EMT and stemness: flexible processes tuned by alternative splicing in development and cancer progression

A dynamic intron retention program in the mammalian megakaryocyte and erythrocyte lineages

(2016) C. R. Edwards et al.   BLOOD

EMT: 2016

(2016) M. Angela Nieto et al.   CELL

Alternative splicing and cell survival: from tissue homeostasis to disease

(2016) Maria Paola Paronetto et al.   CELL DEATH AND DIFFERENTIATION

RNA Splicing Modulation Selectively Impairs Leukemia Stem Cell Maintenance in Secondary Human AML

(2016) Leslie A. Crews et al.   Cell Stem Cell

Muscleblind-like 1 suppresses breast cancer metastatic colonization and stabilizes metastasis suppressor transcripts

(2016) Lisa Fish et al.   GENES & DEVELOPMENT

Large-scale analysis of genome and transcriptome alterations in multiple tumors unveils novel cancer-relevant splicing networks

(2016) Endre Sebestyén et al.   GENOME RESEARCH

ZEB1 drives epithelial-to-mesenchymal transition in lung cancer

(2016) Jill E. Larsen et al.   JOURNAL OF CLINICAL INVESTIGATION

Determination of a Comprehensive Alternative Splicing Regulatory Network and Combinatorial Regulation by Key Factors during the Epithelial-to-Mesenchymal Transition

(2016) Yueqin Yang et al.   MOLECULAR AND CELLULAR BIOLOGY

RBM4 Regulates Neuronal Differentiation of Mesenchymal Stem Cells by Modulating Alternative Splicing of Pyruvate Kinase M

(2016) Chun-Hao Su et al.   MOLECULAR AND CELLULAR BIOLOGY

Regulation of epithelial-mesenchymal transition through epigenetic and post-translational modifications

(2016) Silvia Juliana Serrano-Gomez et al.   Molecular Cancer

Tight junctions: from simple barriers to multifunctional molecular gates

(2016) Ceniz Zihni et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The neurogenetics of alternative splicing

(2016) Celine K. Vuong et al.   NATURE REVIEWS NEUROSCIENCE

Epithelial splicing regulatory protein 1 and 2 paralogues correlate with splice signatures and favorable outcome in human colorectal cancer

(2016) Abigail J. Deloria et al.   Oncotarget

Multiphasic and Dynamic Changes in Alternative Splicing during Induction of Pluripotency Are Coordinated by Numerous RNA-Binding Proteins

(2016) Benjamin Cieply et al.   Cell Reports

RNAi Reveals Phase-Specific Global Regulators of Human Somatic Cell Reprogramming

(2016) Cheng-Xu Delon Toh et al.   Cell Reports

Epithelial-mesenchymal transition and senescence: two cancer-related processes are crossing paths

(2016) Marjon A. Smit et al.   Aging-US

Mechanisms and Regulation of Alternative Pre-mRNA Splicing

(2015) Yeon Lee et al.   Annual Review of Biochemistry

Expression of tumor-related Rac1b antagonizes B-Raf-induced senescence in colorectal cells

(2015) Andreia F.A. Henriques et al.   CANCER LETTERS

Tracking and Functional Characterization of Epithelial-Mesenchymal Transition and Mesenchymal Tumor Cells during Prostate Cancer Metastasis

(2015) M. Ruscetti et al.   CANCER RESEARCH

Rho GTPase signalling in cell migration

(2015) Anne J Ridley   CURRENT OPINION IN CELL BIOLOGY

An overview of the clinical application of antisense oligonucleotides for RNA-targeting therapies

(2015) Graham McClorey et al.   CURRENT OPINION IN PHARMACOLOGY

Snail2/Slug cooperates with Polycomb repressive complex 2 (PRC2) to regulate neural crest development

(2015) C.-L. Tien et al.   DEVELOPMENT

Cadherin Switch during EMT in Neural Crest Cells Leads to Contact Inhibition of Locomotion via Repolarization of Forces

(2015) Elena Scarpa et al.   DEVELOPMENTAL CELL

Myc and SAGA rewire an alternative splicing network during early somatic cell reprogramming

(2015) Calley L. Hirsch et al.   GENES & DEVELOPMENT

SRSF1-Regulated Alternative Splicing in Breast Cancer

(2015) Olga Anczuków et al.   MOLECULAR CELL

Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer

(2015) Xiaofeng Zheng et al.   NATURE

Epithelial-to-mesenchymal transition is not required for lung metastasis but contributes to chemoresistance

(2015) Kari R. Fischer et al.   NATURE

Modulation of PKM alternative splicing by PTBP1 promotes gemcitabine resistance in pancreatic cancer cells

(2015) S Calabretta et al.   ONCOGENE

Aberrant RNA splicing in cancer; expression changes and driver mutations of splicing factor genes

(2015) A Sveen et al.   ONCOGENE

Stemness of the hybrid Epithelial/Mesenchymal State in Breast Cancer and Its Association with Poor Survival

(2015) Anne Grosse-Wilde et al.   PLoS One

Reversion to an embryonic alternative splicing program enhances leukemia stem cell self-renewal

(2015) Frida Holm et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epithelial–Mesenchymal Plasticity: A Central Regulator of Cancer Progression

(2015) Xin Ye et al.   TRENDS IN CELL BIOLOGY

The alternative splicing factor Nova2 regulates vascular development and lumen formation

(2015) Costanza Giampietro et al.   Nature Communications

Functional roles of alternative splicing factors in human disease

(2015) Benjamin Cieply et al.   Wiley Interdisciplinary Reviews-RNA

SAM68: Signal Transduction and RNA Metabolism in Human Cancer

(2015) Paola Frisone et al.   Biomed Research International

The splicing regulators Esrp1 and Esrp2 direct an epithelial splicing program essential for mammalian development

(2015) Thomas W Bebee et al.   eLife

Transcriptome Signature and Regulation in Human Somatic Cell Reprogramming

(2015) Yoshiaki Tanaka et al.   Stem Cell Reports

Spherical Cancer Models in Tumor Biology

(2015) Louis-Bastien Weiswald et al.   NEOPLASIA

Epithelial–Mesenchymal Transitions during Neural Crest and Somite Development

(2015) Chaya Kalcheim   Journal of Clinical Medicine

Implications of the Hybrid Epithelial/Mesenchymal Phenotype in Metastasis

(2015) Mohit Kumar Jolly   Frontiers in Oncology

Genome-wide comparison of the transcriptomes of highly enriched normal and chronic myeloid leukemia stem and progenitor cell populations

(2015) Jonathan M. Gerber et al.   Oncotarget

The Splicing Factor RBM4 Controls Apoptosis, Proliferation, and Migration to Suppress Tumor Progression

(2014) Yang Wang et al.   CANCER CELL

CD44v8-10 Is a Cancer-Specific Marker for Gastric Cancer Stem Cells

(2014) W. M. Lau et al.   CANCER RESEARCH

Circulating Tumor Cell Clusters Are Oligoclonal Precursors of Breast Cancer Metastasis

(2014) Nicola Aceto et al.   CELL

Building Robust Transcriptomes with Master Splicing Factors

(2014) Mohini Jangi et al.   CELL

CD44v6 Is a Marker of Constitutive and Reprogrammed Cancer Stem Cells Driving Colon Cancer Metastasis

(2014) Matilde Todaro et al.   Cell Stem Cell

Epigenetic Regulation of EMT: The Snail Story

(2014) Yiwei Lin et al.   CURRENT PHARMACEUTICAL DESIGN

C to U RNA editing mediated by APOBEC1 requires RNA-binding protein RBM47

(2014) N. Fossat et al.   EMBO REPORTS

Deletion of serine/arginine-rich splicing factor 3 in hepatocytes predisposes to hepatocellular carcinoma in mice

(2014) Supriya Sen et al.   HEPATOLOGY

Epithelial Splicing Regulatory Proteins 1 (ESRP1) and 2 (ESRP2) Suppress Cancer Cell Motility via Different Mechanisms

(2014) Hiroki Ishii et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Extracellular cleavage of E-cadherin promotes epithelial cell extrusion

(2014) Adam G. Grieve et al.   JOURNAL OF CELL SCIENCE

Lineage-specific splicing of a brain-enriched alternative exon promotes glioblastoma progression

(2014) Roberto Ferrarese et al.   JOURNAL OF CLINICAL INVESTIGATION

Rbfox2-Coordinated Alternative Splicing of Mef2d and Rock2 Controls Myoblast Fusion during Myogenesis

(2014) Ravi K. Singh et al.   MOLECULAR CELL

Loss of MBNL Leads to Disruption of Developmentally Regulated Alternative Polyadenylation in RNA-Mediated Disease

(2014) Ranjan Batra et al.   MOLECULAR CELL

Context-dependent control of alternative splicing by RNA-binding proteins

(2014) Xiang-Dong Fu et al.   NATURE REVIEWS GENETICS

Molecular mechanisms of epithelial–mesenchymal transition

(2014) Samy Lamouille et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Phosphorylation of SRSF1 by SRPK1 regulates alternative splicing of tumor-related Rac1b in colorectal cells

(2014) V. Goncalves et al.   RNA

Transcriptional diversity during lineage commitment of human blood progenitors

(2014) L. Chen et al.   SCIENCE

Splicing factor mutations and cancer

(2014) Kenichi Yoshida et al.   Wiley Interdisciplinary Reviews-RNA

Loss of the multifunctional RNA-binding protein RBM47 as a source of selectable metastatic traits in breast cancer

(2014) Sakari Vanharanta et al.   eLife

Crosstalk of Oncogenic Signaling Pathways during Epithelial–Mesenchymal Transition

(2014) Stephan Lindsey et al.   Frontiers in Oncology

Stress-Response Protein RBM3 Attenuates the Stem-like Properties of Prostate Cancer Cells by Interfering with CD44 Variant Splicing

(2013) Yu Zeng et al.   CANCER RESEARCH

Dynamic Integration of Splicing within Gene Regulatory Pathways

(2013) Ulrich Braunschweig et al.   CELL

A Pan-BCL2 Inhibitor Renders Bone-Marrow-Resident Human Leukemia Stem Cells Sensitive to Tyrosine Kinase Inhibition

(2013) Daniel J. Goff et al.   Cell Stem Cell

Posttranscriptional regulation by RNA-binding proteins during epithelial-to-mesenchymal transition

(2013) Luis A. Aparicio et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Tumor-Specific Isoform Switch of the Fibroblast Growth Factor Receptor 2 Underlies the Mesenchymal and Malignant Phenotypes of Clear Cell Renal Cell Carcinomas

(2013) Q. Zhao et al.   CLINICAL CANCER RESEARCH

Three Functions of Cadherins in Cell Adhesion

(2013) Jean-Léon Maître et al.   CURRENT BIOLOGY

Scrib is required for epithelial cell identity and prevents epithelial to mesenchymal transition in the mouse

(2013) Idella F. Yamben et al.   DEVELOPMENTAL BIOLOGY

Setting appropriate boundaries: Fate, patterning and competence at the neural plate border

(2013) Andrew K. Groves et al.   DEVELOPMENTAL BIOLOGY

Triptolide reverses hypoxia-induced epithelial-mesenchymal transition and stem-like features in pancreatic cancer by NF-κB downregulation

(2013) Li Liu et al.   INTERNATIONAL JOURNAL OF CANCER

Sip1 mediates an E-cadherin-to-N-cadherin switch during cranial neural crest EMT

(2013) Crystal D. Rogers et al.   JOURNAL OF CELL BIOLOGY

The tumor microenvironment at a glance

(2013) F. R. Balkwill et al.   JOURNAL OF CELL SCIENCE

p120-catenin and β-catenin differentially regulate cadherin adhesive function

(2013) Rebecca G. Oas et al.   MOLECULAR BIOLOGY OF THE CELL

Genome-wide Analysis Reveals SR Protein Cooperation and Competition in Regulated Splicing

(2013) Shatakshi Pandit et al.   MOLECULAR CELL

MBNL proteins repress ES-cell-specific alternative splicing and reprogramming

(2013) Hong Han et al.   NATURE

SON connects the splicing-regulatory network with pluripotency in human embryonic stem cells

(2013) Xinyi Lu et al.   NATURE CELL BIOLOGY

HnRNP A1 controls a splicing regulatory circuit promoting mesenchymal-to-epithelial transition

(2013) S. Bonomi et al.   NUCLEIC ACIDS RESEARCH

The centrosomal kinase NEK2 is a novel splicing factor kinase involved in cell survival

(2013) C. Naro et al.   NUCLEIC ACIDS RESEARCH

The RNA-binding protein Rbfox2: an essential regulator of EMT-driven alternative splicing and a mediator of cellular invasion

(2013) C Braeutigam et al.   ONCOGENE

Epithelial splicing regulatory protein 1 is a favorable prognostic factor in pancreatic cancer that attenuates pancreatic metastases

(2013) J Ueda et al.   ONCOGENE

The transcriptional co-activator SND1 is a novel regulator of alternative splicing in prostate cancer cells

(2013) M Cappellari et al.   ONCOGENE

Quaking and PTB control overlapping splicing regulatory networks during muscle cell differentiation

(2013) M. P. Hall et al.   RNA

Circulating Breast Tumor Cells Exhibit Dynamic Changes in Epithelial and Mesenchymal Composition

(2013) M. Yu et al.   SCIENCE

Riding the crest of the wave: parallels between the neural crest and cancer in epithelial-to-mesenchymal transition and migration

(2013) Davalyn R. Powell et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

MBNL1 and RBFOX2 cooperate to establish a splicing programme involved in pluripotent stem cell differentiation

(2013) Julian P. Venables et al.   Nature Communications

Global Splicing Pattern Reversion during Somatic Cell Reprogramming

(2013) Sho Ohta et al.   Cell Reports

Matrix metalloproteinase-9 expression correlates with prognosis and involved in ovarian cancer cell invasion

(2012) Xiaoxia Hu et al.   ARCHIVES OF GYNECOLOGY AND OBSTETRICS

Metastatic Colonization Requires the Repression of the Epithelial-Mesenchymal Transition Inducer Prrx1

(2012) Oscar H. Ocaña et al.   CANCER CELL

EMT and Dissemination Precede Pancreatic Tumor Formation

(2012) Andrew D. Rhim et al.   CELL

Cancer Stem Cells: Current Status and Evolving Complexities

(2012) Jane E. Visvader et al.   Cell Stem Cell

Making alternative splicing decisions during epithelial-to-mesenchymal transition (EMT)

(2012) Giuseppe Biamonti et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Epithelial-mesenchymal transitions: insights from development

(2012) J. Lim et al.   DEVELOPMENT

Ptbp2 represses adult-specific splicing to regulate the generation of neuronal precursors in the embryonic brain

(2012) D. D. Licatalosi et al.   GENES & DEVELOPMENT

Coordinated regulation of neuronal mRNA steady-state levels through developmentally controlled intron retention

(2012) K. Yap et al.   GENES & DEVELOPMENT

Early events in cell adhesion and polarity during epithelial-mesenchymal transition

(2012) R. Y.-J. Huang et al.   JOURNAL OF CELL SCIENCE

Epithelial-mesenchymal transition can suppress major attributes of human epithelial tumor-initiating cells

(2012) Toni Celià-Terrassa et al.   JOURNAL OF CLINICAL INVESTIGATION

G9a interacts with Snail and is critical for Snail-mediated E-cadherin repression in human breast cancer

(2012) Chenfang Dong et al.   JOURNAL OF CLINICAL INVESTIGATION

RBFOX2 Is an Important Regulator of Mesenchymal Tissue-Specific Splicing in both Normal and Cancer Tissues

(2012) J. P. Venables et al.   MOLECULAR AND CELLULAR BIOLOGY

Involvement of ZEB1 and E-cadherin in the invasion of lung squamous cell carcinoma

(2012) Jiaxing Zhang et al.   MOLECULAR BIOLOGY REPORTS

The splicing factor SRSF1 regulates apoptosis and proliferation to promote mammary epithelial cell transformation

(2012) Olga Anczuków et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Interaction with Suv39H1 is critical for Snail-mediated E-cadherin repression in breast cancer

(2012) C Dong et al.   ONCOGENE

Dysregulation of Cell Polarity Proteins Synergize with Oncogenes or the Microenvironment to Induce Invasive Behavior in Epithelial Cells

(2012) Samit Chatterjee et al.   PLoS One

Abnormal Expression of the Pre-mRNA Splicing Regulators SRSF1, SRSF2, SRPK1 and SRPK2 in Non Small Cell Lung Carcinoma

(2012) Stephanie Gout et al.   PLoS One

Splicing program of human MENA produces a previously undescribed isoform associated with invasive, mesenchymal-like breast tumors

(2012) F. Di Modugno et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Complex changes in alternative pre-mRNA splicing play a central role in the epithelial-to-mesenchymal transition (EMT)

(2012) Claude C. Warzecha et al.   SEMINARS IN CANCER BIOLOGY

Cancer stem cells and epithelial–mesenchymal transition: Concepts and molecular links

(2012) Christina Scheel et al.   SEMINARS IN CANCER BIOLOGY

Rocking cell metabolism: revised functions of the key glycolytic regulator PKM2 in cancer

(2012) Barbara Chaneton et al.   TRENDS IN BIOCHEMICAL SCIENCES

Epithelial-Mesenchymal Transition: General Principles and Pathological Relevance with Special Emphasis on the Role of Matrix Metalloproteinases

(2012) P. Nistico et al.   Cold Spring Harbor Perspectives in Biology

Oncogenic Splicing Factor SRSF1 Is a Critical Transcriptional Target of MYC

(2012) Shipra Das et al.   Cell Reports

Aberrant Overexpression of the Cell Polarity Module Scribble in Human Cancer

(2011) Valentina Vaira et al.   AMERICAN JOURNAL OF PATHOLOGY

Epithelial to Mesenchymal Transition Is a Determinant of Sensitivity to Chemoradiotherapy in Non-Small Cell Lung Cancer

(2011) Yasushi Shintani et al.   ANNALS OF THORACIC SURGERY

CD44 isoforms are heterogeneously expressed in breast cancer and correlate with tumor subtypes and cancer stem cell markers

(2011) Eleonor Olsson et al.   BMC CANCER

Detection of circulating tumour cells with a hybrid (epithelial/mesenchymal) phenotype in patients with metastatic non-small cell lung cancer

(2011) A Lecharpentier et al.   BRITISH JOURNAL OF CANCER

Splicing Factor hnRNP A2/B1 Regulates Tumor Suppressor Gene Splicing and Is an Oncogenic Driver in Glioblastoma

(2011) R. Golan-Gerstl et al.   CANCER RESEARCH

An Alternative Splicing Switch Regulates Embryonic Stem Cell Pluripotency and Reprogramming

(2011) Mathieu Gabut et al.   CELL

Tumor Metastasis: Molecular Insights and Evolving Paradigms

(2011) Scott Valastyan et al.   CELL

Tracking the intermediate stages of epithelial-mesenchymal transition in epithelial stem cells and cancer

(2011) Nicole Vincent Jordan et al.   CELL CYCLE

Genome-Wide Analysis of Self-Renewal in Drosophila Neural Stem Cells by Transgenic RNAi

(2011) Ralph A. Neumüller et al.   Cell Stem Cell

TGF-β regulates isoform switching of FGF receptors and epithelial-mesenchymal transition

(2011) Takuya Shirakihara et al.   EMBO JOURNAL

The RNA-binding protein Sam68 is a multifunctional player in human cancer

(2011) P. Bielli et al.   ENDOCRINE-RELATED CANCER

Alternative Splicing Produces Nanog Protein Variants with Different Capacities for Self-renewal and Pluripotency in Embryonic Stem Cells

(2011) Satyabrata Das et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dynamics of adherens junctions in epithelial establishment, maintenance, and remodeling

(2011) Buzz Baum et al.   JOURNAL OF CELL BIOLOGY

CD44 splice isoform switching in human and mouse epithelium is essential for epithelial-mesenchymal transition and breast cancer progression

(2011) Rhonda L. Brown et al.   JOURNAL OF CLINICAL INVESTIGATION

Functional consequences of developmentally regulated alternative splicing

(2011) Auinash Kalsotra et al.   NATURE REVIEWS GENETICS

TGF-β drives epithelial-mesenchymal transition through δEF1-mediated downregulation of ESRP

(2011) K Horiguchi et al.   ONCOGENE

PTBP1 Is Required for Embryonic Development before Gastrulation

(2011) Jakob Suckale et al.   PLoS One

An EMT–Driven Alternative Splicing Program Occurs in Human Breast Cancer and Modulates Cellular Phenotype

(2011) Irina M. Shapiro et al.   PLoS Genetics

Evolution of SR protein and hnRNP splicing regulatory factors

(2011) Anke Busch et al.   Wiley Interdisciplinary Reviews-RNA

Epidermal Growth Factor Receptor and Mutant p53 Expand an Esophageal Cellular Subpopulation Capable of Epithelial-to-Mesenchymal Transition through ZEB Transcription Factors

(2010) S. Ohashi et al.   CANCER RESEARCH

hnRNP A2/B1 Modulates Epithelial-Mesenchymal Transition in Lung Cancer Cell Lines

(2010) J. Tauler et al.   CANCER RESEARCH

Dynamic and Static Interactions between p120 Catenin and E-Cadherin Regulate the Stability of Cell-Cell Adhesion

(2010) Noboru Ishiyama et al.   CELL

A Mesenchymal-to-Epithelial Transition Initiates and Is Required for the Nuclear Reprogramming of Mouse Fibroblasts

(2010) Ronghui Li et al.   Cell Stem Cell

Tracing the Derivation of Embryonic Stem Cells from the Inner Cell Mass by Single-Cell RNA-Seq Analysis

(2010) Fuchou Tang et al.   Cell Stem Cell

Epithelial to mesenchymal transition during gastrulation: An embryological view

(2010) Yukiko Nakaya et al.   DEVELOPMENT GROWTH & DIFFERENTIATION

An ESRP-regulated splicing programme is abrogated during the epithelial–mesenchymal transition

(2010) Claude C Warzecha et al.   EMBO JOURNAL

Alternative pre-mRNA splicing regulation in cancer: pathways and programs unhinged

(2010) C. J. David et al.   GENES & DEVELOPMENT

The 19-Amino Acid Insertion in the Tumor-associated Splice Isoform Rac1b Confers Specific Binding to p120 Catenin

(2010) Lidiya Orlichenko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MicroRNAs-10a and -10b Contribute to Retinoic Acid-induced Differentiation of Neuroblastoma Cells and Target the Alternative Splicing Regulatory Factor SFRS1 (SF2/ASF)

(2010) Salvador Meseguer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sam68 regulates EMT through alternative splicing–activated nonsense-mediated mRNA decay of the SF2/ASF proto-oncogene

(2010) Cristina Valacca et al.   JOURNAL OF CELL BIOLOGY

Snail1 suppresses TGF- -induced apoptosis and is sufficient to trigger EMT in hepatocytes

(2010) D. L. Franco et al.   JOURNAL OF CELL SCIENCE

Matrix Metalloproteinase-Induced Epithelial-Mesenchymal Transition in Breast Cancer

(2010) Evette S. Radisky et al.   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

Expansion of the eukaryotic proteome by alternative splicing

(2010) Timothy W. Nilsen et al.   NATURE

Adherens junctions: from molecules to morphogenesis

(2010) Tony J. C. Harris et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Alternative splicing of Tcf7l2 transcripts generates protein variants with differential promoter-binding and transcriptional activation properties at Wnt/β-catenin targets

(2010) Andreas Weise et al.   NUCLEIC ACIDS RESEARCH

Global regulation of alternative splicing during myogenic differentiation

(2010) Christopher S. Bland et al.   NUCLEIC ACIDS RESEARCH

Requirement of the histone demethylase LSD1 in Snai1-mediated transcriptional repression during epithelial-mesenchymal transition

(2010) T Lin et al.   ONCOGENE

Dynamic transcriptomes during neural differentiation of human embryonic stem cells revealed by short, long, and paired-end sequencing

(2010) J. Q. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes

(2010) J. H. Taube et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The epithelial splicing factors ESRP1 and ESRP2 positively and negatively regulate diverse types of alternative splicing events

(2010) Claude C. Warzecha et al.   RNA Biology

Pro-metastatic splicing of Ron proto-oncogene mRNA can be reversed: Therapeutic potential of bifunctional oligonucleotides and indole derivatives

(2010) Claudia Ghigna et al.   RNA Biology

Numb

(2010) Zezhou Wang et al.   Cell Adhesion & Migration

ZEB1 in Pancreatic Cancer

(2010) Ulrich Wellner et al.   Cancers

Epithelial Phenotype Confers Resistance of Ovarian Cancer Cells to Oncolytic Adenoviruses

(2009) R. Strauss et al.   CANCER RESEARCH

Epithelial-Mesenchymal Transitions in Development and Disease

(2009) Jean Paul Thiery et al.   CELL

Numb regulates cell–cell adhesion and polarity in response to tyrosine kinase signalling

(2009) Zezhou Wang et al.   EMBO JOURNAL

Polypyrimidine tract-binding protein is essential for early mouse development and embryonic stem cell proliferation

(2009) Masaki Shibayama et al.   FEBS Journal

Regulation of Vascular Endothelial Growth Factor (VEGF) Splicing from Pro-angiogenic to Anti-angiogenic Isoforms

(2009) Dawid G. Nowak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The basics of epithelial-mesenchymal transition

(2009) Raghu Kalluri et al.   JOURNAL OF CLINICAL INVESTIGATION

ESRP1 and ESRP2 Are Epithelial Cell-Type-Specific Regulators of FGFR2 Splicing

(2009) Claude C. Warzecha et al.   MOLECULAR CELL

HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer

(2009) Charles J. David et al.   NATURE

An RNA code for the FOX2 splicing regulator revealed by mapping RNA-protein interactions in stem cells

(2009) Gene W Yeo et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Glycogen synthase kinase 3  missplicing contributes to leukemia stem cell generation

(2009) A. E. Abrahamsson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Residual breast cancers after conventional therapy display mesenchymal as well as tumor-initiating features

(2009) C. J. Creighton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Snail and Slug Mediate Radioresistance and Chemoresistance by Antagonizing p53-Mediated Apoptosis and Acquiring a Stem-Like Phenotype in Ovarian Cancer Cells

(2009) Nawneet K. Kurrey et al.   STEM CELLS

Remodeling Epithelial Cell Organization: Transitions Between Front-Rear and Apical-Basal Polarity

(2009) W. J. Nelson   Cold Spring Harbor Perspectives in Biology

Induction of EMT by Twist Proteins as a Collateral Effect of Tumor-Promoting Inactivation of Premature Senescence

(2008) Stéphane Ansieau et al.   CANCER CELL

Loss of E-Cadherin Promotes Metastasis via Multiple Downstream Transcriptional Pathways

(2008) T. T. Onder et al.   CANCER RESEARCH

Identification of invasion specific splice variants of the cytoskeletal protein Mena present in mammary tumor cells during invasion in vivo

(2008) Sumanta Goswami et al.   CLINICAL & EXPERIMENTAL METASTASIS

Human Mena+11a Isoform Serves as a Marker of Epithelial Phenotype and Sensitivity to Epidermal Growth Factor Receptor Inhibition in Human Pancreatic Cancer Cell Lines

(2008) M. S. Pino et al.   CLINICAL CANCER RESEARCH

Epithelial-Mesenchymal Transition: At the Crossroads of Development and Tumor Metastasis

(2008) Jing Yang et al.   DEVELOPMENTAL CELL

A p120 Catenin Isoform Switch Affects Rho Activity, Induces Tumor Cell Invasion, and Predicts Metastatic Disease

(2008) Masahiro Yanagisawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cell polarity and cancer - cell and tissue polarity as a non-canonical tumor suppressor

(2008) M. Lee et al.   JOURNAL OF CELL SCIENCE

hnRNP H and hnRNP F Complex with Fox2 To Silence Fibroblast Growth Factor Receptor 2 Exon IIIc

(2008) D. M. Mauger et al.   MOLECULAR AND CELLULAR BIOLOGY

Polycomb Complex 2 Is Required for E-cadherin Repression by the Snail1 Transcription Factor

(2008) N. Herranz et al.   MOLECULAR AND CELLULAR BIOLOGY

Oct4/Sox2-Regulated miR-302 Targets Cyclin D1 in Human Embryonic Stem Cells

(2008) D. A. Greer Card et al.   MOLECULAR AND CELLULAR BIOLOGY

Stromal gene expression predicts clinical outcome in breast cancer

(2008) Greg Finak et al.   NATURE MEDICINE

Stem cell transcriptome profiling via massive-scale mRNA sequencing

(2008) Nicole Cloonan et al.   NATURE METHODS

The multiple lives of NMD factors: balancing roles in gene and genome regulation

(2008) Olaf Isken et al.   NATURE REVIEWS GENETICS

From cells to organs: building polarized tissue

(2008) David M. Bryant et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Transcriptional regulation of cell polarity in EMT and cancer

(2008) G Moreno-Bueno et al.   ONCOGENE

Seeding and Propagation of Untransformed Mouse Mammary Cells in the Lung

(2008) K. Podsypanina et al.   SCIENCE

Involvement of CD44, a molecule with a thousand faces, in cancer dissemination

(2008) David Naor et al.   SEMINARS IN CANCER BIOLOGY

OCT4 Spliced Variants Are Differentially Expressed in Human Pluripotent and Nonpluripotent Cells

(2008) Yaser Atlasi et al.   STEM CELLS

Epithelial–mesenchymal transition and the invasive potential of tumors

(2008) Nancy Gavert et al.   TRENDS IN MOLECULAR MEDICINE