Organoids of liver diseases: From bench to bedside

Generation of matched patient-derived xenograft in vitro-in vivo models using 3D macroporous hydrogels for the study of liver cancer

(2018) Eliza Li Shan Fong et al.   BIOMATERIALS

Patient-derived organoid models help define personalized management of gastrointestinal cancer

(2018) M. R. Aberle et al.   BRITISH JOURNAL OF SURGERY

Single Particle Imaging of Polarized Hepatoma Organoids upon Hepatitis C Virus Infection Reveals an Ordered and Sequential Entry Process

(2018) Yasmine Baktash et al.   Cell Host & Microbe

Human Pancreatic Tumor Organoids Reveal Loss of Stem Cell Niche Factor Dependence during Disease Progression

(2018) Takashi Seino et al.   Cell Stem Cell

Liver ‘organ on a chip’

(2018) Colin H. Beckwitt et al.   EXPERIMENTAL CELL RESEARCH

MIR21 Drives Resistance to Heat Shock Protein 90 Inhibition in Cholangiocarcinoma

(2018) Andrea Lampis et al.   GASTROENTEROLOGY

Intestinal Failure and Aberrant Lipid Metabolism in Patients With DGAT1 Deficiency

(2018) Jorik M. van Rijn et al.   GASTROENTEROLOGY

Self-assembled liver organoids recapitulate hepatobiliary organogenesis in vitro

(2018) Dipen Vyas et al.   HEPATOLOGY

Burden of liver disease in Europe: Epidemiology and analysis of risk factors to identify prevention policies

(2018) Laura Pimpin et al.   JOURNAL OF HEPATOLOGY

CRIPTO promotes an aggressive tumour phenotype and resistance to treatment in hepatocellular carcinoma

(2018) Sofia Karkampouna et al.   JOURNAL OF PATHOLOGY

CRISPR/Cas9 for cancer research and therapy

(2018) Tianzuo Zhan et al.   SEMINARS IN CANCER BIOLOGY

Colorectal cancer liver metastases organoids retain characteristics of original tumor and acquire chemotherapy resistance

(2018) Jon N. Buzzelli et al.   Stem Cell Research

Induction of differentiation of intrahepatic cholangiocarcinoma cells to functional hepatocytes using an organoid culture system

(2018) Yoshimasa Saito et al.   Scientific Reports

Basal interferon signaling and therapeutic use of interferons in controlling rotavirus infection in human intestinal cells and organoids

(2018) Mohamad S. Hakim et al.   Scientific Reports

Human iPSC-Derived Posterior Gut Progenitors Are Expandable and Capable of Forming Gut and Liver Organoids

(2018) Ran-Ran Zhang et al.   Stem Cell Reports

Cell Culture System for Analysis of Genetic Heterogeneity Within Hepatocellular Carcinomas and Response to Pharmacologic Agents

(2017) Qiang Gao et al.   GASTROENTEROLOGY

In vivo genome editing and organoid transplantation models of colorectal cancer and metastasis

(2017) Jatin Roper et al.   NATURE BIOTECHNOLOGY

A three-dimensional model of human lung development and disease from pluripotent stem cells

(2017) Ya-Wen Chen et al.   NATURE CELL BIOLOGY

Patient-derived xenografts undergo mouse-specific tumor evolution

(2017) Uri Ben-David et al.   NATURE GENETICS

Human primary liver cancer–derived organoid cultures for disease modeling and drug screening

(2017) Laura Broutier et al.   NATURE MEDICINE

Colonic organoids derived from human induced pluripotent stem cells for modeling colorectal cancer and drug testing

(2017) Miguel Crespo et al.   NATURE MEDICINE

Enteroviruses infect human enteroids and induce antiviral signaling in a cell lineage-specific manner

(2017) Coyne G. Drummond et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biliary epithelial injury-induced regenerative response by IL-33 promotes cholangiocarcinogenesis from peribiliary glands

(2017) Hayato Nakagawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Disease Modeling in Stem Cell-Derived 3D Organoid Systems

(2017) Devanjali Dutta et al.   TRENDS IN MOLECULAR MEDICINE

HGF/R-spondin1 rescues liver dysfunction through the induction of Lgr5+ liver stem cells

(2017) Yuan Lin et al.   Nature Communications

Microenvironment of a tumor-organoid system enhances hepatocellular carcinoma malignancy-related hallmarks

(2017) Yang Wang et al.   Organogenesis

Organoid-based epithelial to mesenchymal transition (OEMT) model: from an intestinal fibrosis perspective

(2017) Soojung Hahn et al.   Scientific Reports

Long-Term Adult Feline Liver Organoid Cultures for Disease Modeling of Hepatic Steatosis

(2017) Hedwig S. Kruitwagen et al.   Stem Cell Reports

Novel human hepatic organoid model enables testing of drug-induced liver fibrosis in vitro

(2016) Sofia B. Leite et al.   BIOMATERIALS

Antitumor effect of FGFR inhibitors on a novel cholangiocarcinoma patient derived xenograft mouse model endogenously expressing an FGFR2-CCDC6 fusion protein

(2016) Yu Wang et al.   CANCER LETTERS

Modeling Development and Disease with Organoids

(2016) Hans Clevers   CELL

Generation of pediatric liver cancer patient-derived xenograft platforms for pediatric liver cancer: A critical stage in the development of anticancer treatments

(2016) Gregory Tiao et al.   HEPATOLOGY

Influence of surgical margins on overall survival after resection of intrahepatic cholangiocarcinoma

(2016) Haowen Tang et al.   MEDICINE

Culture and establishment of self-renewing human and mouse adult liver and pancreas 3D organoids and their genetic manipulation

(2016) Laura Broutier et al.   Nature Protocols

Replication of human noroviruses in stem cell-derived human enteroids

(2016) K. Ettayebi et al.   SCIENCE

Concise Review: Organoids Are a Powerful Tool for the Study of Liver Disease and Personalized Treatment Design in Humans and Animals

(2016) Sathidpak Nantasanti et al.   Stem Cells Translational Medicine

Modeling rotavirus infection and antiviral therapy using primary intestinal organoids

(2015) Yuebang Yin et al.   ANTIVIRAL RESEARCH

Global cancer statistics, 2012

(2015) Lindsey A. Torre et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Long-Term Culture of Genome-Stable Bipotent Stem Cells from Adult Human Liver

(2015) Meritxell Huch et al.   CELL

Prospective Derivation of a Living Organoid Biobank of Colorectal Cancer Patients

(2015) Marc van de Wetering et al.   CELL

Organoid Models of Human and Mouse Ductal Pancreatic Cancer

(2015) Sylvia F. Boj et al.   CELL

Pathophysiology of Liver Fibrosis

(2015) Massimo Pinzani   DIGESTIVE DISEASES

Nonalcoholic Steatohepatitis Is the Second Leading Etiology of Liver Disease Among Adults Awaiting Liver Transplantation in the United States

(2015) Robert J. Wong et al.   GASTROENTEROLOGY

Nonalcoholic Fatty Liver Disease

(2015) Mary E. Rinella   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Modeling colorectal cancer using CRISPR-Cas9–mediated engineering of human intestinal organoids

(2015) Mami Matano et al.   NATURE MEDICINE

Advances in experimental systems to study hepatitis C virus in vitro and in vivo

(2015) Maria Teresa Catanese et al.   VIROLOGY

Disease Modeling and Gene Therapy of Copper Storage Disease in Canine Hepatic Organoids

(2015) Sathidpak Nantasanti et al.   Stem Cell Reports

The global burden of liver disease: a challenge for methods and for public health

(2014) Peter Byass   BMC Medicine

Projecting Cancer Incidence and Deaths to 2030: The Unexpected Burden of Thyroid, Liver, and Pancreas Cancers in the United States

(2014) L. Rahib et al.   CANCER RESEARCH

The global burden of liver disease: The major impact of China

(2014) Fu-Sheng Wang et al.   HEPATOLOGY

Modelling human development and disease in pluripotent stem-cell-derived gastric organoids

(2014) Kyle W. McCracken et al.   NATURE

Oncogenic transformation of diverse gastrointestinal tissues in primary organoid culture

(2014) Xingnan Li et al.   NATURE MEDICINE

IL-6/STAT3 promotes regeneration of airway ciliated cells from basal stem cells

(2014) T. Tadokoro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Organogenesis in a dish: Modeling development and disease using organoid technologies

(2014) M. A. Lancaster et al.   SCIENCE

The organoid-initiating cells in mouse pancreas and liver are phenotypically and functionally similar

(2014) Craig Dorrell et al.   Stem Cell Research

Differentiated Troy+ Chief Cells Act as Reserve Stem Cells to Generate All Lineages of the Stomach Epithelium

(2013) Daniel E. Stange et al.   CELL

Genomic Instability in Pluripotent Stem Cells: Implications for Clinical Applications

(2013) Suzanne E. Peterson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Spheroid-based three-dimensional liver-on-a-chip to investigate hepatocyte–hepatic stellate cell interactions and flow effects

(2013) Seung-A Lee et al.   LAB ON A CHIP

In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration

(2013) Meritxell Huch et al.   NATURE

Vascularized and functional human liver from an iPSC-derived organ bud transplant

(2013) Takanori Takebe et al.   NATURE

Cerebral organoids model human brain development and microcephaly

(2013) Madeline A. Lancaster et al.   NATURE

Identification of small molecules for human hepatocyte expansion and iPS differentiation

(2013) Jing Shan et al.   Nature Chemical Biology

Monitoring and robust induction of nephrogenic intermediate mesoderm from human pluripotent stem cells

(2013) Shin-Ichi Mae et al.   Nature Communications

Self-Formation of Optic Cups and Storable Stratified Neural Retina from Human ESCs

(2012) Tokushige Nakano et al.   Cell Stem Cell

Self-formation of layered neural structures in three-dimensional culture of ES cells

(2012) Mototsugu Eiraku et al.   CURRENT OPINION IN NEUROBIOLOGY

Cholangiocarcinomas can originate from hepatocytes in mice

(2012) Biao Fan et al.   JOURNAL OF CLINICAL INVESTIGATION

Directed differentiation of human pluripotent stem cells into mature airway epithelia expressing functional CFTR protein

(2012) Amy P Wong et al.   NATURE BIOTECHNOLOGY

Stem Cell-Derived Human Intestinal Organoids as an Infection Model for Rotaviruses

(2012) S. R. Finkbeiner et al.   mBio

Jagged1 in the portal vein mesenchyme regulates intrahepatic bile duct development: insights into Alagille syndrome

(2010) J. J. Hofmann et al.   DEVELOPMENT

Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro

(2010) Jason R. Spence et al.   NATURE

The tumor microenvironment in hepatocellular carcinoma: Current status and therapeutic targets

(2010) Ju Dong Yang et al.   SEMINARS IN CANCER BIOLOGY

Highly efficient differentiation of human ES cells and iPS cells into mature pancreatic insulin-producing cells

(2009) Donghui Zhang et al.   CELL RESEARCH

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE

From Human to Mouse and Back: 'Tumorgraft' Models Surge in Popularity

(2008) K. Garber   JNCI-Journal of the National Cancer Institute

In Vitro Differentiation of Liver Progenitor Cells Derived from Healthy Dog Livers

(2008) Brigitte Arends et al.   STEM CELLS AND DEVELOPMENT