[11C]JNJ54173717, a novel P2X7 receptor radioligand as marker for neuroinflammation: human biodistribution, dosimetry, brain kinetic modelling and quantification of brain P2X7 receptors in patients with Parkinson’s disease and healthy volunteers

PET Imaging of the P2X7 Ion Channel with a Novel Tracer [18F]JNJ-64413739 in a Rat Model of Neuroinflammation

(2019) Tamara Berdyyeva et al.   MOLECULAR IMAGING AND BIOLOGY

Synthesis and preliminary biological evaluation of a novel P2X7R radioligand [ 18 F]IUR-1601

(2018) Mingzhang Gao et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and in vitro characterization of a P2X7 radioligand [ 123 I]TZ6019 and its response to neuroinflammation in a mouse model of Alzheimer disease

(2018) Hongjun Jin et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

[11C]PK11195 binding in Alzheimer disease and progressive supranuclear palsy

(2018) Luca Passamonti et al.   NEUROLOGY

An Inflammation-Centric View of Neurological Disease: Beyond the Neuron

(2018) Stephen D. Skaper et al.   Frontiers in Cellular Neuroscience

Identification of the allosteric P2X7 receptor antagonist [11C]SMW139 as a PET tracer of microglial activation

(2018) Bieneke Janssen et al.   Scientific Reports

18F-JNJ-64413739, a novel PET ligand for the P2X7 ion channel: radiation dosimetry, kinetic modeling, test-retest variability and occupancy of the P2X7 antagonist JNJ-54175446

(2018) Michel Koole et al.   JOURNAL OF NUCLEAR MEDICINE

Synthesis and initial in vitro characterization of a new P2X7R radioligand [18F]IUR-1602

(2018) Mingzhang Gao et al.   APPLIED RADIATION AND ISOTOPES

Molecular Targets for PET Imaging of Activated Microglia: The Current Situation and Future Expectations

(2017) Claire Tronel et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Microglial activation in Parkinson’s disease using [18F]-FEPPA

(2017) Christine Ghadery et al.   Journal of Neuroinflammation

P2X7 receptor antagonism in amyotrophic lateral sclerosis

(2017) Ronald Sluyter et al.   Neural Regeneration Research

Pharmacologic characterizations of a P2X7 receptor-specific radioligand, [11C]GSK1482160 for neuroinflammatory response

(2017) Junbin Han et al.   NUCLEAR MEDICINE COMMUNICATIONS

Design, synthesis and evaluation in an LPS rodent model of neuroinflammation of a novel 18F-labelled PET tracer targeting P2X7

(2017) Enrico Raffaele Fantoni et al.   EJNMMI Research

Extrastriatal spreading of microglial activation in Parkinson’s disease: a positron emission tomography study

(2016) Tatsuhiro Terada et al.   ANNALS OF NUCLEAR MEDICINE

Neuroinflammation in Synucleinopathies

(2016) Somin Lim et al.   BRAIN PATHOLOGY

BRCA Testing by Single-Molecule Molecular Inversion Probes

(2016) Kornelia Neveling et al.   CLINICAL CHEMISTRY

The microglial ATP-gated ion channel P2X7 as a CNS drug target

(2016) Anindya Bhattacharya et al.   GLIA

Cerebral glucose metabolism and cognition in newly diagnosed Parkinson's disease: ICICLE-PD study

(2016) M J Firbank et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Preclinical Evaluation of a P2X7 Receptor-Selective Radiotracer: PET Studies in a Rat Model with Local Overexpression of the Human P2X7 Receptor and in Nonhuman Primates

(2016) D. Ory et al.   JOURNAL OF NUCLEAR MEDICINE

Characterization of 11 C-GSK1482160 for Targeting the P2X7 Receptor as a Biomarker for Neuroinflammation

(2016) Paul R. Territo et al.   JOURNAL OF NUCLEAR MEDICINE

Inhibiting purinergic P2X7 receptors with the antagonist brilliant blue G is neuroprotective in an intranigral lipopolysaccharide animal model of Parkinson's disease

(2016) Xin-Hong Wang et al.   Molecular Medicine Reports

The role of P2X7 receptors in a rodent PCP-induced schizophrenia model

(2016) Bence Koványi et al.   Scientific Reports

Synthesis of [11C]GSK1482160 as a new PET agent for targeting P2X7 receptor

(2015) Mingzhang Gao et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Effect of the myeloperoxidase inhibitor AZD3241 on microglia: a PET study in Parkinson’s disease

(2015) Aurelija Jucaite et al.   BRAIN

Mechanism of microglia neuroprotection: Involvement of P2X7, TNFα, and valproic acid

(2015) Annette Masuch et al.   GLIA

Imaging Striatal Microglial Activation in Patients with Parkinson’s Disease

(2015) Yuko Koshimori et al.   PLoS One

Synthesis and initial preclinical evaluation of the P2X7receptor antagonist [11C]A-740003 as a novel tracer of neuroinflammation

(2014) Bieneke Janssen et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Brilliant Blue G improves cognition in an animal model of Alzheimer’s disease and inhibits amyloid-β-induced loss of filopodia and dendrite spines in hippocampal neurons

(2014) X. Chen et al.   NEUROSCIENCE

Ablation of P2X7 receptor exacerbates gliosis and motoneuron death in the SOD1-G93A mouse model of amyotrophic lateral sclerosis

(2013) S. Apolloni et al.   HUMAN MOLECULAR GENETICS

Diffusion-weighted imaging and its relationship to microglial activation in parkinsonian syndromes

(2013) Christopher Kobylecki et al.   PARKINSONISM & RELATED DISORDERS

Suggested pathway to assess radiation safety of 11C-labeled PET tracers for first-in-human studies

(2011) Paolo Zanotti-Fregonara et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Lack of neuroprotection in the absence of P2X7 receptors in toxin-induced animal models of Parkinson's disease

(2011) Zsuzsanna Hracskó et al.   Molecular Neurodegeneration

In vivo P2X7 inhibition reduces amyloid plaques in Alzheimer's disease through GSK3β and secretases

(2011) Juan Ignacio Diaz-Hernandez et al.   NEUROBIOLOGY OF AGING

Receptor localization, native tissue binding and ex vivo occupancy for centrally penetrant P2X7 antagonists in the rat

(2010) SL Able et al.   BRITISH JOURNAL OF PHARMACOLOGY

Microglia: Proliferation and activation driven by the P2X7 receptor

(2010) Mastura Monif et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Systematic review of levodopa dose equivalency reporting in Parkinson's disease

(2010) Claire L. Tomlinson et al.   MOVEMENT DISORDERS

Minocycline 1-year therapy in multiple-system-atrophy: Effect on clinical symptoms and [11C](R)-PK11195 PET (MEMSA-trial)

(2009) Richard Dodel et al.   MOVEMENT DISORDERS

[11C]-PK11195 PET: Quantification of neuroinflammation and a monitor of anti-inflammatory treatment in Parkinson's disease?

(2009) A.L. Bartels et al.   PARKINSONISM & RELATED DISORDERS

Genetics of the P2X7 receptor and human disease

(2009) Stephen J. Fuller et al.   Purinergic Signalling