos Acosta et al.   NATURE CELL BIOLOGY

The Effects of N-Acetylcysteine and Ozone Therapy on Oxidative Stress and Inflammation in Acetaminophen-Induced Nephrotoxicity Model

(2013) Fatma Ucar et al.   RENAL FAILURE

Autophagy regulation and its role in cancer

(2013) Séverine Lorin et al.   SEMINARS IN CANCER BIOLOGY

Telomerase: central regulator of all of the hallmarks of cancer

(2013) Kee Chung Low et al.   TRENDS IN BIOCHEMICAL SCIENCES

Post-Translational Control of IL-1β via the Human Papillomavirus Type 16 E6 Oncoprotein: A Novel Mechanism of Innate Immune Escape Mediated by the E3-Ubiquitin Ligase E6-AP and p53

(2013) Martina Niebler et al.   PLoS Pathogens

Dysregulation of mTOR activity through LKB1 inactivation

(2013) Wei Zhou et al.   Chinese Journal of Cancer

Macrophage-tumor cell interactions regulate the function of nitric oxide

(2013) Michal A. Rahat et al.   Frontiers in Physiology

Protective role of quercetin against lead-induced inflammatory response in rat kidney through the ROS-mediated MAPKs and NF-κB pathway

(2012) Chan-Min Liu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Phosphoglycerate Mutase 1 Coordinates Glycolysis and Biosynthesis to Promote Tumor Growth

(2012) Taro Hitosugi et al.   CANCER CELL

Role of mTOR Signaling in Tumor Cell Motility, Invasion and Metastasis

(2012) Shile Huang et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Everolimus in the treatment of hormone receptor-positive breast cancer

(2012) Mariana Chavez-MacGregor et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Second-line systemic therapy for the treatment of metastatic renal cell cancer

(2012) Stephan Kruck et al.   Expert Review of Anticancer Therapy

Curcumin and resveratrol in combination modulates benzo(a)pyrene-induced genotoxicity during lung carcinogenesis

(2012) A Malhotra et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

The Role of α-synuclein and Tau Hyperphosphorylation-Mediated Autophagy and Apoptosis in Lead-induced Learning and Memory Injury

(2012) Jianbin Zhang et al.   International Journal of Biological Sciences

Nickel-induced Epithelial-Mesenchymal Transition by Reactive Oxygen Species Generation and E-cadherin Promoter Hypermethylation

(2012) Chih-Hsien Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The emerging role of MIR-146A in the control of hematopoiesis, immune function and cancer

(2012) Catherine Labbaye et al.   Journal of Hematology & Oncology

Lung tumorigenesis promoted by anti-apoptotic effects of cotinine, a nicotine metabolite through activation of PI3K/Akt pathway

(2012) Tomohisa Nakada et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

Age-related differences in the expression of circulating microRNAs: miR-21 as a new circulating marker of inflammaging

(2012) Fabiola Olivieri et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Macrophages, Inflammation, and Tumor Suppressors: ARF, a New Player in the Game

(2012) Paqui G. Través et al.   MEDIATORS OF INFLAMMATION

Anti-Cancer Targeting Telomerase Inhibitors: β-Rubromycin and Oleic Acid

(2012) Yoshiyuki Mizushina et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Carcinogen-specific mutational and epigenetic alterations in INK4A, INK4B and p53 tumour-suppressor genes drive induced senescence bypass in normal diploid mammalian cells

(2012) H Yasaei et al.   ONCOGENE

Everolimus: Targeted Therapy on the Horizon for the Treatment of Breast Cancer

(2012) Chad M. Barnett   PHARMACOTHERAPY

The hTERT Promoter Enhances the Antitumor Activity of an Oncolytic Adenovirus under a Hypoxic Microenvironment

(2012) Yuuri Hashimoto et al.   PLoS One

Akt signaling-associated metabolic effects of dietary gold nanoparticles in Drosophila

(2012) Bin Wang et al.   Scientific Reports

Cotinine inhibits the pro-inflammatory response initiated by multiple cell surface Toll-like receptors in monocytic THP cells

(2012) Juhi Bagaitkar et al.   Tobacco Induced Diseases

The telomerase activator TA-65 elongates short telomeres and increases health span of adult/old mice without increasing cancer incidence

(2011) Bruno Bernardes de Jesus et al.   AGING CELL

The effect of sodium selenite on liver growth and thioredoxin reductase expression in regenerative and neoplastic liver cell proliferation

(2011) Suvd Erkhembayar et al.   BIOCHEMICAL PHARMACOLOGY

Pancreatitis-Induced Inflammation Contributes to Pancreatic Cancer by Inhibiting Oncogene-Induced Senescence

(2011) Carmen Guerra et al.   CANCER CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Resveratrol: A multitargeted agent for age-associated chronic diseases

(2011) Kuzhuvelil B. Harikumar et al.   CELL CYCLE

TOR-driven aging: Speeding car without brakes

(2011) Mikhail V Blagosklonny   CELL CYCLE

Calorie restriction: Decelerating mTOR-driven aging from cells to organisms (including humans)

(2011) Mikhail V Blagosklonny   CELL CYCLE

Spinophilin acts as a tumor suppressor by regulating Rb phosphorylation

(2011) Irene Ferrer et al.   CELL CYCLE

Cancer Chemoprevention by Targeting the Epigenome

(2011) Joseph Huang et al.   CURRENT DRUG TARGETS

Mechanisms maintaining genomic integrity in embryonic stem cells and induced pluripotent stem cells

(2011) Elisia D Tichy   EXPERIMENTAL BIOLOGY AND MEDICINE

Arsenic-induced oxidative stress and its reversibility

(2011) Swaran J.S. Flora   FREE RADICAL BIOLOGY AND MEDICINE

The dual role of p53: DNA protection and antioxidant

(2011) Consuelo Borrás et al.   FREE RADICAL RESEARCH

Deletion of Rb Accelerates Pancreatic Carcinogenesis by Oncogenic Kras and Impairs Senescence in Premalignant Lesions

(2011) Catherine Carrière et al.   GASTROENTEROLOGY

Links between mutant p53 and genomic instability

(2011) Walter Hanel et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Effect of lead on apoptosis in cultured rat primary osteoblasts

(2011) Yushui Ma et al.   TOXICOLOGY AND INDUSTRIAL HEALTH

Silver nanoparticles down-regulate Nrf2-mediated 8-oxoguanine DNA glycosylase 1 through inactivation of extracellular regulated kinase and protein kinase B in human Chang liver cells

(2011) Mei Jing Piao et al.   TOXICOLOGY LETTERS

Effect of bisphenol-A on the expression of selected genes involved in cell cycle and apoptosis in the OVCAR-3 cell line

(2011) Anna Ptak et al.   TOXICOLOGY LETTERS

DNA Damage Repair and Telomere Length in Normal Breast, Preneoplastic Lesions, and Invasive Cancer

(2010) Christophe M. Raynaud et al.   AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS

Rapamycin Extends Maximal Lifespan in Cancer-Prone Mice

(2010) Vladimir N. Anisimov et al.   AMERICAN JOURNAL OF PATHOLOGY

Manganese superoxide dismutase: beyond life and death

(2010) Aaron K. Holley et al.   AMINO ACIDS

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

Selenium: a double-edged sword for defense and offence in cancer

(2010) Jela Brozmanová et al.   ARCHIVES OF TOXICOLOGY

Epigenetic mechanisms in senescence, immortalisation and cancer

(2010) Amancio Carnero et al.   BIOLOGICAL REVIEWS

Growth stimulation leads to cellular senescence when the cell cycle is blocked

(2010) Zoya N. Demidenko et al.   CELL CYCLE

Aging: ROS or TOR

(2010) Mikhail V Blagosklonny   CELL CYCLE

Bypassing cellular senescence by genetic screening tools

(2010) Mar Vergel et al.   Clinical & Translational Oncology

Understanding FOXO, New Views on Old Transcription Factors

(2010) F. Zanella et al.   CURRENT CANCER DRUG TARGETS

Cellular senescence: putting the paradoxes in perspective

(2010) Judith Campisi   CURRENT OPINION IN GENETICS & DEVELOPMENT

Nitric Oxide and Cancer Therapy: The Emperor has NO Clothes

(2010) Jason Hickok et al.   CURRENT PHARMACEUTICAL DESIGN

Quantitative assessment of markers for cell senescence

(2010) Conor Lawless et al.   EXPERIMENTAL GERONTOLOGY

A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis

(2010) Andrea Alimonti et al.   JOURNAL OF CLINICAL INVESTIGATION

The role of mutant p53 in human cancer

(2010) Amanda M Goh et al.   JOURNAL OF PATHOLOGY

Nickel(II)-Induced Oxidative Stress, Apoptosis, G2/M Arrest, and Genotoxicity in Normal Rat Kidney Cells

(2010) Chang-Yu Chen et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES

Regulation of the mTOR Complex 1 Pathway by Nutrients, Growth Factors, and Stress

(2010) Shomit Sengupta et al.   MOLECULAR CELL

Nitric oxide and neuronal death

(2010) Guy C. Brown   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Gold nanoparticles attenuate LPS-induced NO production through the inhibition of NF-κB and IFN-β/STAT1 pathways in RAW264.7 cells

(2010) Ji Su Ma et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Exploring the Gain of Function Contribution of AKT to Mammary Tumorigenesis in Mouse Models

(2010) Carmen Blanco-Aparicio et al.   PLoS One

Sulforaphane Causes Epigenetic Repression of hTERT Expression in Human Breast Cancer Cell Lines

(2010) Syed M. Meeran et al.   PLoS One

A Natural Product Telomerase Activator As Part of a Health Maintenance Program

(2010) Calvin B. Harley et al.   REJUVENATION RESEARCH

Silver nanoparticles induce oxidative cell damage in human liver cells through inhibition of reduced glutathione and induction of mitochondria-involved apoptosis

(2010) Mei Jing Piao et al.   TOXICOLOGY LETTERS

Multiple molecular targets of resveratrol: Anti-carcinogenic mechanisms

(2009) Mohammad Athar et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Effects of Nickel on Cyclin Expression, Cell Cycle Progression and Cell Proliferation in Human Pulmonary Cells

(2009) J. Ding et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Telomeres and telomerase in cancer

(2009) S. E. Artandi et al.   CARCINOGENESIS

Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability

(2009) F. Colotta et al.   CARCINOGENESIS

Silver nanoparticles inhibit VEGF induced cell proliferation and migration in bovine retinal endothelial cells

(2009) Kalimuthu Kalishwaralal et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Acute toxicity testing of chemicals—Opportunities to avoid redundant testing and use alternative approaches

(2009) Stuart Creton et al.   CRITICAL REVIEWS IN TOXICOLOGY

Mouse Models to Decipher the PI3K Signaling Network in Human Cancer

(2009) Oliver Renner et al.   CURRENT MOLECULAR MEDICINE

The PKB/AKT Pathway in Cancer

(2009) Amancio Carnero   CURRENT PHARMACEUTICAL DESIGN

Telomerase: cellular immortalization and neoplastic transformation. Multiple functions of a multifaceted complex

(2009) C. Belgiovine et al.   CYTOGENETIC AND GENOME RESEARCH

Sirtuin activators

(2009) Francisco J Alcaín et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Inactivation of p53 and Pten promotes invasive bladder cancer

(2009) A. M. Puzio-Kuter et al.   GENES & DEVELOPMENT

Genistein depletes telomerase activity through cross-talk between genetic and epigenetic mechanisms

(2009) Yuanyuan Li et al.   INTERNATIONAL JOURNAL OF CANCER

Epigenetics in metal carcinogenesis: nickel, arsenic, chromium and cadmium

(2009) Adriana Arita et al.   Metallomics

Senescence induction; a possible cancer therapy

(2009) Matilde E LLeonart et al.   Molecular Cancer

CENPA overexpression promotes genome instability in pRb-depleted human cells

(2009) Angela Amato et al.   Molecular Cancer

Effects of nickel, chromate, and arsenite on histone 3 lysine methylation

(2009) Xue Zhou et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Cotinine-induced convergence of the cholinergic and PI3 kinase-dependent anti-inflammatory pathways in innate immune cells

(2008) Kunal Rehani et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Resveratrol reduces endothelial progenitor cells senescence through augmentation of telomerase activity by Akt-dependent mechanisms

(2008) L Xia et al.   BRITISH JOURNAL OF PHARMACOLOGY

Mammalian Target of Rapamycin Repression by 3,3'-Diindolylmethane Inhibits Invasion and Angiogenesis in Platelet-Derived Growth Factor-D-Overexpressing PC3 Cells

(2008) D. Kong et al.   CANCER RESEARCH

Activation of Phosphatidylinositol 3-Kinase by Membrane Localization of p110  Predisposes Mammary Glands to Neoplastic Transformation

(2008) O. Renner et al.   CANCER RESEARCH

Chemokine Signaling via the CXCR2 Receptor Reinforces Senescence

(2008) Juan C. Acosta et al.   CELL

Establishment of Immortalized Human Hepatocytes by Introduction of HPV16 E6/E7 and hTERT as Cell Sources for Liver Cell-Based Therapy

(2008) Yosuke Tsuruga et al.   CELL TRANSPLANTATION

Comparison of global DNA methylation profiles in replicative versus premature senescence

(2008) Wenjuan Zhang et al.   LIFE SCIENCES

Replicative stress, stem cells and aging

(2008) Yaroslava Ruzankina et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Id1 delays senescence of primary human melanocytes

(2008) Staci D. Cummings et al.   MOLECULAR CARCINOGENESIS

Many roads lead to oncogene-induced senescence

(2008) S Courtois-Cox et al.   ONCOGENE

The FoxO code

(2008) D R Calnan et al.   ONCOGENE

Characterization of the p53 Response to Oncogene-Induced Senescence

(2008) Lidia Ruiz et al.   PLoS One

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

(2008) Jean-Philippe Coppé et al.   PLOS BIOLOGY

Allelic loss and mutations in a new ETRG-1 gene are early events in diethylstilbestrol-induced renal carcinogenesis in Syrian hamsters

(2007) Kamaleshwar P. Singh et al.   GENE

Genotoxic effects of environmental estrogen-like compounds in CHO-K1 cells

(2007) Sumiko Tayama et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Arsenic-induced health effects and genetic damage in keratotic individuals: Involvement of p53 arginine variant and chromosomal aberrations in arsenic susceptibility

(2007) S DECHAUDHURI et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH