Digoxin, an Overlooked Agonist of RORγ/RORγT

The cardenolides strophanthidin, digoxigenin and dihydroouabain act as activators of the human RORγ/RORγT receptors

(2018) Kaja Karaś et al.   TOXICOLOGY LETTERS

Digoxin Attenuates Murine Experimental Colitis by Downregulating Th17-related Cytokines

(2017) Shinya Tani et al.   INFLAMMATORY BOWEL DISEASES

Structural studies unravel the active conformation of apo RORγt nuclear receptor and a common inverse agonism of two diverse classes of RORγt inhibitors

(2017) Xiang Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differentiation stage-specific effect of histone deacetylase inhibitors on the expression of RORγT in human lymphocytes

(2017) Anna Sałkowska et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Salmon provides fast and bias-aware quantification of transcript expression

(2017) Rob Patro et al.   NATURE METHODS

Plant-derived cardiac glycosides: Role in heart ailments and cancer management

(2016) Seema Patel   BIOMEDICINE & PHARMACOTHERAPY

Digoxin reduces atherosclerosis in apolipoprotein E-deficient mice

(2016) Huairui Shi et al.   BRITISH JOURNAL OF PHARMACOLOGY

Expression of human gene coding RORγT receptor depends on the Sp2 transcription factor

(2016) Marcin Ratajewski et al.   JOURNAL OF LEUKOCYTE BIOLOGY

OUP accepted manuscript

(2016)   NUCLEIC ACIDS RESEARCH

PANTHER version 11: expanded annotation data from Gene Ontology and Reactome pathways, and data analysis tool enhancements

(2016) Huaiyu Mi et al.   NUCLEIC ACIDS RESEARCH

Isoflavones enhance interleukin-17 gene expression via retinoic acid receptor-related orphan receptors α and γ

(2015) Hiroyuki Kojima et al.   TOXICOLOGY

Endogenous Digitalis-Like Factors: An Overview of the History

(2015) Vardaman M. Buckalew   Frontiers in Endocrinology

Why isn't endogenous ouabain more widely accepted?

(2014) Mordecai P. Blaustein   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Small-Molecule RORγt Antagonists Inhibit T Helper 17 Cell Transcriptional Network by Divergent Mechanisms

(2014) Sheng Xiao et al.   IMMUNITY

Retinoic Acid-Related Orphan Receptor γ (RORγ): A Novel Participant in the Diurnal Regulation of Hepatic Gluconeogenesis and Insulin Sensitivity

(2014) Yukimasa Takeda et al.   PLoS Genetics

Th17 Cells in Cancer: The Ultimate Identity Crisis

(2014) Stefanie R. Bailey et al.   Frontiers in Immunology

The role of the IL-23/IL-17 axis in the pathogenesis of Graves^|^rsquo; disease

(2013) Li Zheng et al.   ENDOCRINE JOURNAL

Digoxin Attenuates Acute Cardiac Allograft Rejection by Antagonizing RORγt Activity

(2013) Jie Wu et al.   TRANSPLANTATION

Therapeutic Ranges of Serum Digoxin Concentrations in Patients With Heart Failure

(2012) Zachary D. Goldberger et al.   AMERICAN JOURNAL OF CARDIOLOGY

A Validated Regulatory Network for Th17 Cell Specification

(2012) Maria Ciofani et al.   CELL

Hormones and Endocrine-Disrupting Chemicals: Low-Dose Effects and Nonmonotonic Dose Responses

(2012) Laura N. Vandenberg et al.   ENDOCRINE REVIEWS

Upstream Stimulating Factors Regulate the Expression of ROR T in Human Lymphocytes

(2012) M. Ratajewski et al.   JOURNAL OF IMMUNOLOGY

Methylhonokiol attenuates neuroinflammation: a role for cannabinoid receptors?

(2012) Jürg Gertsch et al.   Journal of Neuroinflammation

Fast gapped-read alignment with Bowtie 2

(2012) Ben Langmead et al.   NATURE METHODS

RORγ directly regulates the circadian expression of clock genes and downstream targets in vivo

(2012) Yukimasa Takeda et al.   NUCLEIC ACIDS RESEARCH

Structural Basis of Digoxin That Antagonizes RORγt Receptor Activity and Suppresses Th17 Cell Differentiation and Interleukin (IL)-17 Production

(2011) Saori Fujita-Sato et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

1,25-Dihydroxyvitamin D3 Ameliorates Th17 Autoimmunity via Transcriptional Modulation of Interleukin-17A

(2011) S. Joshi et al.   MOLECULAR AND CELLULAR BIOLOGY

Digoxin and its derivatives suppress TH17 cell differentiation by antagonizing RORγt activity

(2011) Jun R. Huh et al.   NATURE

Retinoic acid-related orphan receptor γ directly regulates neuronal PAS domain protein 2 transcription in vivo

(2011) Yukimasa Takeda et al.   NUCLEIC ACIDS RESEARCH

A second class of nuclear receptors for oxysterols: Regulation of RORα and RORγ activity by 24S-hydroxycholesterol (cerebrosterol)

(2010) Yongjun Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Ligand regulation of retinoic acid receptor-related orphan receptors: implications for development of novel therapeutics

(2010) Laura A Solt et al.   CURRENT OPINION IN LIPIDOLOGY

Vitamin D Suppresses Th17 Cytokine Production by Inducing C/EBP Homologous Protein (CHOP) Expression

(2010) Seon Hee Chang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Basis for Hydroxycholesterols as Natural Ligands of Orphan Nuclear Receptor RORγ

(2010) Lihua Jin et al.   MOLECULAR ENDOCRINOLOGY

Differential expression analysis for sequence count data

(2010) Simon Anders et al.   GENOME BIOLOGY

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

The role of retinoic acid‐related orphan receptor variant 2 and IL‐17 in the development and function of human CD4+T cells

(2009) Sarah Q. Crome et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Th17 cytokines and their emerging roles in inflammation and autoimmunity

(2009) Lynette A. Fouser et al.   IMMUNOLOGICAL REVIEWS

T helper 17 T cells do good for cancer immunotherapy

(2009) Glenda Canderan et al.   Immunotherapy

Modulation of Retinoic Acid Receptor-related Orphan Receptor α and γ Activity by 7-Oxygenated Sterol Ligands

(2009) Yongjun Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

(2009) Garrett M. Morris et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

The Benzenesulfoamide T0901317 [N-(2,2,2-Trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-benzenesulfonamide] Is a Novel Retinoic Acid Receptor-Related Orphan Receptor- /  Inverse Agonist

(2009) N. Kumar et al.   MOLECULAR PHARMACOLOGY

Tumor-specific Th17-polarized cells eradicate large established melanoma

(2008) P. Muranski et al.   BLOOD

A Fundamental Role for Interleukin-21 in the Generation of T Follicular Helper Cells

(2008) Alexis Vogelzang et al.   IMMUNITY

Neutral red uptake assay for the estimation of cell viability/cytotoxicity

(2008) Guillermo Repetto et al.   Nature Protocols

Aryl hydrocarbon receptor regulates Stat1 activation and participates in the development of Th17 cells

(2008) A. Kimura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA