Retinoic Acid Receptor-Related Orphan Receptors: Critical Roles in Tumorigenesis

On the role of classical and novel forms of vitamin D in melanoma progression and management

(2018) Andrzej T. Slominski et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Novel protective role of the circadian nuclear receptor retinoic acid-related orphan receptor-α in diabetic cardiomyopathy

(2017) Yichao Zhao et al.   JOURNAL OF PINEAL RESEARCH

Endogenously produced nonclassical vitamin D hydroxy-metabolites act as “biased” agonists on VDR and inverse agonists on RORα and RORγ

(2017) Andrzej T. Slominski et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Vitamin D signaling and melanoma: role of vitamin D and its receptors in melanoma progression and management

(2017) Andrzej T Slominski et al.   LABORATORY INVESTIGATION

Up-regulated NRIP2 in colorectal cancer initiating cells modulates the Wnt pathway by targeting RORβ

(2017) Zhenzhen Wen et al.   Molecular Cancer

RORα controls hepatic lipid homeostasis via negative regulation of PPARγ transcriptional network

(2017) Kyeongkyu Kim et al.   Nature Communications

Characterization of a new pathway that activates lumisterol in vivo to biologically active hydroxylumisterols

(2017) Andrzej T. Slominski et al.   Scientific Reports

Retinoid-related orphan receptor γ (RORγ) adult induced knockout mice develop lymphoblastic lymphoma

(2016) Maria Liljevald et al.   AUTOIMMUNITY REVIEWS

RORα is not a receptor for melatonin (response to DOI 10.1002/bies.201600018)

(2016) Andrzej T. Slominski et al.   BIOESSAYS

Itch inhibits IL-17-mediated colon inflammation and tumorigenesis by ROR-γt ubiquitination

(2016) Mahesh Kathania et al.   NATURE IMMUNOLOGY

Erratum: Corrigendum: ROR-γ drives androgen receptor expression and represents a therapeutic target in castration-resistant prostate cancer

(2016) Junjian Wang et al.   NATURE MEDICINE

Melanin content in melanoma metastases affects the outcome of radiotherapy

(2016) Anna A. Brożyna et al.   Oncotarget

RORα and RORγ expression inversely correlates with human melanoma progression

(2016) Anna A. Brożyna et al.   Oncotarget

Synthetic RORγ agonists regulate multiple pathways to enhance antitumor immunity

(2016) Xiao Hu et al.   OncoImmunology

The Nuclear Receptor, RORγ, Regulates Pathways Necessary for Breast Cancer Metastasis

(2016) Tae Gyu Oh et al.   EBioMedicine

The existence of Th22, pure Th17 and Th1 cells in CIN and Cervical Cancer along with their frequency variation in different stages of cervical cancer

(2015) Wenjing Zhang et al.   BMC CANCER

RORC1 Regulates Tumor-Promoting “Emergency” Granulo-Monocytopoiesis

(2015) Laura Strauss et al.   CANCER CELL

Batf-dependent Th17 cells critically regulate IL-23 driven colitis-associated colon cancer

(2015) Elise Punkenburg et al.   GUT

Retinoic acid-related orphan receptor alpha reprograms glucose metabolism in glutamine-deficient hepatoma cells

(2015) Jun-Kyu Byun et al.   HEPATOLOGY

Disturbed Th17/Treg Balance in Patients with Non-small Cell Lung Cancer

(2015) Min-Chao Duan et al.   INFLAMMATION

The Expression Levels of Transcription Factors T-bet, GATA-3, RORγt and FOXP3 in Peripheral Blood Lymphocyte (PBL) of Patients with Liver Cancer and their Significance

(2015) Ze-Wei Lin et al.   International Journal of Medical Sciences

Retinoic acid-related orphan receptor C isoform 2 expression and its prognostic significance for non-small cell lung cancer

(2015) Qi Huang et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Melatonin suppresses activation of hepatic stellate cells through RORα-mediated inhibition of 5-lipoxygenase

(2015) Shiva Shajari et al.   JOURNAL OF PINEAL RESEARCH

Decreased IL-27 Negatively Correlated with Th17 Cells in Non-Small-Cell Lung Cancer Patients

(2015) Minchao Duan et al.   MEDIATORS OF INFLAMMATION

Isoflavones enhance interleukin-17 gene expression via retinoic acid receptor-related orphan receptors α and γ

(2015) Hiroyuki Kojima et al.   TOXICOLOGY

Elevated Th22 as well as Th17 cells associated with therapeutic outcome and clinical stage are potential targets in patients with multiple myeloma

(2015) Min Wang et al.   Oncotarget

Human ectonucleotidase-expressing CD25highTh17 cells accumulate in breast cancer tumors and exert immunosuppressive functions

(2015) Marion Thibaudin et al.   OncoImmunology

Detection and significance of TregFoxP3+ and Th17 cells in peripheral blood of non-small cell lung cancer patients

(2014) Sha Li et al.   Archives of Medical Science

FOXP3 and CTLA4 overexpression in multiple myeloma bone marrow as a sign of accumulation of CD4+ T regulatory cells

(2014) Walter Moises Tobias Braga et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

RORα and ROR γ are expressed in human skin and serve as receptors for endogenously produced noncalcemic 20-hydroxy- and 20,23-dihydroxyvitamin D

(2014) Andrzej T. Slominski et al.   FASEB JOURNAL

The Alteration and Clinical Significance of Th1/Th2/Th17/Treg Cells in Patients with Multiple Myeloma

(2014) Ping Feng et al.   INFLAMMATION

PRMT2 and RORγ Expression Are Associated With Breast Cancer Survival Outcomes

(2014) Tae Gyu Oh et al.   MOLECULAR ENDOCRINOLOGY

REV-ERB and ROR nuclear receptors as drug targets

(2014) Douglas J. Kojetin et al.   NATURE REVIEWS DRUG DISCOVERY

Increased expression of the Th17-IL-6R/pSTAT3/BATF/RorγT-axis in the tumoural region of adenocarcinoma as compared to squamous cell carcinoma of the lung

(2014) Ljubov Balabko et al.   Scientific Reports

Enrichment of regulatory T cells in invasive breast tumor correlates with the upregulation of IL-17A expression and invasiveness of the tumor

(2013) Luciana Benevides et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Gene expression signatures of primary and metastatic uterine leiomyosarcoma

(2013) Ben Davidson et al.   HUMAN PATHOLOGY

Microarray analyses reveal liver metastasis-related genes in metastatic colorectal cancer cell model

(2013) Qiang Chen et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Imbalance in the Th17/Treg and cytokine environment in peripheral blood of patients with adenocarcinoma and squamous cell carcinoma

(2013) Lei Zhao et al.   MEDICAL ONCOLOGY

The Retinoid-Related Orphan Receptor RORα Promotes Keratinocyte Differentiation via FOXN1

(2013) Jun Dai et al.   PLoS One

Pharmacologic Repression of Retinoic Acid Receptor-Related Orphan Nuclear Receptor γ Is Therapeutic in the Collagen-Induced Arthritis Experimental Model

(2013) Mi Ra Chang et al.   Arthritis & Rheumatology

Retinoic acid-related orphan receptors α and γ: key regulators of lipid/glucose metabolism, inflammation, and insulin sensitivity

(2013) Anton M. Jetten et al.   Frontiers in Endocrinology

ROR  Suppresses Breast Tumor Invasion by Inducing SEMA3F Expression

(2012) G. Xiong et al.   CANCER RESEARCH

RORα, a Potential Tumor Suppressor and Therapeutic Target of Breast Cancer

(2012) Jun Du et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Nuclear receptors in regenerating liver and hepatocellular carcinoma

(2012) Michele Vacca et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Regulation of the Human Hydroxysteroid Sulfotransferase (SULT2A1) by RORα and RORγ and Its Potential Relevance to Human Liver Diseases

(2012) Zhimin Ou et al.   MOLECULAR ENDOCRINOLOGY

Robust tumor immunity to melanoma mediated by interleukin-9–producing T cells

(2012) Rahul Purwar et al.   NATURE MEDICINE

RORγ directly regulates the circadian expression of clock genes and downstream targets in vivo

(2012) Yukimasa Takeda et al.   NUCLEIC ACIDS RESEARCH

Regulation of p53 Stability and Apoptosis by a ROR Agonist

(2012) Yongjun Wang et al.   PLoS One

Expression of ROR t Marks a Pathogenic Regulatory T Cell Subset in Human Colon Cancer

(2012) N. R. Blatner et al.   Science Translational Medicine

Th17 and Th17-stimulated CD8+ T cells play a distinct role in Th17-induced preventive and therapeutic antitumor immunity

(2011) Manjunatha Ankathatti Munegowda et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

The orphan nuclear receptor EAR2 is overexpressed in colorectal cancer and it regulates survivability of colon cancer cells

(2011) Xue-bing Li et al.   CANCER LETTERS

The dual role of TLR3 in metastatic cell line

(2011) Tanja Matijevic et al.   CLINICAL & EXPERIMENTAL METASTASIS

The molecular pathogenesis of STAT3-driven gastric tumourigenesis in mice is independent of IL-17

(2011) Catherine L Kennedy et al.   JOURNAL OF PATHOLOGY

Melatonin synthesized by T lymphocytes as a ligand of the retinoic acid-related orphan receptor

(2011) Patricia J. Lardone et al.   JOURNAL OF PINEAL RESEARCH

Gender-related invasion differences associated with mRNA expression levels of melatonin membrane receptors in colorectal cancer

(2011) Josefa León et al.   MOLECULAR CARCINOGENESIS

Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand

(2011) Laura A. Solt et al.   NATURE

Retinoic acid-related orphan receptor γ directly regulates neuronal PAS domain protein 2 transcription in vivo

(2011) Yukimasa Takeda et al.   NUCLEIC ACIDS RESEARCH

Ligand regulation of retinoic acid receptor-related orphan receptors: implications for development of novel therapeutics

(2010) Laura A Solt et al.   CURRENT OPINION IN LIPIDOLOGY

Foxp3+ IL-17+ T cells promote development of cancer-initiating cells in colorectal cancer

(2010) Shaobo Yang et al.   JOURNAL OF LEUKOCYTE BIOLOGY

RORα Attenuates Wnt/β-Catenin Signaling by PKCα-Dependent Phosphorylation in Colon Cancer

(2010) Ji Min Lee et al.   MOLECULAR CELL

Activation of Aromatase Expression by Retinoic Acid Receptor-related Orphan Receptor (ROR) α in Breast Cancer Cells

(2009) Hiroki Odawara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY