Melatonin Mitigates Mitochondrial Meltdown: Interactions with SIRT3

Role of Sirtuin1-p53 regulatory axis in aging, cancer and cellular reprogramming

(2018) Agnes L.C. Ong et al.   AGEING RESEARCH REVIEWS

Sirtuins in mitochondrial stress: Indispensable helpers behind the scenes

(2018) Shuangzhe Lin et al.   AGEING RESEARCH REVIEWS

Melatonin Rescues Mesenchymal Stem Cells from Senescence Induced by the Uremic Toxin p-Cresol via Inhibiting mTOR-Dependent Autophagy

(2018) Seung Pil Yun et al.   Biomolecules & Therapeutics

The Mitochondrial Acylome Emerges: Proteomics, Regulation by Sirtuins, and Metabolic and Disease Implications

(2018) Chris Carrico et al.   Cell Metabolism

Functions of the sirtuin deacylase SIRT5 in normal physiology and pathobiology

(2018) Surinder Kumar et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Indoles - gut bacteria metabolites of tryptophan with pharmacotherapeutic potential

(2018) Piotr Konopelski et al.   CURRENT DRUG METABOLISM

Seq-ing answers: uncovering the unexpected in global gene regulation

(2018) George Maxwell Otto et al.   CURRENT GENETICS

Melatonin and Oxidative Stress in the Diabetic State: Clinical Implications and Potential Therapeutic Applications

(2018) Javier Espino et al.   CURRENT MEDICINAL CHEMISTRY

Synthetic post-translational modification of histones

(2018) Simon Nadal et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Epigenetic modifications in the embryonic and induced pluripotent stem cells

(2018) Rasoul Godini et al.   GENE EXPRESSION PATTERNS

Synchronizing effects of melatonin on diurnal and circadian rhythms

(2018) Martina Pfeffer et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

Sirtuins in gamete biology and reproductive physiology: emerging roles and therapeutic potential in female and male infertility

(2018) Carla Tatone et al.   HUMAN REPRODUCTION UPDATE

Daily melatonin protects the endothelial lineage and functional integrity against the aging process, oxidative stress, and toxic environment and restores blood flow in critical limb ischemia area in mice

(2018) Fan-Yen Lee et al.   JOURNAL OF PINEAL RESEARCH

Melatonin and its derivatives counteract the ultraviolet B radiation-induced damage in human and porcine skin ex vivo

(2018) Cezary Skobowiat et al.   JOURNAL OF PINEAL RESEARCH

Mitochondria: Central Organelles for Melatonin′s Antioxidant and Anti-Aging Actions

(2018) Russel Reiter et al.   MOLECULES

Melatonin: A Versatile Protector against Oxidative DNA Damage

(2018) Annia Galano et al.   MOLECULES

The Key Role of Epigenetics in Human Disease Prevention and Mitigation

(2018) Andrew P. Feinberg   NEW ENGLAND JOURNAL OF MEDICINE

Reply to Ahluwalia et al.: Contributions of melatonin receptors are tissue-dependent

(2018) Yalikun Suofu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Melatonin protects mouse spermatogonial stem cells against hexavalent chromium-induced apoptosis and epigenetic histone modification

(2018) Yinghua Lv et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Same agent, different messages: insight into transcriptional regulation by SIN3 isoforms

(2018) Ashlesha Chaubal et al.   Epigenetics & Chromatin

Melatonin attenuates lung ischaemia–reperfusion injury via inhibition of oxidative stress and inflammation

(2018) Ming-Liang Wang et al.   Interactive Cardiovascular and Thoracic Surgery

Melatonin-mediated upregulation of Sirt3 attenuates sodium fluoride-induced hepatotoxicity by activating the MT1-PI3K/AKT-PGC-1α signaling pathway

(2017) Chao Song et al.   FREE RADICAL BIOLOGY AND MEDICINE

Low-Energy Electron Interaction with Melatonin and Related Compounds

(2017) Stanislav A. Pshenichnyuk et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Long-term melatonin treatment delays ovarian aging

(2017) Hiroshi Tamura et al.   JOURNAL OF PINEAL RESEARCH

Dynamin-related protein 1-mediated mitochondrial fission contributes to post-traumatic cardiac dysfunction in rats and the protective effect of melatonin

(2017) Mingge Ding et al.   JOURNAL OF PINEAL RESEARCH

Human transporters, PEPT1/2, facilitate melatonin transportation into mitochondria of cancer cells: An implication of the therapeutic potential

(2017) Xiaokui Huo et al.   JOURNAL OF PINEAL RESEARCH

Melatonin protects against diabetic cardiomyopathy through Mst1/Sirt3 signaling

(2017) Mingming Zhang et al.   JOURNAL OF PINEAL RESEARCH

Melatonin protects against maternal obesity-associated oxidative stress and meiotic defects in oocytes via the SIRT3-SOD2-dependent pathway

(2017) Longsen Han et al.   JOURNAL OF PINEAL RESEARCH

Melatonin ameliorates myocardial ischemia reperfusion injury through SIRT3-dependent regulation of oxidative stress and apoptosis

(2017) Mengen Zhai et al.   JOURNAL OF PINEAL RESEARCH

Melatonin and sirtuins: A “not-so unexpected” relationship

(2017) Juan C. Mayo et al.   JOURNAL OF PINEAL RESEARCH

Pre-ischemia melatonin treatment alleviated acute neuronal injury after ischemic stroke by inhibiting endoplasmic reticulum stress-dependent autophagy via PERK and IRE1 signalings

(2017) Dayun Feng et al.   JOURNAL OF PINEAL RESEARCH

Aging ovary and the role for advanced glycation end products

(2017) Magdalena Pertynska-Marczewska et al.   MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY

Therapeutic role of sirtuins in neurodegenerative disease and their modulation by polyphenols

(2017) Marjan Ajami et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

DNA Methylation and the Potential Role of Methyl-Containing Nutrients in Cardiovascular Diseases

(2017) Gang Liu et al.   Oxidative Medicine and Cellular Longevity

Cigarette smoke is associated with altered expression of antioxidant enzymes in granulosa cells from women undergoing in vitro fertilization

(2017) Maria Cristina Budani et al.   ZYGOTE

Associations among Metabolism, Circadian Rhythm and Age-Associated Diseases

(2017) Yiwei Cao et al.   Aging and Disease

Melatonin ameliorates myocardial ischemia/reperfusion injury in type 1 diabetic rats by preserving mitochondrial function: role of AMPK-PGC-1α-SIRT3 signaling

(2017) Liming Yu et al.   Scientific Reports

The role of sirtuins in aging and age-related diseases

(2016) Mateusz Wątroba et al.   Advances in Medical Sciences

Mitochondrial Dynamics Is Linked to Longevity and Protects from End-Organ Injury: The Emerging Role of Sirtuin 3

(2016) Ariela Benigni et al.   ANTIOXIDANTS & REDOX SIGNALING

Melatonin receptors as therapeutic targets in the suprachiasmatic nucleus

(2016) Paul Pévet   EXPERT OPINION ON THERAPEUTIC TARGETS

The antioxidative property of melatonin against brain ischemia

(2016) Irene Paterniti et al.   Expert Review of Neurotherapeutics

Lipid profile, inflammation, and oxidative status in peri- and postmenopausal women

(2016) Ouarda Taleb-Belkadi et al.   GYNECOLOGICAL ENDOCRINOLOGY

Melatonin is a redundant entraining signal in the rat circadian system

(2016) Pavel Houdek et al.   HORMONES AND BEHAVIOR

Melatonin effects on myocardial ischemia–reperfusion injury: Impact on the outcome in patients undergoing coronary artery bypass grafting surgery

(2016) Karar H. Dwaich et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Melatonin: A Mitochondrial Targeting Molecule Involving Mitochondrial Protection and Dynamics

(2016) Dun-Xian Tan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Potential benefits of melatonin in organ transplantation: a review

(2016) Eduardo Esteban-Zubero et al.   JOURNAL OF ENDOCRINOLOGY

A review of the protective role of melatonin during phosphine-induced cardiotoxicity: focus on mitochondrial dysfunction, oxidative stress and apoptosis

(2016) Mohammad Hossein Asghari et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Melatonin prevents abnormal mitochondrial dynamics resulting from the neurotoxicity of cadmium by blocking calcium-dependent translocation of Drp1 to the mitochondria

(2016) Shangcheng Xu et al.   JOURNAL OF PINEAL RESEARCH

Melatonin as an antioxidant: under promises but over delivers

(2016) Russel J. Reiter et al.   JOURNAL OF PINEAL RESEARCH

The key role of the sequential proton loss electron transfer mechanism on the free radical scavenging activity of some melatonin-related compounds

(2016) Ruslán Álvarez-Diduk et al.   THEORETICAL CHEMISTRY ACCOUNTS

The antioxidative property of melatonin against brain ischemia

(2016) Irene Paterniti et al.   Expert Review of Neurotherapeutics

Melatonin improves age-induced fertility decline and attenuates ovarian mitochondrial oxidative stress in mice

(2016) Chao Song et al.   Scientific Reports

Protective effects of melatonin against oxidative damage induced by Egyptian cobra (Naja haje) crude venom in rats

(2015) Ahmed E. Abdel Moneim et al.   ACTA TROPICA

Endosymbiosis and Eukaryotic Cell Evolution

(2015) John M. Archibald   CURRENT BIOLOGY

Sirtuin-dependent clock control

(2015) Selma Masri   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Melatonin Redox Activity. Its Potential Clinical Applications in Neurodegenerative Disorders

(2015) Elzbieta Miller et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Quinone reductase 2 as a promising target of melatonin therapeutic actions

(2015) Jean A Boutin   EXPERT OPINION ON THERAPEUTIC TARGETS

Melatonin protects hepatocytes against bile acid-induced mitochondrial oxidative stress via the AMPK-SIRT3-SOD2 pathway

(2015) Y. Chen et al.   FREE RADICAL RESEARCH

Daily differential expression of melatonin-related genes and clock genes in rat cumulus-oocyte complex: changes after pinealectomy

(2015) L. A. Coelho et al.   JOURNAL OF PINEAL RESEARCH

Melatonin and endoplasmic reticulum stress: relation to autophagy and apoptosis

(2015) Anna Fernández et al.   JOURNAL OF PINEAL RESEARCH

Melatonin uptake through glucose transporters: a new target for melatonin inhibition of cancer

(2015) David Hevia et al.   JOURNAL OF PINEAL RESEARCH

Melatonin decreases muscular oxidative stress and inflammation induced by strenuous exercise and stimulates growth factor synthesis

(2015) Leandro da Silva Borges et al.   JOURNAL OF PINEAL RESEARCH

Molecular basis of ligand recognition and transport by glucose transporters

(2015) Dong Deng et al.   NATURE

SIRT3 regulates progression and development of diseases of aging

(2015) Eoin McDonnell et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

A review of melatonin in hepatic ischemia/reperfusion injury and clinical liver disease

(2014) Yue Li et al.   ANNALS OF MEDICINE

Sirt3 controls chromosome alignment by regulating spindle dynamics during mitosis

(2014) Byung-Soo Choi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Delivery of pineal melatonin to the brain and SCN: role of canaliculi, cerebrospinal fluid, tanycytes and Virchow–Robin perivascular spaces

(2014) Russel J. Reiter et al.   Brain Structure & Function

Melatonin and the circadian system: contributions to successful female reproduction

(2014) Russel J. Reiter et al.   FERTILITY AND STERILITY

Melatonin from Cerebrospinal Fluid but Not from Blood Reaches Sheep Cerebral Tissues Under Physiological Conditions

(2014) C. Legros et al.   JOURNAL OF NEUROENDOCRINOLOGY

Melatonin improves mitochondrial function in inguinal white adipose tissue of Zücker diabetic fatty rats

(2014) Aroa Jimenéz-Aranda et al.   JOURNAL OF PINEAL RESEARCH

Mitochondrial catastrophe during doxorubicin-induced cardiotoxicity: a review of the protective role of melatonin

(2014) Jenelle Govender et al.   JOURNAL OF PINEAL RESEARCH

Melatonin and its metabolites as copper chelating agents and their role in inhibiting oxidative stress: a physicochemical analysis

(2014) Annia Galano et al.   JOURNAL OF PINEAL RESEARCH

Protective effects of melatonin in reducing oxidative stress and in preserving the fluidity of biological membranes: a review

(2014) Joaquín J. García et al.   JOURNAL OF PINEAL RESEARCH

Melatonin blunts the mitochondrial/NLRP3 connection and protects against radiation-induced oral mucositis

(2014) Francisco Ortiz et al.   JOURNAL OF PINEAL RESEARCH

Melatonin: Exceeding Expectations

(2014) Russel J. Reiter et al.   PHYSIOLOGY

Skin, Reactive Oxygen Species, and Circadian Clocks

(2013) Mary A. Ndiaye et al.   ANTIOXIDANTS & REDOX SIGNALING

Structure and Evolution of Human Sirtuins

(2013) Domenico Bordo   CURRENT DRUG TARGETS

SIRT3 deacetylates FOXO3 to protect mitochondria against oxidative damage

(2013) Anne H.H. Tseng et al.   FREE RADICAL BIOLOGY AND MEDICINE

SIRT3: As Simple As It Seems?

(2013) David B. Lombard et al.   GERONTOLOGY

Melatonin and stable circadian rhythms optimize maternal, placental and fetal physiology

(2013) Russel J. Reiter et al.   HUMAN REPRODUCTION UPDATE

Correction: Proteomic Analysis of Liver in Rats Chronically Exposed to Fluoride

(2013) Heloísa Aparecida Barbosa da Silva Pereira et al.   PLoS One

Neuroendocrine, immune and oxidative stress in shift workers

(2013) Brice Faraut et al.   SLEEP MEDICINE REVIEWS

Forever young: SIRT3 a shield against mitochondrial meltdown, aging, and neurodegeneration

(2013) Brad Kincaid et al.   Frontiers in Aging Neuroscience

Melatonin-mitochondria Interplay in Health and Disease

(2012) Dario Acuna Castroviejo et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

SIRT3 regulation of mitochondrial oxidative stress

(2012) Alexandra S. Bause et al.   EXPERIMENTAL GERONTOLOGY

Seven sirtuins for seven deadly diseases ofaging

(2012) Brian J. Morris   FREE RADICAL BIOLOGY AND MEDICINE

Gene regulation by melatonin linked to epigenetic phenomena

(2012) Ahmet Korkmaz et al.   GENE

Mitochondria and chloroplasts as the original sites of melatonin synthesis: a hypothesis related to melatonin's primary function and evolution in eukaryotes

(2012) Dun-Xian Tan et al.   JOURNAL OF PINEAL RESEARCH

On the free radical scavenging activities of melatonin's metabolites, AFMK and AMK

(2012) Annia Galano et al.   JOURNAL OF PINEAL RESEARCH

Hypoxia-inducible factor as a therapeutic target for cardioprotection

(2012) Sang-Ging Ong et al.   PHARMACOLOGY & THERAPEUTICS

Sirtuin 1 and Sirtuin 3: Physiological Modulators of Metabolism

(2012) Ruben Nogueiras et al.   PHYSIOLOGICAL REVIEWS

A survey of molecular details in the human pineal gland in the light of phylogeny, structure, function and chronobiological diseases

(2011) Jörg H. Stehle et al.   JOURNAL OF PINEAL RESEARCH

Melatonin as a natural ally against oxidative stress: a physicochemical examination

(2011) Annia Galano et al.   JOURNAL OF PINEAL RESEARCH

Extrapineal melatonin: analysis of its subcellular distribution and daily fluctuations

(2011) Carmen Venegas et al.   JOURNAL OF PINEAL RESEARCH

Sirt3 Promotes the Urea Cycle and Fatty Acid Oxidation during Dietary Restriction

(2011) William C. Hallows et al.   MOLECULAR CELL

On the direct scavenging activity of melatonin towards hydroxyl and a series of peroxyl radicals

(2011) Annia Galano   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Mitochondrial sirtuins

(2010) Jing-Yi Huang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Melatonin enhances antioxidant action of α-tocopherol and ascorbate against NADPH- and iron-dependent lipid peroxidation in human placental mitochondria

(2010) Ryszard Milczarek et al.   JOURNAL OF PINEAL RESEARCH

The mechanism for the neuroprotective effect of melatonin against methamphetamine-induced autophagy

(2010) Chutikorn Nopparat et al.   JOURNAL OF PINEAL RESEARCH

Role of melatonin in mucosal gastroprotection against aspirin-induced gastric lesions in humans

(2010) P. C. Konturek et al.   JOURNAL OF PINEAL RESEARCH

Protective effect of melatonin against Opisthorchis viverrini-induced oxidative and nitrosative DNA damage and liver injury in hamsters

(2010) Umawadee Laothong et al.   JOURNAL OF PINEAL RESEARCH

Sirtuin 1 Modulates Cellular Responses to Hypoxia by Deacetylating Hypoxia-Inducible Factor 1α

(2010) Ji-Hong Lim et al.   MOLECULAR CELL

Function and regulation of the mitochondrial Sirtuin isoform Sirt5 in Mammalia

(2009) Melanie Gertz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

SIRT1 controls circadian clock circuitry and promotes cell survival: a connection with age-related neoplasms

(2009) Brittney Jung-Hynes et al.   FASEB JOURNAL

Sirt3 blocks the cardiac hypertrophic response by augmenting Foxo3a-dependent antioxidant defense mechanisms in mice

(2009) Nagalingam R. Sundaresan et al.   JOURNAL OF CLINICAL INVESTIGATION

Melatonin provides neuroprotection by reducing oxidative stress and HSP70 expression during chronic cerebral hypoperfusion in ovariectomized rats

(2009) Veysel H. Ozacmak et al.   JOURNAL OF PINEAL RESEARCH

Kynuramines, metabolites of melatonin and other indoles: the resurrection of an almost forgotten class of biogenic amines

(2009) Rüdiger Hardeland et al.   JOURNAL OF PINEAL RESEARCH

Visualization of melatonin’s multiple mitochondrial levels of protection against mitochondrial Ca2+-mediated permeability transition and beyond in rat brain astrocytes

(2009) Mei-Jie Jou et al.   JOURNAL OF PINEAL RESEARCH

Sirtuins, melatonin and circadian rhythms: building a bridge between aging and cancer

(2009) Brittney Jung-Hynes et al.   JOURNAL OF PINEAL RESEARCH

Melatonin and the ovary: physiological and pathophysiological implications

(2008) Hiroshi Tamura et al.   FERTILITY AND STERILITY

Oxidative stress impairs oocyte quality and melatonin protects oocytes from free radical damage and improves fertilization rate

(2007) Hiroshi Tamura et al.   JOURNAL OF PINEAL RESEARCH

Melatonin antagonizes the intrinsic pathway of apoptosis via mitochondrial targeting of Bcl-2

(2007) Flavia Radogna et al.   JOURNAL OF PINEAL RESEARCH