Natural genetic variation determines microglia heterogeneity in wild-derived mouse models of Alzheimer’s disease

Novel Alzheimer risk genes determine the microglia response to amyloid‐β but not to TAU pathology

(2020) Annerieke Sierksma et al.   EMBO Molecular Medicine

Impaired Innate Immunity Mechanisms in the Brain of Alzheimer’s Disease

(2020) Martina Romagnoli et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Staging Alzheimer’s Disease in the Brain and Retina of B6.APP/PS1 Mice by Transcriptional Profiling

(2020) Sumana R. Chintapaludi et al.   JOURNAL OF ALZHEIMERS DISEASE

Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer’s disease

(2020) Yingyue Zhou et al.   NATURE MEDICINE

Type I interferon response drives neuroinflammation and synapse loss in Alzheimer disease

(2020) Ethan R. Roy et al.   JOURNAL OF CLINICAL INVESTIGATION

Large-scale proteomic analysis of Alzheimer’s disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation

(2020) Erik C. B. Johnson et al.   NATURE MEDICINE

Do infections have a role in the pathogenesis of Alzheimer disease?

(2020) Ruth F. Itzhaki et al.   Nature Reviews Neurology

The innate immunity protein IFITM3 modulates γ-secretase in Alzheimer’s disease

(2020) Ji-Yeun Hur et al.   NATURE

Single-Nucleus RNA-Seq Is Not Suitable for Detection of Microglial Activation Genes in Humans

(2020) Nicola Thrupp et al.   Cell Reports

Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer’s disease risk

(2019) Iris E. Jansen et al.   NATURE GENETICS

Integrative single-cell analysis

(2019) Tim Stuart et al.   NATURE REVIEWS GENETICS

Microglia in Alzheimer's Disease: Exploring How Genetics and Phenotype Influence Risk

(2019) Amanda McQuade et al.   JOURNAL OF MOLECULAR BIOLOGY

Single-cell transcriptomic analysis of Alzheimer’s disease

(2019) Hansruedi Mathys et al.   NATURE

The Major Risk Factors for Alzheimer’s Disease: Age, Sex, and Genes Modulate the Microglia Response to Aβ Plaques

(2019) Carlo Sala Frigerio et al.   Cell Reports

Enhancing face validity of mouse models of Alzheimer’s disease with natural genetic variation

(2019) Kristen D. Onos et al.   PLoS Genetics

IFITM3 protects the heart during influenza virus infection

(2019) Adam D. Kenney et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transcriptome profiling of brain myeloid cells revealed activation of Itgal, Trem1, and Spp1 in western diet-induced obesity

(2019) Hongtian Yang et al.   Journal of Neuroinflammation

A Bayesian mixture model for the analysis of allelic expression in single cells

(2019) Kwangbom Choi et al.   Nature Communications

Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer’s disease model

(2019) Elizabeth Spangenberg et al.   Nature Communications

Cross-Species Single-Cell Analysis Reveals Divergence of the Primate Microglia Program

(2019) Laufey Geirsdottir et al.   CELL

Cerebral amyloid angiopathy and Alzheimer disease — one peptide, two pathways

(2019) Steven M. Greenberg et al.   Nature Reviews Neurology

Linking APOE-ε4, blood-brain barrier dysfunction, and inflammation to Alzheimer's pathology

(2019) Joost M. Riphagen et al.   NEUROBIOLOGY OF AGING

Reduced central and peripheral inflammatory responses and increased mitochondrial activity contribute to diet-induced obesity resistance in WSB/EiJ mice

(2019) Jérémy Terrien et al.   Scientific Reports

Hierarchical analysis of RNA-seq reads improves the accuracy of allele-specific expression

(2018) Narayanan Raghupathy et al.   BIOINFORMATICS

Identification and therapeutic modulation of a pro-inflammatory subset of disease-associated-microglia in Alzheimer’s disease

(2018) Srikant Rangaraju et al.   Molecular Neurodegeneration

Integrating single-cell transcriptomic data across different conditions, technologies, and species

(2018) Andrew Butler et al.   NATURE BIOTECHNOLOGY

A transcriptomic atlas of aged human microglia

(2018) Marta Olah et al.   Nature Communications

Diverse Brain Myeloid Expression Profiles Reveal Distinct Microglial Activation States and Aspects of Alzheimer’s Disease Not Evident in Mouse Models

(2018) Brad A. Friedman et al.   Cell Reports

Microglial translational profiling reveals a convergent APOE pathway from aging, amyloid, and tau

(2018) Silvia S. Kang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Microglial signatures and their role in health and disease

(2018) Oleg Butovsky et al.   NATURE REVIEWS NEUROSCIENCE

OUP accepted manuscript

(2018)   NUCLEIC ACIDS RESEARCH

Innate immune alterations are elicited in microglial cells before plaque deposition in the Alzheimer’s disease mouse model 5xFAD

(2018) Antonio Boza-Serrano et al.   Scientific Reports

Microglia in Alzheimer's Disease: A Role for Ion Channels

(2018) Laura Thei et al.   Frontiers in Neuroscience

Single-Cell RNA Sequencing of Microglia throughout the Mouse Lifespan and in the Injured Brain Reveals Complex Cell-State Changes

(2018) Timothy R. Hammond et al.   IMMUNITY

Modulation of Immune Responses to Herpes Simplex Virus Type 1 by IFNL3 and IRF7 Polymorphisms: A Study in Alzheimer’s Disease

(2017) Andrea Saul Costa et al.   JOURNAL OF ALZHEIMERS DISEASE

Detecting Activated Cell Populations Using Single-Cell RNA-Seq

(2017) Ye Emily Wu et al.   NEURON

An environment-dependent transcriptional network specifies human microglia identity

(2017) David Gosselin et al.   SCIENCE

Influenza H3N2 infection of the collaborative cross founder strains reveals highly divergent host responses and identifies a unique phenotype in CAST/EiJ mice

(2016) Sarah R. Leist et al.   BMC GENOMICS

Purinergic receptor P2RY12-dependent microglial closure of the injured blood–brain barrier

(2016) Nanhong Lou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

destiny: diffusion maps for large-scale single-cell data in R

(2015) Philipp Angerer et al.   BIOINFORMATICS

NPD1-mediated stereoselective regulation of BIRC3 expression through cREL is decisive for neural cell survival

(2015) J M Calandria et al.   CELL DEATH AND DIFFERENTIATION

Neutralization of TNFSF10 ameliorates functional outcome in a murine model of Alzheimer’s disease

(2014) Giuseppina Cantarella et al.   BRAIN

Calcium ion influx in microglial cells: Physiological and therapeutic significance

(2014) Purnima Sharma et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Microglial Dynamics and Role in the Healthy and Diseased Brain

(2014) Diego Gomez-Nicola et al.   NEUROSCIENTIST

Clustering of transcriptional profiles identifies changes to insulin signaling as an early event in a mouse model of Alzheimer’s disease

(2013) Harriet M Jackson et al.   BMC GENOMICS

Lethal Monkeypox Virus Infection of CAST/EiJ Mice Is Associated with a Deficient Gamma Interferon Response

(2012) P. L. Earl et al.   JOURNAL OF VIROLOGY

Differential expression analysis of multifactor RNA-Seq experiments with respect to biological variation

(2012) Davis J. McCarthy et al.   NUCLEIC ACIDS RESEARCH

Dysfunction of TGF-β1 signaling in Alzheimer’s disease: perspectives for neuroprotection

(2011) Filippo Caraci et al.   CELL AND TISSUE RESEARCH

Enhancement of Reactive Oxygen Species Production and Chlamydial Infection by the Mitochondrial Nod-like Family Member NLRX1

(2010) Ali A. Abdul-Sater et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

Ultrafast and memory-efficient alignment of short DNA sequences to the human genome

(2009) Ben Langmead et al.   GENOME BIOLOGY