Activation of P2X7 receptor and NLRP3 inflammasome assembly in hippocampal glial cells mediates chronic stress-induced depressive-like behaviors

Psychological Stress Activates the Inflammasome via Release of Adenosine Triphosphate and Stimulation of the Purinergic Type 2X7 Receptor

(2016) Masaaki Iwata et al.   BIOLOGICAL PSYCHIATRY

Effects of IL1B single nucleotide polymorphisms on depressive and anxiety symptoms are determined by severity and type of life stress

(2016) David Kovacs et al.   BRAIN BEHAVIOR AND IMMUNITY

NLRP3 inflammasome activation mediates estrogen deficiency-induced depression- and anxiety-like behavior and hippocampal inflammation in mice

(2016) Yongjun Xu et al.   BRAIN BEHAVIOR AND IMMUNITY

Chronic glucocorticoids exposure enhances neurodegeneration in the frontal cortex and hippocampus via NLRP-1 inflammasome activation in male mice

(2016) Wen Hu et al.   BRAIN BEHAVIOR AND IMMUNITY

Differential effects of stress on microglial cell activation in male and female medial prefrontal cortex

(2016) Justin L. Bollinger et al.   BRAIN BEHAVIOR AND IMMUNITY

Disease-Induced Neuroinflammation and Depression

(2016) Cristina Benatti et al.   CNS & Neurological Disorders-Drug Targets

Mental Health Comorbidity in MS: Depression, Anxiety, and Bipolar Disorder

(2016) Aaron P. Turner et al.   Current Neurology and Neuroscience Reports

Energy metabolism and inflammation in brain aging and Alzheimer’s disease

(2016) Fei Yin et al.   FREE RADICAL BIOLOGY AND MEDICINE

Differential expression of P2X7 receptor and IL-1β in nociceptive and neuropathic pain

(2016) Benjamin Luchting et al.   Journal of Neuroinflammation

Minocycline Suppresses NLRP3 Inflammasome Activation in Experimental Ischemic Stroke

(2016) Yunnan Lu et al.   NEUROIMMUNOMODULATION

Learned helplessness activates hippocampal microglia in rats: A potential target for the antidepressant imipramine

(2016) Masaaki Iwata et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Variations of ATP and its metabolites in the hippocampus of rats subjected to pilocarpine-induced temporal lobe epilepsy

(2016) Flávia Doná et al.   Purinergic Signalling

Activation of protein kinase A in the amygdala modulates anxiety-like behaviors in social defeat exposed mice

(2016) Liu Yang et al.   Molecular Brain

P2X7 Receptor Suppression Preserves Blood-Brain Barrier through Inhibiting RhoA Activation after Experimental Intracerebral Hemorrhage in Rats

(2016) Hengli Zhao et al.   Scientific Reports

Extracellular ATP enhances radiation-induced brain injury through microglial activation and paracrine signaling via P2X7 receptor

(2015) Pengfei Xu et al.   BRAIN BEHAVIOR AND IMMUNITY

NLRP3 Inflammasome Mediates Chronic Mild Stress-Induced Depression in Mice via Neuroinflammation

(2015) Y. Zhang et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

P2X7R blockade prevents NLRP3 inflammasome activation and brain injury in a rat model of intracerebral hemorrhage: involvement of peroxynitrite

(2015) Liang Feng et al.   Journal of Neuroinflammation

Microglia-Mediated Inflammation and Neurodegenerative Disease

(2015) Ling Xu et al.   MOLECULAR NEUROBIOLOGY

Alternatively activated microglia and macrophages in the central nervous system

(2015) Rafael Franco et al.   PROGRESS IN NEUROBIOLOGY

ATP-Induced IL-1β Specific Secretion: True Under Stringent Conditions

(2015) Monique Stoffels et al.   Frontiers in Immunology

Microglial NLRP3 inflammasome activation mediates IL-1β-related inflammation in prefrontal cortex of depressive rats

(2014) Ying Pan et al.   BRAIN BEHAVIOR AND IMMUNITY

NLRP3 Inflammasome: A New Target in Major Depressive Disorder

(2014) Elísabet Alcocer-Gómez et al.   CNS Neuroscience & Therapeutics

A review of the relationship between proinflammatory cytokines and major depressive disorder

(2014) Juan Joseph Young et al.   JOURNAL OF AFFECTIVE DISORDERS

A Key Role for Redox Signaling in Rapid P2X7 Receptor-Induced IL-1  Processing in Human Monocytes

(2014) J. Hewinson et al.   JOURNAL OF IMMUNOLOGY

P2X7 receptor: an emerging target in central nervous system diseases

(2014) Beáta Sperlágh et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

NLRP3 inflammasome contributes to inflammation after intracerebral hemorrhage

(2013) Qingyi Ma et al.   ANNALS OF NEUROLOGY

Electroacupuncture upregulates ERK signaling pathways and promotes adult hippocampal neural progenitors proliferation in a rat model of depression

(2013) Liu Yang et al.   BMC Complementary and Alternative Medicine

Involvement of Inflammasome Activation in Lipopolysaccharide-induced Mice Depressive-like Behaviors

(2013) Yi Zhang et al.   CNS Neuroscience & Therapeutics

P2X7 Receptor Antagonism Inhibits p38 Mitogen-Activated Protein Kinase Activation and Ameliorates Neuronal Apoptosis After Subarachnoid Hemorrhage in Rats

(2013) Sheng Chen et al.   CRITICAL CARE MEDICINE

Increased neocortical expression of the P2X7 receptor after status epilepticus and anticonvulsant effect of P2X7 receptor antagonist A-438079

(2013) Alba Jimenez-Pacheco et al.   EPILEPSIA

Can we switch microglia's phenotype to foster neuroprotection? Focus on multiple sclerosis

(2013) Debora Giunti et al.   IMMUNOLOGY

Astrocyte-derived ATP modulates depressive-like behaviors

(2013) Xiong Cao et al.   NATURE MEDICINE

P2X7R/cryopyrin inflammasome axis inhibition reduces neuroinflammation after SAH

(2013) Sheng Chen et al.   NEUROBIOLOGY OF DISEASE

Involvement of the spinal NALP1 inflammasome in neuropathic pain and aspirin-triggered-15-epi-lipoxin A4 induced analgesia

(2013) Q. Li et al.   NEUROSCIENCE

Quercetin suppress microglial neuroinflammatory response and induce antidepressent-like effect in olfactory bulbectomized rats

(2013) P. Rinwa et al.   NEUROSCIENCE

Clomipramine reverses hypoalgesia/hypoesthesia and improved depressive-like behaviors induced by inescapable shock in rats

(2013) Bing Li et al.   NEUROSCIENCE LETTERS

Neurochemical Changes in the Mouse Hippocampus Underlying the Antidepressant Effect of Genetic Deletion of P2X7 Receptors

(2013) Cecilia Csölle et al.   PLoS One

The inflammasome: Pathways linking psychological stress, depression, and systemic illnesses

(2012) Masaaki Iwata et al.   BRAIN BEHAVIOR AND IMMUNITY

Activation of the P2X7receptor induces migration of glial cells by inducing cathepsin B degradation of tissue inhibitor of metalloproteinase 1

(2012) Niamh Murphy et al.   JOURNAL OF NEUROCHEMISTRY

Prenatal stress causes alterations in the morphology of microglia and the inflammatory response of the hippocampus of adult female mice

(2012) Yolanda Diz-Chaves et al.   Journal of Neuroinflammation

The role of the innate immune system in psychiatric disorders

(2012) Kenneth A. Jones et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

P2 Receptors for Extracellular Nucleotides in the Central Nervous System: Role of P2X7 and P2Y2 Receptor Interactions in Neuroinflammation

(2012) Gary A. Weisman et al.   MOLECULAR NEUROBIOLOGY

NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

(2012) Michael T. Heneka et al.   NATURE

The Inflammasome NLRs in Immunity, Inflammation, and Associated Diseases

(2011) Beckley K. Davis et al.   Annual Review of Immunology

Neuroimmunological effects of physical exercise in depression

(2011) Harris Eyre et al.   BRAIN BEHAVIOR AND IMMUNITY

Evidence that Microglia Mediate the Neurobiological Effects of Chronic Psychological Stress on the Medial Prefrontal Cortex

(2011) M. Hinwood et al.   CEREBRAL CORTEX

Ecto-ATPase inhibition: ATP and adenosine release under physiological and ischemic in vivo conditions in the rat striatum

(2011) Alessia Melani et al.   EXPERIMENTAL NEUROLOGY

The inflammasome: an integrated view

(2011) Olaf Gross et al.   IMMUNOLOGICAL REVIEWS

P2X7 receptor activation ameliorates CA3 neuronal damage via a tumor necrosis factor-α-mediated pathway in the rat hippocampus following status epilepticus

(2011) Ji-Eun Kim et al.   Journal of Neuroinflammation

Comparison of Glucocorticoid Receptor and Ionized Calcium-Binding Adapter Molecule 1 Immunoreactivity in the Adult and Aged Gerbil Hippocampus Following Repeated Restraint Stress

(2011) Joon Ha Park et al.   NEUROCHEMICAL RESEARCH

Resilience and reduced c-Fos expression in P2X7 receptor knockout mice exposed to repeated forced swim test

(2011) A.A. Boucher et al.   NEUROSCIENCE

The Inflammasomes

(2010) Kate Schroder et al.   CELL

Molecular Mechanism of NLRP3 Inflammasome Activation

(2010) Chengcheng Jin et al.   JOURNAL OF CLINICAL IMMUNOLOGY

P2X7 receptor activation induces CXCL2 production in microglia through NFAT and PKC/MAPK pathways

(2010) Miho Shiratori et al.   JOURNAL OF NEUROCHEMISTRY

P2X7-Dependent Release of Interleukin-1  and Nociception in the Spinal Cord following Lipopolysaccharide

(2010) A. K. Clark et al.   JOURNAL OF NEUROSCIENCE

Depression: A repair response to stress-induced neuronal microdamage that can grade into a chronic neuroinflammatory condition?

(2010) Karen Wager-Smith et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Nuclear factor- B is a critical mediator of stress-impaired neurogenesis and depressive behavior

(2010) J. W. Koo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inflammation and Its Discontents: The Role of Cytokines in the Pathophysiology of Major Depression

(2009) Andrew H. Miller et al.   BIOLOGICAL PSYCHIATRY

The P2X7 Receptor Drives Microglial Activation and Proliferation: A Trophic Role for P2X7R Pore

(2009) M. Monif et al.   JOURNAL OF NEUROSCIENCE

Neuroinflammation in Parkinson's disease: Its role in neuronal death and implications for therapeutic intervention

(2009) Malú G. Tansey et al.   NEUROBIOLOGY OF DISEASE

Behavioral profile of P2X7 receptor knockout mice in animal models of depression and anxiety: Relevance for neuropsychiatric disorders

(2008) Ana M. Basso et al.   BEHAVIOURAL BRAIN RESEARCH

The inflammatory & neurodegenerative (I&ND) hypothesis of depression: leads for future research and new drug developments in depression

(2008) Michael Maes et al.   METABOLIC BRAIN DISEASE

ATP is released by monocytes stimulated with pathogen-sensing receptor ligands and induces IL-1  and IL-18 secretion in an autocrine way

(2008) A. Piccini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IL-1 is an essential mediator of the antineurogenic and anhedonic effects of stress

(2008) J. W. Koo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neurotransmitter, peptide and cytokine processes in relation to depressive disorder: Comorbidity between depression and neurodegenerative disorders

(2008) H ANISMAN et al.   PROGRESS IN NEUROBIOLOGY

The Dexamethasone/Corticotropin-Releasing Factor Test in Men with Major Depression: Role of Childhood Trauma

(2007) Christine Heim et al.   BIOLOGICAL PSYCHIATRY

In vitro and in vivo evidence for a role of the P2X7 receptor in the release of IL-1β in the murine brain

(2007) Rozenn Mingam et al.   BRAIN BEHAVIOR AND IMMUNITY