The druggable genome and support for target identification and validation in drug development
Published 2017 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
The druggable genome and support for target identification and validation in drug development
Authors
Keywords
-
Journal
Science Translational Medicine
Volume 9, Issue 383, Pages eaag1166
Publisher
American Association for the Advancement of Science (AAAS)
Online
2017-03-30
DOI
10.1126/scitranslmed.aag1166
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Metabolomic Profiling of Statin Use and Genetic Inhibition of HMG-CoA Reductase
- (2016) Peter Würtz et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- 2015 FDA drug approvals
- (2016) Asher Mullard NATURE REVIEWS DRUG DISCOVERY
- A comprehensive map of molecular drug targets
- (2016) Rita Santos et al. NATURE REVIEWS DRUG DISCOVERY
- A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease
- (2016) Robert A. Scott et al. Science Translational Medicine
- How Good Is “Evidence” from Clinical Studies of Drug Effects and Why Might Such Evidence Fail in the Prediction of the Clinical Utility of Drugs?
- (2015) Huseyin Naci et al. Annual Review of Pharmacology and Toxicology
- HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials
- (2015) Daniel I Swerdlow et al. LANCET
- A global reference for human genetic variation
- (2015) Richard A. Gibbs et al. NATURE
- The support of human genetic evidence for approved drug indications
- (2015) Matthew R Nelson et al. NATURE GENETICS
- The fickle P value generates irreproducible results
- (2015) Lewis G Halsey et al. NATURE METHODS
- DGIdb 2.0: mining clinically relevant drug–gene interactions
- (2015) Alex H. Wagner et al. NUCLEIC ACIDS RESEARCH
- The SIDER database of drugs and side effects
- (2015) Michael Kuhn et al. NUCLEIC ACIDS RESEARCH
- Risk of Bias in Reports of In Vivo Research: A Focus for Improvement
- (2015) Malcolm R. Macleod et al. PLOS BIOLOGY
- Second-generation PLINK: rising to the challenge of larger and richer datasets
- (2015) Christopher C Chang et al. GigaScience
- The Ensembl REST API: Ensembl Data for Any Language
- (2014) Andrew Yates et al. BIOINFORMATICS
- Lessons learned from the fate of AstraZeneca's drug pipeline: a five-dimensional framework
- (2014) David Cook et al. NATURE REVIEWS DRUG DISCOVERY
- UniProt: a hub for protein information
- (2014) NUCLEIC ACIDS RESEARCH
- Bayesian Test for Colocalisation between Pairs of Genetic Association Studies Using Summary Statistics
- (2014) Claudia Giambartolomei et al. PLoS Genetics
- An investigation of the false discovery rate and the misinterpretation of p-values
- (2014) D. Colquhoun Royal Society Open Science
- The Druggable Genome: Evaluation of Drug Targets in Clinical Trials Suggests Major Shifts in Molecular Class and Indication
- (2013) Mathias Rask-Andersen et al. Annual Review of Pharmacology and Toxicology
- How far in-silico computing meets real experiments. A study on the structure and dynamics of spin labeled vinculin tail protein by molecular dynamics simulations and EPR spectroscopy
- (2013) MNV Prasad Gajula et al. BMC GENOMICS
- Secretory Phospholipase A 2 -IIA and Cardiovascular Disease
- (2013) Michael V. Holmes et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Phase II and Phase III attrition rates 2011–2012
- (2013) John Arrowsmith et al. NATURE REVIEWS DRUG DISCOVERY
- Validating therapeutic targets through human genetics
- (2013) Robert M. Plenge et al. NATURE REVIEWS DRUG DISCOVERY
- DrugBank 4.0: shedding new light on drug metabolism
- (2013) Vivian Law et al. NUCLEIC ACIDS RESEARCH
- The IUPHAR/BPS Guide to PHARMACOLOGY: an expert-driven knowledgebase of drug targets and their ligands
- (2013) Adam J. Pawson et al. NUCLEIC ACIDS RESEARCH
- The ChEMBL bioactivity database: an update
- (2013) A. Patrícia Bento et al. NUCLEIC ACIDS RESEARCH
- Pfam: the protein families database
- (2013) Robert D. Finn et al. NUCLEIC ACIDS RESEARCH
- Prioritizing Potentially Druggable Mutations with dGene: An Annotation Tool for Cancer Genome Sequencing Data
- (2013) Runjun D. Kumar et al. PLoS One
- Pharmacogenomics Knowledge for Personalized Medicine
- (2012) M Whirl-Carrillo et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
- Identification of cis-regulatory variation influencing protein abundance levels in human plasma
- (2012) Anbarasu Lourdusamy et al. HUMAN MOLECULAR GENETICS
- Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies
- (2012) LANCET
- The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis
- (2012) LANCET
- Use of genome-wide association studies for drug repositioning
- (2012) Philippe Sanseau et al. NATURE BIOTECHNOLOGY
- The Metabochip, a Custom Genotyping Array for Genetic Studies of Metabolic, Cardiovascular, and Anthropometric Traits
- (2012) Benjamin F. Voight et al. PLoS Genetics
- Abundant Pleiotropy in Human Complex Diseases and Traits
- (2011) Shanya Sivakumaran et al. AMERICAN JOURNAL OF HUMAN GENETICS
- The variant call format and VCFtools
- (2011) P. Danecek et al. BIOINFORMATICS
- Human metabolic individuality in biomedical and pharmaceutical research
- (2011) Karsten Suhre et al. NATURE
- Therapeutic target database update 2012: a resource for facilitating target-oriented drug discovery
- (2011) F. Zhu et al. NUCLEIC ACIDS RESEARCH
- Disease Ontology: a backbone for disease semantic integration
- (2011) L. M. Schriml et al. NUCLEIC ACIDS RESEARCH
- ChEMBL: a large-scale bioactivity database for drug discovery
- (2011) A. Gaulton et al. NUCLEIC ACIDS RESEARCH
- Reengineering Translational Science: The Time Is Right
- (2011) F. S. Collins Science Translational Medicine
- Correlation between endothelial function and carotid atherosclerosis in rheumatoid arthritis patients with long-standing disease
- (2011) Carlos González-Juanatey et al. ARTHRITIS RESEARCH & THERAPY
- PLA2G7 Genotype, Lipoprotein-Associated Phospholipase A 2 Activity, and Coronary Heart Disease Risk in 10 494 Cases and 15 624 Controls of European Ancestry
- (2010) Juan P. Casas et al. CIRCULATION
- The Human Phenotype Ontology
- (2010) PN Robinson et al. CLINICAL GENETICS
- Protein tyrosine phosphatases as drug targets: strategies and challenges of inhibitor development
- (2010) Alastair J Barr Future Medicinal Chemistry
- Genome-wide association analysis identifies multiple loci related to resting heart rate
- (2010) M. Eijgelsheim et al. HUMAN MOLECULAR GENETICS
- The NIH Roadmap Epigenomics Mapping Consortium
- (2010) Bradley E Bernstein et al. NATURE BIOTECHNOLOGY
- How to improve R&D productivity: the pharmaceutical industry's grand challenge
- (2010) Steven M. Paul et al. NATURE REVIEWS DRUG DISCOVERY
- Can Animal Models of Disease Reliably Inform Human Studies?
- (2010) H. Bart van der Worp et al. PLOS MEDICINE
- Separating the Mechanism-Based and Off-Target Actions of Cholesteryl Ester Transfer Protein Inhibitors With CETP Gene Polymorphisms
- (2009) Reecha Sofat et al. CIRCULATION
- Lessons from 60 years of pharmaceutical innovation
- (2009) Bernard Munos NATURE REVIEWS DRUG DISCOVERY
- Potential etiologic and functional implications of genome-wide association loci for human diseases and traits
- (2009) L. A. Hindorff et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Concept, Design and Implementation of a Cardiovascular Gene-Centric 50 K SNP Array for Large-Scale Genomic Association Studies
- (2008) Brendan J. Keating et al. PLoS One
- A Genome-Wide Association Study Identifies Protein Quantitative Trait Loci (pQTLs)
- (2008) David Melzer et al. PLoS Genetics
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started