Phase Ib evaluation of a self-adjuvanted protamine formulated mRNA-based active cancer immunotherapy, BI1361849 (CV9202), combined with local radiation treatment in patients with stage IV non-small cell lung cancer

Abscopal effects of radiotherapy and combined mRNA-based immunotherapy in a syngeneic, OVA-expressing thymoma mouse model

(2018) Lucas Basler et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Immunological Mechanisms Responsible for Radiation-Induced Abscopal Effect

(2018) María E. Rodríguez-Ruiz et al.   TRENDS IN IMMUNOLOGY

Randomized phase II study of pembrolizumab after stereotactic body radiotherapy (SBRT) versus pembrolizumab alone in patients with advanced non-small cell lung cancer: The PEMBRO-RT study.

(2018) Willemijn Theelen et al.   JOURNAL OF CLINICAL ONCOLOGY

Safety and immunogenicity of a mRNA rabies vaccine in healthy adults: an open-label, non-randomised, prospective, first-in-human phase 1 clinical trial

(2017) Martin Alberer et al.   LANCET

Personalized RNA mutanome vaccines mobilize poly-specific therapeutic immunity against cancer

(2017) Ugur Sahin et al.   NATURE

An immunogenic personal neoantigen vaccine for patients with melanoma

(2017) Patrick A. Ott et al.   NATURE

Targeting neoantigens for cancer immunotherapy: Table 1.

(2016) Yong-Chen Lu et al.   INTERNATIONAL IMMUNOLOGY

Efficacy of the MAGE-A3 cancer immunotherapeutic as adjuvant therapy in patients with resected MAGE-A3-positive non-small-cell lung cancer (MAGRIT): a randomised, double-blind, placebo-controlled, phase 3 trial

(2016) Johan F Vansteenkiste et al.   LANCET ONCOLOGY

TG4010 immunotherapy and first-line chemotherapy for advanced non-small-cell lung cancer (TIME): results from the phase 2b part of a randomised, double-blind, placebo-controlled, phase 2b/3 trial

(2016) Elisabeth Quoix et al.   LANCET ONCOLOGY

Distinct transcriptional changes in non-small cell lung cancer patients associated with multi-antigenic RNActive® CV9201 immunotherapy

(2016) Henoch S. Hong et al.   OncoImmunology

Current clinical trials testing the combination of immunotherapy with radiotherapy

(2016) Josephine Kang et al.   Journal for ImmunoTherapy of Cancer

Tumor neoantigens: building a framework for personalized cancer immunotherapy

(2015) Matthew M. Gubin et al.   JOURNAL OF CLINICAL INVESTIGATION

Clinical Trials Integrating Immunotherapy and Radiation for Non–Small-Cell Lung Cancer

(2015) Megan E. Daly et al.   Journal of Thoracic Oncology

Role of Local Radiation Therapy in Cancer Immunotherapy

(2015) Sandra Demaria et al.   JAMA Oncology

Self-adjuvanted mRNA vaccination in advanced prostate cancer patients: a first-in-man phase I/IIa study

(2015) Hubert Kübler et al.   Journal for ImmunoTherapy of Cancer

Phase Ib study evaluating a self-adjuvanted mRNA cancer vaccine (RNActive®) combined with local radiation as consolidation and maintenance treatment for patients with stage IV non-small cell lung cancer

(2014) Martin Sebastian et al.   BMC CANCER

Expanding the use of monoclonal antibody therapy of cancer by using ionising radiation to upregulate antibody targets

(2014) M M Wattenberg et al.   BRITISH JOURNAL OF CANCER

Harmonisation of short-term in vitro culture for the expansion of antigen-specific CD8+ T cells with detection by ELISPOT and HLA-multimer staining

(2014) Lindsey Chudley et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Phase II Clinical Trial of Multiple Peptide Vaccination for Advanced Head and Neck Cancer Patients Revealed Induction of Immune Responses and Improved OS

(2014) Y. Yoshitake et al.   CLINICAL CANCER RESEARCH

A phase I study of combination vaccine treatment of five therapeutic epitope-peptides for metastatic colorectal cancer; safety, immunological response, and clinical outcome

(2014) Shoichi Hazama et al.   Journal of Translational Medicine

mRNA-based vaccines synergize with radiation therapy to eradicate established tumors

(2014) Mariola Fotin-Mleczek et al.   Radiation Oncology

A 12-Gene Set Predicts Survival Benefits from Adjuvant Chemotherapy in Non-Small Cell Lung Cancer Patients

(2013) H. Tang et al.   CLINICAL CANCER RESEARCH

Tecemotide (L-BLP25) versus placebo after chemoradiotherapy for stage III non-small-cell lung cancer (START): a randomised, double-blind, phase 3 trial

(2013) Charles Butts et al.   LANCET ONCOLOGY

A novel, disruptive vaccination technology

(2013) Karl-Josef Kallen et al.   Human Vaccines & Immunotherapeutics

An Abscopal Response to Radiation and Ipilimumab in a Patient with Metastatic Non-Small Cell Lung Cancer

(2013) E. B. Golden et al.   Cancer Immunology Research

Abscopal Regression of Antigen Disparate Tumors by Antigen Cascade After Systemic Tumor Vaccination in Combination with Local Tumor Radiation

(2012) James W. Hodge et al.   CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS

Changing the Tumor Microenvironment: New Strategies for Immunotherapy

(2012) P. Berraondo et al.   CANCER RESEARCH

Radiation Therapy to Convert the Tumor Into an In Situ Vaccine

(2012) Silvia C. Formenti et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Comprehensive genomic characterization of squamous cell lung cancers

(2012)   NATURE

Immunologic Correlates of the Abscopal Effect in a Patient with Melanoma

(2012) Michael A. Postow et al.   NEW ENGLAND JOURNAL OF MEDICINE

Maximizing Tumor Immunity With Fractionated Radiation

(2011) Dörthe Schaue et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

In Situ Vaccination With a TLR9 Agonist Induces Systemic Lymphoma Regression: A Phase I/II Study

(2010) Joshua D. Brody et al.   JOURNAL OF CLINICAL ONCOLOGY

Fractionated but Not Single-Dose Radiotherapy Induces an Immune-Mediated Abscopal Effect when Combined with Anti-CTLA-4 Antibody

(2009) M. Z. Dewan et al.   CLINICAL CANCER RESEARCH

Blockade of CTLA-4 on both effector and regulatory T cell compartments contributes to the antitumor activity of anti–CTLA-4 antibodies

(2009) Karl S. Peggs et al.   JOURNAL OF EXPERIMENTAL MEDICINE

New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1)

(2008) E.A. Eisenhauer et al.   EUROPEAN JOURNAL OF CANCER

Phase II Randomized Controlled Trial of an Epidermal Growth Factor Vaccine in Advanced Non–Small-Cell Lung Cancer

(2008) Elia Neninger Vinageras et al.   JOURNAL OF CLINICAL ONCOLOGY