mTORC1 as a Regulator of Mitochondrial Functions and a Therapeutic Target in Cancer
Published 2019 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
mTORC1 as a Regulator of Mitochondrial Functions and a Therapeutic Target in Cancer
Authors
Keywords
-
Journal
Frontiers in Oncology
Volume 9, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2019-12-13
DOI
10.3389/fonc.2019.01373
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Mitochondrial miRNA determines chemoresistance by reprogramming metabolism and regulating mitochondrial transcription
- (2019) Song Fan et al. CANCER RESEARCH
- Targeting Metabolic–Redox Circuits for Cancer Therapy
- (2019) Kui Wang et al. TRENDS IN BIOCHEMICAL SCIENCES
- Consequences of IDH1/2 Mutations in Gliomas and an Assessment of Inhibitors Targeting Mutated IDH Proteins
- (2019) Bozena Kaminska et al. MOLECULES
- Tissue 2-hydroxyglutarate as a biomarker for isocitrate dehydrogenase (IDH) mutations in gliomas
- (2019) Hao-Wen Sim et al. CLINICAL CANCER RESEARCH
- Pro- and antitumor effects of mitochondrial reactive oxygen species
- (2019) Valéry L. Payen et al. CANCER AND METASTASIS REVIEWS
- Transmembrane 4 L Six Family Member 5 Senses Arginine for mTORC1 Signaling
- (2019) Jae Woo Jung et al. Cell Metabolism
- PGC-1α Controls Mitochondrial Biogenesis in Drug-Resistant Colorectal Cancer Cells by Regulating Endoplasmic Reticulum Stress
- (2019) Chul Won Yun et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- The landscape of cancer cell line metabolism
- (2019) Haoxin Li et al. NATURE MEDICINE
- Therapeutic targeting of glutaminolysis as an essential strategy to combat cancer
- (2019) José M. Matés et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- The beneficial effects of metformin on cancer prevention and therapy: a comprehensive review of recent advances
- (2019) Pouya Saraei et al. Cancer Management and Research
- Mitochondrial DNA: Distribution, Mutations, and Elimination
- (2019) Yan et al. Cells
- YY1-Induced Upregulation of Long Noncoding RNA ARAP1-AS1 Promotes Cell Migration and Invasion in Colorectal Cancer Through the Wnt/β-Catenin Signaling Pathway
- (2019) Yaqun Ye et al. CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS
- Small regulatory molecules acting big in cancer: Potential Role of mito-miRs in cancer
- (2019) Praveen Sharma et al. CURRENT MOLECULAR MEDICINE
- PI3K/Akt/mTOR inhibitors in cancer: At the bench and bedside
- (2019) Ali S. Alzahrani SEMINARS IN CANCER BIOLOGY
- Autophagy and mitophagy in cancer metabolic remodelling
- (2019) Fabio Ferro et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- Low expression of miR‑125a‑5p is associated with poor prognosis in patients with gastric cancer
- (2019) Guan Li et al. Oncology Letters
- PI3K/mTOR inhibition of IDH1 mutant glioma leads to reduced 2HG production that is associated with increased survival
- (2019) Georgios Batsios et al. Scientific Reports
- Metabolic Dysregulations and Epigenetics: A Bidirectional Interplay that Drives Tumor Progression
- (2019) Crispo et al. Cells
- A phase II study to assess the safety and efficacy of the dual mTORC1/2 inhibitor vistusertib in relapsed, refractory DLBCL
- (2019) Toby A. Eyre et al. HEMATOLOGICAL ONCOLOGY
- Second Generation mTOR Inhibitors as a Double-Edged Sword in Malignant Glioma Treatment
- (2019) Dennis Heinzen et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Prognostic and clinicopathologic significance of MicroRNA-125a-5p in cancers
- (2019) Haidong Ye et al. MEDICINE
- A phase 2 study of an oral mTORC1/mTORC2 kinase inhibitor (CC-223) for non-pancreatic neuroendocrine tumors with or without carcinoid symptoms
- (2019) Edward Wolin et al. PLoS One
- Fascin Controls Metastatic Colonization and Mitochondrial Oxidative Phosphorylation by Remodeling Mitochondrial Actin Filaments
- (2019) Shengchen Lin et al. Cell Reports
- Dysregulated miR-125a promotes angiogenesis through enhanced glycolysis
- (2019) Sarah M. Wade et al. EBioMedicine
- Reactive Oxygen Species in the Tumor Microenvironment: An Overview
- (2019) Frank Weinberg et al. Cancers
- Low-dose triple drug combination targeting the PI3K/AKT/mTOR pathway and the MAPK pathway is an effective approach in ovarian clear cell carcinoma
- (2019) Joseph J. Caumanns et al. CANCER LETTERS
- Mitochondrial supercomplex assembly promotes breast and endometrial tumorigenesis by metabolic alterations and enhanced hypoxia tolerance
- (2019) Kazuhiro Ikeda et al. Nature Communications
- Oncogene-Driven Metabolic Alterations in Cancer
- (2018) Hye-Young Min et al. Biomolecules & Therapeutics
- AMPK: Sensing Glucose as well as Cellular Energy Status
- (2018) Sheng-Cai Lin et al. Cell Metabolism
- S6 kinase 1 plays a key role in mitochondrial morphology and cellular energy flow
- (2018) Quangdon Tran et al. CELLULAR SIGNALLING
- Everolimus Plus Letrozole for Treatment of Patients With HR + , HER2 – Advanced Breast Cancer Progressing on Endocrine Therapy: An Open-label, Phase II Trial
- (2018) Tamar Safra et al. Clinical Breast Cancer
- First-in human, phase 1, dose-escalation pharmacokinetic and pharmacodynamic study of the oral dual PI3K and mTORC1/2 inhibitor PQR309 in patients with advanced solid tumors (SAKK 67/13)
- (2018) Andreas Wicki et al. EUROPEAN JOURNAL OF CANCER
- TSC2 regulates microRNA biogenesis via mTORC1 and GSK3β
- (2018) Barbara Ogórek et al. HUMAN MOLECULAR GENETICS
- In situ analysis of mTORC1/2 and cellular metabolism-related proteins in human Lymphangioleiomyomatosis
- (2018) Ildiko Krencz et al. HUMAN PATHOLOGY
- miR-125a induces apoptosis, metabolism disorder and migrationimpairment in pancreatic cancer cells by targeting Mfn2-related mitochondrial fission
- (2018) Lichao Pan et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Isocitrate dehydrogenase 2 mutations correlate with leukemic transformation and are predicted by 2-hydroxyglutarate in myelodysplastic syndromes
- (2018) Peipei Lin et al. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
- Sirolimus for Secondary Prevention of Skin Cancer in Kidney Transplant Recipients: 5-Year Results
- (2018) Jacques Dantal et al. JOURNAL OF CLINICAL ONCOLOGY
- Mitochondrial fission promotes cell migration by Ca2+ /CaMKII/ERK/FAK pathway in hepatocellular carcinoma
- (2018) Xiacheng Sun et al. LIVER INTERNATIONAL
- Mitochondria in health and disease
- (2018) Sanjiban Chakrabarty et al. MITOCHONDRION
- The multifaceted contributions of mitochondria to cellular metabolism
- (2018) Jessica B. Spinelli et al. NATURE CELL BIOLOGY
- Additive cytotoxic effects of radiation and mTOR inhibitors in a cervical cancer cell line
- (2018) Daniele Xavier Assad et al. PATHOLOGY RESEARCH AND PRACTICE
- Dysregulation of mitochondrial dynamics proteins are a targetable feature of human tumors
- (2018) Grace R. Anderson et al. Nature Communications
- Streptomyces sp metabolite(s) promotes Bax mediated intrinsic apoptosis and autophagy involving inhibition of mTOR pathway in cervical cancer cell lines
- (2018) Vipin Mohan Dan et al. Scientific Reports
- Targeting mTORC1/2 Complexes Inhibit Tumorigenesis and Enhance Sensitivity to 5-Flourouracil (5-FU) in Hepatocellular Carcinoma: A Preclinical Study of mTORC1/2-Targeted Therapy in Hepatocellular Carcinoma (HCC)
- (2018) Yu Zhang et al. MEDICAL SCIENCE MONITOR
- Everolimus-based combination therapies for HR+, HER2− metastatic breast cancer
- (2018) Joyce O'Shaughnessy et al. CANCER TREATMENT REVIEWS
- Lenvatinib in combination with everolimus in patients with advanced or metastatic renal cell carcinoma: A phase 1 study
- (2018) Nobuaki Matsubara et al. INTERNATIONAL JOURNAL OF UROLOGY
- Targeting mitochondria in cancer: current concepts and immunotherapy approaches
- (2018) Sergey Pustylnikov et al. Translational Research
- mTORC1 Upregulation Leads to Accumulation of the Oncometabolite Fumarate in a Mouse Model of Renal Cell Carcinoma
- (2018) Luca Drusian et al. Cell Reports
- Metabolic reprogramming of mitochondrial respiration in metastatic cancer
- (2018) P. M. Herst et al. CANCER AND METASTASIS REVIEWS
- Phase 1 study of everolimus and low-dose oral cyclophosphamide in patients with metastatic renal cell carcinoma
- (2018) Charlotte M. Huijts et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Hyperpolarized MRI Visualizes Warburg Effects and Predicts Treatment Response to mTOR Inhibitors in Patient-Derived ccRCC Xenograft Models
- (2018) Yiyu Dong et al. CANCER RESEARCH
- Role of HIF-1 in Cancer Progression: Novel Insights. A Review
- (2018) Aldo Pezzuto et al. CURRENT MOLECULAR MEDICINE
- Pathways to balance mitochondrial translation and protein import
- (2018) Chantal Priesnitz et al. GENES & DEVELOPMENT
- The oncometabolite d‑2‑hydroxyglutarate induces angiogenic activity through the vascular endothelial growth factor receptor 2 signaling pathway
- (2018) Jiyoon Seok et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Rapamycin enhances growth inhibition on urothelial carcinoma cells through LKB1 deficiency‐mediated mitochondrial dysregulation
- (2018) Young Mi Whang et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Isocitrate dehydrogenase gene mutations and 2-hydroxyglutarate accumulation in esophageal squamous cell carcinoma
- (2018) Keisuke Miyake et al. MEDICAL ONCOLOGY
- mTOR as a central hub of nutrient signalling and cell growth
- (2018) Joungmok Kim et al. NATURE CELL BIOLOGY
- Dynamin-related protein 1 has membrane constricting and severing abilities sufficient for mitochondrial and peroxisomal fission
- (2018) Sukrut C. Kamerkar et al. Nature Communications
- Reduced miR-125a-5p level in non-small-cell lung cancer is associated with tumour progression
- (2018) Hongxu Liu et al. Open Biology
- Mitochondrial VDAC1 Silencing Leads to Metabolic Rewiring and the Reprogramming of Tumour Cells into Advanced Differentiated States
- (2018) Tasleem Arif et al. Cancers
- YY1-regulated LINC00152 promotes triple negative breast cancer progression by affecting on stability of PTEN protein
- (2018) Xi Shen et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Cell Biology of the Mitochondrion
- (2017) Alexander M. van der Bliek et al. GENETICS
- mTOR as Regulator of Lifespan, Aging, and Cellular Senescence: A Mini-Review
- (2017) Thomas Weichhart GERONTOLOGY
- The role of miR-451 in the switching between proliferation and migration in malignant glioma cells: AMPK signaling, mTOR modulation and Rac1 activation required
- (2017) Kai Zhao et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Rapamycin (mTORC1 inhibitor) reduces the production of lactate and 2-hydroxyglutarate oncometabolites in IDH1 mutant fibrosarcoma cells
- (2017) Zoltán Hujber et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- RICTOR expression in esophageal squamous cell carcinoma and its clinical significance
- (2017) Wei-Jia Jiang et al. MEDICAL ONCOLOGY
- mTOR Controls Mitochondrial Dynamics and Cell Survival via MTFP1
- (2017) Masahiro Morita et al. MOLECULAR CELL
- MicroRNA therapeutics: towards a new era for the management of cancer and other diseases
- (2017) Rajesha Rupaimoole et al. NATURE REVIEWS DRUG DISCOVERY
- A randomized phase II study of everolimus in combination with chemoradiation in newly diagnosed glioblastoma: results of NRG Oncology RTOG 0913
- (2017) Prakash Chinnaiyan et al. NEURO-ONCOLOGY
- Role of mitochondrial function in the invasiveness of human colon cancer cells
- (2017) Chen-Sung Lin et al. ONCOLOGY REPORTS
- Twenty-five years of mTOR: Uncovering the link from nutrients to growth
- (2017) David M. Sabatini PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Metformin synergizes with rapamycin to inhibit the growth of pancreatic cancer in�vitro and in�vivo
- (2017) Jia‑Wei Zhang et al. Oncology Letters
- mTORC1 inhibition in cancer cells protects from glutaminolysis-mediated apoptosis during nutrient limitation
- (2017) Victor H. Villar et al. Nature Communications
- Glutaminolysis drives membrane trafficking to promote invasiveness of breast cancer cells
- (2017) Emmanuel Dornier et al. Nature Communications
- Overexpression of hypoxia-inducible factor and metabolic pathways: possible targets of cancer
- (2017) Davinder Singh et al. Cell and Bioscience
- Cell Biology of the Mitochondrion
- (2017) Alexander M. van der Bliek et al. GENETICS
- Inhibition of Glutaminolysis Inhibits Cell Growth via Down-regulating Mtorc1 Signaling in Lung Squamous Cell Carcinoma
- (2016) XULU YE et al. ANTICANCER RESEARCH
- Glutamine transporters in mammalian cells and their functions in physiology and cancer
- (2016) Yangzom D. Bhutia et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Everolimus pharmacokinetics and its exposure–toxicity relationship in patients with thyroid cancer
- (2016) D. de Wit et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- Mitochondria and Cancer
- (2016) Sejal Vyas et al. CELL
- The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway
- (2016) Lynne Chantranupong et al. CELL
- Metabolic Heterogeneity in Human Lung Tumors
- (2016) Christopher T. Hensley et al. CELL
- Interplay of mitochondrial metabolism and microRNAs
- (2016) Julian Geiger et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- nanoCAGE reveals 5′ UTR features that define specific modes of translation of functionally related MTOR-sensitive mRNAs
- (2016) Valentina Gandin et al. GENOME RESEARCH
- Cooperative and independent roles of the Drp1 adaptors Mff, MiD49 and MiD51 in mitochondrial fission
- (2016) Laura D. Osellame et al. JOURNAL OF CELL SCIENCE
- Mitochondrial Dynamics and Metabolic Regulation
- (2016) Timothy Wai et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- The oncometabolite 2-hydroxyglutarate activates the mTOR signalling pathway
- (2016) Mélissa Carbonneau et al. Nature Communications
- Impaired Mitochondrial Dynamics and Mitophagy in Neuronal Models of Tuberous Sclerosis Complex
- (2016) Darius Ebrahimi-Fakhari et al. Cell Reports
- Glutaminolysis and autophagy in cancer
- (2015) Victor H Villar et al. Autophagy
- A phase I dose-escalation study to assess safety, tolerability, pharmacokinetics, and preliminary efficacy of the dual mTORC1/mTORC2 kinase inhibitor CC-223 in patients with advanced solid tumors or multiple myeloma
- (2015) Johanna C. Bendell et al. CANCER
- 2-Hydroxyglutarate Inhibits ATP Synthase and mTOR Signaling
- (2015) Xudong Fu et al. Cell Metabolism
- Amino Acid-Dependent mTORC1 Regulation by the Lysosomal Membrane Protein SLC38A9
- (2015) Jennifer Jung et al. MOLECULAR AND CELLULAR BIOLOGY
- An mTORC1-Mdm2-Drosha Axis for miRNA Biogenesis in Response to Glucose- and Amino Acid-Deprivation
- (2015) Peiying Ye et al. MOLECULAR CELL
- SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1
- (2015) Manuele Rebsamen et al. NATURE
- Targeting the translation machinery in cancer
- (2015) Mamatha Bhat et al. NATURE REVIEWS DRUG DISCOVERY
- A giant molecular proton pump: structure and mechanism of respiratory complex I
- (2015) Leonid A. Sazanov NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1
- (2015) S. Wang et al. SCIENCE
- Differential regulation of mTORC1 by leucine and glutamine
- (2015) J. L. Jewell et al. SCIENCE
- Regulation of mTORC1 by PI3K signaling
- (2015) Christian C. Dibble et al. TRENDS IN CELL BIOLOGY
- Tumor Cells Switch to Mitochondrial Oxidative Phosphorylation under Radiation via mTOR-Mediated Hexokinase II Inhibition - A Warburg-Reversing Effect
- (2015) Chung-Ling Lu et al. PLoS One
- mTOR-targeted therapy: Differential perturbation to mitochondrial membrane potential and permeability transition pore plays a role in therapeutic response
- (2014) Jae Eun Kim et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Regulation of the 2-oxoglutarate-dependent dioxygenases and implications for cancer
- (2014) Margreet C.M. Vissers et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- mTOR inhibitors and their clinical application in cervical, endometrial and ovarian cancers: A critical review
- (2014) Nader Husseinzadeh et al. GYNECOLOGIC ONCOLOGY
- The Oncometabolite Fumarate Promotes Pseudohypoxia Through Noncanonical Activation of NF-κB Signaling
- (2014) Karthigayan Shanmugasundaram et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Hexokinase-II Positively Regulates Glucose Starvation-Induced Autophagy through TORC1 Inhibition
- (2014) David J. Roberts et al. MOLECULAR CELL
- The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR
- (2014) Randall M. Chin et al. NATURE
- Mitochondrial form and function
- (2014) Jonathan R. Friedman et al. NATURE
- PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis
- (2014) Valerie S. LeBleu et al. NATURE CELL BIOLOGY
- mTORC1 drives HIF-1α and VEGF-A signalling via multiple mechanisms involving 4E-BP1, S6K1 and STAT3
- (2014) K M Dodd et al. ONCOGENE
- The Sestrins Interact with GATOR2 to Negatively Regulate the Amino-Acid-Sensing Pathway Upstream of mTORC1
- (2014) Lynne Chantranupong et al. Cell Reports
- MicroRNAs as regulators of mitochondrial function: Role in cancer suppression
- (2013) Marco Tomasetti et al. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
- Transcription Factor YY1 Contributes to Tumor Growth by Stabilizing Hypoxia Factor HIF-1 in a p53-Independent Manner
- (2013) S. Wu et al. CANCER RESEARCH
- The mTORC1 Pathway Stimulates Glutamine Metabolism and Cell Proliferation by Repressing SIRT4
- (2013) Alfred Csibi et al. CELL
- mTORC1 Controls Mitochondrial Activity and Biogenesis through 4E-BP-Dependent Translational Regulation
- (2013) Masahiro Morita et al. Cell Metabolism
- Phase II study of temsirolimus (CCI-779) in women with recurrent, unresectable, locally advanced or metastatic carcinoma of the cervix. A trial of the NCIC Clinical Trials Group (NCIC CTG IND 199)
- (2013) A.V. Tinker et al. GYNECOLOGIC ONCOLOGY
- Reprogramming of the MicroRNA Transcriptome Mediates Resistance to Rapamycin
- (2013) Hana Totary-Jain et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Mitochondrial complex I activity and NAD+/NADH balance regulate breast cancer progression
- (2013) Antonio F. Santidrian et al. JOURNAL OF CLINICAL INVESTIGATION
- Apoptosis induced by PGC-1β in breast cancer cells is mediated by the mTOR pathway
- (2013) LIBIN WANG et al. ONCOLOGY REPORTS
- The mTOR pathway negatively controls ATM by up-regulating miRNAs
- (2013) C. Shen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Updates of mTOR Inhibitors
- (2012) Hongyu Zhou et al. Anti-Cancer Agents in Medicinal Chemistry
- Glutaminolysis feeds mTORC1
- (2012) Raúl V. Durán et al. CELL CYCLE
- The mTOR Signalling Pathway in Human Cancer
- (2012) Helena Pópulo et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Yin Yang-1 inhibits tumor cell growth and inhibits p21WAF1/Cip1 complex formation with cdk4 and cyclin D1
- (2012) Levon Khachigian INTERNATIONAL JOURNAL OF ONCOLOGY
- Fis1 acts as a mitochondrial recruitment factor for TBC1D15 that is involved in regulation of mitochondrial morphology
- (2012) Kenta Onoue et al. JOURNAL OF CELL SCIENCE
- Defective Mitochondrial Morphology and Bioenergetic Function in Mice Lacking the Transcription Factor Yin Yang 1 in Skeletal Muscle
- (2012) S. M. Blattler et al. MOLECULAR AND CELLULAR BIOLOGY
- Glutaminolysis Activates Rag-mTORC1 Signaling
- (2012) Raúl V. Durán et al. MOLECULAR CELL
- TBC1D7 Is a Third Subunit of the TSC1-TSC2 Complex Upstream of mTORC1
- (2012) Christian C. Dibble et al. MOLECULAR CELL
- HIF-independent role of prolyl hydroxylases in the cellular response to amino acids
- (2012) R V Durán et al. ONCOGENE
- PTEN/Akt Signaling Controls Mitochondrial Respiratory Capacity through 4E-BP1
- (2012) Chong Kiat Goo et al. PLoS One
- Distinct perturbation of the translatome by the antidiabetic drug metformin
- (2012) O. Larsson et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Hyperactivation of oxidative mitochondrial metabolism in epithelial cancer cells in situ
- (2011) Diana Whitaker-Menezes et al. CELL CYCLE
- MiD49 and MiD51, new components of the mitochondrial fission machinery
- (2011) Catherine S Palmer et al. EMBO REPORTS
- Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis
- (2011) J. Y. Guo et al. GENES & DEVELOPMENT
- Mitochondrial autophagy in cells with mtDNA mutations results from synergistic loss of transmembrane potential and mTORC1 inhibition
- (2011) Robert W. Gilkerson et al. HUMAN MOLECULAR GENETICS
- Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia
- (2011) Christian M. Metallo et al. NATURE
- During autophagy mitochondria elongate, are spared from degradation and sustain cell viability
- (2011) Ligia C. Gomes et al. NATURE CELL BIOLOGY
- Rapamycin passes the torch: a new generation of mTOR inhibitors
- (2011) Don Benjamin et al. NATURE REVIEWS DRUG DISCOVERY
- Tubular network formation protects mitochondria from autophagosomal degradation during nutrient starvation
- (2011) A. S. Rambold et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Common Feature of Leukemia-Associated IDH1 and IDH2 Mutations Is a Neomorphic Enzyme Activity Converting α-Ketoglutarate to 2-Hydroxyglutarate
- (2010) Patrick S. Ward et al. CANCER CELL
- Coordination of mitochondrial bioenergetics with G1phase cell cycle progression
- (2010) Stefan M. Schieke et al. CELL CYCLE
- Tti1 and Tel2 Are Critical Factors in Mammalian Target of Rapamycin Complex Assembly
- (2010) Takeshi Kaizuka et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Mff is an essential factor for mitochondrial recruitment of Drp1 during mitochondrial fission in mammalian cells
- (2010) Hidenori Otera et al. JOURNAL OF CELL BIOLOGY
- Glucose Addiction of TSC Null Cells Is Caused by Failed mTORC1-Dependent Balancing of Metabolic Demand with Supply
- (2010) Andrew Y. Choo et al. MOLECULAR CELL
- Physical Association of PDK1 with AKT1 Is Sufficient for Pathway Activation Independent of Membrane Localization and Phosphatidylinositol 3 Kinase
- (2010) Zhiyong Ding et al. PLoS One
- mTORC1-Mediated Cell Proliferation, But Not Cell Growth, Controlled by the 4E-BPs
- (2010) R. J. O. Dowling et al. SCIENCE
- Bidirectional Transport of Amino Acids Regulates mTOR and Autophagy
- (2009) Paul Nicklin et al. CELL
- Autophagy Suppresses Tumorigenesis through Elimination of p62
- (2009) Robin Mathew et al. CELL
- Glutamine homeostasis and mitochondrial dynamics
- (2009) José M. Matés et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Glutamine Deprivation Induces Abortive S-Phase Rescued by Deoxyribonucleotides in K-Ras Transformed Fibroblasts
- (2009) Daniela Gaglio et al. PLoS One
- Direct control of mitochondrial function by mTOR
- (2009) Arvind Ramanathan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling
- (2008) Tsuneo Ikenoue et al. EMBO JOURNAL
- Differential Dependence of Hypoxia-inducible Factors 1α and 2α on mTORC1 and mTORC2
- (2008) Alfredo Toschi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Expression of an activated mammalian target of rapamycin in adenocarcinoma of the cervix: A potential biomarker and molecular target therapy
- (2007) Leri S. Faried et al. MOLECULAR CARCINOGENESIS
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now