Technology Transfer of the Microphysiological Systems: A Case Study of the Human Proximal Tubule Tissue Chip

Organs-on-chips: Progress, challenges, and future directions

(2017) Lucie A Low et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Navigating tissue chips from development to dissemination: A pharmaceutical industry perspective

(2017) Lorna Ewart et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Proximal tubule apical endocytosis is modulated by fluid shear stress via an mTOR-dependent pathway

(2017) Kimberly R. Long et al.   MOLECULAR BIOLOGY OF THE CELL

A novel microfluidic device to model the human proximal tubule and glomerulus

(2017) Courtney M. Sakolish et al.   RSC Advances

A Pipeline for High-Throughput Concentration Response Modeling of Gene Expression for Toxicogenomics

(2017) John S. House et al.   Frontiers in Genetics

The combination of three-dimensional and rotary cell culture system promotes the proliferation and maintains the differentiation potential of rat BMSCs

(2017) Yilong Tang et al.   Scientific Reports

Organoid-on-a-chip and body-on-a-chip systems for drug screening and disease modeling

(2016) Aleksander Skardal et al.   DRUG DISCOVERY TODAY

Human Enteroids as a Model of Upper Small Intestinal Ion Transport Physiology and Pathophysiology

(2016) Jennifer Foulke-Abel et al.   GASTROENTEROLOGY

A chemical–biological similarity-based grouping of complex substances as a prototype approach for evaluating chemical alternatives

(2016) Fabian A. Grimm et al.   GREEN CHEMISTRY

Development of a microphysiological model of human kidney proximal tubule function

(2016) Elijah J. Weber et al.   KIDNEY INTERNATIONAL

Kidney injury molecule-1 (KIM-1) mediates renal epithelial cell repair via ERK MAPK signaling pathway

(2016) Zhiwei Zhang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Polymyxin B Nephrotoxicity: From Organ to Cell Damage

(2016) Maria de Fátima Fernandes Vattimo et al.   PLoS One

Biology-inspired microphysiological system approaches to solve the prediction dilemma of substance testing

(2016) Uwe Marx   ALTEX-Alternatives to Animal Experimentation

Modeling Barrier Tissues In Vitro: Methods, Achievements, and Challenges

(2016) Courtney M. Sakolish et al.   EBioMedicine

Facilitating the commercialization and use of organ platforms generated by the microphysiological systems (Tissue Chip) program through public–private partnerships

(2016) Christine A. Livingston et al.   Computational and Structural Biotechnology Journal

Human Vascular Microphysiological System for in vitro Drug Screening

(2016) C. E. Fernandez et al.   Scientific Reports

Bioprinting of 3D Convoluted Renal Proximal Tubules on Perfusable Chips

(2016) Kimberly A. Homan et al.   Scientific Reports

The vitamin D receptor in the proximal renal tubule is a key regulator of serum 1α,25-dihydroxyvitamin D3

(2015) Yongji Wang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Recreating blood-brain barrier physiology and structure on chip: A novel neurovascular microfluidic bioreactor

(2015) Jacquelyn A. Brown et al.   Biomicrofluidics

A human liver microphysiology platform for investigating physiology, drug safety, and disease models

(2015) Lawrence A Vernetti et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

The Genotype-Tissue Expression (GTEx) pilot analysis: Multitissue gene regulation in humans

(2015) et al.   SCIENCE

The Economics of Reproducibility in Preclinical Research

(2015) Leonard P. Freedman et al.   PLOS BIOLOGY

Shear Stress-Induced Alteration of Epithelial Organization in Human Renal Tubular Cells

(2015) Damien Maggiorani et al.   PLoS One

Characterization of renal biomarkers for use in clinical trials: biomarker evaluation in healthy volunteers

(2014) David Brott et al.   Drug Design Development and Therapy

Polymyxin B Induces Apoptosis in Kidney Proximal Tubular Cells

(2013) Mohammad A. K. Azad et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The current status of biomarkers for predicting toxicity

(2013) Sarah Campion et al.   Expert Opinion on Drug Metabolism & Toxicology

Human kidney proximal tubule-on-a-chip for drug transport and nephrotoxicity assessment

(2013) Kyung-Jin Jang et al.   Integrative Biology

Calcitriol, calcidiol, parathyroid hormone, and fibroblast growth factor-23 interactions in chronic kidney disease

(2013) Joao F. de Brito Galvao et al.   JOURNAL OF VETERINARY EMERGENCY AND CRITICAL CARE

The Genotype-Tissue Expression (GTEx) project

(2013) John Lonsdale et al.   NATURE GENETICS

Characterization of Polymyxin B-Induced Nephrotoxicity: Implications for Dosing Regimen Design

(2012) Kamilia Abdelraouf et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Benzoic acid and specific 2-oxo acids activate hepatic efflux of glutamate at OAT2

(2012) Till Pfennig et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Targeted proximal tubule injury triggers interstitial fibrosis and glomerulosclerosis

(2012) Ivica Grgic et al.   KIDNEY INTERNATIONAL

Simultaneous measurement of plasma vitamin D3 metabolites, including 4β,25-dihydroxyvitamin D3, using liquid chromatography–tandem mass spectrometry

(2011) Zhican Wang et al.   ANALYTICAL BIOCHEMISTRY

Biological Qualification of Biomarkers of Chemical-Induced Renal Toxicity in Two Strains of Male Rat

(2011) Ernie Harpur et al.   TOXICOLOGICAL SCIENCES

From 3D cell culture to organs-on-chips

(2011) Dongeun Huh et al.   TRENDS IN CELL BIOLOGY

Systemic activation of glutamate dehydrogenase increases renal ammoniagenesis: implications for the hyperinsulinism/hyperammonemia syndrome

(2010) Jason R. Treberg et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Neutrophil gelatinase-associated lipocalin: a  promising biomarker for human acute kidney injury

(2010) Prasad Devarajan   Biomarkers in Medicine

An Integrative Overview on the Mechanisms Underlying the Renal Tubular Cytotoxicity of Gentamicin

(2010) Y. Quiros et al.   TOXICOLOGICAL SCIENCES

Kidney injury molecule–1 is a phosphatidylserine receptor that confers a phagocytic phenotype on epithelial cells

(2008) Takaharu Ichimura et al.   JOURNAL OF CLINICAL INVESTIGATION

Shear-induced reorganization of renal proximal tubule cell actin cytoskeleton and apical junctional complexes

(2008) Y. Duan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA