Application of Cancer Organoid Model for Drug Screening and Personalized Therapy

Tumor Tissue Explant Culture of Patient-Derived Xenograft as Potential Prioritization Tool for Targeted Therapy

(2019) Susmita Ghosh et al.   Frontiers in Oncology

Characterization of immune responses to anti-PD-1 mono and combination immunotherapy in hematopoietic humanized mice implanted with tumor xenografts

(2019) A. Capasso et al.   Journal for ImmunoTherapy of Cancer

Drug combinations: a strategy to extend the life of antibiotics in the 21st century

(2019) Mike Tyers et al.   NATURE REVIEWS MICROBIOLOGY

Estimation of clinical trial success rates and related parameters

(2018) Chi Heem Wong et al.   BIOSTATISTICS

A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity

(2018) Norman Sachs et al.   CELL

Tumor Evolution and Drug Response in Patient-Derived Organoid Models of Bladder Cancer

(2018) Suk Hyung Lee et al.   CELL

Colorectal cancer spheroid biobanks: multi-level approaches to drug sensitivity studies

(2018) Maria Laura De Angelis et al.   CELL BIOLOGY AND TOXICOLOGY

Humanized mice in studying efficacy and mechanisms of PD-1-targeted cancer immunotherapy

(2018) Minan Wang et al.   FASEB JOURNAL

Development of a new patient-derived xenograft humanised mouse model to study human-specific tumour microenvironment and immunotherapy

(2018) Yue Zhao et al.   GUT

Three-dimensional organoid culture reveals involvement of Wnt/β-catenin pathway in proliferation of bladder cancer cells

(2018) Takahiro Yoshida et al.   Oncotarget

Promotion of malignant phenotype after disruption of the three-dimensional structure of cultured spheroids from colorectal cancer

(2018) Jose M. Piulats et al.   Oncotarget

Patient-derived conditionally reprogrammed cells maintain intra-tumor genetic heterogeneity

(2018) Bruna R. S. Correa et al.   Scientific Reports

Three-Dimensional in Vitro Cell Culture Models in Drug Discovery and Drug Repositioning

(2018) Sigrid A. Langhans   Frontiers in Pharmacology

Using PDX for Preclinical Cancer Drug Discovery: The Evolving Field

(2018) Juliet Williams   Journal of Clinical Medicine

Generation of Tumor-Reactive T Cells by Co-culture of Peripheral Blood Lymphocytes and Tumor Organoids

(2018) Krijn K. Dijkstra et al.   CELL

Organoid Models of Human Liver Cancers Derived from Tumor Needle Biopsies

(2018) Sandro Nuciforo et al.   Cell Reports

Estimated Costs of Pivotal Trials for Novel Therapeutic Agents Approved by the US Food and Drug Administration, 2015-2016

(2018) Thomas J. Moore et al.   JAMA Internal Medicine

High-throughput screening in colorectal cancer tissue-originated spheroids

(2018) Jumpei Kondo et al.   CANCER SCIENCE

A Comprehensive Human Gastric Cancer Organoid Biobank Captures Tumor Subtype Heterogeneity and Enables Therapeutic Screening

(2018) Helen H.N. Yan et al.   Cell Stem Cell

Small Cell Carcinomas of the Uterine Cervix and Lung: Proteomics Reveals Similar Protein Expression Profiles

(2018) Tomomi Egawa-Takata et al.   INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER

Drug repurposing: progress, challenges and recommendations

(2018) Sudeep Pushpakom et al.   NATURE REVIEWS DRUG DISCOVERY

Progress of immune checkpoint therapy in the clinic (Review)

(2018) Yiqun Fan et al.   ONCOLOGY REPORTS

Head and neck cancer organoids established by modification of the CTOS method can be used to predict in vivo drug sensitivity

(2018) Noriaki Tanaka et al.   ORAL ONCOLOGY

Screening drug effects in patient‐derived cancer cells links organoid responses to genome alterations

(2017) Julia Jabs et al.   Molecular Systems Biology

Long-term, hormone-responsive organoid cultures of human endometrium in a chemically defined medium

(2017) Margherita Y. Turco et al.   NATURE CELL BIOLOGY

Patient-derived xenografts undergo mouse-specific tumor evolution

(2017) Uri Ben-David et al.   NATURE GENETICS

Functional precision cancer medicine—moving beyond pure genomics

(2017) Anthony Letai   NATURE MEDICINE

Conditional reprogramming and long-term expansion of normal and tumor cells from human biospecimens

(2017) Xuefeng Liu et al.   Nature Protocols

Drug development in the era of precision medicine

(2017) Sarah A. Dugger et al.   NATURE REVIEWS DRUG DISCOVERY

Opportunities and challenges in phenotypic drug discovery: an industry perspective

(2017) John G. Moffat et al.   NATURE REVIEWS DRUG DISCOVERY

The impact of in silico screening in the discovery of novel and safer drug candidates

(2017) Didier Rognan   PHARMACOLOGY & THERAPEUTICS

In vivo and ex vivo cetuximab sensitivity assay using three-dimensional primary culture system to stratify KRAS mutant colorectal cancer

(2017) Takahiro Tashiro et al.   PLoS One

Molecular dissection of colorectal cancer in pre-clinical models identifies biomarkers predicting sensitivity to EGFR inhibitors

(2017) Moritz Schütte et al.   Nature Communications

Personalized In Vitro and In Vivo Cancer Models to Guide Precision Medicine

(2017) Chantal Pauli et al.   Cancer Discovery

Primary Patient-Derived Cancer Cells and Their Potential for Personalized Cancer Patient Care

(2017) David P. Kodack et al.   Cell Reports

Dynamic Change of Polarity in Primary Cultured Spheroids of Human Colorectal Adenocarcinoma and Its Role in Metastasis

(2016) Hiroaki Okuyama et al.   AMERICAN JOURNAL OF PATHOLOGY

Drug screening in 3D in vitro tumor models: overcoming current pitfalls of efficacy read-outs

(2016) Vítor E. Santo et al.   Biotechnology Journal

The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice

(2016) Elizabeth C. Townsend et al.   CANCER CELL

Drug screening and grouping by sensitivity with a panel of primary cultured cancer spheroids derived from endometrial cancer

(2016) Yumiko Kiyohara et al.   CANCER SCIENCE

Modeling Development and Disease with Organoids

(2016) Hans Clevers   CELL

Organoids: A historical perspective of thinking in three dimensions

(2016) Marina Simian et al.   JOURNAL OF CELL BIOLOGY

Comparison of cancer cells in 2D vs 3D culture reveals differences in AKT–mTOR–S6K signaling and drug responses

(2016) Angelika Riedl et al.   JOURNAL OF CELL SCIENCE

Innovation in the pharmaceutical industry: New estimates of R&D costs

(2016) Joseph A. DiMasi et al.   JOURNAL OF HEALTH ECONOMICS

Culture and establishment of self-renewing human and mouse adult liver and pancreas 3D organoids and their genetic manipulation

(2016) Laura Broutier et al.   Nature Protocols

Phase II and phase III failures: 2013–2015

(2016) Richard K. Harrison   NATURE REVIEWS DRUG DISCOVERY

The genetics of drug efficacy: opportunities and challenges

(2016) Matthew R. Nelson et al.   NATURE REVIEWS GENETICS

Drug screening in 3D in vitro tumor models: overcoming current pitfalls of efficacy read-outs

(2016) Vítor E. Santo et al.   Biotechnology Journal

Dual pharmacological inhibition of glutathione and thioredoxin systems synergizes to kill colorectal carcinoma stem cells

(2016) Genki Tanaka et al.   Cancer Medicine

High-throughput screening with nanoimprinting 3D culture for efficient drug development by mimicking the tumor environment

(2015) Yukie Yoshii et al.   BIOMATERIALS

Long-Term Culture of Genome-Stable Bipotent Stem Cells from Adult Human Liver

(2015) Meritxell Huch et al.   CELL

Prospective Derivation of a Living Organoid Biobank of Colorectal Cancer Patients

(2015) Marc van de Wetering et al.   CELL

Tissue-engineered models of human tumors for cancer research

(2015) Aranzazu Villasante et al.   Expert Opinion on Drug Discovery

Establishment of patient-derived xenograft models and cell lines for malignancies of the upper gastrointestinal tract

(2015) Helene Damhofer et al.   Journal of Translational Medicine

High-throughput screening using patient-derived tumor xenografts to predict clinical trial drug response

(2015) Hui Gao et al.   NATURE MEDICINE

Drug repurposing in oncology—patient and health systems opportunities

(2015) Francesco Bertolini et al.   Nature Reviews Clinical Oncology

Dynamic Change in p63 Protein Expression during Implantation of Urothelial Cancer Clusters

(2015) Takahiro Yoshida et al.   NEOPLASIA

ROCK Inhibition Facilitates In Vitro Expansion of Glioblastoma Stem-Like Cells

(2015) Samantha G. Tilson et al.   PLoS One

Molecular Characterization of Patient-Derived Human Pancreatic Tumor Xenograft Models for Preclinical and Translational Development of Cancer Therapeutics

(2015) Mike Mattie et al.   NEOPLASIA

Three-Dimensional Cell Culture Systems and Their Applications in Drug Discovery and Cell-Based Biosensors

(2014) Rasheena Edmondson et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

High-dose chemotherapeutics of intravesical chemotherapy rapidly induce mitochondrial dysfunction in bladder cancer-derived spheroids

(2014) Takahiro Yoshida et al.   CANCER SCIENCE

Identification of Multipotent Luminal Progenitor Cells in Human Prostate Organoid Cultures

(2014) Wouter R. Karthaus et al.   CELL

Radiation sensitivity assay with a panel of patient-derived spheroids of small cell carcinoma of the cervix

(2014) Aya Nakajima et al.   INTERNATIONAL JOURNAL OF CANCER

Phenotypic screening in cancer drug discovery — past, present and future

(2014) John G. Moffat et al.   NATURE REVIEWS DRUG DISCOVERY

Organogenesis in a dish: Modeling development and disease using organoid technologies

(2014) M. A. Lancaster et al.   SCIENCE

New cast for a new era: preclinical cancer drug development revisited

(2013) Grit S. Herter-Sprie et al.   JOURNAL OF CLINICAL INVESTIGATION

Spheroid Culture of Primary Lung Cancer Cells with Neuregulin 1/HER3 Pathway Activation

(2013) Hiroko Endo et al.   Journal of Thoracic Oncology

Involvement of Heregulin/HER3 in the Primary Culture of Human Urothelial Cancer

(2013) Hiroaki Okuyama et al.   JOURNAL OF UROLOGY

Patient-derived xenografts, the cancer stem cell paradigm and cancer pathobiology in the 21st century

(2013) Samuel A Williams et al.   LABORATORY INVESTIGATION

In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration

(2013) Meritxell Huch et al.   NATURE

Phase II and Phase III attrition rates 2011–2012

(2013) John Arrowsmith et al.   NATURE REVIEWS DRUG DISCOVERY

Induction of the Stem-like Cell Regulator CD44 by Rho Kinase Inhibition Contributes to the Maintenance of Colon Cancer-Initiating Cells

(2012) H. Ohata et al.   CANCER RESEARCH

Characterization of a Large Panel of Patient-Derived Tumor Xenografts Representing the Clinical Heterogeneity of Human Colorectal Cancer

(2012) S. Julien et al.   CLINICAL CANCER RESEARCH

Self-formation of layered neural structures in three-dimensional culture of ES cells

(2012) Mototsugu Eiraku et al.   CURRENT OPINION IN NEUROBIOLOGY

Deconstructing the third dimension – how 3D culture microenvironments alter cellular cues

(2012) Brendon M. Baker et al.   JOURNAL OF CELL SCIENCE

Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium

(2011) Toshiro Sato et al.   GASTROENTEROLOGY

Tumor grafts derived from women with breast cancer authentically reflect tumor pathology, growth, metastasis and disease outcomes

(2011) Yoko S DeRose et al.   NATURE MEDICINE

Promoter Methylation in Head and Neck Squamous Cell Carcinoma Cell Lines Is Significantly Different than Methylation in Primary Tumors and Xenografts

(2011) Patrick T. Hennessey et al.   PLoS One

Retaining cell-cell contact enables preparation and culture of spheroids composed of pure primary cancer cells from colorectal cancer

(2011) J. Kondo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome remodelling in a basal-like breast cancer metastasis and xenograft

(2010) Li Ding et al.   NATURE

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE

Mouse xenograft models vs GEM models for human cancer therapeutics

(2008) A. Richmond et al.   Disease Models & Mechanisms