Functional and Structural Aspects of La Protein Overexpression in Lung Cancer

Structural dynamics in the La-module of La-related proteins

(2020) Javier Lizarrondo et al.   RNA Biology

Role of the RNA-binding protein La in cancer pathobiology

(2020) Gunhild Sommer et al.   RNA Biology

La proteins couple use of sequence-specific and non-specific binding modes to engage RNA substrates

(2019) Mark A. Bayfield et al.   RNA Biology

Regulation of La/SSB-dependent viral gene expression by pre-tRNA 3′ trailer-derived tRNA fragments

(2019) Hee Cho et al.   NUCLEIC ACIDS RESEARCH

La involvement in tRNA and other RNA processing events including differences among yeast and other eukaryotes

(2018) Nathan H. Blewett et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Human La binds mRNAs through contacts to the poly(A) tail

(2018) Jyotsna Vinayak et al.   NUCLEIC ACIDS RESEARCH

The La and related RNA-binding proteins (LARPs): structures, functions, and evolving perspectives

(2017) Richard J. Maraia et al.   Wiley Interdisciplinary Reviews-RNA

Applying a high-throughput fluorescence polarization assay for the discovery of chemical probes blocking La:RNA interactions in vitro and in cells

(2017) Gunhild Sommer et al.   PLoS One

Distinct Dynamic Modes Enable the Engagement of Dissimilar Ligands in a Promiscuous Atypical RNA Recognition Motif

(2016) Kerene A. Brown et al.   BIOCHEMISTRY

The Lupus Autoantigen La Prevents Mis-channeling of tRNA Fragments into the Human MicroRNA Pathway

(2016) Daniele Hasler et al.   MOLECULAR CELL

SUMO-Modification of the La Protein Facilitates Binding to mRNA In Vitro and in Cells

(2016) Venkatesh Kota et al.   PLoS One

Cellular mRNA recruits the ribosome via eIF3-PABP bridge to initiate internal translation

(2016) Nehal Thakor et al.   RNA Biology

The La protein counteracts cisplatin-induced cell death by stimulating protein synthesis of anti-apoptotic factor Bcl2

(2016) Tilman Heise et al.   Oncotarget

Cap-Independent Translational Control of Carcinogenesis

(2016) Beth Walters et al.   Frontiers in Oncology

eIF3 targets cell-proliferation messenger RNAs for translational activation or repression

(2015) Amy S. Y. Lee et al.   NATURE

The Yeast La Related Protein Slf1p Is a Key Activator of Translation during the Oxidative Stress Response

(2015) Christopher J. Kershaw et al.   PLoS Genetics

Novel RNA chaperone domain of RNA-binding protein La is regulated by AKT phosphorylation

(2014) Julia Kuehnert et al.   NUCLEIC ACIDS RESEARCH

Structure, dynamics and RNA binding of the multi-domain splicing factor TIA-1

(2014) Iren Wang et al.   NUCLEIC ACIDS RESEARCH

Interplay of VEGFa and MMP2 regulates invasion of glioblastoma

(2014) Jie Gong et al.   TUMOR BIOLOGY

The La antigen is over-expressed in lung cancer and is a selective dead cancer cell target for radioimmunotherapy using the La-specific antibody APOMAB®

(2014) Alexander H Staudacher et al.   EJNMMI Research

1H, 15N, 13C assignment and secondary structure determination of two domains of La protein from D. discoideum

(2012) Maria Apostolidi et al.   Biomolecular NMR Assignments

Sjögren Syndrome Antigen B (SSB)/La Promotes Global MicroRNA Expression by Binding MicroRNA Precursors through Stem-Loop Recognition

(2012) Chunyang Liang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

La-motif-dependent mRNA association with Slf1 promotes copper detoxification in yeast

(2012) L. Schenk et al.   RNA

La enhances IRES-mediated translation of laminin B1 during malignant epithelial to mesenchymal transition

(2011) Michaela Petz et al.   NUCLEIC ACIDS RESEARCH

Implication of RNA-Binding Protein La in Proliferation, Migration and Invasion of Lymph Node-Metastasized Hypopharyngeal SCC Cells

(2011) Gunhild Sommer et al.   PLoS One

MDM2 promotes cell motility and invasiveness through a RING-finger independent mechanism

(2010) Radosław Polański et al.   FEBS LETTERS

The RNA-binding protein La contributes to cell proliferation and CCND1 expression

(2010) G Sommer et al.   ONCOGENE

A novel class of small RNAs: tRNA-derived RNA fragments (tRFs)

(2009) Yong Sun Lee et al.   GENES & DEVELOPMENT

SUnSET, a nonradioactive method to monitor protein synthesis

(2009) Enrico K Schmidt et al.   NATURE METHODS

Epigenetic Control of rDNA Loci in Response to Intracellular Energy Status

(2008) Akiko Murayama et al.   CELL

Akt phosphorylation of La regulates specific mRNA translation in glial progenitors

(2008) F Brenet et al.   ONCOGENE

Structural Analysis Reveals Conformational Plasticity in the Recognition of RNA 3′ Ends by the Human La Protein

(2008) Olga Kotik-Kogan et al.   STRUCTURE