Advances in development and application of human organoids

Assembloids

(2021) Nina Vogt   NATURE METHODS

Enteropathogenic Infections: Organoids Go Bacterial

(2021) Viktoria Hentschel et al.   Stem Cells International

Neanderthal-like ‘mini-brains’ created in lab with CRISPR

(2021) Ariana Remmel   NATURE

Reintroduction of the archaic variant of NOVA1 in cortical organoids alters neurodevelopment

(2021) Cleber A. Trujillo et al.   SCIENCE

One-Stop Microfluidic Assembly of Human Brain Organoids To Model Prenatal Cannabis Exposure

(2020) Zheng Ao et al.   ANALYTICAL CHEMISTRY

Chromatin accessibility dynamics in a model of human forebrain development

(2020) Alexandro E. Trevino et al.   SCIENCE

Organoid-based regenerative medicine for inflammatory bowel disease

(2020) Ryuichi Okamoto et al.   Regenerative Therapy

Patient-Specific Retinal Organoids Recapitulate Disease Features of Late-Onset Retinitis Pigmentosa

(2020) Mei-Ling Gao et al.   Frontiers in Cell and Developmental Biology

Human-iPSC-Derived Cardiac Stromal Cells Enhance Maturation in 3D Cardiac Microtissues and Reveal Non-cardiomyocyte Contributions to Heart Disease

(2020) Elisa Giacomelli et al.   Cell Stem Cell

SARS-CoV-2 infection of kidney organoids prevented with soluble human ACE2

(2020) Susan J. Allison   Nature Reviews Nephrology

Recapitulation of SARS-CoV-2 infection and cholangiocyte damage with human liver ductal organoids

(2020) Bing Zhao et al.   Protein & Cell

Organoids as a Powerful Model for Respiratory Diseases

(2020) Yu Li et al.   Stem Cells International

Human cardiac organoids for the modelling of myocardial infarction and drug cardiotoxicity

(2020) Dylan J. Richards et al.   Nature Biomedical Engineering

Midbrain Organoids: A New Tool to Investigate Parkinson’s Disease

(2020) Lisa Maria Smits et al.   Frontiers in Cell and Developmental Biology

Human organoids: model systems for human biology and medicine

(2020) Jihoon Kim et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Modeling and Rescue of RP2 Retinitis Pigmentosa Using iPSC-Derived Retinal Organoids

(2020) Amelia Lane et al.   Stem Cell Reports

Patient-Derived Midbrain Organoids to Explore the Molecular Basis of Parkinson's Disease

(2020) Benjamin Galet et al.   Frontiers in Neurology

Modeling Rett Syndrome With Human Patient-Specific Forebrain Organoids

(2020) Ana Rita Gomes et al.   Frontiers in Cell and Developmental Biology

Generation of lung organoids from human pluripotent stem cells in vitro

(2019) Alyssa J. Miller et al.   Nature Protocols

Assembling human brain organoids

(2019) Sergiu P. Paşca   SCIENCE

From Entry to Early Dissemination—Toxoplasma gondii's Initial Encounter With Its Host

(2019) Estefania Delgado Betancourt et al.   Frontiers in Cellular and Infection Microbiology

Organoids as a new model for improving regenerative medicine and cancer personalized therapy in renal diseases

(2019) Ludovica Grassi et al.   Cell Death & Disease

Differentiation and maturation of oligodendrocytes in human three-dimensional neural cultures

(2019) Rebecca M. Marton et al.   NATURE NEUROSCIENCE

Flow-enhanced vascularization and maturation of kidney organoids in vitro

(2019) Kimberly A. Homan et al.   NATURE METHODS

hESC-Derived Thalamic Organoids Form Reciprocal Projections When Fused with Cortical Organoids

(2019) Yangfei Xiang et al.   Cell Stem Cell

Establishing Cerebral Organoids as Models of Human-Specific Brain Evolution

(2019) Alex A. Pollen et al.   CELL

Polarizing brain organoids

(2019) Yuki Miura et al.   NATURE BIOTECHNOLOGY

Specification of positional identity in forebrain organoids

(2019) Gustav Y. Cederquist et al.   NATURE BIOTECHNOLOGY

Human 3D cellular model of hypoxic brain injury of prematurity

(2019) Anca M. Pașca et al.   NATURE MEDICINE

Organoids of liver diseases: From bench to bedside

(2019) Li-Jun Wu et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Modeling neuropsychiatric disorders using human induced pluripotent stem cells

(2019) Meiyan Wang et al.   Protein & Cell

Therapeutic Regeneration of Lymphatic and Immune Cell Functions upon Lympho-organoid Transplantation

(2019) Elisa Lenti et al.   Stem Cell Reports

Application of Cancer Organoid Model for Drug Screening and Personalized Therapy

(2019) Jumpei Kondo et al.   Cells

Liver organoids: from basic research to therapeutic applications

(2019) Nicole Prior et al.   GUT

Author Correction: Advanced maturation of human cardiac tissue grown from pluripotent stem cells

(2019) Kacey Ronaldson-Bouchard et al.   NATURE

Organoids-on-a-chip

(2019) Sunghee Estelle Park et al.   SCIENCE

Generation of fully functional hepatocyte-like organoids from human induced pluripotent stem cells mixed with Endothelial Cells

(2019) Giuseppe Pettinato et al.   Scientific Reports

Human Organoids: Tools for Understanding Biology and Treating Diseases

(2019) Frans Schutgens et al.   Annual Review of Pathology-Mechanisms of Disease

Engineering of human cardiac muscle electromechanically matured to an adult-like phenotype

(2019) Kacey Ronaldson-Bouchard et al.   Nature Protocols

A virus-induced kidney disease model based on organ-on-a-chip: Pathogenesis exploration of virus-related renal dysfunctions

(2019) Ji Wang et al.   BIOMATERIALS

Patient-derived organoids (PDOs) as a novel in vitro model for neuroblastoma tumours

(2019) P. Fusco et al.   BMC CANCER

Human ESC-derived expandable hepatic organoids enable therapeutic liver repopulation and pathophysiological modeling of alcoholic liver injury

(2019) Shuyong Wang et al.   CELL RESEARCH

Engineering of human brain organoids with a functional vascular-like system

(2019) Bilal Cakir et al.   NATURE METHODS

A Patient-Derived Glioblastoma Organoid Model and Biobank Recapitulates Inter- and Intra-tumoral Heterogeneity

(2019) Fadi Jacob et al.   CELL

Emerging organoid models: leaping forward in cancer research

(2019) Han Fan et al.   Journal of Hematology & Oncology

Development of a functional thyroid model based on an organoid culture system

(2018) Yoshiyuki Saito et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Single Particle Imaging of Polarized Hepatoma Organoids upon Hepatitis C Virus Infection Reveals an Ordered and Sequential Entry Process

(2018) Yasmine Baktash et al.   Cell Host & Microbe

Bench to bedside: Current advances in regenerative medicine

(2018) Gabriella Clarke et al.   CURRENT OPINION IN CELL BIOLOGY

Organoid technology for retinal repair

(2018) Sílvia Llonch et al.   DEVELOPMENTAL BIOLOGY

Cerebral organoids derived from Sandhoff disease-induced pluripotent stem cells exhibit impaired neurodifferentiation

(2018) Maria L. Allende et al.   JOURNAL OF LIPID RESEARCH

Human brain organoid-on-a-chip to model prenatal nicotine exposure

(2018) Yaqing Wang et al.   LAB ON A CHIP

Advanced maturation of human cardiac tissue grown from pluripotent stem cells

(2018) Kacey Ronaldson-Bouchard et al.   NATURE

An in vivo model of functional and vascularized human brain organoids

(2018) Abed AlFatah Mansour et al.   NATURE BIOTECHNOLOGY

Organoids

(2018) Natalie de Souza   NATURE METHODS

Imaging organoids: a bright future ahead

(2018) Anne C Rios et al.   NATURE METHODS

Human brain organoids on a chip reveal the physics of folding

(2018) Eyal Karzbrun et al.   Nature Physics

Generation of spatial-patterned early-developing cardiac organoids using human pluripotent stem cells

(2018) Plansky Hoang et al.   Nature Protocols

Organoid and Enteroid Modeling of Salmonella Infection

(2018) Yuebang Yin et al.   Frontiers in Cellular and Infection Microbiology

Applications of kidney organoids derived from human pluripotent stem cells

(2018) Yong Kyun Kim et al.   KOREAN JOURNAL OF INTERNAL MEDICINE

Expansion of Adult Human Pancreatic Tissue Yields Organoids Harboring Progenitor Cells with Endocrine Differentiation Potential

(2018) Cindy J.M. Loomans et al.   Stem Cell Reports

Modelling Cryptosporidium infection in human small intestinal and lung organoids

(2018) Inha Heo et al.   Nature Microbiology

Organoids for Drug Discovery and Personalized Medicine

(2018) Toshio Takahashi   Annual Review of Pharmacology and Toxicology

Modeling amyloid beta and tau pathology in human cerebral organoids

(2018) Cesar Gonzalez et al.   MOLECULAR PSYCHIATRY

Intra-tumour diversification in colorectal cancer at the single-cell level

(2018) Sophie F. Roerink et al.   NATURE

Generation and assembly of human brain region–specific three-dimensional cultures

(2018) Steven A. Sloan et al.   Nature Protocols

PEG-4MAL hydrogels for human organoid generation, culture, and in vivo delivery

(2018) Ricardo Cruz-Acuña et al.   Nature Protocols

Generating inner ear organoids containing putative cochlear hair cells from human pluripotent stem cells

(2018) Minjin Jeong et al.   Cell Death & Disease

Development of a primary human Small Intestine-on-a-Chip using biopsy-derived organoids

(2018) Magdalena Kasendra et al.   Scientific Reports

Technology Transfer of the Microphysiological Systems: A Case Study of the Human Proximal Tubule Tissue Chip

(2018) Courtney Sakolish et al.   Scientific Reports

Organoid Modeling of the Tumor Immune Microenvironment

(2018) James T. Neal et al.   CELL

Kidneys on Chips

(2018) Catherine K. Yeung et al.   Clinical Journal of the American Society of Nephrology

Generation of human antral and fundic gastric organoids from pluripotent stem cells

(2018) Taylor R. Broda et al.   Nature Protocols

Building Models of Brain Disorders with Three-Dimensional Organoids

(2018) Neal D. Amin et al.   NEURON

Brain Organoids and the Study of Neurodevelopment

(2018) Cleber A. Trujillo et al.   TRENDS IN MOLECULAR MEDICINE

Human Huntington’s Disease iPSC-Derived Cortical Neurons Display Altered Transcriptomics, Morphology, and Maturation

(2018) Shagun R. Mehta et al.   Cell Reports

Bioengineering-inspired three-dimensional culture systems: Organoids to create tumor microenvironment

(2018) Pelin Saglam-Metiner et al.   GENE

Molecular and cellular insights into Zika virus-related neuropathies

(2017) Kai Zhou et al.   JOURNAL OF NEUROVIROLOGY

Assembly of functionally integrated human forebrain spheroids

(2017) Fikri Birey et al.   NATURE

A three-dimensional model of human lung development and disease from pluripotent stem cells

(2017) Ya-Wen Chen et al.   NATURE CELL BIOLOGY

DISC1 Regulates Neurogenesis via Modulating Kinetochore Attachment of Ndel1/Nde1 during Mitosis

(2017) Fei Ye et al.   NEURON

Disease Modeling in Stem Cell-Derived 3D Organoid Systems

(2017) Devanjali Dutta et al.   TRENDS IN MOLECULAR MEDICINE

Prospects for Modeling Abnormal Neuronal Function in Schizophrenia Using Human Induced Pluripotent Stem Cells

(2017) Iya Prytkova et al.   Frontiers in Cellular Neuroscience

Personalized In Vitro and In Vivo Cancer Models to Guide Precision Medicine

(2017) Chantal Pauli et al.   Cancer Discovery

Katanin p80, NuMA and cytoplasmic dynein cooperate to control microtubule dynamics

(2017) Mingyue Jin et al.   Scientific Reports

An Organoid-Based Model of Cortical Development Identifies Non-Cell-Autonomous Defects in Wnt Signaling Contributing to Miller-Dieker Syndrome

(2017) Vira Iefremova et al.   Cell Reports

Humans in a Dish: The Potential of Organoids in Modeling Immunity and Infectious Diseases

(2017) Nino Iakobachvili et al.   Frontiers in Microbiology

Genetic Ablation of AXL Does Not Protect Human Neural Progenitor Cells and Cerebral Organoids from Zika Virus Infection

(2016) Michael F. Wells et al.   Cell Stem Cell

Zika Virus Depletes Neural Progenitors in Human Cerebral Organoids through Activation of the Innate Immune Receptor TLR3

(2016) Jason Dang et al.   Cell Stem Cell

Modeling infectious diseases and host-microbe interactions in gastrointestinal organoids

(2016) Sina Bartfeld   DEVELOPMENTAL BIOLOGY

Human pluripotent stem cell-derived acinar/ductal organoids generate human pancreas upon orthotopic transplantation and allow disease modelling

(2016) Meike Hohwieler et al.   GUT

Nanowires and Electrical Stimulation Synergistically Improve Functions of hiPSC Cardiac Spheroids

(2016) Dylan J. Richards et al.   NANO LETTERS

The Brazilian Zika virus strain causes birth defects in experimental models

(2016) Fernanda R. Cugola et al.   NATURE

Organoids as an in vitro model of human development and disease

(2016) Aliya Fatehullah et al.   NATURE CELL BIOLOGY

Generation of kidney organoids from human pluripotent stem cells

(2016) Minoru Takasato et al.   Nature Protocols

Generation of nephron progenitor cells and kidney organoids from human pluripotent stem cells

(2016) Ryuji Morizane et al.   Nature Protocols

CYP3A5 Mediates Effects of Cocaine on Human Neocorticogenesis: Studies using an In Vitro 3D Self-Organized hPSC Model with a Single Cortex-Like Unit

(2016) Chun-Ting Lee et al.   NEUROPSYCHOPHARMACOLOGY

Deterministically patterned biomimetic human iPSC-derived hepatic model via rapid 3D bioprinting

(2016) Xuanyi Ma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Replication of human noroviruses in stem cell-derived human enteroids

(2016) K. Ettayebi et al.   SCIENCE

Characterizing responses to CFTR-modulating drugs using rectal organoids derived from subjects with cystic fibrosis

(2016) Johanna F. Dekkers et al.   Science Translational Medicine

Generation of Homogenous Three-Dimensional Pancreatic Cancer Cell Spheroids Using an Improved Hanging Drop Technique

(2016) Matthew J. Ware et al.   TISSUE ENGINEERING PART C-METHODS

Editor’s Highlight: Modeling Compound-Induced FibrogenesisIn VitroUsing Three-Dimensional Bioprinted Human Liver Tissues

(2016) Leah M. Norona et al.   TOXICOLOGICAL SCIENCES

Cardiac Non-myocyte Cells Show Enhanced Pharmacological Function Suggestive of Contractile Maturity in Stem Cell Derived Cardiomyocyte Microtissues

(2016) Stephanie M. Ravenscroft et al.   TOXICOLOGICAL SCIENCES

From the Cover: High-Throughput Imaging of Cardiac Microtissues for the Assessment of Cardiac Contraction during Drug Discovery

(2016) Amy Pointon et al.   TOXICOLOGICAL SCIENCES

Biology-inspired microphysiological system approaches to solve the prediction dilemma of substance testing

(2016) Uwe Marx   ALTEX-Alternatives to Animal Experimentation

Retinal Organoids from Pluripotent Stem Cells Efficiently Recapitulate Retinogenesis

(2016) Manuela Völkner et al.   Stem Cell Reports

Self-Organizing 3D Human Neural Tissue Derived from Induced Pluripotent Stem Cells Recapitulate Alzheimer’s Disease Phenotypes

(2016) Waseem K. Raja et al.   PLoS One

Modeling rotavirus infection and antiviral therapy using primary intestinal organoids

(2015) Yuebang Yin et al.   ANTIVIRAL RESEARCH

Biological and Therapeutic Impact of Intratumor Heterogeneity in Cancer Evolution

(2015) Nicholas McGranahan et al.   CANCER CELL

Long-Term Culture of Genome-Stable Bipotent Stem Cells from Adult Human Liver

(2015) Meritxell Huch et al.   CELL

FOXG1-Dependent Dysregulation of GABA/Glutamate Neuron Differentiation in Autism Spectrum Disorders

(2015) Jessica Mariani et al.   CELL

Regeneration of Thyroid Function by Transplantation of Differentiated Pluripotent Stem Cells

(2015) Anita A. Kurmann et al.   Cell Stem Cell

Human Intestinal Enteroids: a New Model To Study Human Rotavirus Infection, Host Restriction, and Pathophysiology

(2015) Kapil Saxena et al.   JOURNAL OF VIROLOGY

Differential responses to lithium in hyperexcitable neurons from patients with bipolar disorder

(2015) Jerome Mertens et al.   NATURE

Ductal pancreatic cancer modeling and drug screening using human pluripotent stem cell– and patient-derived tumor organoids

(2015) Ling Huang et al.   NATURE MEDICINE

Modeling colorectal cancer using CRISPR-Cas9–mediated engineering of human intestinal organoids

(2015) Mami Matano et al.   NATURE MEDICINE

Functional cortical neurons and astrocytes from human pluripotent stem cells in 3D culture

(2015) Anca M Paşca et al.   NATURE METHODS

Human cerebral organoids recapitulate gene expression programs of fetal neocortex development

(2015) J. Gray Camp et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Titin mutations in iPS cells define sarcomere insufficiency as a cause of dilated cardiomyopathy

(2015) J. T. Hinson et al.   SCIENCE

Cell viability assessment using the Alamar blue assay: A comparison of 2D and 3D cell culture models

(2015) F. Bonnier et al.   TOXICOLOGY IN VITRO

Plasticity of Hopx+ type I alveolar cells to regenerate type II cells in the lung

(2015) Rajan Jain et al.   Nature Communications

Generation of functional hippocampal neurons from self-organizing human embryonic stem cell-derived dorsomedial telencephalic tissue

(2015) Hideya Sakaguchi et al.   Nature Communications

Modelling kidney disease with CRISPR-mutant kidney organoids derived from human pluripotent epiblast spheroids

(2015) Benjamin S. Freedman et al.   Nature Communications

Self-Organization of Polarized Cerebellar Tissue in 3D Culture of Human Pluripotent Stem Cells

(2015) Keiko Muguruma et al.   Cell Reports

In vitro generation of human pluripotent stem cell derived lung organoids

(2015) Briana R Dye et al.   eLife

Organoids as Model for Infectious Diseases: Culture of Human and Murine Stomach Organoids and Microinjection of Helicobacter Pylori

(2015) Sina Bartfeld et al.   Jove-Journal of Visualized Experiments

Three-Dimensional Cell Culture Systems and Their Applications in Drug Discovery and Cell-Based Biosensors

(2014) Rasheena Edmondson et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Organoid cultures for the analysis of cancer phenotypes

(2014) Norman Sachs et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Modelling human development and disease in pluripotent stem-cell-derived gastric organoids

(2014) Kyle W. McCracken et al.   NATURE

Alveolar progenitor and stem cells in lung development, renewal and cancer

(2014) Tushar J. Desai et al.   NATURE

An in vivo model of human small intestine using pluripotent stem cells

(2014) Carey L Watson et al.   NATURE MEDICINE

Organogenesis in a dish: Modeling development and disease using organoid technologies

(2014) M. A. Lancaster et al.   SCIENCE

Modeling Hippocampal Neurogenesis Using Human Pluripotent Stem Cells

(2014) Diana Xuan Yu et al.   Stem Cell Reports

Differentiated Troy+ Chief Cells Act as Reserve Stem Cells to Generate All Lineages of the Stomach Epithelium

(2013) Daniel E. Stange et al.   CELL

Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis

(2013) Meritxell Huch et al.   EMBO JOURNAL

TTC7A mutations disrupt intestinal epithelial apicobasal polarity

(2013) Amélie E. Bigorgne et al.   JOURNAL OF CLINICAL INVESTIGATION

Generation of inner ear sensory epithelia from pluripotent stem cells in 3D culture

(2013) Karl R. Koehler et al.   NATURE

Vascularized and functional human liver from an iPSC-derived organ bud transplant

(2013) Takanori Takebe et al.   NATURE

Cerebral organoids model human brain development and microcephaly

(2013) Madeline A. Lancaster et al.   NATURE

Directing human embryonic stem cell differentiation towards a renal lineage generates a self-organizing kidney

(2013) M. Takasato et al.   NATURE CELL BIOLOGY

A functional CFTR assay using primary cystic fibrosis intestinal organoids

(2013) Johanna F Dekkers et al.   NATURE MEDICINE

Efficient Derivation of Purified Lung and Thyroid Progenitors from Embryonic Stem Cells

(2012) Tyler A. Longmire et al.   Cell Stem Cell

Self-Formation of Optic Cups and Storable Stratified Neural Retina from Human ESCs

(2012) Tokushige Nakano et al.   Cell Stem Cell

Self-formation of layered neural structures in three-dimensional culture of ES cells

(2012) Mototsugu Eiraku et al.   CURRENT OPINION IN NEUROBIOLOGY

Generation of functional thyroid from embryonic stem cells

(2012) Francesco Antonica et al.   NATURE

Eye Development and Retinogenesis

(2012) W. Heavner et al.   Cold Spring Harbor Perspectives in Biology

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Dynamic Changes in the Copy Number of Pluripotency and Cell Proliferation Genes in Human ESCs and iPSCs during Reprogramming and Time in Culture

(2011) Louise C. Laurent et al.   Cell Stem Cell

Subregional Specification of Embryonic Stem Cell-Derived Ventral Telencephalic Tissues by Timed and Combinatory Treatment with Extrinsic Signals

(2011) T. Danjo et al.   JOURNAL OF NEUROSCIENCE

Self-organizing optic-cup morphogenesis in three-dimensional culture

(2011) Mototsugu Eiraku et al.   NATURE

High drug attrition rates—where are we going wrong?

(2011) Lisa Hutchinson et al.   Nature Reviews Clinical Oncology

Primitive Cardiac Cells from Human Embryonic Stem Cells

(2011) James Hudson et al.   STEM CELLS AND DEVELOPMENT

DISC1 at 10: connecting psychiatric genetics and neuroscience

(2011) David J. Porteous et al.   TRENDS IN MOLECULAR MEDICINE

Bioengineered 3D platform to explore cell–ECM interactions and drug resistance of epithelial ovarian cancer cells

(2010) Daniela Loessner et al.   BIOMATERIALS

Lgr5+ve Stem Cells Drive Self-Renewal in the Stomach and Build Long-Lived Gastric Units In Vitro

(2010) Nick Barker et al.   Cell Stem Cell

Three hypotheses for developmental defects that may underlie some forms of autism spectrum disorder

(2010) John LR Rubenstein   CURRENT OPINION IN NEUROLOGY

Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro

(2010) Jason R. Spence et al.   NATURE

Ontogeny-recapitulating generation and tissue integration of ES cell–derived Purkinje cells

(2010) Keiko Muguruma et al.   NATURE NEUROSCIENCE

A Novel Flow-Perfusion Bioreactor Supports 3D Dynamic Cell Culture

(2009) Alexander M. Sailon et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE

The cancer genome

(2009) Michael R. Stratton et al.   NATURE

Physiological function and transplantation of scaffold-free and vascularized human cardiac muscle tissue

(2009) K. R. Stevens et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Self-Organized Formation of Polarized Cortical Tissues from ESCs and Its Active Manipulation by Extrinsic Signals

(2008) Mototsugu Eiraku et al.   Cell Stem Cell

Scaffold-Free Human Cardiac Tissue Patch Created from Embryonic Stem Cells

(2008) Kelly R. Stevens et al.   TISSUE ENGINEERING PART A