Melatonin Attenuates Dysregulation of the Circadian Clock Pathway in Mice With CCl4-Induced Fibrosis and Human Hepatic Stellate Cells

The hepatic BMAL1/AKT/lipogenesis axis protects against alcoholic liver disease in mice via promoting PPARα pathway

(2018) Deqiang Zhang et al.   HEPATOLOGY

CLOCK phosphorylation by AKT regulates its nuclear accumulation and circadian gene expression in peripheral tissues

(2018) Amelia K. Luciano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sphingosine 1-Phosphate Signaling as a Target in Hepatic Fibrosis Therapy

(2017) Bárbara González-Fernández et al.   Frontiers in Pharmacology

Inhibition of the SphK1/S1P signaling pathway by melatonin in mice with liver fibrosis and human hepatic stellate cells

(2016) Bárbara González-Fernández et al.   BIOFACTORS

Elafibranor, an Agonist of the Peroxisome Proliferator−Activated Receptor−α and −δ, Induces Resolution of Nonalcoholic Steatohepatitis Without Fibrosis Worsening

(2016) Vlad Ratziu et al.   GASTROENTEROLOGY

Rev-erb agonist and TGF-β similarly affect autophagy but differentially regulate hepatic stellate cell fibrogenic phenotype

(2016) Paul G. Thomes et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Evolving roles of circadian rhythms in liver homeostasis and pathology

(2016) Dexi Zhou et al.   Oncotarget

Anti-proliferative actions of a synthetic REV-ERBα/β agonist in breast cancer cells

(2015) Yongjun Wang et al.   BIOCHEMICAL PHARMACOLOGY

PPARα gene expression correlates with severity and histological treatment response in patients with non-alcoholic steatohepatitis

(2015) Sven Francque et al.   JOURNAL OF HEPATOLOGY

Melatonin suppresses activation of hepatic stellate cells through RORα-mediated inhibition of 5-lipoxygenase

(2015) Shiva Shajari et al.   JOURNAL OF PINEAL RESEARCH

Melatonin inhibits autophagy and endoplasmic reticulum stress in mice with carbon tetrachloride-induced fibrosis

(2015) Beatriz San-Miguel et al.   JOURNAL OF PINEAL RESEARCH

Discrete functions of nuclear receptor Rev-erb  couple metabolism to the clock

(2015) Y. Zhang et al.   SCIENCE

Deficiency of NOX1 or NOX4 Prevents Liver Inflammation and Fibrosis in Mice through Inhibition of Hepatic Stellate Cell Activation

(2015) Tian Lan et al.   PLoS One

Bioinformatics analysis of transcriptional regulation of circadian genes in rat liver

(2014) Tung T Nguyen et al.   BMC BIOINFORMATICS

The circadian clock regulates rhythmic activation of the NRF2/glutathione-mediated antioxidant defense pathway to modulate pulmonary fibrosis

(2014) V. Pekovic-Vaughan et al.   GENES & DEVELOPMENT

Novel role of nuclear receptor rev-erbα in hepatic stellate cell activation: Potential therapeutic target for liver injury

(2014) Ting Li et al.   HEPATOLOGY

Circadian Clock Proteins and Immunity

(2014) Anne M. Curtis et al.   IMMUNITY

PPARs Integrate the Mammalian Clock and Energy Metabolism

(2014) Lihong Chen et al.   PPAR Research

Hepatic PPARs: Their Role in Liver Physiology, Fibrosis and Treatment

(2013) E. Zardi et al.   CURRENT MEDICINAL CHEMISTRY

Deletion of clock gene Per2 exacerbates cholestatic liver injury and fibrosis in mice

(2012) Peng Chen et al.   EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY

Melatonin attenuates inflammation and promotes regeneration in rabbits with fulminant hepatitis of viral origin

(2012) Almudena Laliena et al.   JOURNAL OF PINEAL RESEARCH

Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists

(2012) Laura A. Solt et al.   NATURE

Divergent Roles of Clock Genes in Retinal and Suprachiasmatic Nucleus Circadian Oscillators

(2012) Guo-Xiang Ruan et al.   PLoS One

Melatonin and Associated Signaling Pathways that Control Normal Breast Epithelium and Breast Cancer

(2011) Steven M. Hill et al.   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

Melatonin modulation of intracellular signaling pathways in hepatocarcinoma HepG2 cell line: role of the MT1 receptor

(2011) Sara Carbajo-Pescador et al.   JOURNAL OF PINEAL RESEARCH

The Mammalian Circadian Timing System: Organization and Coordination of Central and Peripheral Clocks

(2010) Charna Dibner et al.   Annual Review of Physiology

Altered circadian rhythm of the clock genes in fibrotic livers induced by carbon tetrachloride

(2010) Peng Chen et al.   FEBS LETTERS

Loss of clock gene mPer2 promotes liver fibrosis induced by carbon tetrachloride

(2010) Peng Chen et al.   HEPATOLOGY RESEARCH

Melatonin prevents the decreased activity of antioxidant enzymes and activates nuclear erythroid 2-related factor 2 signaling in an animal model of fulminant hepatic failure of viral origin

(2010) Irene Crespo et al.   JOURNAL OF PINEAL RESEARCH

Circadian modulation of hepatic transcriptome in transgenic rats expressing human growth hormone

(2010) Jun Hirao et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

Quercetin Administration Ameliorates Pulmonary Complications of Cirrhosis in Rats

(2009) Juliana Tieppo et al.   JOURNAL OF NUTRITION

The Protective Role of Per2 Against Carbon Tetrachloride-Induced Hepatotoxicity

(2008) Peng Chen et al.   AMERICAN JOURNAL OF PATHOLOGY