Pharmacological characterization of a novel centrally permeable P2X7 receptor antagonist: JNJ-47965567

Elevation of cerebrospinal fluid interleukin-1β in bipolar disorder

(2014) Johan Söderlund et al.   JOURNAL OF PSYCHIATRY & NEUROSCIENCE

Synthesis and Pharmacological Characterization of Two Novel, Brain Penetrating P2X7 Antagonists

(2013) Michael A. Letavic et al.   ACS Medicinal Chemistry Letters

The inflammasome: Pathways linking psychological stress, depression, and systemic illnesses

(2012) Masaaki Iwata et al.   BRAIN BEHAVIOR AND IMMUNITY

The role of glutamate release mediated by extrasynaptic P2X7 receptors in animal models of neuropathic pain

(2012) Rómeó D. Andó et al.   BRAIN RESEARCH BULLETIN

P2X7 Receptors: Channels, Pores and More

(2012) C. Volonte et al.   CNS & Neurological Disorders-Drug Targets

The absence of P2X7 receptors (P2rx7) on non-haematopoietic cells leads to selective alteration in mood-related behaviour with dysregulated gene expression and stress reactivity in mice

(2012) Cecilia Csölle et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Efficacy and Safety of CE-224,535, an Antagonist of P2X7 Receptor, in Treatment of Patients with Rheumatoid Arthritis Inadequately Controlled by Methotrexate

(2012) T. C. STOCK et al.   JOURNAL OF RHEUMATOLOGY

The role of the innate immune system in psychiatric disorders

(2012) Kenneth A. Jones et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Molecular mechanism of ATP binding and ion channel activation in P2X receptors

(2012) Motoyuki Hattori et al.   NATURE

Neuromodulation by Extracellular ATP and P2X Receptors in the CNS

(2012) Baljit S. Khakh et al.   NEURON

Inflammation in neurological and psychiatric diseases

(2012) Parto S. Khansari et al.   INFLAMMOPHARMACOLOGY

P2RX7 gene is associated consistently with mood disorders and predicts clinical outcome in three clinical cohorts

(2011) Pia Soronen et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Optimization of the physicochemical and pharmacokinetic attributes in a 6-azauracil series of P2X7 receptor antagonists leading to the discovery of the clinical candidate CE-224,535

(2011) Allen J. Duplantier et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Cognitive manic symptoms associated with the P2RX7 gene in bipolar disorder

(2011) Lena Backlund et al.   BIPOLAR DISORDERS

Guide to Receptors and Channels (GRAC), 5th edition

(2011) SPH Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Physiology, Pharmacology and Future of P2X7 as An Analgesic Drug Target: Hype or Promise?

(2011) Anindya Bhattacharya et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Adenosine and ATP Receptors in the Brain

(2011) Geoffrey Burnstock et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Seizure suppression and neuroprotection by targeting the purinergic P2X7 receptor during status epilepticus in mice

(2011) Tobias Engel et al.   FASEB JOURNAL

In vivo P2X7 inhibition reduces amyloid plaques in Alzheimer's disease through GSK3β and secretases

(2011) Juan Ignacio Diaz-Hernandez et al.   NEUROBIOLOGY OF AGING

Resilience and reduced c-Fos expression in P2X7 receptor knockout mice exposed to repeated forced swim test

(2011) A.A. Boucher et al.   NEUROSCIENCE

Activation and Regulation of Purinergic P2X Receptor Channels

(2011) C. Coddou et al.   PHARMACOLOGICAL REVIEWS

Purinergic signalling: From normal behaviour to pathological brain function

(2011) Geoffrey Burnstock et al.   PROGRESS IN NEUROBIOLOGY

Elusive equilibrium: the challenge of interpreting receptor pharmacology using calcium assays

(2010) Steven J Charlton et al.   BRITISH JOURNAL OF PHARMACOLOGY

Receptor localization, native tissue binding and ex vivo occupancy for centrally penetrant P2X7 antagonists in the rat

(2010) SL Able et al.   BRITISH JOURNAL OF PHARMACOLOGY

Guidelines for reporting experiments involving animals: the ARRIVE guidelines

(2010) JC McGrath et al.   BRITISH JOURNAL OF PHARMACOLOGY

Animal research: Reporting in vivo experiments: The ARRIVE guidelines

(2010) Carol Kilkenny et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cathepsin S release from primary cultured microglia is regulated by the P2X7 receptor

(2010) Anna K. Clark et al.   GLIA

P2X7 receptor activation induces CXCL2 production in microglia through NFAT and PKC/MAPK pathways

(2010) Miho Shiratori et al.   JOURNAL OF NEUROCHEMISTRY

New structure enlivens interest in P2X receptors

(2010) Liam E. Browne et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

P2RX7: A bipolar and unipolar disorder candidate susceptibility gene?

(2009) Elaine K. Green et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Variation inP2RX7candidate gene (rs2230912) is not associated with bipolar I disorder and unipolar major depression in four European samples

(2009) Maria Grigoroiu-Serbanescu et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Mechanism of action of species-selective P2X7 receptor antagonists

(2009) Anton D Michel et al.   BRITISH JOURNAL OF PHARMACOLOGY

Mammalian P2X7 receptor pharmacology: comparison of recombinant mouse, rat and human P2X7 receptors

(2009) Diana L Donnelly-Roberts et al.   BRITISH JOURNAL OF PHARMACOLOGY

A potential role for pro-inflammatory cytokines in regulating synaptic plasticity in major depressive disorder

(2009) Rushaniya A. Khairova et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Antagonists of the P2X7Receptor. From Lead Identification to Drug Development

(2009) Simon D. Guile et al.   JOURNAL OF MEDICINAL CHEMISTRY

Peripheral origin of IL-1β production in the rodent hippocampus under in vivo systemic bacterial lipopolysaccharide (LPS) challenge and its regulation by P2X7 receptors

(2009) C. Csölle et al.   JOURNAL OF NEUROIMMUNOLOGY

Increased excitotoxicity and neuroinflammatory markers in postmortem frontal cortex from bipolar disorder patients

(2009) J S Rao et al.   MOLECULAR PSYCHIATRY

Interleukin-1 receptor null mutant mice show decreased anxiety-like behavior and enhanced fear memory

(2009) Ja Wook Koo et al.   NEUROSCIENCE LETTERS

Association between depression and the Gln460Arg polymorphism of P2RX7 Gene: A dimensional approach

(2008) Krisztina Hejjas et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Signaling at Purinergic P2X Receptors

(2008) Annmarie Surprenant et al.   Annual Review of Physiology

Behavioral profile of P2X7 receptor knockout mice in animal models of depression and anxiety: Relevance for neuropsychiatric disorders

(2008) Ana M. Basso et al.   BEHAVIOURAL BRAIN RESEARCH

P2x7 deficiency suppresses development of experimental autoimmune encephalomyelitis

(2008) Anthony J Sharp et al.   Journal of Neuroinflammation

Case–control studies show that a non-conservative amino-acid change from a glutamine to arginine in the P2RX7 purinergic receptor protein is associated with both bipolar- and unipolar-affective disorders

(2008) A McQuillin et al.   MOLECULAR PSYCHIATRY

Purinergic signalling and disorders of the central nervous system

(2008) Geoffrey Burnstock   NATURE REVIEWS DRUG DISCOVERY

[3H]A-804598 ([3H]2-cyano-1-[(1S)-1-phenylethyl]-3-quinolin-5-ylguanidine) is a novel, potent, and selective antagonist radioligand for P2X7 receptors

(2008) Diana L. Donnelly-Roberts et al.   NEUROPHARMACOLOGY

IL-1 is an essential mediator of the antineurogenic and anhedonic effects of stress

(2008) J. W. Koo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Purinergic signalling in the nervous system: an overview

(2008) Maria P. Abbracchio et al.   TRENDS IN NEUROSCIENCES