PI3K/mTOR inhibition potentiates and extends palbociclib activity in anaplastic thyroid cancer

Everolimus Reverses Palbociclib Resistance in ER+ Human Breast Cancer Cells by Inhibiting Phosphatidylinositol 3-Kinase(PI3K)/Akt/Mammalian Target of Rapamycin (mTOR) Pathway

(2019) Lin Chen et al.   MEDICAL SCIENCE MONITOR

A selective cyclin-dependent kinase 4, 6 dual inhibitor, Ribociclib (LEE011) inhibits cell proliferation and induces apoptosis in aggressive thyroid cancer

(2018) Hyun Joo Lee et al.   CANCER LETTERS

Genetic Analysis of 779 Advanced Differentiated and Anaplastic Thyroid Cancers

(2018) Nikita Pozdeyev et al.   CLINICAL CANCER RESEARCH

Dabrafenib and Trametinib Treatment in Patients With Locally Advanced or Metastatic BRAF V600–Mutant Anaplastic Thyroid Cancer

(2018) Vivek Subbiah et al.   JOURNAL OF CLINICAL ONCOLOGY

Real-World Experience with Targeted Therapy for the Treatment of Anaplastic Thyroid Carcinoma

(2018) Priyanka C. Iyer et al.   THYROID

Salvage pembrolizumab added to kinase inhibitor therapy for the treatment of anaplastic thyroid carcinoma

(2018) Priyanka C. Iyer et al.   Journal for ImmunoTherapy of Cancer

The genetic landscape and clonal evolution of breast cancer resistance to palbociclib plus fulvestrant in the PALOMA-3 trial

(2018) Ben O'Leary et al.   Cancer Discovery

Combined use of CDK4/6 and mTOR inhibitors induce synergistic growth arrest of diffuse intrinsic pontine glioma cells via mutual downregulation of mTORC1 activity

(2018) Daniel Asby et al.   Cancer Management and Research

Arrested Developments: CDK4/6 Inhibitor Resistance and Alterations in the Tumor Immune Microenvironment

(2018) Jessica L.F. Teh et al.   CLINICAL CANCER RESEARCH

Therapeutic advances in anaplastic thyroid cancer: a current perspective

(2018) Shikha Saini et al.   Molecular Cancer

Survival in Response to Multimodal Therapy in Anaplastic Thyroid Cancer

(2017) Naiyarat Prasongsook et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

CDK4/6 and autophagy inhibitors synergistically induce senescence in Rb positive cytoplasmic cyclin E negative cancers

(2017) Smruthi Vijayaraghavan et al.   Nature Communications

Early Adaptation and Acquired Resistance to CDK4/6 Inhibition in Estrogen Receptor–Positive Breast Cancer

(2016) Maria Teresa Herrera-Abreu et al.   CANCER RESEARCH

FDA Approval of Palbociclib in Combination with Fulvestrant for the Treatment of Hormone Receptor-Positive, HER2-Negative Metastatic Breast Cancer

(2016) A. J. Walker et al.   CLINICAL CANCER RESEARCH

Genomic and transcriptomic hallmarks of poorly differentiated and anaplastic thyroid cancers

(2016) Iñigo Landa et al.   JOURNAL OF CLINICAL INVESTIGATION

Characterization of the mutational landscape of anaplastic thyroid cancer via whole-exome sequencing

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Modeling Anaplastic Thyroid Carcinoma in the Mouse

(2014) Devora Champa et al.   Hormones & Cancer

Approach to the Patient with Anaplastic Thyroid Carcinoma

(2012) Robert C. Smallridge   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Concurrent doxorubicin and radiotherapy for anaplastic thyroid cancer: A critical re-evaluation including uniform pathologic review

(2011) Eric J. Sherman et al.   RADIOTHERAPY AND ONCOLOGY

Establishment and Characterization of Cell Lines from a Novel Mouse Model of Poorly Differentiated Thyroid Carcinoma: Powerful Tools for Basic and Preclinical Research

(2011) Mariavittoria Dima et al.   THYROID

Discovery of GSK2126458, a Highly Potent Inhibitor of PI3K and the Mammalian Target of Rapamycin

(2010) Steven D. Knight et al.   ACS Medicinal Chemistry Letters

A proliferation-inducing ligand mediates follicular lymphoma B-cell proliferation and cyclin D1 expression through phosphatidylinositol 3-kinase-regulated mammalian target of rapamycin activation

(2009) M. Gupta et al.   BLOOD

Induction Chemotherapy with Weekly Paclitaxel Administration for Anaplastic Thyroid Carcinoma

(2009) Takuya Higashiyama et al.   THYROID

Mammalian Target of Rapamycin Is the Key Effector of Phosphatidylinositol-3-OH Initiated Proliferative Signals in the Thyroid Follicular Epithelium

(2008) N. Yeager et al.   CANCER RESEARCH

Transcriptional regulation of the cyclin D1 gene at a glance

(2008) E. A. Klein et al.   JOURNAL OF CELL SCIENCE