Two haplotypes of the P2X7 receptor containing the Ala-348 to Thr polymorphism exhibit a gain-of-function effect and enhanced interleukin-1β secretion

P2RX7: A bipolar and unipolar disorder candidate susceptibility gene?

(2009) Elaine K. Green et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Variation inP2RX7candidate gene (rs2230912) is not associated with bipolar I disorder and unipolar major depression in four European samples

(2009) Maria Grigoroiu-Serbanescu et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

A Functional P2X7 Splice Variant with an Alternative Transmembrane Domain 1 Escapes Gene Inactivation in P2X7 Knock-out Mice

(2009) Annette Nicke et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Single nucleotide polymorphisms that were identified in affective mood disorders affect ATP-activated P2X7 receptor functions

(2009) Sébastien Roger et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Crystal structure of the ATP-gated P2X4 ion channel in the closed state

(2009) Toshimitsu Kawate et al.   NATURE

The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis

(2009) Luigi Franchi et al.   NATURE IMMUNOLOGY

Identification and characterization of a novel variant of the human P2X7 receptor resulting in gain of function

(2009) Chengqun Sun et al.   Purinergic Signalling

Genetics of the P2X7 receptor and human disease

(2009) Stephen J. Fuller et al.   Purinergic Signalling

Behavioral profile of P2X7 receptor knockout mice in animal models of depression and anxiety: Relevance for neuropsychiatric disorders

(2008) Ana M. Basso et al.   BEHAVIOURAL BRAIN RESEARCH

P2x7 deficiency suppresses development of experimental autoimmune encephalomyelitis

(2008) Anthony J Sharp et al.   Journal of Neuroinflammation

Case–control studies show that a non-conservative amino-acid change from a glutamine to arginine in the P2RX7 purinergic receptor protein is associated with both bipolar- and unipolar-affective disorders

(2008) A McQuillin et al.   MOLECULAR PSYCHIATRY

Gating the pore of P2X receptor channels

(2008) Mufeng Li et al.   NATURE NEUROSCIENCE

ATP is released by monocytes stimulated with pathogen-sensing receptor ligands and induces IL-1  and IL-18 secretion in an autocrine way

(2008) A. Piccini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

P2RX7 Gln460Arg polymorphism is associated with depression among diabetic patients

(2008) Geza Nagy et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Primer: inflammasomes and interleukin 1β in inflammatory disorders

(2008) Leigh D Church et al.   Nature clinical practice. Rheumatology

From inflammation to sickness and depression: when the immune system subjugates the brain

(2007) Robert Dantzer et al.   NATURE REVIEWS NEUROSCIENCE