New role of P2X7 receptor in an Alzheimer’s disease mouse model

Distinct inflammatory phenotypes of microglia and monocyte-derived macrophages in Alzheimer's disease models: effects of aging and amyloid pathology

(2016) Elodie Martin et al.   AGING CELL

Hippocampal T cell infiltration promotes neuroinflammation and cognitive decline in a mouse model of tauopathy

(2016) Cyril Laurent et al.   BRAIN

ATP-induced IL-1β secretion is selectively impaired in microglia as compared to hematopoietic macrophages

(2016) Saskia Maria Burm et al.   GLIA

Genetically dissecting P2rx7 expression within the central nervous system using conditional humanized mice

(2016) Michael W. Metzger et al.   Purinergic Signalling

CCR5 is a suppressor for cortical plasticity and hippocampal learning and memory

(2016) Miou Zhou et al.   eLife

Emerging role of P2X7 receptors in CNS health and disease

(2015) Manju Tewari et al.   AGEING RESEARCH REVIEWS

Neuroinflammation in Alzheimer's disease

(2015) Michael T Heneka et al.   LANCET NEUROLOGY

Erratum: A2A adenosine receptor deletion is protective in a mouse model of Tauopathy

(2015) C Laurent et al.   MOLECULAR PSYCHIATRY

Innate immunity in Alzheimer's disease

(2015) Michael T Heneka et al.   NATURE IMMUNOLOGY

Immune attack: the role of inflammation in Alzheimer disease

(2015) Frank L. Heppner et al.   NATURE REVIEWS NEUROSCIENCE

The NLRP3 inflammasome is activated by nanoparticles through ATP, ADP and adenosine

(2015) L Baron et al.   Cell Death & Disease

The Chemokine MIP-1α/CCL3 impairs mouse hippocampal synaptic transmission, plasticity and memory

(2015) Elodie Marciniak et al.   Scientific Reports

ATP as a multi-target danger signal in the brain

(2015) Ricardo J. Rodrigues et al.   Frontiers in Neuroscience

Opposing Effects of Membrane-Anchored CX3CL1 on Amyloid and Tau Pathologies via the p38 MAPK Pathway

(2014) S. Lee et al.   JOURNAL OF NEUROSCIENCE

The two-hit hypothesis for neuroinflammation: role of exogenous ATP in modulating inflammation in the brain

(2014) Bernd L. Fiebich et al.   Frontiers in Cellular Neuroscience

Silencing of the P2X7 receptor enhances amyloid-β phagocytosis by microglia

(2013) Jiong Ni et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Loss of P2Y2 Nucleotide Receptors Enhances Early Pathology in the TgCRND8 Mouse Model of Alzheimer's Disease

(2013) Deepa Ajit et al.   MOLECULAR NEUROBIOLOGY

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

(2013) Jean-Charles Lambert et al.   NATURE GENETICS

Functional Impairment of Microglia Coincides with Beta-Amyloid Deposition in Mice with Alzheimer-Like Pathology

(2013) Grietje Krabbe et al.   PLoS One

Neurons as targets for T cells in the nervous system

(2013) Roland S. Liblau et al.   TRENDS IN NEUROSCIENCES

Chemokines in CNS injury and repair

(2012) Anne Jaerve et al.   CELL AND TISSUE RESEARCH

P2X7 Receptors: Channels, Pores and More

(2012) C. Volonte et al.   CNS & Neurological Disorders-Drug Targets

Ezrin/Radixin/Moesin Are Required for the Purinergic P2X7 Receptor (P2X7R)-dependent Processing of the Amyloid Precursor Protein

(2012) Amaria Darmellah et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

P2X7 Receptor-mediated Scavenger Activity of Mononuclear Phagocytes toward Non-opsonized Particles and Apoptotic Cells Is Inhibited by Serum Glycoproteins but Remains Active in Cerebrospinal Fluid

(2012) Ben J. Gu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

(2012) Michael T. Heneka et al.   NATURE

A new role for the P2X7 receptor: a scavenger receptor for bacteria and apoptotic cells in the absence of serum and extracellular ATP

(2012) James S. Wiley et al.   Purinergic Signalling

ATP release and purinergic signaling: a common pathway for particle-mediated inflammasome activation

(2012) N Riteau et al.   Cell Death & Disease

Opposite effects of P2X7 and P2Y2nucleotide receptors on α-secretase-dependent APP processing in Neuro-2a cells

(2011) Miriam León-Otegui et al.   FEBS LETTERS

Neurochemokines: a menage a trois providing new insights on the functions of chemokines in the central nervous system

(2011) William Rostène et al.   JOURNAL OF NEUROCHEMISTRY

Amyloid  -Induced Death in Neurons Involves Glial and Neuronal Hemichannels

(2011) J. A. Orellana et al.   JOURNAL OF NEUROSCIENCE

Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease

(2011) Adam C Naj et al.   NATURE GENETICS

Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease

(2011) Paul Hollingworth et al.   NATURE GENETICS

In vivo P2X7 inhibition reduces amyloid plaques in Alzheimer's disease through GSK3β and secretases

(2011) Juan Ignacio Diaz-Hernandez et al.   NEUROBIOLOGY OF AGING

Microglia activation triggers astrocyte-mediated modulation of excitatory neurotransmission

(2011) O. Pascual et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Purinergic Receptor P2X7 Triggers α-Secretase-dependent Processing of the Amyloid Precursor Protein

(2010) Cécile Delarasse et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of the Macrophage Inflammatory Protein-1α/CC Chemokine Receptor 5 Signaling Pathway in the Neuroinflammatory Response and Cognitive Deficits Induced by β-Amyloid Peptide

(2009) Giselle Fazzioni Passos et al.   AMERICAN JOURNAL OF PATHOLOGY

Altered P2X7-receptor level and function in mouse models of Huntington’s disease and therapeutic efficacy of antagonist administration

(2009) Miguel Díaz-Hernández et al.   FASEB JOURNAL

Activation of Microglia by Amyloid   Requires P2X7 Receptor Expression

(2009) J. M. Sanz et al.   JOURNAL OF IMMUNOLOGY

The P2X7 Receptor Drives Microglial Activation and Proliferation: A Trophic Role for P2X7R Pore

(2009) M. Monif et al.   JOURNAL OF NEUROSCIENCE

Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease

(2009) Jean-Charles Lambert et al.   NATURE GENETICS

Oligomeric amyloid   associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques

(2009) R. M. Koffie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

(2008) Annett Halle et al.   NATURE IMMUNOLOGY

Purinergic signalling and disorders of the central nervous system

(2008) Geoffrey Burnstock   NATURE REVIEWS DRUG DISCOVERY

Block of purinergic P2X7 receptor is neuroprotective in an animal model of Alzheimerʼs disease

(2008) Jae K. Ryu et al.   NEUROREPORT