Melatonin differentially regulates pathological and physiological cardiac hypertrophy: Crucial role of circadian nuclear receptor RORα signaling

GDF11 Decreases Pressure Overload–Induced Hypertrophy, but Can Cause Severe Cachexia and Premature Death

(2019) Shavonn C. Harper et al.   CIRCULATION RESEARCH

Melatonin stabilizes rupture‐prone vulnerable plaques via regulating macrophage polarization in a nuclear circadian receptor RORα‐dependent manner

(2019) Song Ding et al.   JOURNAL OF PINEAL RESEARCH

Protective role of melatonin in cardiac ischemia-reperfusion injury: From pathogenesis to targeted therapy

(2018) Hao Zhou et al.   JOURNAL OF PINEAL RESEARCH

Novel protective role of the circadian nuclear receptor retinoic acid-related orphan receptor-α in diabetic cardiomyopathy

(2017) Yichao Zhao et al.   JOURNAL OF PINEAL RESEARCH

Melatonin protects against the pathological cardiac hypertrophy induced by transverse aortic constriction through activating PGC-1β: In vivo and in vitro studies

(2017) Mengen Zhai et al.   JOURNAL OF PINEAL RESEARCH

Melatonin protects against diabetic cardiomyopathy through Mst1/Sirt3 signaling

(2017) Mingming Zhang et al.   JOURNAL OF PINEAL RESEARCH

Novel Protective Role for Ubiquitin-Specific Protease 18 in Pathological Cardiac RemodelingNovelty and Significance

(2016) Xiaoying Ying et al.   HYPERTENSION

Ubiquitin-Specific Protease 4 Is an Endogenous Negative Regulator of Pathological Cardiac HypertrophyNovelty and Significance

(2016) Ben He et al.   HYPERTENSION

The nuclear melatonin receptor RORαis a novel endogenous defender against myocardial ischemia/reperfusion injury

(2016) Ben He et al.   JOURNAL OF PINEAL RESEARCH

The long noncoding RNA Chaer defines an epigenetic checkpoint in cardiac hypertrophy

(2016) Zhihua Wang et al.   NATURE MEDICINE

YiXin-Shu, a ShengMai-San-based traditional Chinese medicine formula, attenuates myocardial ischemia/reperfusion injury by suppressing mitochondrial mediated apoptosis and upregulating liver-X-receptor α

(2016) Yichao Zhao et al.   Scientific Reports

Vitamin D Receptor Activation Protects Against Myocardial Reperfusion Injury Through Inhibition of Apoptosis and Modulation of Autophagy

(2015) Tianbao Yao et al.   ANTIOXIDANTS & REDOX SIGNALING

Differential Role of G Protein-Coupled Receptor Kinase 5 in Physiological Versus Pathological Cardiac Hypertrophy

(2015) Christopher J Traynham et al.   CIRCULATION RESEARCH

Disruption of the NF-κB/NLRP3 connection by melatonin requires retinoid-related orphan receptor-α and blocks the septic response in mice

(2015) José A. García et al.   FASEB JOURNAL

Liver X receptor agonist treatment attenuates cardiac dysfunction in type 2 diabetic db/db mice

(2014) Qing He et al.   Cardiovascular Diabetology

Cardiac CaM Kinase II Genes δ and γ Contribute to Adverse Remodeling but Redundantly Inhibit Calcineurin-Induced Myocardial Hypertrophy

(2014) Michael M. Kreusser et al.   CIRCULATION

Loss of MicroRNA-155 Protects the Heart From Pathological Cardiac Hypertrophy

(2014) Hee Young Seok et al.   CIRCULATION RESEARCH

RORα suppresses proliferation of vascular smooth muscle cells through activation of AMP-activated protein kinase

(2014) Eun-Jin Kim et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Mitochondrial reactive oxygen species production and respiratory complex activity in rats with pressure overload-induced heart failure

(2014) Michael Schwarzer et al.   JOURNAL OF PHYSIOLOGY-LONDON

Melatonin treatment induces interplay of apoptosis, autophagy, and senescence in human colorectal cancer cells

(2014) Yunkyung Hong et al.   JOURNAL OF PINEAL RESEARCH

REV-ERB and ROR nuclear receptors as drug targets

(2014) Douglas J. Kojetin et al.   NATURE REVIEWS DRUG DISCOVERY

Abnormal Calcium Handling Properties Underlie Familial Hypertrophic Cardiomyopathy Pathology in Patient-Specific Induced Pluripotent Stem Cells

(2013) Feng Lan et al.   Cell Stem Cell

Solving the Cardiac Hypertrophy Riddle

(2013) Daniela Zablocki et al.   CIRCULATION RESEARCH

Antifibrotic effect of melatonin—Perspective protection in hypertensive heart disease

(2013) Fedor Simko et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Signaling effectors underlying pathologic growth and remodeling of the heart

(2013) Jop H. van Berlo et al.   JOURNAL OF CLINICAL INVESTIGATION

Cardiomyocyte-expressed farnesoid-X-receptor is a novel apoptosis mediator and contributes to myocardial ischaemia/reperfusion injury

(2012) Jun Pu et al.   EUROPEAN HEART JOURNAL

Anti-apoptotic and pro-survival effects of exercise training on hypertensive hearts

(2011) Chih-Yang Huang et al.   JOURNAL OF APPLIED PHYSIOLOGY

Reverse remodeling in heart failure—mechanisms and therapeutic opportunities

(2011) Norimichi Koitabashi et al.   Nature Reviews Cardiology

Molecular Pathways Underlying Cardiac Remodeling During Pathophysiological Stimulation

(2010) Izhak Kehat et al.   CIRCULATION

A Novel and Efficient Model of Coronary Artery Ligation and Myocardial Infarction in the Mouse

(2010) Erhe Gao et al.   CIRCULATION RESEARCH

Molecular distinction between physiological and pathological cardiac hypertrophy: Experimental findings and therapeutic strategies

(2010) Bianca C. Bernardo et al.   PHARMACOLOGY & THERAPEUTICS

Melatonin—A pleiotropic, orchestrating regulator molecule

(2010) Rüdiger Hardeland et al.   PROGRESS IN NEUROBIOLOGY

AMP-Activated Protein Kinase Deficiency Enhances Myocardial Ischemia/Reperfusion Injury but Has Minimal Effect on the Antioxidant/Antinitrative Protection of Adiponectin

(2009) Yajing Wang et al.   CIRCULATION

Favorable effects of a prolonged treatment with melatonin on the level of oxidative damage and neurodegeneration in senescence-accelerated mice

(2008) Beatriz Caballero et al.   JOURNAL OF PINEAL RESEARCH