Melatonin inhibits MMP-9 transactivation and renal cell carcinoma metastasis by suppressing Akt-MAPKs pathway and NF-κB DNA-binding activity

HDAC1 inhibition by melatonin leads to suppression of lung adenocarcinoma cells via induction of oxidative stress and activation of apoptotic pathways

(2015) Chongxi Fan et al.   JOURNAL OF PINEAL RESEARCH

Melatonin: an ancient molecule that makes oxygen metabolically tolerable

(2015) Lucien C. Manchester et al.   JOURNAL OF PINEAL RESEARCH

Upregulation of miR-328 and inhibition of CREB-DNA-binding activity are critical for resveratrol-mediated suppression of matrix metalloproteinase-2 and subsequent metastatic ability in human osteosarcomas

(2015) Shun-Fa Yang et al.   Oncotarget

Extrapineal melatonin: sources, regulation, and potential functions

(2014) Darío Acuña-Castroviejo et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Imbalance between MMP-2, 9 and TIMP-1 promote the invasion and metastasis of renal cell carcinoma via SKP2 signaling pathways

(2014) Hongsheng Lu et al.   TUMOR BIOLOGY

Molecular mechanisms of the pro-apoptotic actions of melatonin in cancer: a review

(2013) Mariano Bizzarri et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Inhibition of matrix metalloproteinase-9 and nuclear factor kappa B contribute to melatonin prevention of motility and invasiveness in HepG2 liver cancer cells

(2013) Raquel Ordoñez et al.   JOURNAL OF PINEAL RESEARCH

Expression of tissue levels of matrix metalloproteinases and tissue inhibitors of metalloproteinases in renal cell carcinoma

(2013) Zhen-kui Qiao et al.   World Journal of Surgical Oncology

The efficacy and safety of melatonin in concurrent chemotherapy or radiotherapy for solid tumors: a meta-analysis of randomized controlled trials

(2012) Ye-min Wang et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Melatonin suppresses migration and invasion via inhibition of oxidative stress pathway in glioma cells

(2012) Juntao Wang et al.   JOURNAL OF PINEAL RESEARCH

Melatonin inhibits matrix metalloproteinase-9 activity by binding to its active site

(2012) Deep Sankar Rudra et al.   JOURNAL OF PINEAL RESEARCH

Histological classification of malignant renal tumours at a time of major diagnostic and therapeutic changes

(2012) E. Compérat et al.   Diagnostic and Interventional Imaging

An Alternate Perspective on the Roles of TIMPs and MMPs in Pathology

(2011) Craig S. Moore et al.   AMERICAN JOURNAL OF PATHOLOGY

Basic Mechanisms Involved in the Anti-Cancer Effects of Melatonin

(2011) M. D. Mediavilla et al.   CURRENT MEDICINAL CHEMISTRY

Metastatic function of BMP-2 in gastric cancer cells: The role of PI3K/AKT, MAPK, the NF-κB pathway, and MMP-9 expression

(2011) Myoung Hee Kang et al.   EXPERIMENTAL CELL RESEARCH

Melatonin modulation of intracellular signaling pathways in hepatocarcinoma HepG2 cell line: role of the MT1 receptor

(2011) Sara Carbajo-Pescador et al.   JOURNAL OF PINEAL RESEARCH

Cancer Statistics, 2010

(2010) A. Jemal et al.   CA-A CANCER JOURNAL FOR CLINICIANS

H3K9 Histone Methyltransferase G9a Promotes Lung Cancer Invasion and Metastasis by Silencing the Cell Adhesion Molecule Ep-CAM

(2010) M.-W. Chen et al.   CANCER RESEARCH

Melatonin induces pro-apoptotic signaling pathway in human pancreatic carcinoma cells (PANC-1)

(2010) Anna Leja-Szpak et al.   JOURNAL OF PINEAL RESEARCH

Melittin suppresses PMA-induced tumor cell invasion by inhibiting NF-κB and AP-1-dependent MMP-9 expression

(2010) Jung Hyun Park et al.   MOLECULES AND CELLS

Vascular cell adhesion molecule-1 expression in human intestinal microvascular endothelial cells is regulated by PI 3-kinase/Akt/MAPK/NF-κB: inhibitory role of curcumin

(2009) David G. Binion et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Renal cell carcinoma

(2009) Brian I Rini et al.   LANCET

Matrix Metalloproteinase-9 gene induction by a truncated oncogenic NF-κB2 protein involves the recruitment of MLL1 and MLL2 H3K4 histone methyltransferase complexes

(2009) I Robert et al.   ONCOGENE

Function of Akt/PKB signaling to cell motility, invasion and the tumor stroma in cancer

(2008) Y. Rebecca Chin et al.   CELLULAR SIGNALLING

ROCK-regulated cytoskeletal dynamics participate in the inhibitory effect of melatonin on cancer cell migration

(2008) Leonardo Ortíz-López et al.   JOURNAL OF PINEAL RESEARCH