Effects of AntagomiRs on Different Lung Diseases in Human, Cellular, and Animal Models

New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries

(2019) Nick Shrine et al.   NATURE GENETICS

Endothelial miR-30c suppresses tumor growth via inhibition of TGF-β–induced Serpine1

(2019) James V. McCann et al.   JOURNAL OF CLINICAL INVESTIGATION

Effect of long-term corticosteroid treatment on microRNA and gene-expression profiles in Chronic Obstructive Pulmonary Disease

(2019) Alen Faiz et al.   EUROPEAN RESPIRATORY JOURNAL

Downregulation of miR-146a inhibits influenza A virus replication by enhancing the type I interferon response in vitro and in vivo

(2019) Fuming Zhang et al.   BIOMEDICINE & PHARMACOTHERAPY

MicroRNAs in COPD: small molecules with big potential

(2019) Brian D. Hobbs et al.   EUROPEAN RESPIRATORY JOURNAL

MiR‐21 upregulation increases IL‐8 expression and tumorigenesis program in airway epithelial cells exposed to cigarette smoke

(2019) Elisabetta Pace et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Diagnostic biomarker and therapeutic target applications of miR‐326 in cancers: A systematic review

(2019) Golamreza Jadideslam et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Pharmacological strategies to regain steroid sensitivity in severe asthma and COPD

(2019) Dan Mei et al.   CURRENT OPINION IN PHARMACOLOGY

Mesenchymal stromal cells-derived exosomes alleviate ischemia/reperfusion injury in mouse lung by transporting anti-apoptotic miR-21-5p

(2019) Ji wei Li et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Exosomal miR-499a-5p promotes cell proliferation, migration and EMT via mTOR signaling pathway in lung adenocarcinoma

(2019) Shan He et al.   EXPERIMENTAL CELL RESEARCH

Pleiotropic microRNA-21 in pulmonary remodeling: novel insights for molecular mechanism and present advancements

(2019) Congshan Jiang et al.   Allergy Asthma and Clinical Immunology

MK2 mediates macrophage activation and acute lung injury by regulating let-7e miRNA

(2018) Yaxian Wu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Metazoan MicroRNAs

(2018) David P. Bartel   CELL

Macrophage-derived extracellular vesicles mediates smooth muscle hyperplasia: role of altered miRNA cargo in response to HIV-infection and substance abuse

(2018) Himanshu Sharma et al.   FASEB JOURNAL

miR-34b-5p inhibition attenuates lung inflammation and apoptosis in an LPS-induced acute lung injury mouse model by targeting progranulin

(2018) Wang Xie et al.   JOURNAL OF CELLULAR PHYSIOLOGY

miR-1 is increased in pulmonary hypertension and downregulates Kv1.5 channels in rat pulmonary arteries

(2018) Gema Mondejar-Parreño et al.   JOURNAL OF PHYSIOLOGY-LONDON

MicroRNA-92a antagonism attenuates lipopolysaccharide (LPS)-induced pulmonary inflammation and injury in mice through suppressing the PTEN/AKT/NF-κB signaling pathway

(2018) Liming Fu et al.   BIOMEDICINE & PHARMACOTHERAPY

MicroRNA-570 is a novel regulator of cellular senescence and inflammaging

(2018) Jonathan R. Baker et al.   FASEB JOURNAL

Control Interventions can Impact Alveolarization and the Transcriptome in Developing Mouse Lungs

(2018) Joshua Fehl et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

Exosomal transfer of miR-214 mediates gefitinib resistance in non-small cell lung cancer

(2018) Yan Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Downregulated microRNA-27b attenuates lipopolysaccharide-induced acute lung injury via activation of NF-E2-related factor 2 and inhibition of nuclear factor κB signaling pathway

(2018) Yan Huang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Inhibition of MicroRNA-21 by an antagomir ameliorates allergic inflammation in a mouse model of asthma

(2017) Hwa Young Lee et al.   EXPERIMENTAL LUNG RESEARCH

miR-768-3p is involved in the proliferation, invasion and migration of non-small cell lung carcinomas

(2017) Zuozhou Xie et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

MicroRNA-21 drives severe, steroid-insensitive experimental asthma by amplifying phosphoinositide 3-kinase–mediated suppression of histone deacetylase 2

(2017) Richard Y. Kim et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

MiR-125a regulates mitochondrial homeostasis through targeting mitofusin 1 to control hypoxic pulmonary vascular remodeling

(2017) Cui Ma et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Oligonucleotide Therapy for Obstructive and Restrictive Respiratory Diseases

(2017) Wupeng Liao et al.   MOLECULES

cfa-miR-143 Promotes Apoptosis via the p53 Pathway in Canine Influenza Virus H3N2-Infected Cells

(2017) Pei Zhou et al.   Viruses-Basel

Thy-1 dependent uptake of mesenchymal stem cell-derived extracellular vesicles blocks myofibroblastic differentiation

(2017) Tzu-Pin Shentu et al.   Scientific Reports

DNA Methylation of miR-7 is a Mechanism Involved in Platinum Response through MAFG Overexpression in Cancer Cells

(2017) Olga Vera et al.   Theranostics

MicroRNA-346 facilitates cell growth and metastasis, and suppresses cell apoptosis in human non-small cell lung cancer by regulation of XPC/ERK/Snail/E-cadherin pathway

(2016) Cheng-Cao Sun et al.   Aging-US

MicroRNA-155 regulates host immune response to postviral bacterial pneumonia via IL-23/IL-17 pathway

(2016) Amy Podsiad et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

TREM-1-accentuated lung injury via miR-155 is inhibited by LP17 nanomedicine

(2016) Zhihong Yuan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Impaired Antiviral Stress Granule and IFN-β Enhanceosome Formation Enhances Susceptibility to Influenza Infection in Chronic Obstructive Pulmonary Disease Epithelium

(2016) Alan C.-Y. Hsu et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Targeting oncomiRNAs and mimicking tumor suppressor miRNAs: New trends in the development of miRNA therapeutic strategies in oncology (Review)

(2016) ROBERTO GAMBARI et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Correlation between serum IL-1β and miR-144-3p as well as their prognostic values in LUAD and LUSC patients

(2016) Chen Wu et al.   Oncotarget

In Vivo Therapeutic Success of MicroRNA-155 Antagomir in a Mouse Model of Lupus Alveolar Hemorrhage

(2016) Shiyu Zhou et al.   Arthritis & Rheumatology

Reversal of MicroRNA Dysregulation in an Animal Model of Pulmonary Hypertension

(2016) Igor B. Gubrij et al.   PLoS One

Oxidative stress dependent microRNA-34a activation via PI3Kα reduces the expression of sirtuin-1 and sirtuin-6 in epithelial cells

(2016) J. R. Baker et al.   Scientific Reports

Cyclooxygenase-2 and MicroRNA-155 Expression Are Elevated in Asthmatic Airway Smooth Muscle Cells

(2015) Brian S. Comer et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Tumor-derived microRNA-494 promotes angiogenesis in non-small cell lung cancer

(2015) Guangmei Mao et al.   ANGIOGENESIS

miR-25 targets the modulator of apoptosis 1 gene in lung cancer

(2015) Tangwei Wu et al.   CARCINOGENESIS

2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension

(2015) Nazzareno Galiè et al.   EUROPEAN HEART JOURNAL

High levels of apoptosis are induced in human glioma cell lines by co-administration of peptide nucleic acids targeting miR-221 and miR-222

(2015) ELEONORA BROGNARA et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

MicroRNA-9 regulates steroid-resistant airway hyperresponsiveness by reducing protein phosphatase 2A activity

(2015) Jing Jing Li et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Role of miR206 in genistein-induced rescue of pulmonary hypertension in monocrotaline model

(2015) Salil Sharma et al.   JOURNAL OF APPLIED PHYSIOLOGY

Simultaneous delivery of therapeutic antagomirs with paclitaxel for the management of metastatic tumors by a pH-responsive anti-microbial peptide-mediated liposomal delivery system

(2015) Qianyu Zhang et al.   JOURNAL OF CONTROLLED RELEASE

Antagomir-1290 suppresses CD133+ cells in non-small cell lung cancer by targeting fyn-related Src family tyrosine kinase

(2015) Bo Sun et al.   TUMOR BIOLOGY

miR-96 induces cisplatin chemoresistance in non-small cell lung cancer cells by downregulating SAMD9

(2015) LIN WU et al.   Oncology Letters

Targeting of RUNX3 by miR-130a and miR-495 cooperatively increases cell proliferation and tumor angiogenesis in gastric cancer cells

(2015) Sun Hee Lee et al.   Oncotarget

ADAM9 enhances CDCP1 protein expression by suppressing miR-218 for lung tumor metastasis

(2015) Kuo-Liang Chiu et al.   Scientific Reports

MicroRNA Expression Is Altered in an Ovalbumin-Induced Asthma Model and Targeting miR-155 with Antagomirs Reveals Cellular Specificity

(2015) Maximilian W. Plank et al.   PLoS One

An 11-nt sequence polymorphism at the 3′UTR of human SFTPA1 and SFTPA2 gene variants differentially affect gene expression levels and miRNA regulation in cell culture

(2014) Patricia Silveyra et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Impaired Angiogenesis and Peripheral Muscle Microcirculation Loss Contributes to Exercise Intolerance in Pulmonary Arterial Hypertension

(2014) François Potus et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Expression of microRNA-93 and Interleukin-8 duringPseudomonas aeruginosa–Mediated Induction of Proinflammatory Responses

(2014) Enrica Fabbri et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

The microRNA miR-17 regulates lung FoxA1 expression during lipopolysaccharide-induced acute lung injury

(2014) Zhaojun Xu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Honeysuckle-encoded atypical microRNA2911 directly targets influenza A viruses

(2014) Zhen Zhou et al.   CELL RESEARCH

The microRNA miR-34a Inhibits Non-Small Cell Lung Cancer (NSCLC) Growth and the CD44hi Stem-Like NSCLC Cells

(2014) Yang Shi et al.   PLoS One

MicroRNA-147b Regulates Vascular Endothelial Barrier Function by Targeting ADAM15 Expression

(2014) Victor Chatterjee et al.   PLoS One

Chronic Ethanol Consumption Modulates Growth Factor Release, Mucosal Cytokine Production, and MicroRNA Expression in Nonhuman Primates

(2013) Mark Asquith et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

MicroRNA Regulation of Nonmuscle Myosin Light Chain Kinase Expression in Human Lung Endothelium

(2013) Djanybek M. Adyshev et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

First microRNA mimic enters clinic

(2013) Aaron Bouchie   NATURE BIOTECHNOLOGY

Treatment of HCV Infection by Targeting MicroRNA

(2013) Harry L.A. Janssen et al.   NEW ENGLAND JOURNAL OF MEDICINE

MicroRNA-135b promotes lung cancer metastasis by regulating multiple targets in the Hippo pathway and LZTS1

(2013) Ching-Wen Lin et al.   Nature Communications

MicroRNA profiles in nasal mucosa of patients with allergic and nonallergic rhinitis and asthma

(2013) Hille Suojalehto et al.   International Forum of Allergy & Rhinology

Role of microRNAs in Lung Development and Pulmonary Diseases

(2013) Roberto Sessa et al.   Pulmonary Circulation

AntagomiR directed against miR-20a restores functional BMPR2 signalling and prevents vascular remodelling in hypoxia-induced pulmonary hypertension

(2012) Matthias Brock et al.   EUROPEAN HEART JOURNAL

miR-451 Regulates Dendritic Cell Cytokine Responses to Influenza Infection

(2012) C. M. Rosenberger et al.   JOURNAL OF IMMUNOLOGY

MicroRNA-302 Replacement Therapy Sensitizes Breast Cancer Cells to Ionizing Radiation

(2012) Zhongxing Liang et al.   PHARMACEUTICAL RESEARCH

Inhibition of MicroRNA-17 Improves Lung and Heart Function in Experimental Pulmonary Hypertension

(2011) Soni S. Pullamsetti et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Inhibition of house dust mite–induced allergic airways disease by antagonism of microRNA-145 is comparable to glucocorticoid treatment

(2011) Adam Collison et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Elevated miR-155 Promotes Inflammation in Cystic Fibrosis by Driving Hyperexpression of Interleukin-8

(2011) Sharmistha Bhattacharyya et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Integrating microRNAs into a system biology approach to acute lung injury

(2011) Tong Zhou et al.   Translational Research

Inhibition and Role of let-7d in Idiopathic Pulmonary Fibrosis

(2010) Kusum V. Pandit et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

miR-212 Increases Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand Sensitivity in Non–Small Cell Lung Cancer by Targeting the Antiapoptotic Protein PED

(2010) Mariarosaria Incoronato et al.   CANCER RESEARCH

MicroRNA-519c Suppresses Hypoxia-Inducible Factor-1α Expression and Tumor Angiogenesis

(2010) Shih-Ting Cha et al.   CANCER RESEARCH

MicroRNA-21 (miR-21) represses tumor suppressor PTEN and promotes growth and invasion in non-small cell lung cancer (NSCLC)

(2010) Ji-guang Zhang et al.   CLINICA CHIMICA ACTA

Gene expression profiling of drug-resistant small cell lung cancer cells by combining microRNA and cDNA expression analysis

(2010) Linlang Guo et al.   EUROPEAN JOURNAL OF CANCER

miR-21 mediates fibrogenic activation of pulmonary fibroblasts and lung fibrosis

(2010) Gang Liu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The widespread regulation of microRNA biogenesis, function and decay

(2010) Jacek Krol et al.   NATURE REVIEWS GENETICS

Down-Regulation of miR-133a Contributes to Up-Regulation of RhoA in Bronchial Smooth Muscle Cells

(2009) Yoshihiko Chiba et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Potential Uses of MicroRNA in Lung Cancer Diagnosis, Prognosis, and Therapy

(2009) Qi Wang et al.   CURRENT CANCER DRUG TARGETS

MicroRNA Signature Predicts Survival and Relapse in Lung Cancer

(2008) Sung-Liang Yu et al.   CANCER CELL