ROR: Nuclear Receptor for Melatonin or Not?

RORα Regulates Odontoblastic Differentiation and Mediates the Pro-Odontogenic Effect of Melatonin on Dental Papilla Cells

(2021) Jun Kang et al.   MOLECULES

Melatonin relieves sepsis-induced myocardial injury via regulating JAK2/STAT3 signaling pathway

(2021) Genshen ZHEN et al.   MINERVA MEDICA

MicroRNA-7, synergizes with RORα, negatively controls the pathology of brain tissue inflammation

(2020) Dongxu Yue et al.   Journal of Neuroinflammation

SIRT1 Mediates Melatonin’s Effects on Microglial Activation in Hypoxia: In Vitro and In Vivo Evidence

(2020) Sara Merlo et al.   Biomolecules

Hepatic stellate cells promote the progression of hepatocellular carcinoma through microRNA-1246-RORα-Wnt/β-Catenin axis

(2020) Jin-Long Huang et al.   CANCER LETTERS

Nuclear Receptor Coactivators (NCOAs) and Corepressors (NCORs) in the Brain

(2020) Zheng Sun et al.   ENDOCRINOLOGY

Melatonin inhibits apoptosis in mouse Leydig cells via the retinoic acid-related orphan nuclear receptor α/p53 pathway

(2020) Zhiqiang Li et al.   LIFE SCIENCES

Global Knockdown of Retinoid-related Orphan Receptor α in Mature Purkinje Cells Reveals Aberrant Cerebellar Phenotypes of Spinocerebellar Ataxia

(2020) Hiroyuki Yasui et al.   NEUROSCIENCE

Transcriptional Regulators of T Helper 17 Cell Differentiation in Health and Autoimmune Diseases

(2020) Alessia Capone et al.   Frontiers in Immunology

Orphan nuclear receptor RORγ confers doxorubicin resistance in prostate cancer

(2020) Menghan Gao et al.   CELL BIOLOGY INTERNATIONAL

Melatonin prevents endothelial dysfunction in SLE by activating the nuclear receptor retinoic acid-related orphan receptor-α

(2020) Huijing Huang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Melatonin mediates monochromatic light–induced proliferation of T/B lymphocytes in the spleen via the membrane receptor or nuclear receptor

(2020) Juanjuan Xiong et al.   POULTRY SCIENCE

Melatonin Act as an Antidepressant via Attenuation of Neuroinflammation by Targeting Sirt1/Nrf2/HO-1 Signaling

(2020) Tahir Ali et al.   Frontiers in Molecular Neuroscience

RORα Regulates Cholesterol Metabolism of CD8+ T Cells for Anticancer Immunity

(2020) In Kyu Lee et al.   Cancers

Melatonin and urological cancers: a new therapeutic approach

(2020) Mohammad Hossein Pourhanifeh et al.   Cancer Cell International

ROR agonist hampers the proliferation and survival of postactivated CD8 + T cells through the downregulation of cholesterol synthesis‐related genes

(2020) Zimeng Cai et al.   IMMUNOLOGY AND CELL BIOLOGY

Melatonin ameliorates methamphetamine-induced cognitive impairments by inhibiting neuroinflammation via suppression of the TLR4/MyD88/NFκB signaling pathway in the mouse hippocampus

(2020) Thit Lwin et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Cortical RORβ is required for layer 4 transcriptional identity and barrel integrity

(2020) Erin A Clark et al.   eLife

Pharmacological modulation of RORα controls fat browning, adaptive thermogenesis, and body weight in mice

(2020) Martine Auclair et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Melatonin Ameliorates Inflammation and Oxidative Stress by Suppressing the p38MAPK Signaling Pathway in LPS-Induced Sheep Orchitis

(2020) Shou-Long Deng et al.   Antioxidants

Melatonin derivatives combat with inflammation-related cancer by targeting the Main Culprit STAT3

(2020) Shumeng Ma et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Digoxin, an Overlooked Agonist of RORγ/RORγT

(2019) Kaja Karaś et al.   Frontiers in Pharmacology

Activation of Melatonin Receptor 2 But Not Melatonin Receptor 1 Mediates Melatonin‐conferred Cardio‐protection Against Myocardial Ischemia/Reperfusion Injury

(2019) Dong Han et al.   JOURNAL OF PINEAL RESEARCH

A maresin 1/RORα/12-lipoxygenase autoregulatory circuit prevents inflammation and progression of nonalcoholic steatohepatitis

(2019) Yong-Hyun Han et al.   JOURNAL OF CLINICAL INVESTIGATION

The orphan nuclear receptor RORα is a potential endogenous protector in renal ischemia/reperfusion injury

(2019) Jieru Cai et al.   FASEB JOURNAL

N-Terminal Domain Mediated Regulation of RORα1 Inhibits Invasive Growth in Prostate Cancer

(2019) Su Park et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Melatonin differentially regulates pathological and physiological cardiac hypertrophy: Crucial role of circadian nuclear receptor RORα signaling

(2019) Longwei Xu et al.   JOURNAL OF PINEAL RESEARCH

Melatonin stabilizes rupture‐prone vulnerable plaques via regulating macrophage polarization in a nuclear circadian receptor RORα‐dependent manner

(2019) Song Ding et al.   JOURNAL OF PINEAL RESEARCH

Estradiol-induced RORα expression positively regulates osteoblast differentiation

(2019) Hyeon-Young Min et al.   STEROIDS

Modulating PKCα Activity to Target Wnt/β-Catenin Signaling in Colon Cancer

(2019) Sébastien Dupasquier et al.   Cancers

ROR alpha protects against LPS-induced inflammation by down-regulating SIRT1/NF-kappa B pathway

(2019) Shichao Han et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

(Inverse) Agonists of Retinoic Acid–Related Orphan Receptor γ: Regulation of Immune Responses, Inflammation, and Autoimmune Disease

(2019) Anton M. Jetten et al.   Annual Review of Pharmacology and Toxicology

RORα suppresses interleukin-6-mediated hepatic acute phase response

(2019) Ju-Yeon Kim et al.   Scientific Reports

Retinoic Acid Receptor-Related Receptor Alpha Ameliorates Autoimmune Arthritis via Inhibiting of Th17 Cells and Osteoclastogenesis

(2019) Jin-Sil Park et al.   Frontiers in Immunology

Melatonin Target Proteins: Too Many or Not Enough?

(2019) Lei Liu et al.   Frontiers in Endocrinology

Effect of melatonin on T/B cell activation and immune regulation in pinealectomy mice

(2019) Jianhua Luo et al.   LIFE SCIENCES

Melatonin Suppresses Estrogen Deficiency-Induced Osteoporosis and Promotes Osteoblastogenesis by Inactivating the NLRP3 Inflammasome

(2018) Lijun Xu et al.   CALCIFIED TISSUE INTERNATIONAL

A cellular and molecular view of T helper 17 cell plasticity in autoimmunity

(2018) Ralph Stadhouders et al.   JOURNAL OF AUTOIMMUNITY

Melatonin attenuates osteosarcoma cell invasion by suppression of C-C motif chemokine ligand 24 through inhibition of the c-Jun N-terminal kinase pathway

(2018) Ko-Hsiu Lu et al.   JOURNAL OF PINEAL RESEARCH

Melatonin modulates dysregulated circadian clocks in mice with diethylnitrosamine-induced hepatocellular carcinoma

(2018) Diana I. Sánchez et al.   JOURNAL OF PINEAL RESEARCH

Melatonin prevents Drp1-mediated mitochondrial fission in diabetic hearts through SIRT1-PGC1α pathway

(2018) Mingge Ding et al.   JOURNAL OF PINEAL RESEARCH

Melatonin Attenuates Dysregulation of the Circadian Clock Pathway in Mice With CCl4-Induced Fibrosis and Human Hepatic Stellate Cells

(2018) Bárbara González-Fernández et al.   Frontiers in Pharmacology

Retinoic Acid Receptor-Related Orphan Receptors: Critical Roles in Tumorigenesis

(2018) Jinshuo Fan et al.   Frontiers in Immunology

Melatonin Mitigates Mitochondrial Meltdown: Interactions with SIRT3

(2018) Russel Reiter et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Melatonin and inflammation - story of a double-edged blade

(2018) Rüdiger Hardeland   JOURNAL OF PINEAL RESEARCH

miR-219a-5p Regulates Rorβ During Osteoblast Differentiation and in Age-related Bone Loss

(2018) Ruben Aquino-Martinez et al.   JOURNAL OF BONE AND MINERAL RESEARCH

SUMOylation of ROR-γt inhibits IL-17 expression and inflammation via HDAC2

(2018) Amir Kumar Singh et al.   Nature Communications

MicroRNA-transcription factor network analysis reveals miRNAs cooperatively suppress RORA in oral squamous cell carcinoma

(2018) Xueqing Zheng et al.   Oncogenesis

Osteoprotection Through the Deletion of the Transcription Factor Rorβ in Mice

(2017) Joshua N Farr et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Topical ROR Inverse Agonists Suppress Inflammation in Mouse Models of Atopic Dermatitis and Acute Irritant Dermatitis

(2017) Jun Dai et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Lamina propria group 2 innate lymphoid cells impair the antibacterial defense of burned mice to enterococcal translocation

(2017) Ichiaki Ito et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Novel protective role of the circadian nuclear receptor retinoic acid-related orphan receptor-α in diabetic cardiomyopathy

(2017) Yichao Zhao et al.   JOURNAL OF PINEAL RESEARCH

Up-regulated NRIP2 in colorectal cancer initiating cells modulates the Wnt pathway by targeting RORβ

(2017) Zhenzhen Wen et al.   Molecular Cancer

Reversing SKI–SMAD4-mediated suppression is essential for TH17 cell differentiation

(2017) Song Zhang et al.   NATURE

Melatonin up-regulates the expression of the GATA-4 transcription factor and increases testosterone secretion from Leydig cells through RORα signaling in an in vitro goat spermatogonial stem cell differentiation culture system

(2017) Shou-Long Deng et al.   Oncotarget

Melatonin Suppresses Neuropathic Pain via MT2-Dependent and -Independent Pathways in Dorsal Root Ganglia Neurons of Mice

(2017) Jia-Ji Lin et al.   Theranostics

Inhibition of the Nuclear Receptor RORγ and Interleukin-17A Suppresses Neovascular RetinopathyHighlights

(2016) Dean M. Talia et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Anti-inflammatory effects of melatonin in multiple sclerosis

(2016) Mauricio F. Farez et al.   BIOESSAYS

Digoxin reduces atherosclerosis in apolipoprotein E-deficient mice

(2016) Huairui Shi et al.   BRITISH JOURNAL OF PHARMACOLOGY

Loss of function of the retinoid-related nuclear receptor (RORB) gene and epilepsy

(2016) Gabrielle Rudolf et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Melatonin inhibits MMP-9 transactivation and renal cell carcinoma metastasis by suppressing Akt-MAPKs pathway and NF-κB DNA-binding activity

(2016) Yung-Wei Lin et al.   JOURNAL OF PINEAL RESEARCH

The nuclear melatonin receptor RORαis a novel endogenous defender against myocardial ischemia/reperfusion injury

(2016) Ben He et al.   JOURNAL OF PINEAL RESEARCH

Itch inhibits IL-17-mediated colon inflammation and tumorigenesis by ROR-γt ubiquitination

(2016) Mahesh Kathania et al.   NATURE IMMUNOLOGY

Circadian regulation of lipid metabolism

(2016) Joshua J Gooley   PROCEEDINGS OF THE NUTRITION SOCIETY

Melatonin downregulates nuclear receptor RZR/RORγ expression causing growth-inhibitory and anti-angiogenesis activity in human gastric cancer cells in vitro and in vivo

(2016) Ri-Xiong Wang et al.   Oncology Letters

Melatonin Contributes to the Seasonality of Multiple Sclerosis Relapses

(2015) Mauricio F. Farez et al.   CELL

ROR Inverse Agonist Suppresses Insulitis and Prevents Hyperglycemia in a Mouse Model of Type 1 Diabetes

(2015) Laura A. Solt et al.   ENDOCRINOLOGY

Group 3 innate lymphoid cells (ILC3s): Origin, differentiation, and plasticity in humans and mice

(2015) Elisa Montaldo et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Disruption of the NF-κB/NLRP3 connection by melatonin requires retinoid-related orphan receptor-α and blocks the septic response in mice

(2015) José A. García et al.   FASEB JOURNAL

Digoxin ameliorates autoimmune arthritis via suppression of Th17 differentiation

(2015) Jennifer Lee et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Retinoic acid-related orphan receptor RORβ, circadian rhythm abnormalities and tumorigenesis (Review)

(2015) SHUJIONG FENG et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Melatonin suppresses activation of hepatic stellate cells through RORα-mediated inhibition of 5-lipoxygenase

(2015) Shiva Shajari et al.   JOURNAL OF PINEAL RESEARCH

Inter-relationships of the chronobiotic, melatonin, with leptin and adiponectin: implications for obesity

(2015) Karolina Szewczyk-Golec et al.   JOURNAL OF PINEAL RESEARCH

ROR nuclear receptors: structures, related diseases and drug discovery

(2014) Yan Zhang et al.   ACTA PHARMACOLOGICA SINICA

Nuclear Receptors, RXR, and the Big Bang

(2014) Ronald M. Evans et al.   CELL

Inhibiting RORγt/Th17 axis for autoimmune disorders

(2014) Fujio Isono et al.   DRUG DISCOVERY TODAY

RORα and ROR γ are expressed in human skin and serve as receptors for endogenously produced noncalcemic 20-hydroxy- and 20,23-dihydroxyvitamin D

(2014) Andrzej T. Slominski et al.   FASEB JOURNAL

Feedback Induction of a Photoreceptor-specific Isoform of Retinoid-related Orphan Nuclear Receptor β by the Rod Transcription Factor NRL

(2014) Yulong Fu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Melatonin treatment induces interplay of apoptosis, autophagy, and senescence in human colorectal cancer cells

(2014) Yunkyung Hong et al.   JOURNAL OF PINEAL RESEARCH

Association of Nocturnal Melatonin Secretion With Insulin Resistance in Nondiabetic Young Women

(2013) C. J. McMullan et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

SIRT1 Mediates Central Circadian Control in the SCN by a Mechanism that Decays with Aging

(2013) Hung-Chun Chang et al.   CELL

An isoform of retinoid-related orphan receptor β directs differentiation of retinal amacrine and horizontal interneurons

(2013) Hong Liu et al.   Nature Communications

Pharmacologic Repression of Retinoic Acid Receptor-Related Orphan Nuclear Receptor γ Is Therapeutic in the Collagen-Induced Arthritis Experimental Model

(2013) Mi Ra Chang et al.   Arthritis & Rheumatology

A novel microdeletion syndrome at 9q21.13 characterised by mental retardation, speech delay, epilepsy and characteristic facial features

(2012) Elise Boudry-Labis et al.   European Journal of Medical Genetics

Melatonin influences proliferation and differentiation of rat dental papilla cells in vitro and dentine formation in vivo by altering mitochondrial activity

(2012) Jie Liu et al.   JOURNAL OF PINEAL RESEARCH

Melatonin membrane receptors in peripheral tissues: Distribution and functions

(2012) Radomir M. Slominski et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

A new perspective in Oral health: Potential importance and actions of melatonin receptors MT1, MT2, MT3, and RZR/ROR in the oral cavity

(2011) Antonio Cutando et al.   ARCHIVES OF ORAL BIOLOGY

Adipogenesis and insulin sensitivity in obesity are regulated by retinoid-related orphan receptor gamma

(2011) Bettina Meissburger et al.   EMBO Molecular Medicine

Ursolic Acid Suppresses Interleukin-17 (IL-17) Production by Selectively Antagonizing the Function of RORγt Protein

(2011) Tao Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Basis of Digoxin That Antagonizes RORγt Receptor Activity and Suppresses Th17 Cell Differentiation and Interleukin (IL)-17 Production

(2011) Saori Fujita-Sato et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Melatonin synthesized by T lymphocytes as a ligand of the retinoic acid-related orphan receptor

(2011) Patricia J. Lardone et al.   JOURNAL OF PINEAL RESEARCH

Retinoid-related orphan receptor alpha and the regulation of lipid homeostasis

(2011) Rebecca L. Fitzsimmons et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand

(2011) Laura A. Solt et al.   NATURE

Ligand regulation of retinoic acid receptor-related orphan receptors: implications for development of novel therapeutics

(2010) Laura A Solt et al.   CURRENT OPINION IN LIPIDOLOGY

Structural Basis for Hydroxycholesterols as Natural Ligands of Orphan Nuclear Receptor RORγ

(2010) Lihua Jin et al.   MOLECULAR ENDOCRINOLOGY

Modulation of Retinoic Acid Receptor-related Orphan Receptor α and γ Activity by 7-Oxygenated Sterol Ligands

(2009) Yongjun Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Benzenesulfoamide T0901317 [N-(2,2,2-Trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-benzenesulfonamide] Is a Novel Retinoic Acid Receptor-Related Orphan Receptor- /  Inverse Agonist

(2009) N. Kumar et al.   MOLECULAR PHARMACOLOGY

Transcriptional Activation of HIF-1 by RORα and its Role in Hypoxia Signaling

(2008) Eun-Jin Kim et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Melatonin as a major skin protectant: from free radical scavenging to DNA damage repair

(2008) Tobias W. Fischer et al.   EXPERIMENTAL DERMATOLOGY