P2X7 Receptors in Neurodegeneration: Potential Therapeutic Applications From Basic to Clinical Approaches
Published 2021 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
P2X7 Receptors in Neurodegeneration: Potential Therapeutic Applications From Basic to Clinical Approaches
Authors
Keywords
-
Journal
Frontiers in Cellular Neuroscience
Volume 15, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2021-04-06
DOI
10.3389/fncel.2021.617036
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Natural genetic variation determines microglia heterogeneity in wild-derived mouse models of Alzheimer’s disease
- (2021) Hongtian Stanley Yang et al. Cell Reports
- The P2X7 receptor antagonist JNJ-47965567 administered thrice weekly from disease onset does not alter progression of amyotrophic lateral sclerosis in SOD1G93A mice
- (2020) Diane Ly et al. Purinergic Signalling
- P2X7 Receptor Antagonism as a Potential Therapy in Amyotrophic Lateral Sclerosis
- (2020) Cristina Ruiz-Ruiz et al. Frontiers in Molecular Neuroscience
- Duality of P2X7 Receptor in Amyotrophic Lateral Sclerosis
- (2020) Cinzia Volonté et al. Frontiers in Pharmacology
- P2X7 is a cytotoxic receptor….maybe not: implications for cancer
- (2020) Francesco Di Virgilio Purinergic Signalling
- P2X7 Receptor Upregulation in Huntington’s Disease Brains
- (2020) Ivana Ollà et al. Frontiers in Molecular Neuroscience
- Preclinical evaluation and non-human primate receptor occupancy study of 18F-JNJ-64413739, a novel PET radioligand for P2X7 receptors
- (2019) Hartmuth Kolb et al. JOURNAL OF NUCLEAR MEDICINE
- Increased expression of the P2X7 receptor in temporal lobe epilepsy: Animal models and clinical evidence
- (2019) Penghui Song et al. Molecular Medicine Reports
- [11C]JNJ54173717, a novel P2X7 receptor radioligand as marker for neuroinflammation: human biodistribution, dosimetry, brain kinetic modelling and quantification of brain P2X7 receptors in patients with Parkinson’s disease and healthy volunteers
- (2019) Donatienne Van Weehaeghe et al. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
- P2X7 Receptor Signaling in Stress and Depression
- (2019) Deidiane Elisa Ribeiro et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Mapping the Site of Action of Human P2X7 Receptor Antagonists AZ11645373, Brilliant Blue G, KN-62, Calmidazolium, and ZINC58368839 to the Intersubunit Allosteric Pocket
- (2019) Anfal Bin Dayel et al. MOLECULAR PHARMACOLOGY
- Pleiotropic Roles of P2X7 in the Central Nervous System
- (2019) Jean M. Kanellopoulos et al. Frontiers in Cellular Neuroscience
- P2X7 Interactions and Signaling – Making Head or Tail of It
- (2019) Robin Kopp et al. Frontiers in Molecular Neuroscience
- The P2X7 receptor tracer [11C]SMW139 as an in vivo marker of neuroinflammation in multiple sclerosis: a first-in man study
- (2019) Marloes H. J. Hagens et al. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
- The P2X7 receptor: A main player in inflammation
- (2018) Elena Adinolfi et al. BIOCHEMICAL PHARMACOLOGY
- Synthesis and preliminary biological evaluation of a novel P2X7R radioligand [ 18 F]IUR-1601
- (2018) Mingzhang Gao et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Depression and sterile inflammation: Essential role of danger associated molecular patterns
- (2018) Tina C. Franklin et al. BRAIN BEHAVIOR AND IMMUNITY
- New role of P2X7 receptor in an Alzheimer’s disease mouse model
- (2018) Elodie Martin et al. MOLECULAR PSYCHIATRY
- Neuropsychopharmacology of JNJ-55308942: evaluation of a clinical candidate targeting P2X7 ion channels in animal models of neuroinflammation and anhedonia
- (2018) Anindya Bhattacharya et al. NEUROPSYCHOPHARMACOLOGY
- The Elusive P2X7 Macropore
- (2018) Francesco Di Virgilio et al. TRENDS IN CELL BIOLOGY
- Identification of the allosteric P2X7 receptor antagonist [11C]SMW139 as a PET tracer of microglial activation
- (2018) Bieneke Janssen et al. Scientific Reports
- Purinergic Receptors in Neurological Diseases With Motor Symptoms: Targets for Therapy
- (2018) Ágatha Oliveira-Giacomelli et al. Frontiers in Pharmacology
- Recent Advances in CNS P2X7 Physiology and Pharmacology: Focus on Neuropsychiatric Disorders
- (2018) Anindya Bhattacharya Frontiers in Pharmacology
- 18F-JNJ-64413739, a novel PET ligand for the P2X7 ion channel: radiation dosimetry, kinetic modeling, test-retest variability and occupancy of the P2X7 antagonist JNJ-54175446
- (2018) Michel Koole et al. JOURNAL OF NUCLEAR MEDICINE
- Emerging role of the P2X7-NLRP3-IL1β pathway in mood disorders
- (2018) Anindya Bhattacharya et al. PSYCHONEUROENDOCRINOLOGY
- P2X7 Receptor Antagonist A804598 Inhibits Inflammation in Brain and Liver in C57BL/6J Mice Exposed to Chronic Ethanol and High Fat Diet
- (2018) Daniel Freire et al. Journal of Neuroimmune Pharmacology
- Purinergic receptors P2RX4 and P2RX7 in familial multiple sclerosis
- (2017) A Dessa Sadovnick et al. HUMAN MUTATION
- The P2X7 Receptor in Infection and Inflammation
- (2017) Francesco Di Virgilio et al. IMMUNITY
- 4-Methyl-6,7-dihydro-4H-triazolo[4,5-c]pyridine-Based P2X7 Receptor Antagonists: Optimization of Pharmacokinetic Properties Leading to the Identification of a Clinical Candidate
- (2017) Michael A. Letavic et al. JOURNAL OF MEDICINAL CHEMISTRY
- A Dipolar Cycloaddition Reaction To Access 6-Methyl-4,5,6,7-tetrahydro-1H-[1,2,3]triazolo[4,5-c]pyridines Enables the Discovery Synthesis and Preclinical Profiling of a P2X7 Antagonist Clinical Candidate
- (2017) Christa C. Chrovian et al. JOURNAL OF MEDICINAL CHEMISTRY
- Purinergic receptors P2Y12R and P2X7R: potential targets for PET imaging of microglia phenotypes in multiple sclerosis
- (2017) Wissam Beaino et al. Journal of Neuroinflammation
- Activation of P2X7 receptor and NLRP3 inflammasome assembly in hippocampal glial cells mediates chronic stress-induced depressive-like behaviors
- (2017) Na Yue et al. Journal of Neuroinflammation
- The role of microglial P2X7: modulation of cell death and cytokine release
- (2017) Yingbo He et al. Journal of Neuroinflammation
- Heterozygosity for the Mood Disorder-Associated Variant Gln460Arg Alters P2X7 Receptor Function and Sleep Quality
- (2017) Michael W. Metzger et al. JOURNAL OF NEUROSCIENCE
- Neuronal P2X7 Receptors Revisited: Do They Really Exist?
- (2017) Peter Illes et al. JOURNAL OF NEUROSCIENCE
- Adult Hippocampal Neurogenesis along the Dorsoventral Axis Contributes Differentially to Environmental Enrichment Combined with Voluntary Exercise in Alleviating Chronic Inflammatory Pain in Mice
- (2017) Jie Zheng et al. JOURNAL OF NEUROSCIENCE
- Extracellular ATP and adenosine: The Yin and Yang in immune responses?
- (2017) M.M. Faas et al. MOLECULAR ASPECTS OF MEDICINE
- Purinergic Antagonism Prevents Mitochondrial Dysfunction and Behavioral Deficits Associated with Dopaminergic Toxicity Induced by 6-OHDA in Rats
- (2017) Saket Kumar et al. NEUROCHEMICAL RESEARCH
- Effects of P2X7 receptor antagonists on hypoxia-induced neonatal seizures in mice
- (2017) Natalia Rodriguez-Alvarez et al. NEUROPHARMACOLOGY
- Role of the purinergic signaling in epilepsy
- (2017) Marek Cieślak et al. Pharmacological Reports
- Distinct roles for motor neuron autophagy early and late in the SOD1G93Amouse model of ALS
- (2017) Noam D. Rudnick et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- P2X7 receptor-pannexin 1 interaction mediates extracellular alpha-synuclein-induced ATP release in neuroblastoma SH-SY5Y cells
- (2017) Anna Wilkaniec et al. Purinergic Signalling
- P2X7 Receptor Activation Modulates Autophagy in SOD1-G93A Mouse Microglia
- (2017) Paola Fabbrizio et al. Frontiers in Cellular Neuroscience
- Modulation of Central Synapses by Astrocyte-Released ATP and Postsynaptic P2X Receptors
- (2017) Eric Boué-Grabot et al. NEURAL PLASTICITY
- The ATP-Gated P2X7 Receptor As a Target for the Treatment of Drug-Resistant Epilepsy
- (2017) Edward Beamer et al. Frontiers in Neuroscience
- P2X7 antagonism using Brilliant Blue G reduces body weight loss and prolongs survival in female SOD1G93Aamyotrophic lateral sclerosis mice
- (2017) Rachael Bartlett et al. PeerJ
- Modulation of P2X7 Receptor during Inflammation in Multiple Sclerosis
- (2017) Susanna Amadio et al. Frontiers in Immunology
- P2X7 receptor antagonists: a patent review (2010–2015)
- (2016) Jin-Hee Park et al. EXPERT OPINION ON THERAPEUTIC PATENTS
- The microglial ATP-gated ion channel P2X7 as a CNS drug target
- (2016) Anindya Bhattacharya et al. GLIA
- Identification of (R)-(2-Chloro-3-(trifluoromethyl)phenyl)(1-(5-fluoropyridin-2-yl)-4-methyl-6,7-dihydro-1H-imidazo[4,5-c]pyridin-5(4H)-yl)methanone (JNJ 54166060), a Small Molecule Antagonist of the P2X7 receptor
- (2016) Devin M. Swanson et al. JOURNAL OF MEDICINAL CHEMISTRY
- How does adenosine control neuronal dysfunction and neurodegeneration?
- (2016) Rodrigo A. Cunha JOURNAL OF NEUROCHEMISTRY
- Transient P2X7 Receptor Antagonism Produces Lasting Reductions in Spontaneous Seizures and Gliosis in Experimental Temporal Lobe Epilepsy
- (2016) Alba Jimenez-Pacheco et al. JOURNAL OF NEUROSCIENCE
- Preclinical Evaluation of a P2X7 Receptor-Selective Radiotracer: PET Studies in a Rat Model with Local Overexpression of the Human P2X7 Receptor and in Nonhuman Primates
- (2016) D. Ory et al. JOURNAL OF NUCLEAR MEDICINE
- Characterization of 11 C-GSK1482160 for Targeting the P2X7 Receptor as a Biomarker for Neuroinflammation
- (2016) Paul R. Territo et al. JOURNAL OF NUCLEAR MEDICINE
- Early P2X7R-related astrogliosis in autoimmune encephalomyelitis
- (2016) Tomasz Grygorowicz et al. MOLECULAR AND CELLULAR NEUROSCIENCE
- Inhibiting purinergic P2X7 receptors with the antagonist brilliant blue G is neuroprotective in an intranigral lipopolysaccharide animal model of Parkinson's disease
- (2016) Xin-Hong Wang et al. Molecular Medicine Reports
- P2X7 receptor antagonism reduces the severity of spontaneous seizures in a chronic model of temporal lobe epilepsy
- (2016) Halima Amhaoul et al. NEUROPHARMACOLOGY
- ATPergic signalling during seizures and epilepsy
- (2016) Tobias Engel et al. NEUROPHARMACOLOGY
- Purinergic mechanisms in neuroinflammation: An update from molecules to behavior
- (2016) Edward Beamer et al. NEUROPHARMACOLOGY
- Purinergic contribution to amyotrophic lateral sclerosis
- (2016) Cinzia Volonté et al. NEUROPHARMACOLOGY
- Medicinal chemistry of adenosine, P2Y and P2X receptors
- (2016) Kenneth A. Jacobson et al. NEUROPHARMACOLOGY
- An introduction to the roles of purinergic signalling in neurodegeneration, neuroprotection and neuroregeneration
- (2016) Geoffrey Burnstock NEUROPHARMACOLOGY
- P2X7 as a new target for chrysophanol to treat lipopolysaccharide-induced depression in mice
- (2016) Kai Zhang et al. NEUROSCIENCE LETTERS
- Down-regulation of purinergic P2X7 receptor expression and intracellular calcium dysregulation in peripheral blood mononuclear cells of patients with amyotrophic lateral sclerosis
- (2016) Jingyu Liu et al. NEUROSCIENCE LETTERS
- Co-Expression of Wild-Type P2X7R with Gln460Arg Variant Alters Receptor Function
- (2016) Fernando Aprile-Garcia et al. PLoS One
- Critical Evaluation of P2X7 Receptor Antagonists in Selected Seizure Models
- (2016) Wolfgang Fischer et al. PLoS One
- Novel methyl substituted 1-(5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanones are P2X7 antagonists
- (2015) Dale A. Rudolph et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- A novel radioligand for the ATP-gated ion channel P2X7: [3H] JNJ-54232334
- (2015) Brian Lord et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- P2X7 receptor antagonist activity of the anti-allergic agent oxatomide
- (2015) Kazuki Yoshida et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- A rare P2X7 variant Arg307Gln with absent pore formation function protects against neuroinflammation in multiple sclerosis
- (2015) Ben J. Gu et al. HUMAN MOLECULAR GENETICS
- P2X7R blockade prevents NLRP3 inflammasome activation and brain injury in a rat model of intracerebral hemorrhage: involvement of peroxynitrite
- (2015) Liang Feng et al. Journal of Neuroinflammation
- Is Ecto-nucleoside Triphosphate Diphosphohydrolase (NTPDase)-based Therapy of Central Nervous System Disorders Possible?
- (2015) Katarzyna Roszek et al. MINI-REVIEWS IN MEDICINAL CHEMISTRY
- Purinergic signalling in neuroregeneration
- (2015) Geoffrey Burnstock Neural Regeneration Research
- P2X7 receptor is critical in α-synuclein–mediated microglial NADPH oxidase activation
- (2015) Tianfang Jiang et al. NEUROBIOLOGY OF AGING
- Enzymatic conversion of ATP to adenosine contributes to ATP-induced inhibition of glutamate release in rat medullary dorsal horn neurons
- (2015) In-Sun Choi et al. NEUROPHARMACOLOGY
- Synthesis, SAR, and Pharmacological Characterization of Brain Penetrant P2X7 Receptor Antagonists
- (2015) Brad M. Savall et al. ACS Medicinal Chemistry Letters
- ATP as a multi-target danger signal in the brain
- (2015) Ricardo J. Rodrigues et al. Frontiers in Neuroscience
- P2X7 on Mouse T Cells: One Channel, Many Functions
- (2015) Björn Rissiek et al. Frontiers in Immunology
- Extracellular nucleotide and nucleoside signaling in vascular and blood disease
- (2014) M. Idzko et al. BLOOD
- P2X7 Receptor Inhibition Interrupts the Progression of Seizures in Immature Rats and Reduces Hippocampal Damage
- (2014) Guillaume Mesuret et al. CNS Neuroscience & Therapeutics
- Spinal cord pathology is ameliorated by P2X7 antagonism in a SOD1-mutant mouse model of amyotrophic lateral sclerosis
- (2014) S. Apolloni et al. Disease Models & Mechanisms
- Non-Synonymous Single Nucleotide Polymorphisms in the P2X Receptor Genes: Association with Diseases, Impact on Receptor Functions and Potential Use as Diagnosis Biomarkers
- (2014) Emily Caseley et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Synthesis and initial preclinical evaluation of the P2X7receptor antagonist [11C]A-740003 as a novel tracer of neuroinflammation
- (2014) Bieneke Janssen et al. JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
- The P2X7 receptor antagonist Brilliant Blue G attenuates contralateral rotations in a rat model of Parkinsonism through a combined control of synaptotoxicity, neurotoxicity and gliosis
- (2014) Marta R.S. Carmo et al. NEUROPHARMACOLOGY
- Brilliant Blue G improves cognition in an animal model of Alzheimer’s disease and inhibits amyloid-β-induced loss of filopodia and dendrite spines in hippocampal neurons
- (2014) X. Chen et al. NEUROSCIENCE
- P2X7 receptor: an emerging target in central nervous system diseases
- (2014) Beáta Sperlágh et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- The two-hit hypothesis for neuroinflammation: role of exogenous ATP in modulating inflammation in the brain
- (2014) Bernd L. Fiebich et al. Frontiers in Cellular Neuroscience
- ATP/P2X7 axis modulates myeloid-derived suppressor cell functions in neuroblastoma microenvironment
- (2014) G Bianchi et al. Cell Death & Disease
- Silencing of the P2X7 receptor enhances amyloid-β phagocytosis by microglia
- (2013) Jiong Ni et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Purinergic receptor P2X7: A novel target for anti-inflammatory therapy
- (2013) Nisha Mehta et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Pharmacological characterization of a novel centrally permeable P2X7 receptor antagonist: JNJ-47965567
- (2013) Anindya Bhattacharya et al. BRITISH JOURNAL OF PHARMACOLOGY
- P2X7 Receptor Antagonism Inhibits p38 Mitogen-Activated Protein Kinase Activation and Ameliorates Neuronal Apoptosis After Subarachnoid Hemorrhage in Rats
- (2013) Sheng Chen et al. CRITICAL CARE MEDICINE
- P2X4 receptors control the fate and survival of activated microglia
- (2013) Nuria Vázquez-Villoldo et al. GLIA
- The NADPH Oxidase Pathway Is Dysregulated by the P2X7 Receptor in the SOD1-G93A Microglia Model of Amyotrophic Lateral Sclerosis
- (2013) S. Apolloni et al. JOURNAL OF IMMUNOLOGY
- P2X7R/cryopyrin inflammasome axis inhibition reduces neuroinflammation after SAH
- (2013) Sheng Chen et al. NEUROBIOLOGY OF DISEASE
- P2X7 receptor activation regulates microglial cell death during oxygen-glucose deprivation
- (2013) Ukpong B. Eyo et al. NEUROPHARMACOLOGY
- The phenothiazine-class antipsychotic drugs prochlorperazine and trifluoperazine are potent allosteric modulators of the human P2X7 receptor
- (2013) Christoph Hempel et al. NEUROPHARMACOLOGY
- The Second Transmembrane Domain of P2X7 Contributes to Dilated Pore Formation
- (2013) Chengqun Sun et al. PLoS One
- Block of P2X7 receptors could partly reverse the delayed neuronal death in area CA1 of the hippocampus after transient global cerebral ischemia
- (2013) Qiang Yu et al. Purinergic Signalling
- CAY10593 inhibits the human P2X7 receptor independently of phospholipase D1 stimulation
- (2013) A. Pupovac et al. Purinergic Signalling
- P2X receptors as targets for the treatment of status epilepticus
- (2013) David C. Henshall et al. Frontiers in Cellular Neuroscience
- Neurotransmitter signaling in the pathophysiology of microglia
- (2013) María Domercq et al. Frontiers in Cellular Neuroscience
- Insights into the Molecular Mechanisms Underlying Mammalian P2X7 Receptor Functions and Contributions in Diseases, Revealed by Structural Modeling and Single Nucleotide Polymorphisms
- (2013) Lin-Hua Jiang et al. Frontiers in Pharmacology
- Clinical evaluation of the efficacy of the P2X7purinergic receptor antagonist AZD9056 on the signs and symptoms of rheumatoid arthritis in patients with active disease despite treatment with methotrexate or sulphasalazine
- (2012) Edward C Keystone et al. ANNALS OF THE RHEUMATIC DISEASES
- Pharmacokinetic and pharmacodynamic profiling of a P2X7 receptor allosteric modulator GSK1482160 in healthy human subjects
- (2012) Zahid Ali et al. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
- P2X7 Receptors: Channels, Pores and More
- (2012) C. Volonte et al. CNS & Neurological Disorders-Drug Targets
- Inhibition of P2X7 receptor ameliorates transient global cerebral ischemia/reperfusion injury via modulating inflammatory responses in the rat hippocampus
- (2012) Ketan Chu et al. Journal of Neuroinflammation
- Efficacy and Safety of CE-224,535, an Antagonist of P2X7 Receptor, in Treatment of Patients with Rheumatoid Arthritis Inadequately Controlled by Methotrexate
- (2012) T. C. STOCK et al. JOURNAL OF RHEUMATOLOGY
- P2 Receptors for Extracellular Nucleotides in the Central Nervous System: Role of P2X7 and P2Y2 Receptor Interactions in Neuroinflammation
- (2012) Gary A. Weisman et al. MOLECULAR NEUROBIOLOGY
- Genetically determined P2X7 receptor pore formation regulates variability in chronic pain sensitivity
- (2012) Robert E Sorge et al. NATURE MEDICINE
- Alternative Splicing of the N-Terminal Cytosolic and Transmembrane Domains of P2X7 Controls Gating of the Ion Channel by ADP-Ribosylation
- (2012) Nicole Schwarz et al. PLoS One
- Activation of P2X7 Promotes Cerebral Edema and Neurological Injury after Traumatic Brain Injury in Mice
- (2012) Donald E. Kimbler et al. PLoS One
- Pathophysiology of astroglial purinergic signalling
- (2012) Heike Franke et al. Purinergic Signalling
- Inflammatory Pathways in Parkinson’s Disease; A BNE Microarray Study
- (2012) Pascal. F. Durrenberger et al. Parkinsons Disease
- Gain-of-function of P2X7 receptor gene variants in multiple sclerosis
- (2011) Olatz Oyanguren-Desez et al. CELL CALCIUM
- Mechanisms of epileptogenesis and potential treatment targets
- (2011) Asla Pitkänen et al. LANCET NEUROLOGY
- Lack of neuroprotection in the absence of P2X7 receptors in toxin-induced animal models of Parkinson's disease
- (2011) Zsuzsanna Hracskó et al. Molecular Neurodegeneration
- Inhibition of Neuronal Voltage-Gated Sodium Channels by Brilliant Blue G
- (2011) S. Jo et al. MOLECULAR PHARMACOLOGY
- In vivo P2X7 inhibition reduces amyloid plaques in Alzheimer's disease through GSK3β and secretases
- (2011) Juan Ignacio Diaz-Hernandez et al. NEUROBIOLOGY OF AGING
- Purinergic signalling: From normal behaviour to pathological brain function
- (2011) Geoffrey Burnstock et al. PROGRESS IN NEUROBIOLOGY
- Development of a comprehensive set of P2 receptor pharmacological research compounds
- (2011) R. A. Felix et al. Purinergic Signalling
- The human P2X7 receptor and its role in innate immunity
- (2011) J. S. Wiley et al. TISSUE ANTIGENS
- The Role of the P2X7 Receptor in Infectious Diseases
- (2011) Catherine M. Miller et al. PLoS Pathogens
- Discovery and structure–activity relationships of a series of pyroglutamic acid amide antagonists of the P2X7 receptor
- (2010) Muna H. Abdi et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Two haplotypes of the P2X7 receptor containing the Ala-348 to Thr polymorphism exhibit a gain-of-function effect and enhanced interleukin-1β secretion
- (2010) Leanne Stokes et al. FASEB JOURNAL
- Microglia: Proliferation and activation driven by the P2X7 receptor
- (2010) Mastura Monif et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- The Purinergic Receptor P2X7 Triggers α-Secretase-dependent Processing of the Amyloid Precursor Protein
- (2010) Cécile Delarasse et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- On the role of P2X7 receptors in dopamine nerve cell degeneration in a rat model of Parkinson’s disease: studies with the P2X7 receptor antagonist A-438079
- (2010) Daniel Marcellino et al. JOURNAL OF NEURAL TRANSMISSION
- Extracellular ATP and the P2X7 receptor in astrocyte-mediated motor neuron death: implications for amyotrophic lateral sclerosis
- (2010) Mandi Gandelman et al. Journal of Neuroinflammation
- Temporal expression of P2X7 purinergic receptor during the course of experimental autoimmune encephalomyelitis
- (2010) Tomasz Grygorowicz et al. NEUROCHEMISTRY INTERNATIONAL
- The genetics of epilepsy—The past, the present and future
- (2010) Mark I. Rees SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
- The antihyperalgesic activity of a selective P2X7 receptor antagonist, A-839977, is lost in IL-1αβ knockout mice
- (2009) Prisca Honore et al. BEHAVIOURAL BRAIN RESEARCH
- Mammalian P2X7 receptor pharmacology: comparison of recombinant mouse, rat and human P2X7 receptors
- (2009) Diana L Donnelly-Roberts et al. BRITISH JOURNAL OF PHARMACOLOGY
- Altered P2X7-receptor level and function in mouse models of Huntington’s disease and therapeutic efficacy of antagonist administration
- (2009) Miguel Díaz-Hernández et al. FASEB JOURNAL
- P2X7 receptors mediate ischemic damage to oligodendrocytes
- (2009) Maria Domercq et al. GLIA
- Analysis of Assembly and Trafficking of Native P2X4 and P2X7 Receptor Complexes in Rodent Immune Cells
- (2009) Miyyada Boumechache et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Activation of Microglia by Amyloid Requires P2X7 Receptor Expression
- (2009) J. M. Sanz et al. JOURNAL OF IMMUNOLOGY
- The Proinflammatory Action of Microglial P2 Receptors Is Enhanced in SOD1 Models for Amyotrophic Lateral Sclerosis
- (2009) N. D'Ambrosi et al. JOURNAL OF IMMUNOLOGY
- Activation of the NLRP3 inflammasome in dendritic cells induces IL-1β–dependent adaptive immunity against tumors
- (2009) François Ghiringhelli et al. NATURE MEDICINE
- Systemic administration of an antagonist of the ATP-sensitive receptor P2X7 improves recovery after spinal cord injury
- (2009) W. Peng et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Purinergic signalling in inflammation of the central nervous system
- (2009) Francesco Di Virgilio et al. TRENDS IN NEUROSCIENCES
- Signaling at Purinergic P2X Receptors
- (2008) Annmarie Surprenant et al. Annual Review of Physiology
- Behavioral profile of P2X7 receptor knockout mice in animal models of depression and anxiety: Relevance for neuropsychiatric disorders
- (2008) Ana M. Basso et al. BEHAVIOURAL BRAIN RESEARCH
- Homotrimeric complexes are the dominant assembly state of native P2X7 subunits
- (2008) Annette Nicke BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Nucleotide- and nucleoside-converting ectoenzymes: Important modulators of purinergic signalling cascade
- (2008) Gennady G. Yegutkin BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Synthesis and in vitro activity of 1-(2,3-dichlorophenyl)-N-(pyridin-3-ylmethyl)-1H-1,2,4-triazol-5-amine and 4-(2,3-dichlorophenyl)-N-(pyridin-3-ylmethyl)-4H-1,2,4-triazol-3-amine P2X7 antagonists
- (2008) Alan S. Florjancic et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Purinergic systems in microglia
- (2008) K. Inoue CELLULAR AND MOLECULAR LIFE SCIENCES
- Inhibition of P2X7 receptors by divalent cations: old action and new insight
- (2008) Lin-Hua Jiang EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
- Characterization of N-(Adamantan-1-ylmethyl)-5-[(3R-aminopyrrolidin-1-yl)methyl]-2-chloro-benzamide, a P2X7 Antagonist in Animal Models of Pain and Inflammation
- (2008) D. C. Broom et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Purinergic signalling and disorders of the central nervous system
- (2008) Geoffrey Burnstock NATURE REVIEWS DRUG DISCOVERY
- Block of purinergic P2X7 receptor is neuroprotective in an animal model of Alzheimerʼs disease
- (2008) Jae K. Ryu et al. NEUROREPORT
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now