Purinergic receptors P2Y12R and P2X7R: potential targets for PET imaging of microglia phenotypes in multiple sclerosis

New Insights into the Role of IL-1β in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis

(2017) Chih-Chung Lin et al.   JOURNAL OF IMMUNOLOGY

The microglial ATP-gated ion channel P2X7 as a CNS drug target

(2016) Anindya Bhattacharya et al.   GLIA

P2Y12receptor is expressed on human microglia under physiological conditions throughout development and is sensitive to neuroinflammatory diseases

(2016) Alexander Mildner et al.   GLIA

Preclinical Evaluation of a P2X7 Receptor-Selective Radiotracer: PET Studies in a Rat Model with Local Overexpression of the Human P2X7 Receptor and in Nonhuman Primates

(2016) D. Ory et al.   JOURNAL OF NUCLEAR MEDICINE

Oral Presentations

(2015)   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Activation Status of Human Microglia Is Dependent on Lesion Formation Stage and Remyelination in Multiple Sclerosis

(2015) Laura A.N. Peferoen et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Imaging Microglial Activation with TSPO PET: Lighting Up Neurologic Diseases?

(2015) L. Vivash et al.   JOURNAL OF NUCLEAR MEDICINE

An update on immunopathogenesis, diagnosis, and treatment of multiple sclerosis

(2015) Neeta Garg et al.   Brain and Behavior

ATP as a multi-target danger signal in the brain

(2015) Ricardo J. Rodrigues et al.   Frontiers in Neuroscience

Microglia: unique and common features with other tissue macrophages

(2014) Marco Prinz et al.   ACTA NEUROPATHOLOGICA

Synthesis and initial preclinical evaluation of the P2X7receptor antagonist [11C]A-740003 as a novel tracer of neuroinflammation

(2014) Bieneke Janssen et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

The role of microglial activation in disease progression

(2014) Jorge Correale   Multiple Sclerosis Journal

Microglial Dynamics and Role in the Healthy and Diseased Brain

(2014) Diego Gomez-Nicola et al.   NEUROSCIENTIST

Can we switch microglia's phenotype to foster neuroprotection? Focus on multiple sclerosis

(2013) Debora Giunti et al.   IMMUNOLOGY

Macrophages in inflammatory multiple sclerosis lesions have an intermediate activation status

(2013) Daphne YS Vogel et al.   Journal of Neuroinflammation

Identification of a unique TGF-β–dependent molecular and functional signature in microglia

(2013) Oleg Butovsky et al.   NATURE NEUROSCIENCE

Physiology of Microglia

(2011) Helmut Kettenmann et al.   PHYSIOLOGICAL REVIEWS

Microglia dynamics and function in the CNS

(2010) Christopher N Parkhurst et al.   CURRENT OPINION IN NEUROBIOLOGY

Microglia: Proliferation and activation driven by the P2X7 receptor

(2010) Mastura Monif et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

P2X7-Dependent Release of Interleukin-1  and Nociception in the Spinal Cord following Lipopolysaccharide

(2010) A. K. Clark et al.   JOURNAL OF NEUROSCIENCE

Cellular localization of P2X7 receptor mRNA in the rat brain

(2008) Yong Yu et al.   BRAIN RESEARCH

Type II-activated macrophages suppress the development of experimental autoimmune encephalomyelitis

(2008) Joanna B Tierney et al.   IMMUNOLOGY AND CELL BIOLOGY