- Home
- Publications
- Publication Search
- Publication Details
Title
RNA-based therapies: A cog in the wheel of lung cancer defense
Authors
Keywords
-
Journal
Molecular Cancer
Volume 20, Issue 1, Pages -
Publisher
Springer Science and Business Media LLC
Online
2021-03-19
DOI
10.1186/s12943-021-01338-2
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Cancer statistics, 2020
- (2020) Rebecca L. Siegel et al. CA-A CANCER JOURNAL FOR CLINICIANS
- ARL4C is associated with initiation and progression of lung adenocarcinoma and represents a therapeutic target
- (2020) Kenji Kimura et al. CANCER SCIENCE
- Genetic and Epigenetic Modulation of Drug Resistance in Cancer: Challenges and Opportunities
- (2020) Kanisha Shah et al. CURRENT DRUG METABOLISM
- A novel tumour suppressor lncRNA F630028O10Rik inhibits lung cancer angiogenesis by regulating miR‐223‐3p
- (2020) Limei Qin et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Randomized Clinical Trials Towards a Single‐Visit Cure for Chronic Hepatitis C: Oral GSK2878175 and Injectable RG‐101 in Chronic Hepatitis C Patients and Long‐Acting Injectable GSK2878175 in Healthy Participants
- (2020) Yanli Deng et al. JOURNAL OF VIRAL HEPATITIS
- m6A demethylase ALKBH5 inhibits tumor growth and metastasis by reducing YTHDFs-mediated YAP expression and inhibiting miR-107/LATS2–mediated YAP activity in NSCLC
- (2020) Dan Jin et al. Molecular Cancer
- mRNA modification orchestrates cancer stem cell fate decisions
- (2020) Weicheng Liang et al. Molecular Cancer
- Role of non-coding RNAs and RNA modifiers in cancer therapy resistance
- (2020) Xinyi Zhang et al. Molecular Cancer
- Directed RNase H Cleavage of Nascent Transcripts Causes Transcription Termination
- (2020) Fan Lai et al. MOLECULAR CELL
- AON-induced splice-switching and DMPK pre-mRNA degradation as potential therapeutic approaches for Myotonic Dystrophy type 1
- (2020) Ewa Stepniak-Konieczna et al. NUCLEIC ACIDS RESEARCH
- LncRNA NNT‐AS1 promotes non‐small cell lung cancer progression through regulating miR‐22‐3p/YAP1 axis
- (2020) Wenlong He et al. Thoracic Cancer
- MicroRNA‐based biomarkers for diagnosis of non‐small cell lung cancer (NSCLC)
- (2020) Jipei Liao et al. Thoracic Cancer
- RNA-based pharmacotherapy for tumors: From bench to clinic and back
- (2020) Xiangping Liang et al. BIOMEDICINE & PHARMACOTHERAPY
- Cancer immunotherapy: Pros, cons and beyond
- (2020) Shuzhen Tan et al. BIOMEDICINE & PHARMACOTHERAPY
- LINC00667 promotes the proliferation, migration, and pathological angiogenesis in non–small cell lung cancer through stabilizing VEGFA by EIF4A3
- (2020) Huizhen Yang et al. CELL BIOLOGY INTERNATIONAL
- LncRNA NNT-AS1 promotes lung squamous cell carcinoma progression by regulating the miR-22/FOXM1 axis
- (2020) Jing Ma et al. CELLULAR & MOLECULAR BIOLOGY LETTERS
- MicroRNA Networks in Pancreatic Islet Cells: Normal Function and Type 2 Diabetes
- (2020) Lena Eliasson et al. DIABETES
- Mechanisms of Multidrug Resistance in Cancer Chemotherapy
- (2020) Karol Bukowski et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Novel insight into the regulatory roles of diverse RNA modifications: Re-defining the bridge between transcription and translation
- (2020) Hanhan Shi et al. Molecular Cancer
- LINC00173.v1 promotes angiogenesis and progression of lung squamous cell carcinoma by sponging miR-511-5p to regulate VEGFA expression
- (2020) Jiarong Chen et al. Molecular Cancer
- RNA therapeutics on the rise
- (2020) Feng Wang et al. NATURE REVIEWS DRUG DISCOVERY
- A transient α-helix in the N-terminal RNA recognition motif of polypyrimidine tract binding protein senses RNA secondary structure
- (2020) Christophe Maris et al. NUCLEIC ACIDS RESEARCH
- Small Molecule KRAS Inhibitors: The Future for Targeted Pancreatic Cancer Therapy?
- (2020) Josef Gillson et al. Cancers
- Enzymatically synthesized 2'-fluoro-modified Dicer-substrate siRNA swarms against herpes simplex virus demonstrate enhanced antiviral efficacy and low cytotoxicity
- (2020) Alesia A. Levanova et al. ANTIVIRAL RESEARCH
- Challenges and Opportunities in Cancer Drug Resistance
- (2020) Richard A. Ward et al. CHEMICAL REVIEWS
- First-line angiogenesis inhibitor plus erlotinib versus erlotinib alone for advanced non-small-cell lung cancer harboring an EGFR mutation
- (2020) Thierry Landre et al. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
- SARS-CoV-2 mRNA vaccine design enabled by prototype pathogen preparedness
- (2020) Kizzmekia S. Corbett et al. NATURE
- An RNA vaccine drives immunity in checkpoint-inhibitor-treated melanoma
- (2020) Ugur Sahin et al. NATURE
- Advances in oligonucleotide drug delivery
- (2020) Thomas C. Roberts et al. NATURE REVIEWS DRUG DISCOVERY
- Phase 3 Trial of RNAi Therapeutic Givosiran for Acute Intermittent Porphyria
- (2020) Manisha Balwani et al. NEW ENGLAND JOURNAL OF MEDICINE
- Evaluation of the mRNA-1273 Vaccine against SARS-CoV-2 in Nonhuman Primates
- (2020) Kizzmekia S. Corbett et al. NEW ENGLAND JOURNAL OF MEDICINE
- An mRNA Vaccine against SARS-CoV-2 — Preliminary Report
- (2020) Lisa A. Jackson et al. NEW ENGLAND JOURNAL OF MEDICINE
- 3′-Terminal 2′-O-methylation of lung cancer miR-21-5p enhances its stability and association with Argonaute 2
- (2020) Hongwei Liang et al. NUCLEIC ACIDS RESEARCH
- Epigenetic deregulation in cancer: Enzyme players and non-coding RNAs
- (2020) Ammad Ahmad Farooqi et al. SEMINARS IN CANCER BIOLOGY
- OIP5‑AS1 modulates epigenetic regulator HDAC7 to enhance non‑small cell lung cancer metastasis via miR‑140‑5p
- (2020) Jiazhuan Mei et al. Oncology Letters
- Antisense oligonucleotide modulation of non-productive alternative splicing upregulates gene expression
- (2020) Kian Huat Lim et al. Nature Communications
- miR-4634 augments the anti-tumor effects of RAD001 and associates well with clinical prognosis of non-small cell lung cancer
- (2020) Sile Liu et al. Scientific Reports
- Small cell transformation of non-small cell lung cancer on immune checkpoint inhibitors: uncommon or under-recognized?
- (2020) Kartik Sehgal et al. Journal for ImmunoTherapy of Cancer
- Antisense Oligonucleotides: An Emerging Area in Drug Discovery and Development
- (2020) Karishma Dhuri et al. Journal of Clinical Medicine
- Self-Assembled DNA–PEG Bottlebrushes Enhance Antisense Activity and Pharmacokinetics of Oligonucleotides
- (2020) Yuyan Wang et al. ACS Applied Materials & Interfaces
- Induction of potent cell growth inhibition by schizophyllan/K-ras antisense complex in combination with gemcitabine
- (2020) Shogo Sasaki et al. BIOORGANIC & MEDICINAL CHEMISTRY
- The pH-triggered polyglutamate brush co-delivery of MDR1 and survivin-targeting siRNAs efficiently overcomes multi-drug resistance of NSCLC
- (2020) Zhongjuan Wang et al. DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
- Targeting STAT3 in Cancer Immunotherapy
- (2020) Sailan Zou et al. Molecular Cancer
- Base editing: advances and therapeutic opportunities
- (2020) Elizabeth M. Porto et al. NATURE REVIEWS DRUG DISCOVERY
- RNA Drugs and RNA Targets for Small Molecules: Principles, Progress, and Challenges
- (2020) Ai-Ming Yu et al. PHARMACOLOGICAL REVIEWS
- The Impact of Adipose Tissue–Derived miRNAs in Metabolic Syndrome, Obesity, and Cancer
- (2020) Gabriella Simões Heyn et al. Frontiers in Endocrinology
- Association of microRNA-21 with p53 at mutant sites R175H and R248Q, clinicopathological features, and prognosis of non-small cell lung cancer
- (2020) Yaodong Zhou et al. Molecular Therapy-Oncolytics
- Regulatory Mechanisms of Epigenetic miRNA Relationships in Human Cancer and Potential as Therapeutic Targets
- (2020) K. M. Taufiqul Arif et al. Cancers
- The Clinical Utility of miR-21 and let-7 in Non-small Cell Lung Cancer (NSCLC). A Systematic Review and Meta-Analysis
- (2020) Cecilia Pop-Bica et al. Frontiers in Oncology
- The sustained expression of Cas9 targeting toxic RNAs reverses disease phenotypes in mouse models of myotonic dystrophy type 1
- (2020) Ranjan Batra et al. Nature Biomedical Engineering
- Beyond Blocking: Engineering RNAi-Mediated Targeted Immune Checkpoint Nanoblocker Enables T-Cell-Independent Cancer Treatment
- (2020) Xiaoyan Han et al. ACS Nano
- RNAi mediated silencing of Nanog expression suppresses the growth of human colorectal cancer stem cells
- (2020) Chen Zhang et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- microRNA-let-7e in serum-derived exosomes inhibits the metastasis of non-small-cell lung cancer in a SUV39H2/LSD1/CDH1-dependent manner
- (2020) Shufeng Xu et al. CANCER GENE THERAPY
- Therapeutic Targeting of Metadherin Suppresses Colorectal and Lung Cancer Progression and Metastasis
- (2020) Minhong Shen et al. CANCER RESEARCH
- Molecular testing and targeted therapy for non-small cell lung cancer: Current status and perspectives
- (2020) Evgeny N. Imyanitov et al. CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
- Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors for the treatment of non-small cell lung cancer: a patent review (2014-present)
- (2020) Xin Sun et al. EXPERT OPINION ON THERAPEUTIC PATENTS
- Downregulation of miR-506-3p Facilitates EGFR-TKI Resistance through Induction of Sonic Hedgehog Signaling in Non-Small-Cell Lung Cancer Cell Lines
- (2020) Inamul Haque et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Epigenetic Targets for Oligonucleotide Therapies of Pulmonary Arterial Hypertension
- (2020) William Gerthoffer INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Diagnostic and Therapeutic Implications of microRNAs in Non-Small Cell Lung Cancer
- (2020) Young-Ho Ahn et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Extracellular vesicles‐encapsulated let‐7i shed from bone mesenchymal stem cells suppress lung cancer via KDM3A/DCLK1/FXYD3 axis
- (2020) Jiefeng Liu et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Functional and Structural Aspects of La Protein Overexpression in Lung Cancer
- (2020) Eleni G. Kaliatsi et al. JOURNAL OF MOLECULAR BIOLOGY
- Recent Advances on the Role of EGFR Tyrosine Kinase Inhibitors in the Management of NSCLC With Uncommon, Non Exon 20 Insertions, EGFR Mutations
- (2020) Antonio Passaro et al. Journal of Thoracic Oncology
- Erlotinib plus bevacizumab vs erlotinib monotherapy as first-line treatment for advanced EGFR mutation-positive non-squamous non-small-cell lung cancer: Survival follow-up results of the randomized JO25567 study
- (2020) N. Yamamoto et al. LUNG CANCER
- Long non-coding RNA NEAT1 promotes bone metastasis of prostate cancer through N6-methyladenosine
- (2020) Simeng Wen et al. Molecular Cancer
- miR‑139‑5p enhances cisplatin sensitivity in non‑small cell lung cancer cells by inhibiting cell proliferation and promoting apoptosis via the targeting of Homeobox protein Hox‑B2
- (2020) Hailian Du et al. Molecular Medicine Reports
- Discovery and validation of extracellular vesicle‐associated miRNAs as noninvasive detection biomarkers for early‐stage non‐small‐cell lung cancer
- (2020) Yujie Zhong et al. Molecular Oncology
- Moderna COVID vaccine becomes second to get US authorization
- (2020) Heidi Ledford NATURE
- Anti-PD1 therapy induces lymphocyte-derived exosomal miRNA-4315 release inhibiting Bim-mediated apoptosis of tumor cells
- (2020) Nina Guyon et al. Cell Death & Disease
- Tumor evolutionary trajectories during the acquisition of invasiveness in early stage lung adenocarcinoma
- (2020) Siwei Wang et al. Nature Communications
- Exosomal miR‐3180‐3p inhibits proliferation and metastasis of non‐small cell lung cancer by downregulating FOXP4
- (2020) Tengfei Chen et al. Thoracic Cancer
- MicroRNA ‐99 family in cancer and immunity
- (2020) Joseph Eniafe et al. Wiley Interdisciplinary Reviews-RNA
- Stem Cells: Current Status and Therapeutic Implications
- (2020) Kaladhar B. Reddy Genes
- EpCAM-Targeted 3WJ RNA Nanoparticle Harboring Delta-5-Desaturase siRNA Inhibited Lung Tumor Formation via DGLA Peroxidation
- (2020) Lizhi Pang et al. Molecular Therapy-Nucleic Acids
- miR-146b-5p Enhances the Sensitivity of NSCLC to EGFR Tyrosine Kinase Inhibitors by Regulating the IRAK1/NF-κB Pathway
- (2020) Yi-Nan Liu et al. Molecular Therapy-Nucleic Acids
- The Advisory Committee on Immunization Practices’ Interim Recommendation for Use of Pfizer-BioNTech COVID-19 Vaccine — United States, December 2020
- (2020) Sara E. Oliver et al. MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT
- Osimertinib for Front-Line Treatment of Locally Advanced or Metastatic EGFR-Mutant NSCLC Patients: Efficacy, Acquired Resistance and Perspectives for Subsequent Treatments
- (2020) Marc G Denis et al. Cancer Management and Research
- Extracellular MicroRNAs as Intercellular Mediators and Noninvasive Biomarkers of Cancer
- (2020) Blanca Ortiz-Quintero Cancers
- Single‐nucleotide polymorphism rs4142441 and MYC co‐modulated long non‐coding RNA OSER1‐AS1 suppresses non‐small cell lung cancer by sequestering ELAVL1
- (2020) Weijia Xie et al. CANCER SCIENCE
- Epigenetic landscape of small cell lung cancer: small image of a giant recalcitrant disease
- (2020) Parvez Khan et al. SEMINARS IN CANCER BIOLOGY
- Cancer statistics, 2019
- (2019) Rebecca L. Siegel et al. CA-A CANCER JOURNAL FOR CLINICIANS
- Phase Ib evaluation of a self-adjuvanted protamine formulated mRNA-based active cancer immunotherapy, BI1361849 (CV9202), combined with local radiation treatment in patients with stage IV non-small cell lung cancer
- (2019) Alexandros Papachristofilou et al. Journal for ImmunoTherapy of Cancer
- Durable anticancer immunity from intratumoral administration of IL-23, IL-36γ, and OX40L mRNAs
- (2019) Susannah L. Hewitt et al. Science Translational Medicine
- Phase 1 Trial of an RNA Interference Therapy for Acute Intermittent Porphyria
- (2019) Eliane Sardh et al. NEW ENGLAND JOURNAL OF MEDICINE
- The current state and future directions of RNAi-based therapeutics
- (2019) Ryan L. Setten et al. NATURE REVIEWS DRUG DISCOVERY
- Second-line targeted therapies after nivolumab-ipilimumab failure in metastatic renal cell carcinoma
- (2019) Marie Auvray et al. EUROPEAN JOURNAL OF CANCER
- The Role of Angiogenesis Inhibitors in the Era of Immune Checkpoint Inhibitors and Targeted Therapy in Metastatic Non-Small Cell Lung Cancer
- (2019) Kirstin Perdrizet et al. CURRENT TREATMENT OPTIONS IN ONCOLOGY
- RNA-Targeted Therapeutics
- (2019) Stanley T. Crooke et al. Cell Metabolism
- VEGF in Signaling and Disease: Beyond Discovery and Development
- (2019) Rajendra S. Apte et al. CELL
- A phase I/IIa study of the mRNA-based cancer immunotherapy CV9201 in patients with stage IIIB/IV non-small cell lung cancer
- (2019) Martin Sebastian et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Therapeutic Antisense Oligonucleotides Are Coming of Age
- (2019) C. Frank Bennett Annual Review of Medicine
- Quick synthesis of a novel combinatorial delivery system of siRNA and doxorubicin for a synergistic anticancer effect
- (2019) Mengchun Chen et al. International Journal of Nanomedicine
- Association of expression quantitative trait loci for long noncoding RNAs with lung cancer risk in Asians
- (2019) Qi Sun et al. MOLECULAR CARCINOGENESIS
- Silencing AXL by covalent siRNA-gelatin-antibody nanoconjugate inactivates mTOR/EMT pathway and stimulates p53 for TKI sensitization in NSCLC
- (2019) Dhananjay Suresh et al. Nanomedicine-Nanotechnology Biology and Medicine
- RNases H: Structure and mechanism
- (2019) Malwina Hyjek et al. DNA REPAIR
- Interferon-inducible miR-128 modulates HIV-1 replication by targeting TNPO3 mRNA
- (2019) Aurore Bochnakian et al. JOURNAL OF VIROLOGY
- Highly efficient silencing of microRNA by heteroduplex oligonucleotides
- (2019) Kotaro Yoshioka et al. NUCLEIC ACIDS RESEARCH
- mRNA levels can be reduced by antisense oligonucleotides via no-go decay pathway
- (2019) Xue-hai Liang et al. NUCLEIC ACIDS RESEARCH
- PVT1 Promotes Angiogenesis by Regulating miR-29c/Vascular Endothelial Growth Factor (VEGF) Signaling Pathway in Non-Small-Cell Lung Cancer (NSCLC)
- (2019) Zejun Mao et al. MEDICAL SCIENCE MONITOR
- Effects of gold nanoprism-assisted human PD-L1 siRNA on both gene down-regulation and photothermal therapy on lung cancer
- (2019) Bin Liu et al. Acta Biomaterialia
- Effects of AntagomiRs on Different Lung Diseases in Human, Cellular, and Animal Models
- (2019) Giuseppe Murdaca et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- A divalent siRNA chemical scaffold for potent and sustained modulation of gene expression throughout the central nervous system
- (2019) Julia F. Alterman et al. NATURE BIOTECHNOLOGY
- A Randomized, Double‐Blinded, Phase II Trial of Carboplatin and Pemetrexed with or without Apatorsen (OGX‐427) in Patients with Previously Untreated Stage IV Non‐Squamous‐Non‐Small‐Cell Lung Cancer: The SPRUCE Trial
- (2019) David R. Spigel et al. ONCOLOGIST
- Rare epidermal growth factor receptor (EGFR) mutations in non-small cell lung cancer
- (2019) Peter T Harrison et al. SEMINARS IN CANCER BIOLOGY
- New Horizons in KRAS-Mutant Lung Cancer: Dawn After Darkness
- (2019) Haitang Yang et al. Frontiers in Oncology
- Long Non-coding RNA MALAT1 Promotes Angiogenesis and Immunosuppressive Properties of HCC Cells by sponging miR-140
- (2019) Zhou-Hua Hou et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- Non-coding RNA and Lung Cancer Progression
- (2019) Ishola Afeez Adekunle et al. Journal of the Chinese Medical Association
- AXL receptor tyrosine kinase as a promising anti-cancer approach: functions, molecular mechanisms and clinical applications
- (2019) Chenjing Zhu et al. Molecular Cancer
- A view on drug resistance in cancer
- (2019) Neil Vasan et al. NATURE
- Antitumor activity of an engineered decoy receptor targeting CLCF1–CNTFR signaling in lung adenocarcinoma
- (2019) Jun W. Kim et al. NATURE MEDICINE
- Pseudouridinylation of mRNA coding sequences alters translation
- (2019) Daniel E. Eyler et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The human secretome
- (2019) Mathias Uhlén et al. Science Signaling
- Discovery and preclinical evaluation of anti-miR-17 oligonucleotide RGLS4326 for the treatment of polycystic kidney disease
- (2019) Edmund C. Lee et al. Nature Communications
- RNase H1 and H2 Are Differentially Regulated to Process RNA-DNA Hybrids
- (2019) Arianna Lockhart et al. Cell Reports
- RNases H: Multiple roles in maintaining genome integrity
- (2019) Susana M. Cerritelli et al. DNA REPAIR
- Comparison of DNA and mRNA vaccines against cancer
- (2019) Zohreh Jahanafrooz et al. DRUG DISCOVERY TODAY
- Combined treatment with the histone deacetylase inhibitor LBH589 and a splice‐switch antisense oligonucleotide enhances SMN2 splicing and SMN expression in Spinal Muscular Atrophy cells
- (2019) Vittoria Pagliarini et al. JOURNAL OF NEUROCHEMISTRY
- Overcoming malignant cell-based mechanisms of resistance to immune checkpoint blockade antibodies
- (2019) Reham Ajina et al. SEMINARS IN CANCER BIOLOGY
- Uniform sarcolemmal dystrophin expression is required to prevent extracellular microRNA release and improve dystrophic pathology
- (2019) Tirsa L.E. Westering et al. Journal of Cachexia Sarcopenia and Muscle
- Argonaute Proteins and Mechanisms of RNA Interference in Eukaryotes and Prokaryotes
- (2018) A. V. Olina et al. BIOCHEMISTRY-MOSCOW
- PTBP1-Mediated Alternative Splicing Regulates the Inflammatory Secretome and the Pro-tumorigenic Effects of Senescent Cells
- (2018) Athena Georgilis et al. CANCER CELL
- Tumor Mutational Burden and Efficacy of Nivolumab Monotherapy and in Combination with Ipilimumab in Small-Cell Lung Cancer
- (2018) Matthew D. Hellmann et al. CANCER CELL
- Complex consisting of antisense DNA and β-glucan promotes internalization into cell through Dectin-1 and hybridizes with target mRNA in cytosol
- (2018) Nobuaki Fujiwara et al. CANCER GENE THERAPY
- Metazoan MicroRNAs
- (2018) David P. Bartel CELL
- RNA-Targeted Therapeutics
- (2018) Stanley T. Crooke et al. Cell Metabolism
- The nucleotides they are a-changin’: function of RNA binding proteins in post-transcriptional messenger RNA editing and modification in Arabidopsis
- (2018) Marianne C Kramer et al. CURRENT OPINION IN PLANT BIOLOGY
- Stromal PD-L1–Positive Regulatory T cells and PD-1–Positive CD8-Positive T cells Define the Response of Different Subsets of Non–Small Cell Lung Cancer to PD-1/PD-L1 Blockade Immunotherapy
- (2018) Si-Pei Wu et al. Journal of Thoracic Oncology
- Clinical Features and Management of Acquired Resistance to PD-1 Axis Inhibitors in 26 Patients With Advanced Non–Small Cell Lung Cancer
- (2018) Scott N. Gettinger et al. Journal of Thoracic Oncology
- Targeting Gas6/TAM in cancer cells and tumor microenvironment
- (2018) Guiling Wu et al. Molecular Cancer
- STAT3 Cyclic Decoy Demonstrates Robust Antitumor Effects in Non-Small Cell Lung Cancer
- (2018) Christian Njatcha et al. MOLECULAR CANCER THERAPEUTICS
- Self-Delivering RNAi Targeting PD-1 Improves Tumor-Specific T Cell Functionality for Adoptive Cell Therapy of Malignant Melanoma
- (2018) Maarten A. Ligtenberg et al. MOLECULAR THERAPY
- mRNA vaccines — a new era in vaccinology
- (2018) Norbert Pardi et al. NATURE REVIEWS DRUG DISCOVERY
- Patisiran, an RNAi Therapeutic, for Hereditary Transthyretin Amyloidosis
- (2018) David Adams et al. NEW ENGLAND JOURNAL OF MEDICINE
- STK11/LKB1 Mutations and PD-1 Inhibitor Resistance in KRAS -Mutant Lung Adenocarcinoma
- (2018) Ferdinandos Skoulidis et al. Cancer Discovery
- Alternative-splicing defects in cancer: Splicing regulators and their downstream targets, guiding the way to novel cancer therapeutics
- (2018) Laura M. Urbanski et al. Wiley Interdisciplinary Reviews-RNA
- Polymorphisms in the H19 gene and the risk of lung Cancer among female never smokers in Shenyang, China
- (2018) Zhihua Yin et al. BMC CANCER
- Cobomarsen, an oligonucleotide inhibitor of miR-155, co-ordinately regulates multiple survival pathways to reduce cellular proliferation and survival in cutaneous T-cell lymphoma
- (2018) Anita G. Seto et al. BRITISH JOURNAL OF HAEMATOLOGY
- Exploiting vulnerabilities in cancer signalling networks to combat targeted therapy resistance
- (2018) Peter T. Harrison et al. Essays in Biochemistry
- T7 Peptide-Conjugated Lipid Nanoparticles for Dual Modulation of Bcl-2 and Akt-1 in Lung and Cervical Carcinomas
- (2018) Xinwei Cheng et al. MOLECULAR PHARMACEUTICS
- An RNA toolbox for cancer immunotherapy
- (2018) Fernando Pastor et al. NATURE REVIEWS DRUG DISCOVERY
- Pembrolizumab plus Chemotherapy in Lung Cancer
- (2018) NEW ENGLAND JOURNAL OF MEDICINE
- MicroRNA-506 inhibits the proliferation and invasion of mantle cell lymphoma cells by targeting B7 H3
- (2018) Xiao-wen Zhu et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- The positive feedback between lncRNA TNK2-AS1 and STAT3 enhances angiogenesis in non-small cell lung cancer
- (2018) Yue Wang et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- A microRNA-29 mimic (remlarsen) represses extracellular matrix expression and fibroplasia in the skin
- (2018) Corrie L. Gallant-Behm et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- RNA Interference-Based Cancer Drugs: The Roadblocks, and the “Delivery” of the Promise
- (2018) Manisit Das et al. Nucleic Acid Therapeutics
- STAT3 antisense oligonucleotide AZD9150 in a subset of patients with heavily pretreated lymphoma: results of a phase 1b trial
- (2018) Matthew J. Reilley et al. Journal for ImmunoTherapy of Cancer
- DNA methylation aberrancies as a guide for surveillance and treatment of human cancers
- (2017) Gangning Liang et al. Epigenetics
- Immune phenotype and function of natural killer and T cells in chronic hepatitis C patients who received a single dose of anti-MicroRNA-122, RG-101
- (2017) Femke Stelma et al. HEPATOLOGY
- Angiogenesis Inhibitors in NSCLC
- (2017) Anna Manzo et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Safety, tolerability, and antiviral effect of RG-101 in patients with chronic hepatitis C: a phase 1B, double-blind, randomised controlled trial
- (2017) Meike H van der Ree et al. LANCET
- Lack of response to nivolumab in a patient with EGFR -mutant non-small cell lung cancer adenocarcinoma sub-type transformed to small cell lung cancer
- (2017) Nadza Tokaca et al. LUNG CANCER
- Pilot phase II study of metronomic chemotherapy in combination with bevacizumab in patients with advanced non-squamous non-small cell lung cancer
- (2017) Benjamin S. Jones et al. LUNG CANCER
- EMT and stemness: flexible processes tuned by alternative splicing in development and cancer progression
- (2017) Davide Pradella et al. Molecular Cancer
- Vulnerability of Small-Cell Lung Cancer to Apoptosis Induced by the Combination of BET Bromodomain Proteins and BCL2 Inhibitors
- (2017) Lloyd T. Lam et al. MOLECULAR CANCER THERAPEUTICS
- RNase H1-Dependent Antisense Oligonucleotides Are Robustly Active in Directing RNA Cleavage in Both the Cytoplasm and the Nucleus
- (2017) Xue-Hai Liang et al. MOLECULAR THERAPY
- The chemical evolution of oligonucleotide therapies of clinical utility
- (2017) Anastasia Khvorova et al. NATURE BIOTECHNOLOGY
- Cellular uptake and trafficking of antisense oligonucleotides
- (2017) Stanley T Crooke et al. NATURE BIOTECHNOLOGY
- The LINK-A lncRNA interacts with PtdIns(3,4,5)P3 to hyperactivate AKT and confer resistance to AKT inhibitors
- (2017) Aifu Lin et al. NATURE CELL BIOLOGY
- Unravelling the biology of SCLC: implications for therapy
- (2017) Joshua K. Sabari et al. Nature Reviews Clinical Oncology
- MicroRNA therapeutics: towards a new era for the management of cancer and other diseases
- (2017) Rajesha Rupaimoole et al. NATURE REVIEWS DRUG DISCOVERY
- Detecting RNA modifications in the epitranscriptome: predict and validate
- (2017) Mark Helm et al. NATURE REVIEWS GENETICS
- 5΄-Vinylphosphonate improves tissue accumulation and efficacy of conjugated siRNAs in vivo
- (2017) Reka A. Haraszti et al. NUCLEIC ACIDS RESEARCH
- Antisense oligonucleotides targeting translation inhibitory elements in 5′ UTRs can selectively increase protein levels
- (2017) Xue-hai Liang et al. NUCLEIC ACIDS RESEARCH
- Targeting KRAS-dependent tumors with AZD4785, a high-affinity therapeutic antisense oligonucleotide inhibitor of KRAS
- (2017) Sarah J. Ross et al. Science Translational Medicine
- The druggable genome and support for target identification and validation in drug development
- (2017) Chris Finan et al. Science Translational Medicine
- Biogenesis and Function of Ago-Associated RNAs
- (2017) Iben Daugaard et al. TRENDS IN GENETICS
- Function of Axl receptor tyrosine kinase in non-small cell lung cancer (Review)
- (2017) Guoan Zhang et al. Oncology Letters
- Development of Exon Skipping Therapies for Duchenne Muscular Dystrophy: A Critical Review and a Perspective on the Outstanding Issues
- (2017) Annemieke Aartsma-Rus et al. Nucleic Acid Therapeutics
- Molecular Mechanisms of Antisense Oligonucleotides
- (2017) Stanley T. Crooke Nucleic Acid Therapeutics
- Efforts to Develop KRAS Inhibitors
- (2017) Matthew Holderfield Cold Spring Harbor Perspectives in Medicine
- Induced-Decay of Glycine Decarboxylase Transcripts as an Anticancer Therapeutic Strategy for Non-Small-Cell Lung Carcinoma
- (2017) Jing Lin et al. Molecular Therapy-Nucleic Acids
- siRNA-Encapsulated Hybrid Nanoparticles Target Mutant K- ras and Inhibit Metastatic Tumor Burden in a Mouse Model of Lung Cancer
- (2017) Maryna Perepelyuk et al. Molecular Therapy-Nucleic Acids
- siRNA Delivery Strategies: A Comprehensive Review of Recent Developments
- (2017) Katyayani Tatiparti et al. Nanomaterials
- OncomiR or Tumor Suppressor? The Duplicity of MicroRNAs in Cancer
- (2016) Alexander A. Svoronos et al. CANCER RESEARCH
- Dendritic Cell-Based Immunotherapy: State of the Art and Beyond
- (2016) K. F. Bol et al. CLINICAL CANCER RESEARCH
- RNA epigenetics — chemical messages for posttranscriptional gene regulation
- (2016) Ian A Roundtree et al. CURRENT OPINION IN CHEMICAL BIOLOGY
- Foxp transcription factors suppress a non-pulmonary gene expression program to permit proper lung development
- (2016) Shanru Li et al. DEVELOPMENTAL BIOLOGY
- Knockdown of delta-5-desaturase promotes the anti-cancer activity of dihomo-γ-linolenic acid and enhances the efficacy of chemotherapy in colon cancer cells expressing COX-2
- (2016) Yi Xu et al. FREE RADICAL BIOLOGY AND MEDICINE
- Highly stable polyglutamate derivatives/siRNA polyplex efficiently down-relegate survivin expression and augment the efficacy of cisplatin
- (2016) Zhongjuan Wang et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Arl4c is a key regulator of tubulogenesis and tumourigenesis as a target gene of Wnt–β-catenin and growth factor–Ras signalling
- (2016) Shinji Matsumoto et al. JOURNAL OF BIOCHEMISTRY
- Structural Analysis of Human Argonaute-2 Bound to a Modified siRNA Guide
- (2016) Nicole T. Schirle et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Reducible Dimeric Conjugates of Small Internally Segment Interfering RNA for Efficient Gene Silencing
- (2016) Cheol Am Hong et al. MACROMOLECULAR BIOSCIENCE
- Pairing beyond the Seed Supports MicroRNA Targeting Specificity
- (2016) James P. Broughton et al. MOLECULAR CELL
- Translation efficiency of mRNAs is increased by antisense oligonucleotides targeting upstream open reading frames
- (2016) Xue-hai Liang et al. NATURE BIOTECHNOLOGY
- ViableRNaseH1knockout mice show RNaseH1 is essential for R loop processing, mitochondrial and liver function
- (2016) Walt F. Lima et al. NUCLEIC ACIDS RESEARCH
- Enhanced Anti-Tumor Efficacy of Lipid-Modified Platinum Derivatives in Combination with Survivin Silencing siRNA in Resistant Non-Small Cell Lung Cancer
- (2016) George Mattheolabakis et al. PHARMACEUTICAL RESEARCH
- Lipid Nanoparticles Loaded with an Antisense Oligonucleotide Gapmer Against Bcl-2 for Treatment of Lung Cancer
- (2016) Xinwei Cheng et al. PHARMACEUTICAL RESEARCH
- Re-evaluation of the roles ofDROSHA,Exportin 5, andDICERin microRNA biogenesis
- (2016) Young-Kook Kim et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Cracking the epitranscriptome
- (2016) Schraga Schwartz RNA
- Messenger RNA modifications: Form, distribution, and function
- (2016) W. V. Gilbert et al. SCIENCE
- Cyclooxygenase-2 is associated with malignant phenotypes in human lung cancer
- (2016) Weiying Li et al. Oncology Letters
- Association of variations in HLA class II and other loci with susceptibility to EGFR-mutated lung adenocarcinoma
- (2016) Kouya Shiraishi et al. Nature Communications
- Heterogeneity of the resistance to gefitinib treatment in a non-small cell lung cancer patient with active epidermal growth factor receptor mutation
- (2016) Chong-Rui Xu et al. Thoracic Cancer
- Translating the Genome in Time and Space: Specialized Ribosomes, RNA Regulons, and RNA-Binding Proteins
- (2015) Zhen Shi et al. Annual Review of Cell and Developmental Biology
- Small-Molecule Bcl2 BH4 Antagonist for Lung Cancer Therapy
- (2015) Bingshe Han et al. CANCER CELL
- Cyclooxygenase-2 promotes tumor growth and suppresses tumor immunity
- (2015) Bing Liu et al. Cancer Cell International
- Single-Molecule Imaging Reveals that Argonaute Reshapes the Binding Properties of Its Nucleic Acid Guides
- (2015) William E. Salomon et al. CELL
- 5′ UTR m6A Promotes Cap-Independent Translation
- (2015) Kate D. Meyer et al. CELL
- N6-methyladenosine Modulates Messenger RNA Translation Efficiency
- (2015) Xiao Wang et al. CELL
- Cancer arises from stem cells: opportunities for anticancer drug discovery
- (2015) Miguel López-Lázaro DRUG DISCOVERY TODAY
- Potent effect of adenoviral vector expressing short hairpin RNA targeting ribonucleotide reductase large subunit M1 on cell viability and chemotherapeutic sensitivity to gemcitabine in non-small cell lung cancer cells
- (2015) Yoshimasa Tokunaga et al. EUROPEAN JOURNAL OF CANCER
- Cyclooxygenase-2 inhibitors in lung cancer treatment: Bench to bed
- (2015) Rui Liu et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Linking RNA biology to lncRNAs
- (2015) Loyal A. Goff et al. GENOME RESEARCH
- Anti-angiogenic-specific adverse events in patients with non-small cell lung cancer treated with nintedanib and docetaxel
- (2015) Martin Reck et al. LUNG CANCER
- Comprehensive genomic profiles of small cell lung cancer
- (2015) Julie George et al. NATURE
- Dynamic m6A mRNA methylation directs translational control of heat shock response
- (2015) Jun Zhou et al. NATURE
- Nucleotide modifications within bacterial messenger RNAs regulate their translation and are able to rewire the genetic code
- (2015) Thomas Philipp Hoernes et al. NUCLEIC ACIDS RESEARCH
- AZD9150, a next-generation antisense oligonucleotide inhibitor of STAT3 with early evidence of clinical activity in lymphoma and lung cancer
- (2015) David Hong et al. Science Translational Medicine
- A randomized phase II study of the telomerase inhibitor imetelstat as maintenance therapy for advanced non-small-cell lung cancer
- (2014) A. A. Chiappori et al. ANNALS OF ONCOLOGY
- In VitroAntiviral Activity and Preclinical and Clinical Resistance Profile of Miravirsen, a Novel Anti-Hepatitis C Virus Therapeutic Targeting the Human Factor miR-122
- (2014) Søren Ottosen et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Highly effective inhibition of lung cancer growth and metastasis by systemic delivery of siRNA via multimodal mesoporous silica-based nanocarrier
- (2014) Yijie Chen et al. BIOMATERIALS
- AXL Mediates Resistance to Cetuximab Therapy
- (2014) T. M. Brand et al. CANCER RESEARCH
- FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis
- (2014) Xu Zhao et al. CELL RESEARCH
- Anti–microRNA-21 oligonucleotides prevent Alport nephropathy progression by stimulating metabolic pathways
- (2014) Ivan G. Gomez et al. JOURNAL OF CLINICAL INVESTIGATION
- Evaluation of Antitumor Activity Using Change in Tumor Size of the Survivin Antisense Oligonucleotide LY2181308 in Combination with Docetaxel for Second-Line Treatment of Patients with Non–Small-Cell Lung Cancer: A Randomized Open-Label Phase II Study
- (2014) Ronald Natale et al. Journal of Thoracic Oncology
- A 3′UTR polymorphism modulates mRNA stability of the oncogene and drug target Polo-like Kinase 1
- (2014) Neval Akdeli et al. Molecular Cancer
- N6-methyladenosine modification destabilizes developmental regulators in embryonic stem cells
- (2014) Yang Wang et al. NATURE CELL BIOLOGY
- mRNA-based therapeutics — developing a new class of drugs
- (2014) Ugur Sahin et al. NATURE REVIEWS DRUG DISCOVERY
- Arl4c expression in colorectal and lung cancers promotes tumorigenesis and may represent a novel therapeutic target
- (2014) S Fujii et al. ONCOGENE
- Small RNA combination therapy for lung cancer
- (2014) W. Xue et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- RNAi Therapies: Drugging the Undruggable
- (2014) S. Y. Wu et al. Science Translational Medicine
- Axl-altered microRNAs regulate tumorigenicity and gefitinib resistance in lung cancer
- (2014) Y Wang et al. Cell Death & Disease
- Molecular Mechanisms of RNA Interference
- (2013) Ross C. Wilson et al. Annual Review of Biophysics
- Systematic Identification of Molecular Subtype-Selective Vulnerabilities in Non-Small-Cell Lung Cancer
- (2013) Hyun Seok Kim et al. CELL
- Novel Hydrophobically Modified Asymmetric RNAi Compounds (sd-rxRNA) Demonstrate Robust Efficacy in the Eye
- (2013) Michael Byrne et al. JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS
- Codelivery of VEGF siRNA and Gemcitabine Monophosphate in a Single Nanoparticle Formulation for Effective Treatment of NSCLC
- (2013) Yuan Zhang et al. MOLECULAR THERAPY
- N6-methyladenosine-dependent regulation of messenger RNA stability
- (2013) Xiao Wang et al. NATURE
- Molecular dissection of human Argonaute proteins by DNA shuffling
- (2013) Nina Schürmann et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Treatment of HCV Infection by Targeting MicroRNA
- (2013) Harry L.A. Janssen et al. NEW ENGLAND JOURNAL OF MEDICINE
- Effect of siRNAs targeting the EGFR T790M mutation in a non-small cell lung cancer cell line resistant to EGFR tyrosine kinase inhibitors and combination with various agents
- (2012) Gang Chen et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Glycine Decarboxylase Activity Drives Non-Small Cell Lung Cancer Tumor-Initiating Cells and Tumorigenesis
- (2012) Wen Cai Zhang et al. CELL
- Single-Stranded RNAs Use RNAi to Potently and Allele-Selectively Inhibit Mutant Huntingtin Expression
- (2012) Dongbo Yu et al. CELL
- Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism
- (2012) Haoqiang Ying et al. CELL
- Single-Stranded siRNAs Activate RNAi in Animals
- (2012) Walt F. Lima et al. CELL
- Discovering the first microRNA-targeted drug
- (2012) Morten Lindow et al. JOURNAL OF CELL BIOLOGY
- A step towards treating KRAS-mutant NSCLC
- (2012) Sarah B Goldberg et al. LANCET ONCOLOGY
- Stabilization of hepatitis C virus RNA by an Ago2-miR-122 complex
- (2012) T. Shimakami et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The birth of the Epitranscriptome: deciphering the function of RNA modifications
- (2012) Yogesh Saletore et al. GENOME BIOLOGY
- MicroRNAs and the cell cycle
- (2011) María José Bueno et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Involvement of DNA ligase III and ribonuclease H1 in mitochondrial DNA replication in cultured human cells
- (2011) Heini Ruhanen et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Cellular Uptake and Intracellular Trafficking of Antisense and siRNA Oligonucleotides
- (2011) Rudolph L. Juliano et al. BIOCONJUGATE CHEMISTRY
- Phase I/II Trial of Custirsen (OGX-011), an Inhibitor of Clusterin, in Combination with a Gemcitabine and Platinum Regimen in Patients with Previously Untreated Advanced Non-small Cell Lung Cancer
- (2011) Janessa J. Laskin et al. Journal of Thoracic Oncology
- Small-cell lung cancer
- (2011) Jan P van Meerbeeck et al. LANCET
- miR-34a and miR-15a/16 are co-regulated in non-small cell lung cancer and control cell cycle progression in a synergistic and Rb-dependent manner
- (2011) Nora Bandi et al. Molecular Cancer
- RNA Targeting Therapeutics: Molecular Mechanisms of Antisense Oligonucleotides as a Therapeutic Platform
- (2010) C. Frank Bennett et al. Annual Review of Pharmacology and Toxicology
- Targeting microRNA-122 to Treat Hepatitis C Virus Infection
- (2010) Catherine L. Jopling Viruses-Basel
- β-Glucans and Dectin-1
- (2009) S. Vicky Tsoni et al. Annals of the New York Academy of Sciences
- Non-Small Cell Lung Cancer: Epidemiology, Risk Factors, Treatment, and Survivorship
- (2009) Julian R. Molina et al. MAYO CLINIC PROCEEDINGS
- Tumour-initiating cells: challenges and opportunities for anticancer drug discovery
- (2009) Bin-Bing S. Zhou et al. NATURE REVIEWS DRUG DISCOVERY
- Randomized Phase II Study of Carboplatin and Etoposide With or Without thebcl-2Antisense Oligonucleotide Oblimersen for Extensive-Stage Small-Cell Lung Cancer: CALGB 30103
- (2008) Charles M. Rudin et al. JOURNAL OF CLINICAL ONCOLOGY
- Incorporation of Pseudouridine Into mRNA Yields Superior Nonimmunogenic Vector With Increased Translational Capacity and Biological Stability
- (2008) Katalin Karikó et al. MOLECULAR THERAPY
- Tumor Angiogenesis
- (2008) Robert S. Kerbel NEW ENGLAND JOURNAL OF MEDICINE
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started